Opiate binding sites spectrum on bovine adrenal medullas and six human pheochromocytomas.

abstract：:The effect of 32 mM ascorbate on the time courses of phosphocreatine (PCr), inorganic phosphate (Pi), adenosine triphosphate (ATP) and intracellular pH in rat skeletal muscle during ischemia and reperfusion was investigated in vivo using 31P nuclear magnetic resonance (NMR) spectroscopy. Ascorbate was administered int...

journal_title：Life sciences

authors： Lagerwall K,Daneryd P,Scherstén T,Soussi B

更新日期：1995-01-01 00:00:00

abstract：:Hexokinase and glucose-6-phosphate dehydrogenase activities were studied in brain regions after intraventricular injection of kainic acid. Hexokinase activity was decreased by 10-15% in various regions while glucose-6-phosphate dehydrogenase activity remained unaltered. Soluble hexokinase activity, which remained the ...

journal_title：Life sciences

authors： Leong SF

更新日期：1991-01-01 00:00:00

abstract：:The potential for a drug interaction between cyclosporin A and phenytoin was investigated in rats. Rats were treated daily for 14 days with cyclosporin A (50 mg/Kg, s.c.) and on the day of the experiment phenytoin (10 mg/Kg) was administered intravenously. The mean residence time, the elimination half-life and the vol...

journal_title：Life sciences

authors： Wasfi IA,Tanira MO

更新日期：1993-01-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), a major steroid secreted by the adrenal gland, is known to have antiproliferative effects but the mechanism is unclear. We recently reported that DHEA induces growth inhibition and apoptosis in BV-2 cells and these effects are inversely associated with glucose concentrations in the mediu...

journal_title：Life sciences

authors： Yang NC,Jeng KC,Ho WM,Hu ML

更新日期：2002-03-15 00:00:00

abstract：UNLABELLED:Limited clinical and experimental studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit gastric cancer growth. However, the mechanisms involved are not completely understood and cannot be explained by COX-2 inhibition alone. MAPK signaling pathway is essential for cell proliferation...

journal_title：Life sciences

authors： Husain SS,Szabo IL,Pai R,Soreghan B,Jones MK,Tarnawski AS

更新日期：2001-11-09 00:00:00

abstract：:Cognitive function of rats treated with saline (control), THA (8 mg/kg, i.p.), scopolamine (5 mg/kg, i.p.), or a combination of THA (8 mg/kg) and scopolamine (5 mg/kg) was tested in the Morris water maze. The latency to find the platform in the water maze was used to evaluate performance. THA did not significantly alt...

journal_title：Life sciences

authors： Jackson JJ,Soliman MR

更新日期：1996-01-01 00:00:00

abstract：:The present study analyses the expression and distribution of neuronal nitric oxide synthase (nNOS) in the brainstem of animals pre-treated with Escherichia coli or Helicobacter pylori LPS, at doses that modulate gastric motor function. Systemic administration of H. pylori LPS prevented in a dose-dependent manner (5, ...

journal_title：Life sciences

authors： Quintana E,Hernández C,Moran AP,Esplugues JV,Barrachina MD

更新日期：2005-07-15 00:00:00

abstract：:Vanadate has been suggested as an intracellular regulator of (Na+ + K+)-ATPase. To test this hypothesis we examined the stimulatory and inhibitory effects of vanadate on 86--Rb efflux and influx (measurements of the activity of the Na-pump) in rat ileum under conditions of normal, reduced and increased (Na+ + K+)-ATPa...

journal_title：Life sciences

authors： Hajjar JJ,Rowe WA,Tomicic TK

更新日期：1988-01-01 00:00:00

abstract：:Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site. In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone re...

journal_title：Life sciences

authors： Porreca F,Dray A

更新日期：1984-06-25 00:00:00

abstract：:Short-chain fatty acids (SCFA) are produced by fermentation of water-soluble fiber by anaerobic bacteria in the large bowel. Fiber-rich diets decrease the risk of developing inflammatory bowel disease (IBD) and butyrate enemas are effective as a therapy in some patients. Crohn's disease, one form of IBD, appears to in...

journal_title：Life sciences

authors： Cavaglieri CR,Nishiyama A,Fernandes LC,Curi R,Miles EA,Calder PC

更新日期：2003-08-15 00:00:00

abstract：:The present study was designed to investigate the effects of chronic administration of the alcoholic extract of Terminalia arjuna (TAAE) bark on isoproterenol induced myocardial injury. The TAAE was administered orally to Wistar albino rats (150-200 g) in three different doses, by gastric gavage [3.4 mg/kg: (T1), 6.75...

journal_title：Life sciences

authors： Karthikeyan K,Bai BR,Gauthaman K,Sathish KS,Devaraj SN

更新日期：2003-10-10 00:00:00

abstract：:This study demonstrates the formation of gamma-glutamyl peptides from glutamine and plasma amino acids, as catalyzed by gamma-glutamyl transpeptidase. It also establishes the effect of various amino acids in modulating the rate of glutamine utilization as well as the hydrolytic or transfer product formed. The mechanis...

journal_title：Life sciences

authors： Dass PD

更新日期：1983-10-31 00:00:00

abstract：AIMS:Dyslipidemia-associated diabetic retinopathy is featured by macular edema and retinal angiogenesis. This study investigated the in vitro lipotoxicity of free fatty acids and their modulatory roles in regulation of autophagy and angiogenic factor production in cultured human retinal pigment epithelium (RPE) ARPE-19...

journal_title：Life sciences

authors： Chang YC,Lin CW,Chang YS,Chen PH,Li CY,Wu WC,Kao YH

更新日期：2020-10-15 00:00:00

abstract：AIMS:Endothelin-1 (ET-1) is a mediator of various physiological and pathological processes, including vascular inflammation, cell proliferation and vasoconstriction. Attenuation of ET action using ET-1 antagonists reduces pulmonary vascular leakage and inflammation in several models of lung injuries and experimental ac...

journal_title：Life sciences

authors： Kamiyama J,Jesmin S,Sakuramoto H,Shimojo N,Islam MM,Khatun T,Oki M,Kawano S,Mizutani T

更新日期：2014-11-24 00:00:00

abstract：:The O2 affinity of "stripped" (cofactor-free) hemoglobin (Hb) of the elasmobranch, Squalus acanthias is decreased by ATP, the main erythrocytic phosphate cofactor but increased by urea at physiological concentration. When both compounds are present, as in life, urea decreases the ATP sensitivity, indicating that previ...

journal_title：Life sciences

authors： Weber RE,Wells RM,Tougaard S

更新日期：1983-05-02 00:00:00

abstract：AIMS:Nitric oxide (NO) is synthesized from L-arginine (L-Arg) by three different isoforms of NO synthase (NOS), i.e. the constitutive neuronal and endothelial NOS (nNOS and eNOS) and the inducible NOS (iNOS). NO has been involved in the pathophysiology of epilepsy, but available data are conflicting and the actual role...

journal_title：Life sciences

authors： Prieto-Martín AI,Llorens S,Pardal-Fernández JM,Muñoz LJ,López DE,Escribano J,Nava E,de Cabo C

更新日期：2012-04-09 00:00:00

abstract：AIMS:Alterations in the expression of antioxidant enzymes are associated with changes in cancer cell sensitivity to chemotherapeutic drugs (menadione and β-lapachone). Mechanisms of acquisition of resistance to pro-oxidant drugs were investigated using a model of oxidative stress-resistant MCF-7 breast cancer cells (Re...

journal_title：Life sciences

authors： Glorieux C,Sandoval JM,Dejeans N,Ameye G,Poirel HA,Verrax J,Calderon PB

更新日期：2016-01-15 00:00:00

abstract：:To examine the therapeutic effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) on neuronal ischemia-reperfusion injury, we evaluated the neurological score in gerbils subjected to unilateral common carotid occlusion. Using the neurological score method, we selected animals which showed stroke s...

journal_title：Life sciences

authors： Hata R,Matsumoto M,Kitagawa K,Tagaya M,Matsuyama T,Sugita M,Kamada T

更新日期：1995-01-01 00:00:00

abstract：:Silica (SiO2) nanoparticles (NPs) were synthesized by laser ablation method and were characterized by TEM and DLS techniques. Afterwards, their inhibition activity against carbonic anhydrase (CA) isoforms (CA I and CA II) was explored by experimental and theoretical analysis. Also, the protective effect of SiO2 NPs ag...

journal_title：Life sciences

authors： Xu N,Lu W,Meng L,Feng X,Xuan J,Liu F,Feng Z

更新日期：2021-01-12 00:00:00

abstract：AIMS:Long non-coding RNAs (LncRNAs) play central roles in the formation and development of gastric cancer (GC). The aim of this study was to evaluate the expression of PURPL and NONHSAT062994 and the relationship between their expressions with clinical characteristics in GC. MAIN METHODS:PURPL and NONHSAT062994 LncRNA...

journal_title：Life sciences

authors： Moridi H,Karimi J,Tavilani H,Khodadadi I,Emami Razavi AN

更新日期：2019-11-15 00:00:00

abstract：:Respiratory performance, heart rate and blood pressure were studied in halothane anesthetized rats after administration of taurine and the putative taurine antagonist 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine-1, 1-dioxide hydrochloride (TAG). Intracerebroventricular (i.c.v.) taurine depressed ventilation due to...

journal_title：Life sciences

authors： Wessberg P,Hedner T,Hedner J,Jonason J

更新日期：1983-10-24 00:00:00

abstract：:The effect of thapsigargin, a specific inhibitor of intracellular Ca(2+)-ATPases, on endothelium-dependent relaxation was studied in the guinea pig thoracic aorta. Thapsigargin (1 nM-1 microM) produced a concentration-dependent relaxation of aortic strips precontracted by phenylephrine (0.1 microM) in the presence and...

journal_title：Life sciences

authors： Matsuyama S,Shuntoh H,Katayama S,Tanaka C

更新日期：1993-01-01 00:00:00

abstract：AIMS:To investigate the effects of curcumin on alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease (COPD) and its potential mechanism. MAIN METHODS:The rat COPD model was established by cigarette smoke exposure combined with intratracheal administration of lipopolysaccharide. Thirty-eigh...

journal_title：Life sciences

authors： Zhang M,Xie Y,Yan R,Shan H,Tang J,Cai Y,Yin J,Chen M,Zhang J,Yang X,Zhang Q,Li Y

更新日期：2016-11-01 00:00:00

abstract：:Juncusol, phenolic compound, was isolated from the black needlerush, Juncus roemerianus. Different concentrations of this extract were tested for toxicity against selected species of estuarine fish and grass shrimp. Juncusol was ten times more toxic to the various species of fish than to grass shrimp. At 2.0 ppm conce...

journal_title：Life sciences

authors： de la Cruz AA,Miles DH,Chapatwala KD

更新日期：1982-05-24 00:00:00

abstract：:Aminoalkylindoles (AAIs) are structurally dissimilar from the classical cannabinoids (CCs), however, both AAIs and CCs appear to bind at the same site on the cannabinoid receptor. To obtain better insights on the structural correlation between AAIs and CCs, we have studied the conformational properties of the potent c...

journal_title：Life sciences

authors： Xie XQ,Eissenstat M,Makriyannis A

更新日期：1995-01-01 00:00:00

abstract：:The pure estrogen antagonist ICI-182780, at doses above 50 micrograms/kg, effectively inhibited the initiation of embryo implantation in rats when administered on day 4 of pregnancy (day 1 = sperm positive). The same dose inhibited the implantation initiating effect of intravenous 25 ng of estradiol-17 beta in delayed...

journal_title：Life sciences

authors： Chatterjee S,Johnson DC

更新日期：1993-01-01 00:00:00

abstract：:The putative anxiolytic activity of succinic acid was examined in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that diazepam (1.0, 2.0 and 4.0 mg/kg, PO) or succinic acid (3.0 or 6.0 mg/kg,...

journal_title：Life sciences

authors： Chen SW,Xin Q,Kong WX,Min L,Li JF

更新日期：2003-11-07 00:00:00

abstract：:In some cell systems muscarinic receptor stimulation can induce proliferation or transformation. This phenomenon is subtype-specific (only m1 and m3 receptors are effective) and cell type dependent. In 1321N1 astrocytoma cells activation of m3 receptors stimulates phospholipase C, but does not induce DNA synthesis. In...

journal_title：Life sciences

authors： Brown JH,Sah V,Moskowitz S,Ramirez T,Collins L,Post G,Goldstein D

更新日期：1997-01-01 00:00:00

abstract：:Biliary excretion is the main route of disposal of bilirubin and impaired excretion results in jaundice, a well recognisable symptom of liver disease. Conjugation of bilirubin in the liver is essential for its clearance. The glucuronidation of bilirubin is catalysed by the microsomal UDP-glucuronosyltransferase UGT1A1...

journal_title：Life sciences

authors： Bustamante N,Cantarino MH,Arahuetes RM,Cubero FJ,Ortiz A

更新日期：2006-03-06 00:00:00

abstract：AIMS:Doxorubicin is a widely used anthracycline derivative anticancer drug. Unfortunately, the clinical use of doxorubicin has the serious drawback of cardiotoxicity. In this study, we investigated whether baicalein, a bioflavonoid, can prevent doxorubicin-induced cardiotoxicity in vivo and we delineated the possible u...

journal_title：Life sciences

authors： Sahu BD,Kumar JM,Kuncha M,Borkar RM,Srinivas R,Sistla R

更新日期：2016-01-01 00:00:00