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DNA vaccines.

Abstract：

:Immunization with plasmid DNA encoding antigenic proteins elicits both antibody and cell-mediated immune responses. This method of producing the protein antigens of interest directly in host cells can provide appropriate tertiary structure for the induction of conformationally specific antibodies, and also facilitates the induction of cellular immune responses. DNA immunization has provided effective protective immunity in various animal models. The immune responses induced by DNA vaccines may in some instances be preferable to those produced by immunization using conventional methods. DNA vaccination appears to be applicable to a variety of pathogens and is a useful method of raising immune responses. Thus this approach to vaccination has the potential to be a successful method of rapidly screening for antigens capable of inducing protective immunity, and of inducing protective immunity against pathogens of clinical importance.

journal_name

Life Sci

journal_title

Life sciences

authors

Donnelly JJ,Ulmer JB,Liu MA

doi

10.1016/s0024-3205(96)00502-4

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

163-72

issue

3

eissn

0024-3205

issn

1879-0631

pii

S0024320596005024

journal_volume

60

pub_type

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