Abstract:
BACKGROUND:Most hepatocellular carcinoma cases are diagnosed at late stages of the disease, which makes it the second cause of cancer mortality worldwide. For advanced-stage patients, chemotherapeutic drugs are the best treatment option; however, their adverse effects and high cost are still major obstacles for effective treatment. Spirulina microalga is a rich source of nutritional and bioactive elements and potential pharmaceuticals, which has an -proliferative effect against several cancer cell lines. It also has a prophylactic effect against the early stages of some cancer models, including hepatocellular carcinoma. AIMS:The present study was carried out to evaluate the therapeutic anticarcinogenic effect of spirulina against advanced murine hepatocellular carcinoma. MAIN METHODS:Hepatocarcinoma was induced by a single injection of diethylnitrosamine (100 mg/kg, intraperitoneally) followed by 22 weekly injections of carbon-tetrachloride (0.5 mg/kg, i.p). Spirulina (250 and 500 mg/kg bw) was given orally, from week 25 to 28, after the establishment of hepatocellular carcinoma. KEY FINDINGS:Spirulina inhibited HCC structural and functional alterations, manifested by improving the survival rate, significantly decreasing the tumor marker AFP, and the count and size of the hepatic nodules, as well as downstaging HCC. This was accompanied with the augmentation of the endogenous antioxidant capacity, apoptosis (Bax) and the tumor suppressor protein (p53), as well as the suppression of tissue levels of the lipid peroxidation marker (MDA) and neoangiogenesis marker (VEGF). SIGNIFICANCE:In conclusion, spirulina has an anticarcinogenic effect against advanced hepatocellular carcinoma exerted through activating the tumor suppressor protein p53 and apoptosis, and suppressing oxidative stress and angiogenesis.
journal_name
Life Scijournal_title
Life sciencesauthors
Mahmoud YI,Shehata AMM,Fares NH,Mahmoud AAdoi
10.1016/j.lfs.2020.118827subject
Has Abstractpub_date
2021-01-15 00:00:00pages
118827eissn
0024-3205issn
1879-0631pii
S0024-3205(20)31580-0journal_volume
265pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Contractile responses to norepinephrine (NE), and the population of beta-adrenoceptors, were determined in gastric fundus smooth muscle from rats with diabetes induced by streptozotocin (STZ), and age-matched controls. Relaxation and/or contraction of fundus strips of controls and diabetics were induced by 10(-5)M NE....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90505-6
更新日期:1991-01-01 00:00:00
abstract::Vascular smooth muscle cell (VSMC) accumulation and endothelial cell dysfunction are associated with pathogenesis of atherosclerosis. Long noncoding RNA taurine up-regulated gene 1 (TUG1) has been reported to play an important role in cardiovascular diseases, including atherosclerosis. However, the regulatory mechanis...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117287
更新日期:2020-02-15 00:00:00
abstract::The vascular endothelium is recognized as a barrier between blood and blood vessel wall. The abnormality of vascular endothelium is critical for atherosclerosis, hypertension and diabetes. Oxidative stress, inflammation, obesity, hyperlipidemia and insulin resistance are major contributors to endothelial dysfunction i...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2016.11.005
更新日期:2016-12-15 00:00:00
abstract::We report that both Na+ and Ca2+ currents are involved in the action potentials and in the hormone release from rat somatotrophs in primary culture. Single somatotrophs were identified by reverse hemolytic plaque assay (RHPA) and transmembrane voltage and currents were recorded using the whole-cell mode of the patch-c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90021-i
更新日期:1990-01-01 00:00:00
abstract:AIMS:Extensive evidence supports a role for voltage-gated calcium channels (VGCC) and TRPV1 receptors in pain transmission and modulation. We investigated the profile of analgesic interaction between Phα1β toxin (a VGCC blocker) and SB366791 (selective TRPV1 antagonist) in a model of acute pain induced by capsaicin. Ch...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.06.018
更新日期:2017-08-01 00:00:00
abstract::Progressive lysis of bone in loose total hip replacement has been ascribed to the capacity of the synovial-like membrane present at the bone interface to produce prostaglandin E2 and cytokines such as tumor necrosis factor (TNF alpha). Phospholipase A2 (PLA2) produces rate limiting precursor i.e. arachidonic acid in t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00342-6
更新日期:1996-01-01 00:00:00
abstract::Vitamin E treatment was found to lower blood pressure, and increase membrane fluidity in rats. The objectives of this study were to investigate the effects of the antioxidant, vitamin E, on the blood pressure and erythrocyte membrane fluidity in spontaneously hypertensive (SHR) and normotensive (WKY) rats. Membrane fl...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00775-x
更新日期:2000-09-01 00:00:00
abstract:AIMS:The aims of the present study were to investigate the effect of crebanine on memory and cognition impairment in mice and to elucidate the underlying molecular mechanisms. MAIN METHODS:The memory-enhancing effects of crebanine were assessed with a water maze test using scopolamine-induced amnesic mice. The molecul...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.06.017
更新日期:2012-08-21 00:00:00
abstract:AIMS:To explore the role of chemokine CC motif ligand 2 (CCL2) in spatial memory and cognition impairment, and the underlying mechanisms focused on inflammatory, glutamate metabolistic and apoptotic- associated mRNA expression. MATERIALS AND METHODS:Stereotaxic surgery was performed here to establish a rat model by bi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117828
更新日期:2020-08-15 00:00:00
abstract:AIMS:The aim of this study is to investigate the expression and cytoprotective function of a 72-kDa heat shock protein (HSP72) using a reflux esophagitis model in rats. MAIN METHODS:Expression of HSP60, HSP72, and HSP90 in rat esophageal mucosa was evaluated by Western blot analysis before and after hyperthermia (42.5...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2009.01.016
更新日期:2009-04-10 00:00:00
abstract::Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). The inflammatory response, impaired a...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.118641
更新日期:2021-01-01 00:00:00
abstract::The effect of 32 mM ascorbate on the time courses of phosphocreatine (PCr), inorganic phosphate (Pi), adenosine triphosphate (ATP) and intracellular pH in rat skeletal muscle during ischemia and reperfusion was investigated in vivo using 31P nuclear magnetic resonance (NMR) spectroscopy. Ascorbate was administered int...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00904-x
更新日期:1995-01-01 00:00:00
abstract::The purpose of this study was to explore the feasibility of utilizing the granatanol: N-methyl [9-azabicyclo (3.3.1) nonane] 3-alpha-ol as the terminal group in a series of new bisquaternary azabicycyclic diester-type neuromuscular blocking agents. Fifty two bisquaternary ammonium derivatives of several dicarboxylic a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.01.038
更新日期:2006-07-04 00:00:00
abstract::Aging exerts profound influences on the function of the hypothalamic-pituitary-testicular-axis. This work has been performed in order to verify whether, in male rats, the decreased secretion of LH and testosterone (T) occurring in old animals is reflected by modifications of luteinizing hormone-releasing hormone (LHRH...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90643-1
更新日期:1988-01-01 00:00:00
abstract::The influence of different neuropeptides related to pro-opiomelanocortin were tested on acquisition of heroin self-administration in rats. The animals were allowed to self-administer heroin intravenously on a continuous reinforcement schedule during 6 h daily sessions on 5 consecutive days. Treatment was performed sub...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90261-8
更新日期:1983-12-05 00:00:00
abstract:AIMS:Intestinal alkaline phosphatase (IAP) is an intestinal brush border enzyme that is shown to function as a gut mucosal defense factor, but its defensive mechanism remains unclear. The aims of this study were to evaluate the effect of IAP on intestinal epithelial cells and macrophages, and on chronic colitis in inte...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.02.003
更新日期:2014-04-01 00:00:00
abstract::We investigated the mechanism underlying the priming effect of TNF-alpha on fMLP-stimulated superoxide production in human neutrophils. TNF-alpha enhanced fMLP-stimulated superoxide production in a concentration-dependent manner. TNF-alpha also induced sphingomyelin (SM) hydrolysis and increased the formation of its m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00587-1
更新日期:2000-01-01 00:00:00
abstract::In experienced marijuana smokers, marijuana smoking was accompanied by a significant bilateral increase in cerebral blood flow (CBF) especially in the frontal regions and cerebral blood velocity. The post-marijuana CBF increase could not be explained on the basis on changes in general circulation or respiration. Simil...
journal_title:Life sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0024-3205(93)90239-y
更新日期:1993-01-01 00:00:00
abstract:AIMS:Induction of heme oxygenase-1 (HO-1) has been widely accepted to be neuro-protective. This study aimed to examine whether hemin (a HO-1 inducer) attenuates neuronal damage in the hippocampus induced by orthotopic autologous liver transplantation (OALT) in adult rats. MAIN METHODS:Rats were randomly allocated into...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.05.021
更新日期:2015-08-15 00:00:00
abstract::The involvement of atriopeptin in hypertension was investigated in spontaneously hypertensive rats (SHR). It was found that intravenous injection of atriopeptin III (20-80 nmol/kg) markedly decreased the mean arterial pressure in anesthetized SHR in a dose dependent manner. The heart rate was not significantly affecte...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90238-9
更新日期:1986-03-17 00:00:00
abstract::We compared the relative abilities of atropine sulfate and methylatropine, injected i.v. and into the cerebral ventricles (icv), to block pharmacological responses mediated through central and peripheral muscarinic receptors. The hypotensive response to i.v. injection of acetylcholine (peripheral muscarinic receptors)...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90389-x
更新日期:1988-01-01 00:00:00
abstract::Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val, melanin concentrating hormone (MCH), is a cyclic hormone possessing both MCH-like (melanin granule aggregating effect) and melanocyte stimulating hormone (MSH)-like (melanin granule dispersing effect) activities. Nine ring-contracted analogues were s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90460-8
更新日期:1989-01-01 00:00:00
abstract::This review aims to systematically review and synthesize scientific evidence for the influence of air pollution exposure and outdoor exercise on health. We conducted a literature search in the PubMed, Cochrane, EMBASE, and Web of Science for articles that evaluated the combination effect of air pollution exposure and ...
journal_title:Life sciences
pub_type: 杂志文章,meta分析
doi:10.1016/j.lfs.2018.12.036
更新日期:2019-02-01 00:00:00
abstract:AIMS:The roles of miR-141 in various types of cancers and inflammatory bowel diseases are researched, whereas, little information about its function in lung inflammation is available. This study was designed to explore the effect of miR-141 on inflammation injury in WI-38 cells, possibly providing basis for targeted th...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.11.056
更新日期:2019-01-01 00:00:00
abstract::Progesterone's (P) actions in the ventral medial hypothalamus (VMH) and the ventral tegmental area (VTA) are essential for sexual receptivity in hamsters. This study investigates the notion that P works in the VTA in the absence of intracellular P receptors (PRs) by 5 alpha-reduction to progestins, which would subsequ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00548-6
更新日期:1994-01-01 00:00:00
abstract::The metabolism of phosphoinositides plays an important role in the signal transduction pathways. We report here that naturally occurring polyamines affect the activities of phosphatidylinositol (PI) 3-kinase and PI 4-phosphate (PIP) 5-kinase differently. While polyamines inhibited the PI 3-kinase activity, they stimul...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00320-6
更新日期:1995-01-01 00:00:00
abstract::The immunosuppressant cyclosporin A (CsA) has been shown to have neuroprotective action. The inhibition of both calcineurin activation and mitochondrial permeability transition pore (mtPTP) opening are considered the primary neuroprotective mechanisms of CsA. Here we have evaluated the effect of CsA on significantly r...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02267-1
更新日期:2002-12-20 00:00:00
abstract::Histidine-rich glycoprotein (HRG) is a serum protein with possible pluripotent activities. In this study, a method for the quantification of rabbit histidine-rich glycoprotein (rHRG) was developed based upon the high affinity binding profile of rHRG to nickel-nitrilotriacetic acid (Ni-NTA), an improved chelation agent...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00261-3
更新日期:2003-05-23 00:00:00
abstract::The metabolism of haloperidol (HP) to the potentially neurotoxic pyridinium species, HPP+ and RHPP+, has been demonstrated in humans. In vitro studies in microsomes harvested from various animal species indicate that the tetrahydropyridines, HPTP and RHPTP, could be intermediates in this pathway. However, this has not...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00955-7
更新日期:1997-01-01 00:00:00
abstract::Several neuronal cell lines were screened for endogenous expression of neuronal nitric oxide synthase (nNOS) protein using Western blot analysis. Detectable levels of the nNOS protein were evident in the SK-N-SH, SH-SY5Y, and N1E-115 neuroblastoma cell lines, as well as the NG108-15 neuroblastoma x glioma hybrid. Only...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01732-0
更新日期:2002-07-05 00:00:00