Role of phospholamban in NO/EDRF-induced relaxation in rat aorta.

Abstract:

:The role of endothelium-derived nitric oxide (NO) to cause smooth muscle phospholamban (PLB) phosphorylation was studied in the isolated perfused rat aorta precontracted with norepinephrine using a back-phosphorylation technique. NO-induced relaxation was associated with increased PLB-phosphorylation while norepinephrine as such was ineffective. Removal of endothelium significantly reduced PLB-phosphorylation in indomethacin treated vessels. Stimulation of NO-formation by ATP augmented PLB-phosphorylation in intact vessels but was ineffective in denuded aortas. The results indicate that PLB-phosphorylation of vascular smooth muscle plays an important role in mediating NO-dependent relaxation by enhancing Ca(++)-uptake into sarcoplasmic reticulum.

journal_name

Life Sci

journal_title

Life sciences

authors

Karczewski P,Kelm M,Hartmann M,Schrader J

doi

10.1016/0024-3205(92)90357-u

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

1205-10

issue

15

eissn

0024-3205

issn

1879-0631

pii

0024-3205(92)90357-U

journal_volume

51

pub_type

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