Effects of kainate on glucose metabolising enzymes in the brain.

abstract：:Increase of intracellular reactive oxygen species (ROS) has been proposed to cause endothelial injury, and oxidized LDL (oxLDL) actions are associated with an early increase of ROS. Estrogen protects vascular cells partly via its antioxidant effects and by preventing lipid peroxidation. However, whether it can inhibit...

journal_title：Life sciences

authors： Yen CH,Hsieh CC,Chou SY,Lau YT

更新日期：2001-12-14 00:00:00

abstract：:Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the protective mesenteric hyperemia after intraduodenal acidification. Mechanisms associated the sensory neuropeptides, e.g. calcitonin gene-related peptide (CGRP), substance P, and ruthenium red-sensitive cation channels contribute to acid-induc...

journal_title：Life sciences

authors： Leung FW,Iwata F,Kao J,Seno K,Itoh M,Leung JW

更新日期：2002-10-18 00:00:00

abstract：:Synthetic human pancreatic Growth Hormone-Releasing Factor (hpGRF) elevated the plasma concentration of growth hormone (GH) in young and adult domestic fowl. This in vivo effect of hpGRF appeared to be largely similar for both the 32 amino-acid (hpGRF 1-32) or 40 amino-acid (hpGRF 1-40) polypeptide, although the effec...

journal_title：Life sciences

authors： Scanes CG,Carsia RV,Lauterio TJ,Huybrechts L,Rivier J,Vale W

更新日期：1984-03-19 00:00:00

abstract：:Muscarinic receptors are expressed in smooth muscle throughout the body. In most instances, the muscarinic receptor population in smooth muscle is composed of mainly the M2 and M3 subtypes in an 80% to 20% mixture. The M3 subtype mediates phosphoinositide hydrolysis and calcium mobilization, whereas the M2 subtype med...

journal_title：Life sciences

authors： Ehlert FJ,Ostrom RS,Sawyer GW

更新日期：1997-01-01 00:00:00

abstract：AIM:Myokines are associated with regulation of bone and muscle mass. However, limited information is available regarding the impact of myokines on glucocorticoid (GC) mediated adverse effects on the musculoskeletal system. This study investigates the role of myokine fibroblast growth factor-2 (FGF-2) in regulating GC-i...

journal_title：Life sciences

authors： Adhikary S,Choudhary D,Tripathi AK,Karvande A,Ahmad N,Kothari P,Trivedi R

更新日期：2019-07-15 00:00:00

abstract：AIMS:TRAF6 is an intracellular signal adapter molecule plays a significant role in tumor development. However, the specific mechanism causes and promotes of colorectal cancer keep largely unknown. Therefore, we sought to investigate the roles and the molecular mechanisms of TRAF6 in regulation colorectal cancer. MATER...

journal_title：Life sciences

authors： Zhu G,Cheng Z,Huang Y,Zheng W,Yang S,Lin C,Ye J

更新日期：2019-10-15 00:00:00

abstract：:The nonsteroidal anti-inflammatory drug zomepirac (ZP) is metabolised to a chemically reactive acyl glucuronide conjugate (ZAG) which can form covalent adducts with proteins. In vivo, such adducts could initiate immune or toxic responses. In rats given ZP, the major band detected in liver homogenates by immunoblotting...

journal_title：Life sciences

authors： Wang M,Gorrell MD,McGaughan GW,Dickinson RG

更新日期：2001-01-05 00:00:00

abstract：AIM:Over-expression of histone deacetylase 8 (HDAC8) has been demonstrated in breast cancer. But the underlying molecular mechanism of HDAC8 on the progression of breast cancer remains unknown. MicroRNAs (miRs) are proposed as important molecules in cancer progression by targeting specific oncogenes or tumor-suppressor...

journal_title：Life sciences

authors： Menbari MN,Rahimi K,Ahmadi A,Elyasi A,Darvishi N,Hosseini V,Mohammadi-Yeganeh S,Abdi M

更新日期：2019-11-15 00:00:00

abstract：:Estrogen can enhance or reduce lymphocyte functions in vitro depending on dose and exposure duration. The purpose of this study was to determine the effect of in vivo 17 beta-estradiol (E2) on apoptosis and necrosis in lymphoid tissue of female C567BL/6 mice. Animals were ovariectomized (OVX), ovariectomized and 17 be...

journal_title：Life sciences

authors： Zajchowski S,Hoffman-Goetz L

更新日期：2000-03-03 00:00:00

abstract：:Clonidine, when administered for prolonged period showed no tolerance to its analgesic activity. Prior exposure to clonidine attenuated the tolerance development to morphine-induced analgesia and the supersensitivity to acetylcholine (ACh) in ileum during chronic morphine treatment. Further, acute administration of lo...

journal_title：Life sciences

authors： Ramaswamy S,Pillai NP,Gopalakrishnan V,Ghosh MN

更新日期：1983-09-19 00:00:00

abstract：:Almost all diabetic complications are known to be associated with vascular dysfunctions of different tissues. Oxidative stress, on the other hand, has been implicated in the pathogenesis of diabetes mellitus. Therefore in the present study we have investigated the correlation between redox status and oxidative stress ...

journal_title：Life sciences

authors： Yue KK,Chung WS,Leung AW,Cheng CH

更新日期：2003-10-03 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are integral membrane proteins that, in response to activation by extracellular stimuli, regulate intracellular second messenger levels via their coupling to heterotrimeric G proteins. GPCR activation also initiates a series of molecular events that leads to G protein-coupled recept...

journal_title：Life sciences

authors： Seachrist JL,Ferguson SS

更新日期：2003-12-05 00:00:00

abstract：:Neem seed preparations contain not only azadirachtin as the active insect antifeedant or growth regulator but also a variety of their limonoids, some of which are cytotoxic to N1E-115 neuroblastoma (mouse), 143B.TK- osteosarcoma (human) and Sf9 (insect) cultured cell lines. The most potent of these limonoids is nimbol...

journal_title：Life sciences

authors： Cohen E,Quistad GB,Casida JE

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Most hepatocellular carcinoma cases are diagnosed at late stages of the disease, which makes it the second cause of cancer mortality worldwide. For advanced-stage patients, chemotherapeutic drugs are the best treatment option; however, their adverse effects and high cost are still major obstacles for effecti...

journal_title：Life sciences

authors： Mahmoud YI,Shehata AMM,Fares NH,Mahmoud AA

更新日期：2021-01-15 00:00:00

abstract：:The complexes of the type [PtCl(L2)(ACRAMTU)](NO3)2 (ACRAMTU = 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea) were synthesized: PT-ACRAMTU (1), L2 = ethane-1,2-diamine (en); PT(dach)-ACRAMTU (2), L2 = (1R,2R)-1,2-diaminocyclohexane (dach); PT(pda-OH)-ACRAMTU (3), L2 = 2-hydroxy-1,3-propanediamine (pda-OH). The c...

journal_title：Life sciences

authors： Zhou Q,You C,Ling Y,Wu H,Sun B

更新日期：2019-01-15 00:00:00

abstract：:Aim Deformity in the cellular homeostatic event associated with cell survival and apoptosis are committing factors for carcinogenesis. Interventions of these events by pharmacologically active agent gain predominance in cancer treatment. In current investigation Solanidine, a steroidal alkaloid was evaluated on tumori...

journal_title：Life sciences

authors： Malojirao VH,Vigneshwaran V,Thirusangu P,Mahmood R,Prabhakar BT

更新日期：2018-04-15 00:00:00

abstract：AIMS:Azelnidipine, a third-generation dihydropyridine calcium channel blocker (DHP CCB), has a characteristic hypotensive effect that persists even after it has disappeared from the plasma, which is thought to be due to its high hydrophobicity. However, because azelnidipine is unique, it might have other unknown effect...

journal_title：Life sciences

authors： Nasu F,Obara Y,Okamoto Y,Yamaguchi H,Kurakami K,Norota I,Ishii K

更新日期：2021-01-13 00:00:00

abstract：:The aim of this study was to examine the distribution of dopamine and norepinephrine in the proximal alimentary tract of the rat and to assess the contributions of sympathetic and vagal fibers to the tissue concentrations of both catecholamines. Tissues were extracted in perchloric acid and the catecholamines were sep...

journal_title：Life sciences

authors： Orloff LA,Orloff MS,Bunnett NW,Walsh JH

更新日期：1985-04-29 00:00:00

abstract：:Twice daily injection of caffeine (30 mg/kg) for 3-1/2 days shifted the caffeine stimulus generalization curve to the right by 3-fold in rats trained to discriminate saline from 30 mg/kg of caffeine, and by 4-fold in rats trained to discriminate saline from 10 mg/kg of caffeine. The latter group was also tested for cr...

journal_title：Life sciences

authors： Holtzman SG

更新日期：1987-01-26 00:00:00

abstract：AIM:Renin-angiotensin system has a role in inflammation and also involves in learning and memory. In the present study, the effects of captopril on lipopolysaccharide (LPS) induced learning and memory impairments, hippocampal cytokine levels and brain tissues oxidative damage was investigated. MATERIALS AND METHODS:Th...

journal_title：Life sciences

authors： Abareshi A,Hosseini M,Beheshti F,Norouzi F,Khazaei M,Sadeghnia HR,Boskabady MH,Shafei MN,Anaeigoudari A

更新日期：2016-12-15 00:00:00

abstract：:In situ radioligand binding and quantitative autoradiography have been used to measure the density of striatal D1-like, D2-like, and GABAA receptors in rats treated with haloperidol at 0.01 or 0.1 mg/kg/ day or chlorpromazine, olanzapine or clozapine at 0.1 or 1.0 mg/kg/day for 1, 3 or 7 months. [3H]SCH23390 binding t...

journal_title：Life sciences

authors： Dean B,Hussain T,Scarr E,Pavey G,Copolov DL

更新日期：2001-08-03 00:00:00

abstract：:The bone marrow is home to mesenchymal stem cells (MSCs) that are able to differentiate into many different cell types. The effect of hyperbaric oxygen (HBO) on MSCs is poorly understood. Placental growth factor (PlGF) is an attractive therapeutic agent for stimulating revascularization of ischemic tissue. HBO has bee...

journal_title：Life sciences

authors： Shyu KG,Hung HF,Wang BW,Chang H

更新日期：2008-07-04 00:00:00

abstract：:Studies were performed in conscious, chronically catheterized male Sprague-Dawley rats to investigate the effect of administered atrial natriuretic peptide (ANP) on blood pressure, renal hemodynamics and urinary electrolyte excretion. Studies were performed on young adult (3-4 month old) rats and on aging rats (18-24 ...

journal_title：Life sciences

authors： DePriest D,Zimmermann C,Baylis C

更新日期：1990-01-01 00:00:00

abstract：:The central interference induced by dexamethasone and RU-38486, (a glucocorticoid receptor antagonist) on morphine antinociception were studied by using the tail flick test in mice. Dexamethasone, injected intracerebrally (i.c.v.) 10 minutes before morphine, dose-dependently reduced morphine antinociception, whereas R...

journal_title：Life sciences

authors： Capasso A,Di Giannuario A,Loizzo A,Pieretti S,Sorrentino L

更新日期：1992-01-01 00:00:00

abstract：:We investigated the mechanism underlying the priming effect of TNF-alpha on fMLP-stimulated superoxide production in human neutrophils. TNF-alpha enhanced fMLP-stimulated superoxide production in a concentration-dependent manner. TNF-alpha also induced sphingomyelin (SM) hydrolysis and increased the formation of its m...

journal_title：Life sciences

authors： Niwa M,Kozawa O,Matsuno H,Kanamori Y,Hara A,Uematsu T

更新日期：2000-01-01 00:00:00

abstract：AIMS:Dysfunction of the Hippo-Yes-Associated Protein (YAP) signaling pathway is known to be associated with hepatocellular carcinoma (HCC). Evodiamine (Evo), a plant-derived bioactive alkaloid, exerts inhibitory effects on cancer. However, the precise influence of Evo on HCC and its potential effects on Hippo-YAP signa...

journal_title：Life sciences

authors： Zhao S,Xu K,Jiang R,Li DY,Guo XX,Zhou P,Tang JF,Li LS,Zeng D,Hu L,Ran JH,Li J,Chen DL

更新日期：2020-06-15 00:00:00

abstract：:Uric acid values in serum have been analyzed as one of the markers to predict cellular damage due to ischemia reperfusion injury in the field of organ transplantation. The present study was conducted to confirm that uric acid values in serum could be an efficient marker of ischemic injury of liver parenchyma following...

journal_title：Life sciences

authors： Kogure K,Ishizaki M,Nemoto M,Kuwano H,Tatemoto K,Maruyama Y,Ikarashi Y,Makuuchi M

更新日期：1999-01-01 00:00:00

abstract：:This study assessed the effects of acute intravenous L-tryptophan (neutral amino acid precursor for serotonin) administration on cocaine-induced dopaminergic responses. Male Sprague-Dawley rats were surgically implanted with guide cannulas in the nucleus accumbens 5 days prior to the study and with vascular catheters ...

journal_title：Life sciences

authors： Molina PE,Ahmed N,Gatley J,Volkow ND,Abumrad NN

更新日期：2001-09-07 00:00:00

abstract：:DL-alpha-difluoromethylornithine (DFMO), 4-deoxypyridoxine (4-DOP), and methylglyoxal bis (guanylhydrazone) (MGBG) were tested as inhibitors of acute skin graft rejection. Proximal full thickness tail skins were exchanged between C57BL/6 and Balb/C mice. Distal autografts were placed to monitor healing. Inhibitors wer...

journal_title：Life sciences

authors： Campbell RA,Kurtz GL,Norton-Reel DJ

更新日期：1991-01-01 00:00:00

abstract：:In view of the toxicity of cocaine and recent reports on the antimuscarinic properties of cocaine, the present study evaluated the effects of manipulations in cholinergic neurotransmission on the lethal effects of cocaine. Physostigmine pretreatment significantly altered the lethality of cocaine, increasing the LD 50 ...

journal_title：Life sciences

authors： Witkin JM,Goldberg SR,Katz JL,Kuhar MJ

更新日期：1989-01-01 00:00:00