Modulation of the lethal effects of cocaine by cholinomimetics.

abstract：AIMS:Benzodiazepines (BZDs) produce various pharmacological actions by binding to and allosterically regulating GABAA receptors. Several in vitro studies have demonstrated diazepam, the prototypic BZD, produces a high-dose action that cannot be countered with the classical BZD-binding site antagonist flumazenil. Here, ...

journal_title：Life sciences

authors： Cao Y,Yan H,Yu G,Su R

更新日期：2019-12-15 00:00:00

abstract：:Two types of plasma membranes isolated from rat brain cortex were used to study the membrane-perturbing properties of ethanol. Rats administered ethanol in the form of a liquid diet showed an increase in levels of phosphatidylserines, phosphatidylinositols and phosphatidic acids as compared to controls. The results pr...

journal_title：Life sciences

authors： Sun GY,Huang HM,Lee DZ,Sun AY

更新日期：1984-11-19 00:00:00

abstract：AIM:Myocardial infarction (MI), an important cause of morbidity and mortality, can be followed by left ventricular dysfunction and cardiomyocyte loss. Cardiac repair mechanisms may subsequently improve left ventricular function. Exercise training has been suggested to have cardioprotective effects against MI damage, bu...

journal_title：Life sciences

authors： Naderi N,Hemmatinafar M,Gaeini AA,Bahramian A,Ghardashi-Afousi A,Kordi MR,Darbandi-Azar A,Karimzade F,Mohebbi H,Barati M

更新日期：2019-03-15 00:00:00

abstract：:Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...

journal_title：Life sciences

authors： Bastaki S,Aravindhan S,Ahmadpour Saheb N,Afsari Kashani M,Evgenievich Dorofeev A,Karoon Kiani F,Jahandideh H,Beigi Dargani F,Aksoun M,Nikkhoo A,Masjedi A,Mahmoodpoor A,Ahmadi M,Dolati S,Namvar Aghdash S,Jadidi-Niaragh F

更新日期：2021-02-01 00:00:00

abstract：AIMS:TRAF6 is an intracellular signal adapter molecule plays a significant role in tumor development. However, the specific mechanism causes and promotes of colorectal cancer keep largely unknown. Therefore, we sought to investigate the roles and the molecular mechanisms of TRAF6 in regulation colorectal cancer. MATER...

journal_title：Life sciences

authors： Zhu G,Cheng Z,Huang Y,Zheng W,Yang S,Lin C,Ye J

更新日期：2019-10-15 00:00:00

abstract：:The potential photoaffinity ligand 14-beta-(o-nitro, p-azido)-cinnamoyl-amino-N-cyclopropylmethylnormorphinone (NAM) and its derivative NOM, lacking the p-azido function, were synthesised and their opiate receptor activity determined in isolated tissue preparations. The ligands showed slow receptor kinetics. NAM was a...

journal_title：Life sciences

authors： Peers EM,Rance MJ,Barnard EA,Haynes AS,Smith CF

更新日期：1983-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of cyclosporin (CyA) treatment on biliary glutathione efflux in rats of different ages (1, 2, 4, and 24 months). CyA treatment reduced the liver content of total glutathione in 1-, 2- and 24 month old rats (-30%, -43% and -30%, respectively). By contrast, oxidized g...

journal_title：Life sciences

authors： Palomero J,Galán AI,Muñoz ME,Tuñón MJ,González-Gallego J,Jiménez R

更新日期：2003-11-14 00:00:00

abstract：:Involvement of T-type voltage dependent Ca2+ channels (VDCCs) on morphine antinociception, in the development of tolerance and dependence to morphine, and naloxone-precipitated abstinence syndrome in morphine dependent mice was examined by using mibefradil, a T-type VDCCs blocker. Mice were rendered tolerant and depen...

journal_title：Life sciences

authors： Dogrul A,Zagli U,Tulunay FC

更新日期：2002-06-28 00:00:00

abstract：AIMS:The natural phenolic oil compound hydroxytyrosol (HTy) is widely studied because of its antioxidant and neuroprotective properties. Nitroderivatives of HTy have been studied in order to evaluate their putative effects on catechol-O-methyltransferase (COMT) activity. MAIN METHODS:To study its effect on dopamine me...

journal_title：Life sciences

authors： Gallardo E,Madrona A,Palma-Valdés R,Espartero JL,Santiago M

更新日期：2015-08-01 00:00:00

abstract：AIMS:Dietary habits are crucial factors affecting metabolic homeostasis. However, few animal experiments have addressed the effects of long-term feeding with soft food on parameters reflecting systemic health. MAIN METHODS:Using mice, we compared the effects of short (3 days) and long (17 weeks from weaning) feeding p...

journal_title：Life sciences

authors： Tsuchiya M,Niijima-Yaoita F,Yoneda H,Chiba K,Tsuchiya S,Hagiwara Y,Sasaki K,Sugawara S,Endo Y,Tan-No K,Watanabe M

更新日期：2014-05-08 00:00:00

abstract：:The traditional Chinese medicines have been used clinically for a long time in some Asian countries, however, very few studies have been done to demonstrate the working mechanisms of these medicines using recently developed biochemical methodologies. In this study, we examined the anti-inflammatory effect of Huang-Lia...

journal_title：Life sciences

authors： Dai Y,Miki K,Fukuoka T,Tokunaga A,Tachibana T,Kondo E,Noguchi K

更新日期：2000-01-01 00:00:00

abstract：:In 6-[18F]fluoro-L-dopa (Fdopa)/positron emission tomography (PET) studies, carbidopa pretreatment increases the Fdopa bioavailability to the brain and enhances the intensity of striatal PET images. Different PET research teams have used various carbidopa doses and routes of administration in non-human primate studies...

journal_title：Life sciences

authors： Chan GL,Doudet DJ,Dobko T,Hewitt KA,Schofield P,Pate BD,Ruth TJ

更新日期：1995-01-01 00:00:00

abstract：:The alpha 1-adrenoceptors present in liver membranes from rats, hamsters and mice were characterized using [3H]prazosin. In the liver membranes from the three species a relatively large number of receptors was observed (500-900 fmol/mg of protein) and the affinities for [3H]prazosin were very similar (0.2-0.3 nM). Mem...

journal_title：Life sciences

authors： García-Sáinz JA,Casas-González P,Romero-Avila MT,González-Espinosa C

更新日期：1994-01-01 00:00:00

abstract：:Plants are potentially important for novel therapeutic drug leads, but the slowness of conventional methods for investigation of plants limits enthusiasm in the pharmaceutical industry. To overcome some of the drawbacks, we have applied high throughput pharmacological screening (HTPS) to crude plant extracts. Using a ...

journal_title：Life sciences

authors： Littleton J,Rogers T,Falcone D

更新日期：2005-12-22 00:00:00

abstract：AIMS:Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and has been reported as having a wide range of activities that are potentially beneficial for human health. This study aimed to investigate the effects of pretreatment of vitamin D3 (100, 1000, and 10,000 IU/kg) against lipopolysacchar...

journal_title：Life sciences

authors： Mokhtari-Zaer A,Hosseini M,Salmani H,Arab Z,Zareian P

更新日期：2020-07-15 00:00:00

abstract：AIMS:Hypercholesterolemia is a hazard for increasing susceptibility of the heart to myocardial infarction (MI) by inducing platelet hyperaggregability. Clopidogrel and prasugrel have documented cardioprotective effects in clinical studies. Herein, we investigated whether clopidogrel and prasugrel could protect against ...

journal_title：Life sciences

authors： Mohammad HMF,Makary S,Atef H,El-Sherbiny M,Atteia HH,Ibrahim GA,Mohamed AS,Zaitone SA

更新日期：2020-04-15 00:00:00

abstract：:Rat aortic smooth muscle homogenates and membrane preparations contain a phospholipase C which hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2). We discovered that guanyl-5'yl-imidodiphosphate (Gpp(NH)p) activated the hydrolysis of exogenous PIP2 but not of phosphatidylinositol (PI) in rat aortic membranes. Furt...

journal_title：Life sciences

authors： Roth BL

更新日期：1987-08-03 00:00:00

abstract：:Female white-footed mice (Peromyscus leucopus) were injected twice daily with 5, 10, 50, 100 micrograms melatonin (MEL) or saline. Injections were given for 7 weeks at 2 and 12 hours after lights-on under a long day (LD 16:8) photoperiod. Afternoon administration of MEL induced gonadal regression, although a dose of 5...

journal_title：Life sciences

authors： Hall ES,Lynch GR

更新日期：1985-08-26 00:00:00

abstract：:The potencies of several opioid agonists are reduced in diabetic animals and in animals made hyperglycemic via injections of glucose. In this report we examined the effects of streptozotocin-induced diabetes on the feeding responses to centrally administered opioid agonists with differing receptor selectivities. The s...

journal_title：Life sciences

authors： Gosnell BA,Grace M,Billington CJ,Levine AS

更新日期：1989-01-01 00:00:00

abstract：:Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is vital to the regulation of inflammatory responses, as it has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pr...

journal_title：Life sciences

authors： Privratsky JR,Newman DK,Newman PJ

更新日期：2010-07-17 00:00:00

abstract：:A previously unreported anti-bacterial activity against Escherichia coli has been found in porcine and bovine sera, but not in human or chicken sera. The activity is not affected by heat inactivation of the complement system, and is bacteriostatic rather than bactericidal. Growth inhibition is reversible by addition o...

journal_title：Life sciences

authors： Lenard J,VanDeroef R

更新日期：1995-01-01 00:00:00

abstract：:Uncontrolled recreational drugs are proliferating in number and variety. Effects of long-term use are unknown, and regulation is problematic, as efforts to control one chemical often lead to several other structural analogs. Advanced analytical instrumentation and methods are continuing to be developed to identify dru...

journal_title：Life sciences

authors： Thomas BF,Pollard GT,Grabenauer M

更新日期：2013-03-19 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) receptor-mediated 36chloride (36Cl-) uptake was measured in synaptoneurosomes from rat brain. GABA and GABA agonists stimulated 36Cl- uptake in a concentration-dependent manner with the following order of potency: Muscimol greater than GABA greater than piperidine-4-sulfonic acid (P4S)gr...

journal_title：Life sciences

authors： Luu MD,Morrow AL,Paul SM,Schwartz RD

更新日期：1987-09-07 00:00:00

abstract：:The induction of aldose reductase (AR) mRNA expression and its activity by glucose were investigated in fetal rat aortic smooth muscle (A10) cells. The increase in the expression of AR mRNA was observed at 6 h, and reached a maximum (2.3 fold) at 12 h after exposure to 80 mM glucose. On the other hand, increase in AR ...

journal_title：Life sciences

authors： Tawata M,Ohtaka M,Hosaka Y,Onaya T

更新日期：1992-01-01 00:00:00

abstract：AIMS:We have shown that diabetes causes cerebrovascular remodeling in part by the activation of the endothelin (ET-1) system in a glucose-dependent manner. We also reported increased yet dysfunctional cerebral angiogenesis in diabetes. Here, we tested the hypothesis that dual ET-1 receptor antagonism or glycemic contro...

journal_title：Life sciences

authors： Abdelsaid M,Kaczmarek J,Coucha M,Ergul A

更新日期：2014-11-24 00:00:00

abstract：AIMS:Brain injuries based on their causes are divided into two categories, TBI and NTBI. TBI is caused by damages such as head injury, but non-physical injury causes NTBI. Prolactin is one of the blood factors that increase during brain injury. It has been assumed to play a regenerative role in post-injury recovery. M...

journal_title：Life sciences

authors： Yousefvand S,Hadjzadeh MA,Vafaee F,Dolatshad H

更新日期：2020-12-15 00:00:00

abstract：:Based on the finding of decreased mitochondrial complex I activity in the substantia nigra of patients with Parkinson's disease, we propose that the consequent reduction of ATP synthesis and increased generation of reactive oxygen species may be a possible cause of nigrostriatal cell death. Since sulfhydryl groups are...

journal_title：Life sciences

authors： Martínez M,Martínez N,Hernández AI,Ferrándiz ML

更新日期：1999-01-01 00:00:00

abstract：AIMS:The type 2 muscarinic receptor (M2R) differs from the other G-protein-coupled muscarinic receptor (type 4, or M4R) in tissue distribution and physiologic effects. We studied the impact of these receptors on sleep and arousal by using M2R and M4R knock-out (KO) mice. MAIN METHODS:M2R and M4R KO and genetically int...

journal_title：Life sciences

authors： Turner J,Hughes LF,Toth LA

更新日期：2010-01-30 00:00:00

abstract：:The density of bovine peripheral-type benzodiazepine receptors (PBR) in four tissues was highest in adrenal cortex. The adrenal cortex PBR cofractionated with a mitochondrial membrane marker enzyme and could be solubilized with intact ligand binding properties using digitonin. The membrane bound and soluble mitochondr...

journal_title：Life sciences

authors： Parola AL,Laird HE 2nd

更新日期：1991-01-01 00:00:00

abstract：:The effect of the Type I benzodiazepine (BDZ) receptor agonist, CL 218,872, on convulsions generated by low doses of methyl beta-carboline-3-carboxylic acid ( MBCC ), bicuculline, picrotoxin and pentylenetetrazole (PTZ) in mice was examined. Low doses of CL 218,872 enhanced the convulsions produced by all agents excep...

journal_title：Life sciences

authors： Melchior CL,Garrett KM,Tabakoff B

更新日期：1984-05-28 00:00:00