Surgical and pharmacological reductions in sympathetic nerve activity increase the neuropeptide Y-immunoreactivity content of the rat iris but not the vas deferens.

Abstract:

:Decentralization of the superior cervical ganglion (S.C.G.) of the rat elevated the neuropeptide-Y immunoreactivity (NPY-ir) content of the ganglion on day 1 (+43%) but not on day 3 post-surgery. The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidine (+43%), and pempidine (+82%). The levels of NPY-ir in the rat vas deferens were not affected by either surgical or pharmacological treatment. These results suggest NPY is released from sympathetic nerves in the iris but not vas deferens during normal sympathetic activity.

journal_name

Life Sci

journal_title

Life sciences

authors

Maccarrone C,Jarrott B

doi

10.1016/0024-3205(88)90333-5

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

2633-8

issue

25

eissn

0024-3205

issn

1879-0631

pii

0024-3205(88)90333-5

journal_volume

42

pub_type

杂志文章
  • Molecular process in acute liver injury and regeneration induced by carbon tetrachloride.

    abstract::Injection of carbon tetrachloride (CCl4) intraperitoneally into model animals induces acute liver injury mediated by reactive oxygen species (ROS) as normal metabolites in hepatocytes. In this study, the molecular process in this type of liver injury was analyzed from the aspect of liver function and regulatory factor...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2004.02.030

    authors: Taniguchi M,Takeuchi T,Nakatsuka R,Watanabe T,Sato K

    更新日期:2004-08-13 00:00:00

  • Involvement of somatostatin, bombesin and serotonin in the origin of the migrating myoelectric complex in sheep.

    abstract::Antroduodenal myoelectric activity was recorded in conscious sheep by electrodes chronically implanted in the muscular wall. Furthermore, plasma immunoreactive (i.r.) motilin, somatostatin and bombesin concentrations were determined by RIA. The intravenous infusion of somatostatin (20 ng/kg/min), bombesin (10 ng/kg/mi...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(96)00209-3

    authors: Plaza MA,Arruebo MP,Murillo MD

    更新日期:1996-01-01 00:00:00

  • Circadian variation of DSIP-like material in rat plasma.

    abstract::Levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat plasma were measured by radioimmunoassay and found to exhibit a circadian rhythm that parallelled the normal rhythm for corticosterone. The maximal plasma levels of both substances were observed to occur at about 1700h. The lowest concentrat...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(84)90566-6

    authors: Fischman AJ,Kastin AJ,Graf MV

    更新日期:1984-11-12 00:00:00

  • Crosstalk between transforming growth factor-β1 and endoplasmic reticulum stress regulates alpha-smooth muscle cell actin expression in podocytes.

    abstract:AIMS:Transforming growth factor-β1 (TGF-β1) plays a significant role in epithelial-mesenchymal transition (EMT). Furthermore, endoplasmic reticulum (ER) stress also can induce EMT. However, the relationship among TGF-β1, ER stress and EMT in podocytes is still unclear. Consequently, this study examines the crosstalk ef...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2018.07.050

    authors: Chen CA,Chang JM,Chang EE,Chen HC,Yang YL

    更新日期:2018-09-15 00:00:00

  • Protective effects of Curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms.

    abstract::The present study was undertaken to evaluate the cardioprotective potential of Curcuma longa (Turmeric) in the ischemia-reperfusion (I/R) model of myocardial infarction (MI). Wistar rats were divided into three groups and received saline orally (sham, control I/R group) and Curcuma longa 100 mg/kg (CL-100 treated grou...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2004.02.032

    authors: Mohanty I,Singh Arya D,Dinda A,Joshi S,Talwar KK,Gupta SK

    更新日期:2004-08-20 00:00:00

  • Neurosteroids and neuroactive drugs in mental disorders.

    abstract::Clinical and preclinical studies have suggested that fluctuations in the peripheral and brain concentrations of progesterone and deoxycorticosterone and its metabolites 3alpha,5alpha-tetrahydroprogesterone and 3alpha,5alpha-tetrahydrodeoxycorticosterone, respectively, might play an important role in certain pathologic...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2003.12.002

    authors: Pisu MG,Serra M

    更新日期:2004-05-14 00:00:00

  • Cerebrospinal fluid distribution of opioids after intraventricular & lumbar subarachnoid administration in sheep.

    abstract::The study of opioid distribution in blood and cerebrospinal fluid (CSF) is required to understand pharmacokinetic-pharmacodynamic relationships following lumbar intrathecal (it) and intracerebroventicular (i.c.v.) administration, and to investigate the contributions of spinal or supraspinal sites of action. The sheep ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(96)00456-0

    authors: Payne R,Gradert TL,Inturrisi CE

    更新日期:1996-01-01 00:00:00

  • Role of phospholamban in NO/EDRF-induced relaxation in rat aorta.

    abstract::The role of endothelium-derived nitric oxide (NO) to cause smooth muscle phospholamban (PLB) phosphorylation was studied in the isolated perfused rat aorta precontracted with norepinephrine using a back-phosphorylation technique. NO-induced relaxation was associated with increased PLB-phosphorylation while norepinephr...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(92)90357-u

    authors: Karczewski P,Kelm M,Hartmann M,Schrader J

    更新日期:1992-01-01 00:00:00

  • Increase in brain 125I-cholecystokinin (CCK) receptor binding following chronic haloperidol treatment, intracisternal 6-hydroxydopamine or ventral tegmental lesions.

    abstract::Specific 125I-CCK receptor binding was significantly increased in brain tissue taken from guinea pig or mouse following chronic (2-3 week) daily administration of haloperidol (2-3 mg/kg/day). Scatchard analysis indicated the increase in CCK binding was due to an increased receptor number (B max) with no change in affi...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(83)90224-2

    authors: Chang RS,Lotti VJ,Martin GE,Chen TB

    更新日期:1983-02-21 00:00:00

  • ERK activation by zeranol has neuroprotective effect in cerebral ischemia reperfusion.

    abstract:AIMS:Incidence of stroke increases in postmenopausal women with dangerous consequences. In this study we used zeranol to protect ovariectomized (OVX) rats against cerebral I/R damage and our target is to identify the mechanism of its protection, in addition to investigating whether this mechanism inhibits inflammation ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2019.04.035

    authors: Mohamed SK,Ahmed AAE,Elmorsy EM,Nofal S

    更新日期:2019-06-15 00:00:00

  • Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.

    abstract:AIMS:Short-chain acyl-CoA dehydrogenase (SCAD) is a key enzyme in fatty acid oxidation. In the present study we aim to investigate the changes in SCAD between pathological and physiological cardiomyocyte hypertrophy. We also explore the different signaling pathways of pathological and physiological cardiomyocyte hypert...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2015.01.015

    authors: Huang Q,Huang J,Zeng Z,Luo J,Liu P,Chen S,Liu B,Pan X,Zang L,Zhou S

    更新日期:2015-03-01 00:00:00

  • Additive effects of combined valsartan and spironolactone on cardiac aldosterone escape in spontaneously hypertensive rats.

    abstract::The additive effects of combined valsartan and spironolactone on plasma and cardiac aldosterone escape were evaluated in spontaneously hypertensive rats (SHRs). Twenty-four SHRs were treated with valsartan (30 mg/kg body weight per day), spironolactone (20 mg/kg body weight per day) and a combination of both for 4 mon...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2004.04.012

    authors: Liang YH,Wang JM,Zhou Y,Jiang XJ,Jiang H,Huang CX

    更新日期:2004-08-27 00:00:00

  • Flavonoids from the leaves of Diospyros kaki reduce hydrogen peroxide-induced injury of NG108-15 cells.

    abstract::Flavonoids from the leaves of Diospyros kaki L (FLDK-P70) are main therapeutic components of NaoXingQing, which is a novel and patented Traditional Chinese Medicine drug used for the treatment of syndrome of apoplexy for years in China. The present study investigated the effects of FLDK-P70 on hydrogen peroxide (H2O2)...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2004.09.031

    authors: Bei W,Peng W,Ma Y,Xu A

    更新日期:2005-03-11 00:00:00

  • Anxiolytic effect of Kami-Shoyo-San (TJ-24) in mice: possible mediation of neurosteroid synthesis.

    abstract::We assessed the anxiolytic effect of Kami-Shoyo-San (Jia-wei-xiao-yao-san; TJ-24), one of a traditional Chinese herbal medicine used for the treatment of menopausal anxiety, by the social interaction (SI) test in male mice. Acute administration of TJ-24 (25-100 mg/kg, p.o.), as well as the gamma-amino-butyric acidA/be...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(01)01290-5

    authors: Mizowaki M,Toriizuka K,Hanawa T

    更新日期:2001-09-21 00:00:00

  • Ouabain--a local, paracrine, aldosterone synthesis regulating hormone?

    abstract::10(-4) M ouabain increases aldosterone production at 3.6 and 5.4 mM potassium concentrations, whereas at high potassium concentration (7 mM) even lower concentration of ouabain (10(-8) M) decreases it. As ouabain has been shown to be produced by the adrenal cortex, a local paracrine regulation of aldosterone productio...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(93)90466-g

    authors: Szalay KS

    更新日期:1993-01-01 00:00:00

  • The effect of cloricromene, a coumarine derivative, on leukocyte accumulation, myocardial necrosis and TNF-alpha production in myocardial ischaemia-reperfusion injury.

    abstract::The effects of cloricromene, a coumarine derivative, were studied in an anaesthetized rat model of coronary artery ligation (60 min) followed by reperfusion (60 min; MI/R). Sham operated rats were used as controls (Sham MI/R). Myocardial ischaemia-reperfusion injury produced a marked myocardial injury (necrotic area/a...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(93)90753-p

    authors: Squadrito F,Altavilla D,Zingarelli B,Ioculano M,Calapai G,Campo GM,Miceli A,Prosdocimi M,Caputi AP

    更新日期:1993-01-01 00:00:00

  • Effects of maternal ethanol consumption during pregnancy or lactation on intestinal absorption of folic acid in suckling rats.

    abstract::A fostering/crossfostering analysis of the effects of maternal ethanol exposure on jejunal and ileal folate absorption was performed. Male and female rats were randomized into two groups. In the first group, ethanol-treated rats received ad libitum 5, 10 and 15% ethanol in the drinking fluid during three successive we...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(03)00570-8

    authors: Murillo-Fuentes ML,Murillo ML,Carreras O

    更新日期:2003-09-12 00:00:00

  • Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes.

    abstract::[3H]5-HT binding sites were analyzed in membranes prepared from the rabbit caudate nucleus (CN). [3H]5-HT labeled both 5-HT1A and 5-HT1C recognition sites, defined by nanomolar affinity for 8-OH-DPAT and mesulergine respectively; however, these represented only a fraction of total specific [3H]5-HT binding. Saturation...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(89)90033-7

    authors: Xiong WC,Nelson DL

    更新日期:1989-01-01 00:00:00

  • Role of dietary salt in hypertension.

    abstract::Certain things have not changed since my colleague and I last reviewed the role of dietary salt in hypertension [Haddy, F.J., Pamnani, M.B., 1995. Role of dietary salt in hypertension. Journal of the American College of Nutrition 14, 428-438]. Over half of hypertensives are still salt sensitive, i.e., they respond to ...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2006.05.017

    authors: Haddy FJ

    更新日期:2006-09-20 00:00:00

  • Androgen/androgen receptor affects gentamicin-induced nephrotoxicity through regulation of megalin expression.

    abstract:AIM:Investigation whether androgen/androgen receptor (AR) might regulate megalin expression and/or functionality and thus affecting Gentamicin-induced nephrotoxicity (GIN). MAIN METHODS:Male Wistar rats were treated with gentamicin with/out AR ligands (testosterone as agonist and flutamide as antagonist). Megalin expr...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.117628

    authors: Elsakka EGE,Elsisi AM,Mansour OAA,Elsadek BEM,Abd Elaziz AI,Salama SA,Allam S

    更新日期:2020-06-15 00:00:00

  • Berberine hydrochloride inhibits inflammation and fibrosis after canalicular laceration repair in rabbits.

    abstract:AIMS:This study was designed to investigate the molecular mechanisms underlying the anti-inflammatory and anti-fibrosis effects of Berberine hydrochloride (BBR) following canalicular laceration (CL) surgical repair. MAIN METHODS:We used a rabbit CL model in this study. BBR and the control medicine were administered du...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118479

    authors: Bai F,Tao H,Wang P,Wang L,Zhou X,Wang F,Liu C,Huang Y

    更新日期:2020-11-15 00:00:00

  • Histogranin, a modified histone H4 fragment endowed with N-methyl-D-aspartate antagonist and immunostimulatory activities.

    abstract::Histogranin is a naturally-occurring pentadecapeptide with a structure 80% homologous with that a fragment-(86-100) of histone H4. First isolated from bovine adrenal medulla, the peptide was also shown to be present in the pituitary, brain, adrenal glands, blood plasma, lungs and spleen. At the subcellular level, hist...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0024-3205(95)00068-2

    authors: Lemaire S,Rogers C,Dumont M,Shukla VK,Lapierre C,Prasad J,Lemaire I

    更新日期:1995-03-03 00:00:00

  • Clopidogrel or prasugrel reduces mortality and lessens cardiovascular damage from acute myocardial infarction in hypercholesterolemic male rats.

    abstract:AIMS:Hypercholesterolemia is a hazard for increasing susceptibility of the heart to myocardial infarction (MI) by inducing platelet hyperaggregability. Clopidogrel and prasugrel have documented cardioprotective effects in clinical studies. Herein, we investigated whether clopidogrel and prasugrel could protect against ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.117429

    authors: Mohammad HMF,Makary S,Atef H,El-Sherbiny M,Atteia HH,Ibrahim GA,Mohamed AS,Zaitone SA

    更新日期:2020-04-15 00:00:00

  • Rational design of a GLP-1/GIP/Gcg receptor triagonist to correct hyperglycemia, obesity and diabetic nephropathy in rodent animals.

    abstract:AIMS:To design and screen a potent GLP-1/GIP/Gcg receptors triagonist with therapeutic potential in rodent animals with diabetes and obesity. MAIN METHODS:First, we obtained a 12-mer dual GIP/Gcg receptor agonist from a large combinatorial peptide library via high-throughput screening technique and then fused to the E...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118339

    authors: Cui J,Shang A,Wang W,Chen W

    更新日期:2020-11-01 00:00:00

  • Effect of age and photoperiodic conditions on metabolism and oxidative stress related markers at different circadian stages in rat liver and kidney.

    abstract::It has been shown that some cytochrome P450-dependent enzyme activities could present daily fluctuations, particularly CYP3A isoenzymes which are enhanced during the dark period. The aim of this study was to investigate whether age and photoperiodic conditions at different circadian stages could influence these fluctu...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(03)00271-6

    authors: Martin C,Dutertre-Catella H,Radionoff M,Debray M,Benstaali C,Rat P,Thevenin M,Touitou Y,Warnet JM

    更新日期:2003-06-06 00:00:00

  • Naloxone, naltrexone and body temperature.

    abstract::The temperature effects of naloxone and naltrexone (1-30 mg/kg) were examined in well habituated male rats. These drugs had a similar time course and potency, producing a dose-dependent hypothermia followed several hours later by a hyperthermia. A subsequent study found that not only did 30 mg/kg of naloxone or naltre...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(87)90563-7

    authors: Eikelboom R

    更新日期:1987-03-16 00:00:00

  • Increased plasma concentrations of C9, C1-inhibitor and alpha 1-protease inhibitor associated with cigarette smoking.

    abstract::The association between various parameters of acute and chronic smoking status and plasma levels of three proteins, C9, C1-inhibitor (C1-INH) and alpha 1-protease inhibitor (alpha 1-PI) were determined for 49 male cigarette smokers and 49 age-matched nonsmokers (mean age = 32.2 years). The mean number of cigarettes sm...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(85)90391-1

    authors: Bridges RB,Rehm SR,Wyatt RJ

    更新日期:1985-03-11 00:00:00

  • Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells.

    abstract::SGK1 is one of the protein-serine/threonine kinases that is activated by insulin in a PI3K-dependent manner. Although SGK1 mediates a variety of biological activities, the mechanisms regulating its activity remain unclear. In this study, we examined the potential roles of calcium signaling in the activation of SGK1. T...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(03)00092-4

    authors: Imai S,Okayama N,Shimizu M,Itoh M

    更新日期:2003-04-04 00:00:00

  • The role of the ventromedial hypothalamic area in periprandial glucoregulation.

    abstract::There is a great deal of evidence that the ventromedial hypothalamic area (VMH) plays a significant role in glucoregulation. The present review synthesizes new and existing data in a coherent model of a hypothalamic glucoregulatory control system whose function is to stabilize blood glucose levels in the face of disco...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/0024-3205(85)90631-9

    authors: Storlien LH

    更新日期:1985-02-11 00:00:00

  • The involvement of sympathetic nervous system in essence of chicken-facilitated physiological adaption and circadian resetting.

    abstract:AIM:The impact of the sympathetic nervous system (SNS) on the regulation of circadian rhythm and physiological functions is still not clear. Previous studies have found that essence of chicken (EC) supplementation facilitated the physiological adaption and circadian resetting in rats subjected to jet lag. Herein, the e...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2018.03.047

    authors: Ni Y,Ma L,Wu T,Lim AL,Zhang W,Yang L,Nakao Y,Fu Z

    更新日期:2018-05-15 00:00:00