当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Effects of maternal ethanol consumption during pregnancy or lactation on intestinal absorption of folic acid in suckling rats.

Effects of maternal ethanol consumption during pregnancy or lactation on intestinal absorption of folic acid in suckling rats.

Abstract：

:A fostering/crossfostering analysis of the effects of maternal ethanol exposure on jejunal and ileal folate absorption was performed. Male and female rats were randomized into two groups. In the first group, ethanol-treated rats received ad libitum 5, 10 and 15% ethanol in the drinking fluid during three successive weeks. A consumption of 20% was maintained in this group for 5 additional weeks. Ethanol-treated rats were mated. Group 2 served as the control. To study the effect of chronic alcoholism during lactation or gestation separately, at birth (2nd day postpartum) control newborns were cross-fostered to ethanol dams (EG), and the pups issued from the ethanol treated mothers were cross-fostered to control dams (CG). Thus, three experimental groups of pups were formed: (1) control pups receiving no treatment during gestation and lactation (CG); (2) pups exposed to ethanol only during gestation (GG); and (3) pups exposed to ethanol only during lactation (LG). At 21 days postpartum the jejunal and distal ileum folate absorption was determined in the offspring rats by a perfusion technique. Milk folic acid levels were determined by an immunoluminometric assay. The results showed an increase in jejunal folic acid absorption in offsprings exposed to ethanol only during the lactation period (LG). However, in pups exposed to ethanol only during the gestation period (GG), the jejunal folic acid absorption was significantly increased only at concentrations of 0.25, 0.5 and 2.5 microM. No free folic acid absorption occurred in the distal ileum of control pups (CG) at day 21 at all assayed concentrations but in offsprings exposed to ethanol only during the gestation or lactation periods absorption did take place. Pups exposed to ethanol during the gestation period (GG) showed decreased values in ileum folic acid absorption at the lowest assayed concentration (0.25 microM) compared to values obtained for pups exposed to ethanol only during lactation (LG). Milk folic acid levels were significantly decreased in the ethanol-fed dams on day 21 of lactation. These results indicate that exposure of rats to ethanol during the lactation period affects more severely postnatal development of intestinal functions than ethanol exposure only during gestation. In summary, both the exposure to ethanol itself and the decrease in folic acid intake caused alterations in the function of the intestinal mucosa in the offspring, which in turn altered absorption time and development. However, the present results do not explain how ethanol stimulated intestinal absorption of folic acid in pups exposed to ethanol during the gestation or lactation periods. Further studies are needed.

journal_name

Life Sci

journal_title

Life sciences

authors

Murillo-Fuentes ML,Murillo ML,Carreras O

doi

10.1016/s0024-3205(03)00570-8

subject

Has Abstract

pub_date

2003-09-12 00:00:00

pages

2199-209

issue

17

eissn

0024-3205

issn

1879-0631

pii

S0024320503005708

journal_volume

73

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Toxicity of porcelain-fused-to-metal substrate to zebrafish (Danio rerio) embryos and larvae.

    abstract：AIMS:Porcelain-fused-to-metal (PFM) crowns are a standard restoration technique in dentistry, but toxicity of PFM in vivo has not been systematically evaluated. The present study evaluated the effects of various metal alloy shells of PFM crowns on the development of zebrafish embryos and larvae in order to determine th...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.04.019

    authors： Zhao L,Si J,Wei Y,Li S,Jiang Y,Zhou R,Liu B,Zhang H

    更新日期：2018-06-15 00:00:00

  • Activation of CFTR Cl(-) channel by tyrphostins via a protein tyrosine kinase-independent pathway in forskolin-stimulated renal epithelial A6 cells.

    abstract：:We studied effects of tyrphostin A23 (an inhibitor of protein tyrosine kinase; PTK) and tyrphostin A63 (an inactive analog of tyrphostin A23) on forskolin-activated cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and Cl(-) secretion in renal epithelial A6 cells. Tyrphostin A23 and A63 had no ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)01824-6

    authors： Niisato N,Nishio K,Marunaka Y

    更新日期：2002-07-26 00:00:00

  • Phenobarbital pre-treatment prevents kainic acid-induced impairments in acquisition learning.

    abstract：:This study examined the protective effect of phenobarbital on kainic acid-induced deficits in acquisition learning. A single kainic acid injection (9 mg/kg i.p.) was administered five days prior to testing using the Morris water maze test. Kainic acid produced deficits in the acquisition of spatial information observe...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(00)00658-5

    authors： Brown-Croyts LM,Caton PW,Radecki DT,McPherson SL

    更新日期：2000-06-30 00:00:00

  • Respiratory responses to opiates applied to the medullary ventral surface.

    abstract：:The participation of the medullary structures in the total respiratory effect of opiates was studied by restricting the access of the delta-agonist D-ala2-D-leu5-enkephalin and the mu-agonist D-ala2-Me-Phe4-Met (O) ol5-enkephalin, to the ventral medullary surface, and by comparing their responses with those induced af...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(82)90115-1

    authors： Flórez J,Hurlé MA,Mediavilla A

    更新日期：1982-11-15 00:00:00

  • Renin secretion in intact dogs following incubation of epinephrine in blood in vivo.

    abstract：:Previous experiments have shown that epinephrine-induced renin secretion in vivo apparently is initiated by activation of extrarenal adrenoceptors. However the location of these receptors has not been determined despite considerable search. The present experiments were designed to evaluate the hypothesis that epinephr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(87)90747-8

    authors： Johnson MD

    更新日期：1987-10-19 00:00:00

  • Azelnidipine treatment reduces the expression of Cav1.2 protein.

    abstract：AIMS:Azelnidipine, a third-generation dihydropyridine calcium channel blocker (DHP CCB), has a characteristic hypotensive effect that persists even after it has disappeared from the plasma, which is thought to be due to its high hydrophobicity. However, because azelnidipine is unique, it might have other unknown effect...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2021.119043

    authors： Nasu F,Obara Y,Okamoto Y,Yamaguchi H,Kurakami K,Norota I,Ishii K

    更新日期：2021-01-13 00:00:00

  • The effect of thioridazine on haloperidol induced behavioral hypersensitivity.

    abstract：:Behavioral Hypersensitivity (BH) to dopamine agonists occurs following chronic treatment with most neuroleptics including haloperidol. In the present study we observed that the concurrent administration of thioridazine and haloperidol prevented the development of BH. In contrast, another neuroleptic, fluphenazine, coa...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90120-7

    authors： Klawans HL,Carvey PM,Nelson D,Tanner CM,Goetz CG

    更新日期：1986-05-12 00:00:00

  • Effects of pyrroloquinoline quinone (PQQ) and PQQ-oxazole on DNA synthesis of cultured human fibroblasts.

    abstract：:The effects of pyrroloquinoline quinone (PQQ) and PQQ-oxazole (PQQ-glycine adduct) on DNA synthesis were examined using cultured human fibroblasts. Confluent fibroblasts were cultured in serum-free Dulbecco's modified Eagle's media, and various concentrations of PQQ and PQQ-oxazole were added to the media. After incub...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90631-c

    authors： Naito Y,Kumazawa T,Kino I,Suzuki O

    更新日期：1993-01-01 00:00:00

  • Antiproliferative and immunosuppressive properties of microcolin A, a marine-derived lipopeptide.

    abstract：:The immunosuppressive effects of microcolin A, a lipopeptide extracted from the marine blue green alga Lyngbya majuscula were investigated. Microcolin A suppressed concanavalin A (IC50 = 5.8 nM), phytohemagglutinin (IC50 = 12.5 nM) and lipopolysaccharide (IC50 = 8.0 nM) induced proliferation of murine splenocytes. Mix...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(96)00645-5

    authors： Zhang LH,Longley RE,Koehn FE

    更新日期：1997-01-01 00:00:00

  • Is the brain histamine involved in cataleptogenic action of analgesics and haloperidol?

    abstract：:L-Histidine, histamine ivc, and amodiaquine (inhibitor of histamine catabolism) enhanced catalepsy induced by morphine, codeine and fentanyl. Haloperidol catalepsy was increased only by ivc histamine. H1 (but not H2) receptor antagonists have shown anticataleptic effect in the action of analgesics and haloperidol. ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90580-5

    authors： Malec D,Langwiński R

    更新日期：1983-01-01 00:00:00

  • Endomorphin 1[psi] and endomorphin 2[psi], endomorphins analogues containing a reduced (CH2NH) amide bond between Tyr1 and Pro2, display partial agonist potency but significant antinociception.

    abstract：:Endomorphin 1 (EM1) and endomorphin 2 (EM2) are highly potent and selective mu-opioid receptor agonists and have significant antinociceptive action. In the mu-selective pocket of endomorphins (EMs), Pro2 residue is a spacer and directs the Tyr1 and Trp3/Phe3 side chains into the required orientation. The present work ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.03.005

    authors： Zhao QY,Chen Q,Yang DJ,Feng Y,Long Y,Wang P,Wang R

    更新日期：2005-07-22 00:00:00

  • Exposure with the environmental estrogen bisphenol A disrupts the male reproductive tract in young mice.

    abstract：:Environmental estrogens (endocrine disruptive chemicals) have been shown to affect reproduction in wild life and it has been reported that maternal exposure with those chemicals have adverse effects on the male reproductive tract. However, little is known about the potential effects of prepubertal or pubertal exposure...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00502-0

    authors： Takao T,Nanamiya W,Nagano I,Asaba K,Kawabata K,Hashimoto K

    更新日期：1999-01-01 00:00:00

  • Distinct subcellular localization of three isoforms of insulinoma-associated protein 2β in neuroendocrine tissues.

    abstract：AIMS:Insulinoma-associated protein 2β (IA-2β) is considered to play a significant role in regulated secretion. Recent studies have shown that the mouse brain expresses three major isoforms of IA-2β, named IA-2β60, IA-2β64, and IA-2β71. In this study, we analyzed the tissue-, cell- and organelle-specific distributions o...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2011.02.018

    authors： Nakajima K,Wu G,Sakudo A,Onodera T,Takeyama N

    更新日期：2011-04-25 00:00:00

  • Acquisition of enhanced natural killer cell activity under anesthesia.

    abstract：:An increase in natural killer (NK) cell activity can be conditioned with a one trial learning paradigm to demonstrate the interaction between the central nervous system (CNS) and the immune system. In order to demonstrate learning possibilities during 'non-conscious' state, mice were anesthetized with a ketamin/rompun...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90573-8

    authors： Hsueh CM,Lorden JF,Hiramoto RN,Ghanta VK

    更新日期：1992-01-01 00:00:00

  • Structural and histomorphometric evaluations of ferutinin effects on the uterus of ovariectomized rats during osteoporosis treatment.

    abstract：AIMS:The effects of chronic administration of Ferutinin (phytoestrogen found in the plants of genus Ferula), compared with those elicited by estradiol benzoate, were evaluated, following ovariectomy, on the uterus of ovariectomized rats as regard weight, size, structure and histomorphometry. MAIN METHODS:The experimen...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2011.11.001

    authors： Ferretti M,Bertoni L,Cavani F,Benincasa M,Sena P,Carnevale G,Zavatti M,Viesti VD,Zanoli P,Palumbo C

    更新日期：2012-01-16 00:00:00

  • Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice.

    abstract：AIMS:Resveratrol (Res) which is a polyphenolic phytoalexin, has various biological properties. In the present study, we investigated whether Res extracted from Polygonum cuspidatum can reduce oxidative damage and cognitive impairment in senescence-accelerated mouse (SAM). MAIN METHODS:Senescence-accelerated mice were ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2012.08.033

    authors： Liu GS,Zhang ZS,Yang B,He W

    更新日期：2012-10-29 00:00:00

  • Uncoupling of receptors is essential for opiate-induced desensitization (tolerance) in neuroblastoma x glioma hybrid cells NG 108-15.

    abstract：:Neuroblastoma x glioma hybrid cells NG 108-15 were chronically treated with opioid agonists and tested for their development of "tolerance" as evaluated by the loss of inhibitory activity of opioids upon cAMP-accumulation. Desensitization was dose-dependent and non-competitive and highly selective, since the activity ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90512-x

    authors： Wüster M,Costa T,Gramsch C

    更新日期：1983-01-01 00:00:00

  • Correlation between (3H)dopamine specific uptake and (3H)GBR 12783 specific binding during the maturation of rat striatum.

    abstract：:The development of the specific uptake of dopamine in the rat striatum during the early postnatal period is compared with the ontogenetic changes of the specific binding of (3H)GBR 12783 to the site of uptake inhibition. During maturation, the increase in the specific binding of (3H)GBR 12783 parallels the increase in...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90563-8

    authors： Bonnet JJ,Costentin J

    更新日期：1989-01-01 00:00:00

  • Vitamin C and E chronic supplementation differentially affect hepatic insulin signaling in rats.

    abstract：AIM:Vitamin C and vitamin E supplementations and their beneficial effects on type 2 diabetes mellitus (T2DM) have been subjected to countless controversial data. Hence, our aim is to investigate the hepatic molecular mechanisms of any diabetic predisposing risk of the chronic administration of different doses of vitami...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.12.039

    authors： Ali MA,Eid RMHM,Hanafi MY

    更新日期：2018-02-01 00:00:00

  • Phosphorylation: a molecular switch in opioid tolerance.

    abstract：:Protein phosphorylation is a key posttranslational modification mechanism controlling the conformation and activity of many proteins. Increasing evidence has implicated an essential role of phosphorylation by several major protein kinases in promoting and maintaining opioid tolerance. We review some of the most recent...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2006.05.023

    authors： Wang ZJ,Wang LX

    更新日期：2006-09-27 00:00:00

  • BCG modulation of anaphylactic antibody response, airway inflammation and lung hyperreactivity in genetically selected mouse strains (Selection IV-A).

    abstract：:The effect of Bacillus Calmette-Guérin (BCG) treatment in allergic pulmonary reaction was studied in mice genetically selected accordingly to a High (H-IVA) or Low (L-IVA) antibody responsiveness. Mice were immunized with ovalbumin (OVA) or OVA plus BCG. Two days after nasal antigenic challenge, seric IgE and IgG1 ant...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.04.003

    authors： Barros MT,Acencio MM,Garcia ML,Macedo Soares MF,Ibañez OM,Martins MA,Ribeiro OG,Kalil J,Perini A

    更新日期：2005-08-12 00:00:00

  • Effects of resveratrol-related hydroxystilbenes on the nitric oxide production in macrophage cells: structural requirements and mechanism of action.

    abstract：:NF-kappaB that plays an important role in iNOS expression is one of the targets of various potential anti-inflammatory agents including resveratrol. Resveratrol contains a structural similarity with estrogen, and there has been speculation about resveratrol as estrogen agonist. In this study, the mechanism and structu...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)01971-9

    authors： Cho DI,Koo NY,Chung WJ,Kim TS,Ryu SY,Im SY,Kim KM

    更新日期：2002-09-13 00:00:00

  • Adrenergic control of lacrimal secretion in rabbits.

    abstract：:Stimulation of the preganglionic trunk of the ipsilateral superior cervical sympathetic ganglion with square wave electrical pulses produced secretion from the main excretory duct of the rabbit lacrimal gland. The secretion was inhibited by propranolol (1 mg/kg) and metoprolol (10 mg/kg) but not by phenoxybenzamine (2...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90424-7

    authors： Tangkrisanavinont V

    更新日期：1984-06-11 00:00:00

  • Effect of intracellular delivery of energy metabolites on intracellular Ca2+ in mouse islets of Langerhans.

    abstract：:Regulation of glucose-induced oscillations in intracellular Ca2+ concentration ([Ca2+]i) was investigated by using a novel technique, electroporation from an electrolyte-filled capillary, to deliver energy metabolites to the intracellular compartment of mouse islets. Intracellular application of ATP resulted in a nife...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.05.053

    authors： Dahlgren GM,Nolkrantz K,Kennedy RT

    更新日期：2005-10-21 00:00:00

  • Effects of bacteria on male fertility: Spermatogenesis and sperm function.

    abstract：:Bacterial infection can negatively affect different parts of the male genital tract and subsequently cause impaired spermatogenesis and male fertility. However, most of the previous studies have focused on the infected organs of the male genital tract and there are not many studies that investigated the direct effect ...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2020.117891

    authors： Oghbaei H,Rastgar Rezaei Y,Nikanfar S,Zarezadeh R,Sadegi M,Latifi Z,Nouri M,Fattahi A,Ahmadi Y,Bleisinger N

    更新日期：2020-09-01 00:00:00

  • Inhibition of hepatic adenylate cyclase by NADH.

    abstract：:Adenylate cyclase activity in isolated rat liver plasma membranes was inhibited by NADH in a concentration-dependent manner. Half-maximal inhibition of adenylate cyclase was observed at 120 microM concentration of NADH. The effect of NADH was specific since adenylate cyclase activity was not altered by NAD+, NADP+, NA...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90177-d

    authors： Nair BG,Patel TB

    更新日期：1991-01-01 00:00:00

  • Stimulation of uterine ornithine decarboxylase in organ culture by decreasing osmolality: possible relation to in vivo mechanisms.

    abstract：:Ornithine decarboxylase (ODC) activity increases during many growth responses. Some cells and tissues in culture also exhibit elevated enzyme activity with decreasing osmolality of the culture medium. We have found that this also occurs with uterine tissue from ovariectomized rats. Organ culture incubation under hypot...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90551-4

    authors： Webster RA,Zaloudek CJ,Inman BC

    更新日期：1984-03-26 00:00:00

  • N-acetyltransferase 2 activity and folate levels.

    abstract：AIMS:To determine whether increased N-acetyltransferase (NAT) activity might have a toxic effect during development and an influence on folate levels since previous work has shown that only low levels of exogenous NAT can be achieved in constitutionally transgenic mice (Cao et al. 2005). MAIN METHODS:A human NAT1 tet-...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2009.11.008

    authors： Cao W,Strnatka D,McQueen CA,Hunter RJ,Erickson RP

    更新日期：2010-01-16 00:00:00

  • Sleep, activity, temperature and arousal responses of mice deficient for muscarinic receptor M2 or M4.

    abstract：AIMS:The type 2 muscarinic receptor (M2R) differs from the other G-protein-coupled muscarinic receptor (type 4, or M4R) in tissue distribution and physiologic effects. We studied the impact of these receptors on sleep and arousal by using M2R and M4R knock-out (KO) mice. MAIN METHODS:M2R and M4R KO and genetically int...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2009.11.019

    authors： Turner J,Hughes LF,Toth LA

    更新日期：2010-01-30 00:00:00

  • The fos proto-oncogene protein:regulation by morphine in the rat hypothalamus.

    abstract：:Mechanisms by which opiates alter neuronal functions, including neuroendocrine functions, are not well defined. We have previously demonstrated that morphine rapidly and transiently increases expression of the proto-oncogene c-fos in the rat caudate-putamen. This regulation of the c-fos gene by morphine may represent ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90233-h

    authors： Chang SL,Harlan RE

    更新日期：1990-01-01 00:00:00