Abstract：
:Based on the finding of decreased mitochondrial complex I activity in the substantia nigra of patients with Parkinson's disease, we propose that the consequent reduction of ATP synthesis and increased generation of reactive oxygen species may be a possible cause of nigrostriatal cell death. Since sulfhydryl groups are essential in oxidative phosphorylation, thiolic antioxidants may contribute to the preservation of these proteins against oxidative damage. In the present paper, we hypothesize that treatment with a sulfur-containing antioxidant such as N-acetylcysteine may provide a new neuroprotective therapeutic strategy for Parkinson's disease.
journal_name
Life Scijournal_title
Life sciencesauthors
Martínez M,Martínez N,Hernández AI,Ferrándiz MLdoi
10.1016/s0024-3205(98)00472-xsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
1253-7issue
15eissn
0024-3205issn
1879-0631pii
S002432059800472Xjournal_volume
64pub_type
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