Molecular process in acute liver injury and regeneration induced by carbon tetrachloride.


:Injection of carbon tetrachloride (CCl4) intraperitoneally into model animals induces acute liver injury mediated by reactive oxygen species (ROS) as normal metabolites in hepatocytes. In this study, the molecular process in this type of liver injury was analyzed from the aspect of liver function and regulatory factors. Down-regulation of liver-specific genes was accomplished through suppression of liver-enriched transcription factors and box A factors found in the catalase gene, and induction of NF-kappaB, AP-1 and a novel factor denoted as 'cx' in the catalase gene. Expression profiles of these genes were restored to normal levels in the late stage of injury (48 h). On the other hand, hepatocyte growth factor (HGF) and proliferating cell nuclear antigen (PCNA) were induced in the early stage (6 h) and 36 h, respectively. Interestingly, ERK2 was transiently activated at 3 h CCl4-treatment. These observations suggested that hepatotoxin by CCl4-injection concomitantly induces both processes in acute injury and liver regeneration.


Life Sci


Life sciences


Taniguchi M,Takeuchi T,Nakatsuka R,Watanabe T,Sato K




Has Abstract


2004-08-13 00:00:00














  • Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Ucuncu Y,Celik N,Ozturk C,Turkoglu M,Cetin N,Kockara N,Sener E,Dundar C,Arslan A,Dogan H,Kurt N,Suleyman H

    更新日期:2015-06-01 00:00:00

  • The blood pressure effects of alpha-adrenoceptor antagonists injected in the medullary site of action of clonidine: the nucleus reticularis lateralis.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Bousquet P,Feldman J

    更新日期:1987-03-16 00:00:00

  • Presence of immunoreactive atrial natriuretic peptides in pericardial fluid of human subjects with congenital heart diseases.

    abstract::The epicardial release of immunoreactive atrial natriuretic peptides (ir-ANPs) in inside-out perfused rabbit atria has been reported. In order to determine the presence of ir-ANPs in pericardial fluid and to evaluate their biochemical characteristics, we measured the concentration of ir-ANPs in pericardial fluid obtai...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Kuh JH,Kim KS,Kim SH,Cho KW,Seul KH,Koh GY

    更新日期:1990-01-01 00:00:00

  • Reduced expressions of inducible nitric oxide synthase and cyclooxygenase-2 in vascular smooth muscle cells of stroke-prone spontaneously hypertensive rats.

    abstract::Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. The iNOS and COX-2 proteins and their mRNA expressions in cultured vascul...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Hirafuji M,Tsunoda M,Machida T,Hamaue N,Endo T,Miyamoto A,Minami M

    更新日期:2002-01-11 00:00:00

  • Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Chaudhary SC,Alam MS,Siddiqui MS,Athar M

    更新日期:2009-07-31 00:00:00

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Martínez AE,Adler-Graschinsky E

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  • Brief debrisoquin administration to assess central dopaminergic function in children.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Riddle MA,Shaywitz BA,Leckman JF,Anderson GM,Shaywitz SE,Hardin MT,Ort SI,Cohen DJ

    更新日期:1986-03-17 00:00:00

  • Protein kinase C isoforms during the development of deciduomata in pregnant rats.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Shyu JC,Hsieh YS,Chang CL,Tsai CC,Liu HC,Chang AC,Yang LC,Lin LY,Liu JY

    更新日期:1999-01-01 00:00:00

  • Antiproliferative and immunosuppressive properties of microcolin A, a marine-derived lipopeptide.

    abstract::The immunosuppressive effects of microcolin A, a lipopeptide extracted from the marine blue green alga Lyngbya majuscula were investigated. Microcolin A suppressed concanavalin A (IC50 = 5.8 nM), phytohemagglutinin (IC50 = 12.5 nM) and lipopolysaccharide (IC50 = 8.0 nM) induced proliferation of murine splenocytes. Mix...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Zhang LH,Longley RE,Koehn FE

    更新日期:1997-01-01 00:00:00

  • Evidence for two binding sites on membrane-bound angiotensin-converting enzymes (ACE) for exogenous inhibitors except in testis.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Brée F,Hamon G,Tillement JP

    更新日期:1992-01-01 00:00:00

  • The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease.

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    pub_type: 杂志文章,评审


    authors: Amidfar M,de Oliveira J,Kucharska E,Budni J,Kim YK

    更新日期:2020-09-15 00:00:00

  • Inhibition of avian and mammalian hydroxy-indole-o-methyl-transferase (HIOMT) with low molecular weight fractions of mammalian pineal glands.

    abstract::Partially purified fractions from sheep pineal gland extracts, which show a fluorescence like pteridines, were shown to suppress the enzyme hydroxy-indole-o-methyltransferase (HIOMT) isolated from avian pineals and retinas. The results described demonstrate that the mechanism of inhibition of HIOMT activity is indepen...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Ebels I,Cremer-Bartels G

    更新日期:1982-04-19 00:00:00

  • Regional differences of the mouse brain in response to an α-linolenic acid-restricted diet: Neurotrophin content and protein kinase activity.

    abstract:AIMS:The purpose of this study was to determine a relatively short-term effect of feeding an α-linolenic acid (ALA, n-3)-restricted, linoleic acid (LA, n-6)-adequate diet on neurotrophin contents and protein kinase activities in brain regions of the mouse. MAIN METHODS:After feeding mice a safflower oil (SAF) diet (AL...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Miyazawa D,Yasui Y,Yamada K,Ohara N,Okuyama H

    更新日期:2010-10-09 00:00:00

  • Benzodiazepine agonists reverse the effects of noise exposure on central benzodiazepine receptors and cardiac responsiveness.

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    pub_type: 杂志文章


    authors: Breschi MC,Martini C,Scatizzi R,Cristofani R,Giannaccini G,Martinotti E,Lucacchini A

    更新日期:1995-01-01 00:00:00

  • Two pools of beta-endorphin-like immunoreactivity in blood: plasma and erythrocytes.

    abstract::While attempting to delineate the reason for the reported extreme variability of beta-endorphin-like immunoreactivity (beta-ir) in human plasma (eg., nondetectable to 1 ng/ml) by standard radioimmunoassay, we noted that a substantial portion of circulating beta-ir was associated with erythrocytes. That erythrocyte ass...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Fisher A,Comly M,Do R,Tamarkin L,Ghazanfari AF,Mukherjee AB

    更新日期:1984-05-07 00:00:00

  • Changes in the liver protein pattern of female Wistar rats treated with the hypoglycemic agent SDZ PGU 693.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Arce A,Aicher L,Wahl D,Anderson NL,Meheus L,Raymackers J,Cordier A,Steiner S

    更新日期:1998-01-01 00:00:00

  • Gene expression analysis of Gata3-/- mice by using cDNA microarray technology.

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    pub_type: 杂志文章


    authors: Airik R,Kärner M,Karis A,Kärner J

    更新日期:2005-04-15 00:00:00

  • Z-4 allele upstream of the aldose reductase gene is associated with proliferative retinopathy in Japanese patients with NIDDM, and elevated luciferase gene transcription in vitro.

    abstract::We determined by PCR the number of (A-C)n repeats in the 2. 1 kb upstream of the aldose reductase (AR2) gene in healthy control subjects and in patients with NIDDM in Japanese. Sixty-one patients were recruited based on the severity of retinopathy and subdivided into two groups with proliferative retinopathy and witho...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Ikegishi Y,Tawata M,Aida K,Onaya T

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  • Polyamines and the catalytic domain of protein kinase C.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Mezzetti G,Monti MG,Moruzzi MS

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  • Puerarin attenuates palmitate-induced mitochondrial dysfunction, impaired mitophagy and inflammation in L6 myotubes.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Chen X,Yi L,Song S,Wang L,Liang Q,Wang Y,Wu Y,Gao Q

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Demougeot C,Marie C,Beley A

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Bellio P,Mancini A,Di Pietro L,Cracchiolo S,Franceschini N,Reale S,de Angelis F,Perilli M,Amicosante G,Spyrakis F,Tondi D,Cendron L,Celenza G

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Hirano T,Oka K,Kawashima E,Akiba M

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Matsubara K,Saito A,Tanaka A,Nakajima N,Akagi R,Mori M,Mizushina Y

    更新日期:2007-04-03 00:00:00

  • Regulation of growth and macromolecular synthesis by putrescine and spermidine in Pseudomonas aeruginosa.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Bitonti AJ,Kelly SE,McCann PP

    更新日期:1984-04-16 00:00:00

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    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Cha JH,Dure LS 4th

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Rojas-Corrales MO,Gibert-Rahola J,Micó JA

    更新日期:1998-01-01 00:00:00

  • Curcumin-primed exosomes mitigate endothelial cell dysfunction during hyperhomocysteinemia.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Kalani A,Kamat PK,Chaturvedi P,Tyagi SC,Tyagi N

    更新日期:2014-06-27 00:00:00

  • Contraction-dependent TGF-β1 activation is required for thrombin-induced remodeling in human airway smooth muscle cells.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Yao ZH,Xie HJ,Yuan YL,Huo YT,Cao J,Lai WY,Cai RJ,Cheng YX

    更新日期:2018-03-15 00:00:00

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Karler R,Calder LD,Turkanis SA

    更新日期:1990-01-01 00:00:00