Decreased Na,K-ATPase gene expression in cardiomyopathic hamster hearts.

abstract：:In the normal adult brain, glucose provides 90% of the energy requirement, as well as substrate for nucleic acid and lipid synthesis. We have previously observed that ethanol impairs hexose uptake by rat astrocytes in culture. In the present study, male Sprague-Dawley rats, 200-250 g, were fed liquid diet in which 36%...

journal_title：Life sciences

authors： Singh SP,Srivenugopal KS,Yuan XH,Jiang F,Snyder AK

更新日期：1993-01-01 00:00:00

abstract：:Noradrenaline is taken up in noradrenergic neurones via a desipramine-sensitive transport system (uptake1). There are reports which describe the activity of uptake1 being increased by extracellular ATP and ATP gamma S. This was attributed to a protein kinase-mediated mechanism. We reevaluated this phenomenon since a m...

journal_title：Life sciences

authors： Gliese M,Babin-Ebell J,Schömig E,Russ H

更新日期：1994-01-01 00:00:00

abstract：:The effects of (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin of tea, on Ca(2+)-permeable non-selective cation currents (NSCC) and voltage-operated Ca(2+) channels (VOCC) have been investigated in cultured rat aortic smooth muscle cells using the whole-cell voltage-clamp technique. Under the Cs(+)/t...

journal_title：Life sciences

authors： Campos-Toimil M,Orallo F

更新日期：2007-05-16 00:00:00

abstract：:This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive ...

journal_title：Life sciences

authors： Irvine RJ,White JM,Head RJ

更新日期：1995-02-17 00:00:00

abstract：:The profile of endogenous opioid peptides in the peptide-rich fraction obtained from a homogenate of an ACTH-secreting human pituitary tumor is presented. Gradient RP-HPLC is used to separate the mixture into peptide constituents. A preparation of opioid receptors is used in a radioreceptor assay with ethorphine - a r...

journal_title：Life sciences

authors： Desiderio DM,Cezayirli RC,Fridland G,Robertson JT,Sacks H

更新日期：1985-11-11 00:00:00

abstract：AIM:To investigate the cytotoxic effect of Peruvoside and mechanism of action in human cancers. MAIN METHODS:Cell viability was measured by MTT assay and the cell cycle arrest was identified by FACS. Real-time qPCR and western blotting studies were performed to identify important gene and protein expressions in the di...

journal_title：Life sciences

authors： Reddy D,Kumavath R,Tan TZ,Ampasala DR,Kumar AP

更新日期：2020-01-15 00:00:00

abstract：:Intravenous injection of prostacyclin (100 micrograms/kg) in rats resulted in a decrease of systolic blood pressure within 2 minutes. Concentrations of cAMP in 15 brain regions and nuclei were determined by radioimmunoassay. In lower brain stem nuclei, such as the nucleus of the solitary tract and the lateral reticula...

journal_title：Life sciences

authors： Schmid G,Bahner U,Palkovits M,Geiger H,Heidland A

更新日期：1987-12-07 00:00:00

abstract：:In this study we analyzed the N-formyl-Met-Leu-Phe (fMLP)-induced calcium signal in alveolar macrophages (AM) isolated from ovalbumin-sensitized (OA-sensitized AM) and naive (naive AM) guinea-pigs. Guinea-pigs were sensitized by subcutaneous injection of OA and AM were isolated by bronchoalveolar lavage 6 weeks therea...

journal_title：Life sciences

authors： Failli P,Bindi D,Franceschelli F,Tanini A,Ciuffi M,Mazzetti L,Zilletti L

更新日期：2001-08-24 00:00:00

abstract：:Herba Epimedii is an important medicinal plant which has been used in various traditional Chinese formulations for thousands of years as well as in modern proprietary traditional Chinese medicine products. It has extensive clinical indications, especially for the treatment of sexual dysfunction and osteoporosis. There...

journal_title：Life sciences

authors： Li C,Li Q,Mei Q,Lu T

更新日期：2015-04-01 00:00:00

abstract：:The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible ...

journal_title：Life sciences

authors： Pertwee RG

更新日期：1999-01-01 00:00:00

abstract：:Respiring mitochondria represent the major source of superoxide production in most cells, and superoxide anions function as direct precursors of hydrogen peroxide formation within mitochondria. We use a lucigenen-derived chemiluminescence (LDCL) assay to test the hypothesis that intramitochondrial superoxide productio...

journal_title：Life sciences

authors： Capone G,Kim P,Jovanovich S,Payne L,Freund L,Welch K,Miller E,Trush M

更新日期：2002-05-03 00:00:00

abstract：:Mast cells were originally considered wandering histiocytes, but are now known to derive from the bone marrow and enter the tissues as immature or precursor cells which then differentiate under micro-environmental influences such as interleukin-3. At least three types of mature mast cells have been identified as seros...

journal_title：Life sciences

authors： Theoharides TC

更新日期：1990-01-01 00:00:00

abstract：:Aim Deformity in the cellular homeostatic event associated with cell survival and apoptosis are committing factors for carcinogenesis. Interventions of these events by pharmacologically active agent gain predominance in cancer treatment. In current investigation Solanidine, a steroidal alkaloid was evaluated on tumori...

journal_title：Life sciences

authors： Malojirao VH,Vigneshwaran V,Thirusangu P,Mahmood R,Prabhakar BT

更新日期：2018-04-15 00:00:00

abstract：:Colorectal cancer remains to be the most prevalent malignancy in humans and 1.5 million men and women living in the United States are diagnosed with colorectal cancer, with a predicted 145,600 new cases to be diagnosed in 2019. Curcuminoids and its synthetic analogs are now of interest due to their bioactive attribute...

journal_title：Life sciences

authors： Selvam C,Prabu SL,Jordan BC,Purushothaman Y,Umamaheswari A,Hosseini Zare MS,Thilagavathi R

更新日期：2019-12-15 00:00:00

abstract：:The flavonoid quercetin exhibited a biphasic effect on calcium and phospholipid-dependent protein kinase (protein kinase C) activity from rat brain and pig thyroid. At a low concentration (10(-7) M) quercetin stimulated the enzyme activity whereas at higher concentrations quercetin was inhibitory. By contrast the synt...

journal_title：Life sciences

authors： Picq M,Dubois M,Munari-Silem Y,Prigent AF,Pacheco H

更新日期：1989-01-01 00:00:00

abstract：:The aim of this study was to examine the morphological and functional changes in rabbit mesenteric arterial tissue cultured with fetal bovine serum. In the endothelium-denuded arteries cultured under a serum-free condition for one week (serum-free arteries), morphology of the smooth muscle layer was intact. In the ser...

journal_title：Life sciences

authors： Yamawaki H,Sato K,Hori M,Ozaki H,Nakamura S,Nakayama H,Doi K,Karaki H

更新日期：2000-07-07 00:00:00

abstract：:In the present study the possibility of provoking an irreversible blockade of P2-receptors in vivo by photolyzing ANAPP3 was investigated. ANAPP3 administered as an intraarterial infusion produced a short-lived blockade of P2-receptor mediated contractions of cat urinary bladders in situ. However, irradiation of the b...

journal_title：Life sciences

authors： Theobald RJ Jr,Hoffman V

更新日期：1986-04-28 00:00:00

abstract：:The effect of exogenous ascorbic acid intake on biosynthesis of ascorbic acid in mice has been studied. After the mice were on diets containing added ascorbic acid for two months, the activities of ascorbic acid synthesizing enzymes in the mouse liver homogenates were measured using L-gulono-gamma-lactone as a substra...

journal_title：Life sciences

authors： Tsao CS,Young M

更新日期：1989-01-01 00:00:00

abstract：:Growth of P. aeruginosa, slowed by the addition of monofluoromethylornithine, difluoromethylarginine and dicyclohexylammonium sulfate, could be restored by addition of 0.1 mM putrescine plus 0.1 muM spermidine, or 0.1 mM spermidine or 5 mM putrescine by themselves. Lower concentrations of putrescine (0.1 mM - 1 mM) al...

journal_title：Life sciences

authors： Bitonti AJ,Kelly SE,McCann PP

更新日期：1984-04-16 00:00:00

abstract：AIMS:The study aimed to investigate whether IL-23 is amplified in monocyte subsets of MP pneumonia and to determine its relevant pathway. MATERIALS AND METHODS:We firstly analyze the IL-23p19 expression in monocyte subgroups in MP pneumonia patients and healthy controls subjects by using flow cytometry. Then, we also ...

journal_title：Life sciences

authors： Wang Z,Bao H,Liu Y,Wang Y,Qin J,Yang L

更新日期：2020-10-01 00:00:00

abstract：AIMS:Periodic acceleration (pGz) is a method that applies repetitive sinusoidal head-to-foot motion to the horizontally positioned body. pGz adds pulses to the circulation as a function of frequency, thereby increasing shear stress to the endothelium. Pulsatile shear stress increases release of cardioprotective endothe...

journal_title：Life sciences

authors： Adams JA,Wu H,Bassuk JA,Arias J,Uryash A,Jorapur V,Lamas GA,Kurlansky P

更新日期：2010-05-08 00:00:00

abstract：:Microvascular changes in the brain are significant causes of cerebral edema and ischemia injury. A number of studies suggest that angiotensin (Ang) II may be involved in the initiation and regulation of processes occurring in brain ischemia. We recently reported that Ang II injures brain microvascular endothelial cell...

journal_title：Life sciences

authors： Liu HQ,Wei XB,Sun R,Cai YW,Lou HY,Wang JW,Chen AF,Zhang XM

更新日期：2006-02-16 00:00:00

abstract：:There is a growing literature indicating that opioid abuse by human addicts and opioid administration to animals have profound effects on the immune system. In the present study, implantation of morphine pellets in mice was associated with reduced phenotypic expression of the cell surface antigens specific to T-lympho...

journal_title：Life sciences

authors： Kimes AS,Smith WJ,Winchell CJ,London ED

更新日期：1992-01-01 00:00:00

abstract：:Protein kinase C (PKC)-dependent phosphorylation of endogenous substrates was measured in electrically permeabilised rat islets of Langerhans. The PKC-activating phorbol ester, 4 beta-phorbol myristate acetate (PMA), caused a slow but prolonged increase in insulin secretion from permeabilised islets, which was accompa...

journal_title：Life sciences

authors： Jones PM,Persaud SJ,Howell SL

更新日期：1992-01-01 00:00:00

abstract：:This paper gives a short account of the mechanisms regulating choline production. Although choline is absorbed from the GI tract and biosynthesized in the liver, its subsequent metabolism to choline esters and phospholipids seems to dominate in importance as to its regulatory role in maintaining a constant source of f...

journal_title：Life sciences

authors： Freeman JJ

更新日期：1996-01-01 00:00:00

abstract：:Linear sucrose density gradient centrifugation of a crude synaptosomal-mitochondrial preparation of rat striatum was performed at 82,500g for 7.5, 15 and 30 min and 1, 4 and 20 h. After centrifugation various marker enzyme activities were measured throughout the gradients, viz. tyrosine hydroxylase (TH) and DOPA decar...

journal_title：Life sciences

authors： Van der Krogt JA,Koot-Gronsveld E,Van den Berg CJ

更新日期：1983-08-15 00:00:00

abstract：:Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects ...

journal_title：Life sciences

authors： Rahmani S,Pour Khalili N,Khan F,Hassani S,Ghafour-Boroujerdi E,Abdollahi M

更新日期：2018-12-01 00:00:00

abstract：AIM:Nuclear factor-kappa B inhibitor alpha (IκBα) polymorphisms were found to be associated with inflammatory diseases. However, the association between IκBα polymorphisms with gastric cancer is still unknown. We aim to investigate the association between IκBα polymorphisms and gastric cancer risk in a large population...

journal_title：Life sciences

authors： Wang S,Zhang M,Zeng Z,Tian L,Wu K,Chu J,Fan D,Hu P,Sung JJ,Yu J

更新日期：2011-04-25 00:00:00

abstract：:We contrast the effects of three intermediate electron acceptors (IEAs) on the highly quantitative ESTA bioassay for human growth hormone. This is a microculture tetrazolium assay based upon the in vitro reduction of the tetrazolium salt MTT, by Nb2 cells which have been activated with hGH. Each of the IEAs influenced...

journal_title：Life sciences

authors： Goodwin CJ,Holt SJ,Downes S,Marshall NJ

更新日期：1996-01-01 00:00:00

abstract：AIMS:Multiple sclerosis (MS) whose pathogenesis is still unclear is a chronic progressive disease in the central nervous system. Gut microbiota can directly or indirectly affect the immune system through the brain gut axis to engage in the occurrence and development of the disease. MATERIALS AND METHODS:C57BL/6 mice w...

journal_title：Life sciences

authors： Xu L,Zhang C,He D,Jiang N,Bai Y,Xin Y

更新日期：2020-07-15 00:00:00