Increased plasma concentrations of C9, C1-inhibitor and alpha 1-protease inhibitor associated with cigarette smoking.

abstract：:The effects of sucrose feeding on parameters associated with (Na+,K+)-ATPase in brown adipose tissue were compared in rats treated with parenteral 6-hydroxydopamine and vehicle. Sucrose feeding significantly increased K+-p-nitrophenylphosphatase and ouabain binding in brown adipose tissue from rats treated with vehicl...

journal_title：Life sciences

authors： Swann AC

更新日期：1984-01-23 00:00:00

abstract：AIMS:T lymphocytes synthesize acetylcholine (ACh) and express muscarinic and nicotinic ACh receptors (mAChR and nAChR, respectively) responsible for increases in the intracellular Ca2+ concentration ([Ca2+]i). Our aim in the present study was to assess whether autocrine ACh released from T lymphocytes regulates their p...

journal_title：Life sciences

authors： Mashimo M,Iwasaki Y,Inoue S,Saito S,Kawashima K,Fujii T

更新日期：2017-03-01 00:00:00

abstract：:Platelets from normal and malignant hyperthermia (MH)-susceptible pigs were evaluated for differences in 45calcium uptake in the absence or presence of caffeine (2-16 mM), halothane (0.05-0.5%), or halothane and caffeine together. There were no statistically significant differences in basal or halothane-inhibited calc...

journal_title：Life sciences

authors： Miller KE,Brooks RR,Bonk KR,Carpenter JF

更新日期：1991-01-01 00:00:00

abstract：AIMS:Intra-platelet 5-HT (IP 5-HT) and YAP exhibit an important role in hepatocellular carcinoma (HCC). The aim of the study was to investigate whether IP 5-HT and YAP could affect the progression and prognosis of HCC. METHODS:5-HT level and YAP expression were measured and were compared between HCC patients and contr...

journal_title：Life sciences

authors： Liu S,Zhai M,Xiao W,Zhou Q,Zhang D,Gong Y,Deng C,Liu C,Li L,He C

更新日期：2021-01-29 00:00:00

abstract：AIMS:The long non-coding RNA (lncRNA) was reported to be involved in the progress of various cancers, however, its effect in colorectal cancer (CRC) remains unknown. The goal of the present study is to investigate the function role of lncRNA PCAT-1 in colorectal cancer. MAIN METHODS:The expression of lncRNA PCAT-1 in ...

journal_title：Life sciences

authors： Qiao L,Liu X,Tang Y,Zhao Z,Zhang J,Feng Y

更新日期：2017-11-01 00:00:00

abstract：AIMS:Nicotine is a risk factor for various diseases, including osteoporosis, oral cancer, and periodontal disease. Numerous studies have elucidated the effects of nicotine on cell proliferation and differentiation. The purpose of this study was to determine the effects of nicotine on the proliferation and osteoblast di...

journal_title：Life sciences

authors： Kim BS,Kim SJ,Kim HJ,Lee SJ,Park YJ,Lee J,You HK

更新日期：2012-01-16 00:00:00

abstract：:Transport of tyrosine (Tyr) and phenylalanine (Phe) across the rat nasal mucosa was studied using an in situ perfusion technique. It was found that both amino acids were absorbed by active, saturable transport processes. The Km and Vmax values were calculated to be 0.68 mM and 0.44 mM/hr for L-Tyr, and 0.40 mM and 0.3...

journal_title：Life sciences

authors： Tengamnuay P,Mitra AK

更新日期：1988-01-01 00:00:00

abstract：:Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin. Residues in TM3 and TM6 where amino acid sub...

journal_title：Life sciences

authors： Spalding TA,Burstein ES

更新日期：2001-04-27 00:00:00

abstract：:Despite the recent scientific advances made in cancer diagnostics and therapeutics, cancer still remains the second leading cause of death worldwide. Thus, there is a need to identify new potential biomarkers/molecular targets to improve the diagnosis and treatment of cancer patients. In this regard, long non-coding R...

journal_title：Life sciences

authors： Sharma U,Barwal TS,Malhotra A,Pant N,Vivek,Dey D,Gautam A,Tuli HS,Vasquez KM,Jain A

更新日期：2020-09-15 00:00:00

abstract：:Ancylostoma ceylanicum, the human hookworm parasite, exhibited significant secretion of cholinesterase when maintained in vitro in RPMI-1640 medium. Secretion of the enzyme was linear up-to 4 hours of incubation. About 40 percent of the total cholinesterase activity was localized in the soluble fraction, while remaini...

journal_title：Life sciences

authors： Tekwani BL

更新日期：1992-01-01 00:00:00

abstract：:Individuals have an inherent capacity to cope with stressors in the form of stress adaptation. Apart from stress adaptation there is another well documented phenomenon known as cross stress adaptation. In this, there is a reduction in stress responsiveness to a novel stressor (in which the adapted organism had never e...

journal_title：Life sciences

authors： Chauhan E,Bali A,Singh N,Jaggi AS

更新日期：2015-09-15 00:00:00

abstract：:The isolated cat superior cervical ganglion (SCG) was labeled in vitro with either 3H-norepinephrine (3H-NE) or 3H-choline and stimulated through its preganglionic trunk. The release of 3H-NE and 3H-acetylcholine (3H-ACh) elicited by the stimulation was measured under control conditions and in the presence of drugs. T...

journal_title：Life sciences

authors： Martínez AE,Adler-Graschinsky E

更新日期：1985-04-29 00:00:00

abstract：:Using absorption spectroscopy we have found that metallothionein I at concentrations as low as 1 microM reduces ferricytochrome c. This reduction is more potent than that of another abundant intracellular thiol, glutathione. Also, oxidation of ferricytochrome c which had been reduced by metallothionein I occurs more s...

journal_title：Life sciences

authors： Simpkins C,Eudaric P,Torrence C,Yang Z

更新日期：1993-01-01 00:00:00

abstract：AIM:Exosomes, the nano-units (<200 nm), released from diverse cell types in the extracellular body fluid, possess non-immunogenic property and ability to cross the blood-brain barrier (BBB). Since exosomes carry biological information from their cells of origin, we hypothesize that priming cells with potential therapeu...

journal_title：Life sciences

authors： Kalani A,Kamat PK,Chaturvedi P,Tyagi SC,Tyagi N

更新日期：2014-06-27 00:00:00

abstract：AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...

journal_title：Life sciences

authors： Asai M,Kawashima D,Katagiri K,Takeuchi R,Tohnai G,Ohtsuka K

更新日期：2011-02-14 00:00:00

abstract：:The feasibility of using human cells isolated from peritoneal dialysis effluent as a model for studying lipoprotein and cholesterol metabolism was investigated. Human peritoneal cells degraded low density lipoproteins (LDL) and acetylated LDL (acetyl-LDL) by saturable, high affinity receptor-mediated processes. Positi...

journal_title：Life sciences

authors： Winzerling JJ,Jouni ZE,McNamara DJ

更新日期：1996-01-01 00:00:00

abstract：:The effects of taurine on hepatic cholesterol metabolism were investigated in hamsters fed a high-fat diet or normal chow. Two weeks-treatment of taurine at 1% in drinking water prevented high-fat diet-induced increase in cholesterol levels of serum and liver. The decrease in serum cholesterol by taurine was due to de...

journal_title：Life sciences

authors： Murakami S,Kondo Y,Toda Y,Kitajima H,Kameo K,Sakono M,Fukuda N

更新日期：2002-04-05 00:00:00

abstract：:There is no satisfactory assay procedure of PAF in human whole blood in terms of sensitivity, reproducibility and simplicity. This is due to coexisting lipids from plasma and cellular membranes which inhibit measurement of PAF in various assay procedures, including bioassay. In the present study, an attempt was made t...

journal_title：Life sciences

authors： Shinozaki K,Kawasaki T,Kambayashi J,Sakon M,Shiba E,Uemura Y,Ou M,Iwamoto N,Mori T

更新日期：1994-01-01 00:00:00

abstract：:Calcium mobilization has been demonstrated to possess functional importance in myocardial excitation-contraction as well as cellular metabolism. So far, much progress has been made to explore the possibility of involvement of guanine nucleotide binding regulatory protein in the opening and closing of calcium channels ...

journal_title：Life sciences

authors： Fu LX,Waagstein F,Hjalmarson A

更新日期：1991-01-01 00:00:00

abstract：AIMS:Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and has been reported as having a wide range of activities that are potentially beneficial for human health. This study aimed to investigate the effects of pretreatment of vitamin D3 (100, 1000, and 10,000 IU/kg) against lipopolysacchar...

journal_title：Life sciences

authors： Mokhtari-Zaer A,Hosseini M,Salmani H,Arab Z,Zareian P

更新日期：2020-07-15 00:00:00

abstract：AIMS:Solid lipid nanoparticles (SLNs) conjugated with surface 83-14 monoclonal antibody (8314MAb) and anti-epithelial growth factor receptor (AEGFR) were synthesized and applied to permeate the blood-brain barrier (BBB) and inhibit the growth of glioblastoma multiforme (GBM). MAIN METHODS:8314MAb and AEGFR were crossl...

journal_title：Life sciences

authors： Kuo YC,Lee CH

更新日期：2016-02-01 00:00:00

abstract：:It has been previously shown in anesthetized pigs that intravenous infusion of 2 microg/h of 17beta-estradiol primarily dilated renal, iliac and coronary circulations, while higher doses of the hormone were required to cause vasodilation also in the mesenteric vascular bed. In the same experimental model, a tonic beta...

journal_title：Life sciences

authors： Molinari C,Battaglia A,Grossini E,Mary DA,Surico N,Vacca G

更新日期：1999-01-01 00:00:00

abstract：:The activity in cerebrospinal fluid (CSF) of dynorphin-converting enzyme (DCE) has been studied after voluntary exercise in the spontaneously hypertensive (SH) rat. The exercise consisted of spontaneous running in wheels for 4-5 weeks and the average running distance during the last two weeks was 4.0 km/24h. CSF sampl...

journal_title：Life sciences

authors： Persson S,Jónsdóttir I,Thorén P,Post C,Nyberg F,Hoffmann P

更新日期：1993-01-01 00:00:00

abstract：:Recent head-twitch response (HTR) studies in mice have indicated that withdrawal from chronic cocaine exposure produces deficits in CNS conversion of L-tryptophan to 5-HT. In the present study, the ability of 5-HT releaser, d-fenfluramine, was utilized to induce the HTR in mice following abstinence from chronic cocain...

journal_title：Life sciences

authors： Darmani NA

更新日期：1997-01-01 00:00:00

abstract：:The enkephalin analogs, [D-Pen2,L-Cys5]- and [D-Pen2,D-Cys5]-enkephalin are cyclic compounds, conformationally constrained by virtue of their 14-membered, disulfide containing rings and by the rigidizing effect of the beta, beta dimethyl substituents of the penicillamine side chain. The analogs exhibit profound delta ...

journal_title：Life sciences

authors： Mosberg HI,Hurst R,Hruby VJ,Galligan JJ,Burks TF,Gee K,Yamamura HI

更新日期：1983-05-30 00:00:00

abstract：AIMS:To investigate the effects of curcumin on alveolar epithelial injury in a rat model of chronic obstructive pulmonary disease (COPD) and its potential mechanism. MAIN METHODS:The rat COPD model was established by cigarette smoke exposure combined with intratracheal administration of lipopolysaccharide. Thirty-eigh...

journal_title：Life sciences

authors： Zhang M,Xie Y,Yan R,Shan H,Tang J,Cai Y,Yin J,Chen M,Zhang J,Yang X,Zhang Q,Li Y

更新日期：2016-11-01 00:00:00

abstract：:Studies were performed in conscious, chronically catheterized male Sprague-Dawley rats to investigate the effect of administered atrial natriuretic peptide (ANP) on blood pressure, renal hemodynamics and urinary electrolyte excretion. Studies were performed on young adult (3-4 month old) rats and on aging rats (18-24 ...

journal_title：Life sciences

authors： DePriest D,Zimmermann C,Baylis C

更新日期：1990-01-01 00:00:00

abstract：:Despite the fact that numerous studies have been published regarding the possible presence in plasma of an endogenous Na-K pump inhibitor with a digitalis-like structure in essential hypertension, very little is known about this factor in heart disease in general, and in situations characterized by low cardiac output....

journal_title：Life sciences

authors： Delva P,Barbieri E,Devynck MA,Capra C,Pernollet MA,Meyer P,Destro G,Zardini P,Lechi A

更新日期：1990-01-01 00:00:00

abstract：:In order to estimate the intestinal stability of ebiratide [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8-NH2], a novel adrenocorticotropic hormone (ACTH) analogue, after oral administration, the hydrolytic properties of ebiratide were determined in the rat small intestinal fluid and mucosal homogenates. Ebiratide was extr...

journal_title：Life sciences

authors： Okagawa T,Fujita T,Murakami M,Yamamoto A,Shimura T,Tabata S,Kondo S,Muranishi S

更新日期：1994-01-01 00:00:00

abstract：:The role of dopamine (DA) input on the activity of glutamate neurons was investigated on rat striatal and cortical tissue using the measurement of sodium-dependent high affinity glutamate uptake (HAGU) as an index. Incubation of the tissue in the presence of DA, apomorphine or bromocriptine produced marked inhibition ...

journal_title：Life sciences

authors： Nieoullon A,Kerkerian L,Dusticier N

更新日期：1982-04-05 00:00:00