The binding of [3H]AF-DX 384 is reduced in the caudate-putamen of subjects with schizophrenia.

abstract：AIMS:In this study, we investigated the combined effect of Neurotropin® and pregabalin for L5-spinal nerve ligation (L5-SNL) model in rats and thiopental-induced sleep in mice. MAIN METHODS:The left fifth lumbar nerve of rats was tightly ligated with silk sutures under pentobarbital anesthesia. The hindpaw withdrawal ...

journal_title：Life sciences

authors： Okazaki R,Namba H,Yoshida H,Okai H,Taguchi K,Kawamura M

更新日期：2013-03-12 00:00:00

abstract：AIMS:Reactive oxygen species (ROS) are generated in the ischaemic myocardium especially during early reperfusion and affect myocardial function and viability. Monoterpenes have been proposed to play beneficial roles in diverse physiological systems; however, the mechanisms of action remain largely unknown. This study a...

journal_title：Life sciences

authors： Crespo R,Wei K,Rodenak-Kladniew B,Mercola M,Ruiz-Lozano P,Hurtado C

更新日期：2017-03-01 00:00:00

abstract：:Chlorella, a type of unicellular fresh water algae, has been a popular foodstuff in Japan and Taiwan. Studies have shown the hypoglycemic effects of Chlorella in alloxan-induced and Streptozocin (STZ)-induced diabetic animals. However, the mechanisms by which Chlorella treatment affects blood glucose homeostasis have ...

journal_title：Life sciences

authors： Cherng JY,Shih MF

更新日期：2006-02-09 00:00:00

abstract：:Deficiencies in cellular cyclic AMP (cAMP) and nitric oxide (NO) production are thought to be involved in the pathogenesis of diabetic neuropathy. We used a human neuroblastoma cell line, SH-SY5Y, to investigate the effect of cilostazol, a specific cAMP phosphodiesterase inhibitor, on NO production and Na+, K+-ATPase ...

journal_title：Life sciences

authors： Inada H,Shindo H,Tawata M,Onaya T

更新日期：1999-01-01 00:00:00

abstract：AIM:The action of oestrogen has traditionally been attributed to the activation of nuclear receptors (ERα and ERβ). A third receptor, the G protein-coupled oestrogen receptor (GPER), has been described as mediator of the rapid action of oestrogen. Based on the possible protective role of oestrogen in the cardiovascular...

journal_title：Life sciences

authors： Peixoto P,Aires RD,Lemos VS,Bissoli NS,Santos RLD

更新日期：2017-08-15 00:00:00

abstract：:Effects of amphetamine on concentrations of dopamine, norepinephrine and serotonin in several monoamine-containing cell body and terminal regions were examined left and right separately in rats. Results suggest that amphetamine reduced the L-R asymmetry of most of these measures, and this effect is more significant in...

journal_title：Life sciences

authors： Lee EH,Huang SL,Chai CY

更新日期：1987-04-06 00:00:00

abstract：:In order to understand the mechanism of increasing body fat in perimenopausal and postmenopausal women, an ovariectomy-induced obesity model was used to study the role of leptin. In this investigation, a long-term study lasted for 13 weeks was conducted to monitoring the change of serum leptin level in rats after the ...

journal_title：Life sciences

authors： Chu SC,Chou YC,Liu JY,Chen CH,Shyu JC,Chou FP

更新日期：1999-01-01 00:00:00

abstract：:The Thirteenth International Conference on Endothelin (ET-13) was held from September 8-11, 2013 in Tokyo, Japan chaired by Noriaki Emoto, Kobe Pharmaceutical University, Japan, and Takashi Miyauchi, University of Tsukuba, Japan and held on the Tokyo Campus of Tsukuba University. The International Conferences on Endot...

journal_title：Life sciences

authors： Emoto N,Yanagisawa M

更新日期：2014-11-24 00:00:00

abstract：:The alpha 1-adrenoceptors present in liver membranes from rats, hamsters and mice were characterized using [3H]prazosin. In the liver membranes from the three species a relatively large number of receptors was observed (500-900 fmol/mg of protein) and the affinities for [3H]prazosin were very similar (0.2-0.3 nM). Mem...

journal_title：Life sciences

authors： García-Sáinz JA,Casas-González P,Romero-Avila MT,González-Espinosa C

更新日期：1994-01-01 00:00:00

abstract：:A simple, selective reverse-phase HPLC-fluorometric method is described for the determination of serotonin (5HT) in cisternal CSF of the rat. The mean (+/- SE) value of CSF 5HT observed in control adult rats was 457 +/- 83 pg/ml (N = 16). In an attempt to validate the measure as an index of extracellular, or functiona...

journal_title：Life sciences

authors： Anderson GM,Teff KL,Young SN

更新日期：1987-06-08 00:00:00

abstract：:Oxymorphazone (at doses of 50-200 mg/kg) was found to be a relatively weak antinociceptive drug in intact frog (Rana esculenta) when acetic acid was used as pain stimulus. Frogs remained analgesic for at least 48 hrs following oxymorphazone (200 mg/kg) administration. The ligand increased the latency of wiping reflex ...

journal_title：Life sciences

authors： Benyhe S,Hoffmann G,Varga E,Hosztafi S,Toth G,Borsodi A,Wollemann M

更新日期：1989-01-01 00:00:00

abstract：AIMS:Systemic administration of opiate analgesics such as morphine remains the most effective treatment for alleviating severe pain across a range of conditions including acute pain. However, chronic or repeated administration of opiate analgesics results in the development of analgesic tolerance. Glial cells such as m...

journal_title：Life sciences

authors： Harada S,Nakamoto K,Tokuyama S

更新日期：2013-10-11 00:00:00

abstract：:The multidrug transporter MDR1 (P-glycoprotein)-mediated interaction between digoxin and 29 antihypertensive drugs of various types was examined by using the MDR1 overexpressing LLC-GA5-COL150 cells, which were established by transfecting MDR1 cDNA into porcine kidney epithelial LLC-PK1 cells. These cells construct mo...

journal_title：Life sciences

authors： Takara K,Kakumoto M,Tanigawara Y,Funakoshi J,Sakaeda T,Okumura K

更新日期：2002-02-15 00:00:00

abstract：:P75(NTR) is a common neurotrophin receptor which binds all neurotrophins with similar affinities and has been shown to be capable of mediating programmed cell death. In this study, we investigated effects of the antipsychotic drugs (APDs) haloperidol, clozapine, quetiapine, and risperidone on p75(NTR) mRNA levels in P...

journal_title：Life sciences

authors： Bai O,Xu H,Li XM

更新日期：2006-07-04 00:00:00

abstract：AIMS:Brain injuries based on their causes are divided into two categories, TBI and NTBI. TBI is caused by damages such as head injury, but non-physical injury causes NTBI. Prolactin is one of the blood factors that increase during brain injury. It has been assumed to play a regenerative role in post-injury recovery. M...

journal_title：Life sciences

authors： Yousefvand S,Hadjzadeh MA,Vafaee F,Dolatshad H

更新日期：2020-12-15 00:00:00

abstract：:Levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat plasma were measured by radioimmunoassay and found to exhibit a circadian rhythm that parallelled the normal rhythm for corticosterone. The maximal plasma levels of both substances were observed to occur at about 1700h. The lowest concentrat...

journal_title：Life sciences

authors： Fischman AJ,Kastin AJ,Graf MV

更新日期：1984-11-12 00:00:00

abstract：:Morning urine samples were assayed for human EGF (hEGF) in 137 non-insulin dependent diabetic patients with normal serum creatinine and beta 2-microglobulin levels. Serving as controls, 80 age- and sex-matched healthy subjects were also examined. A significant positive correlation between hEGF excretion and the level ...

journal_title：Life sciences

authors： Kawaguchi M,Kamiya Y,Ito J,Fujii T,Hayakawa F,Sakuma N,Fujinami T

更新日期：1993-01-01 00:00:00

abstract：AIMS:Ovarian cancer is the most leading cause of deaths among gynecologic malignancies, and Neuron-restrictive silencer factor (NRSF) can be upregulated or downregulated according to the type of tumor. However, the expression and function of NRSF in ovarian cancer is still unknown. MAIN METHODS:Expression of NRSF in n...

journal_title：Life sciences

authors： Deng P,Zuo Y,Feng S,Li Z,Chen W,Li H,Wang X

更新日期：2018-12-15 00:00:00

abstract：:To examine the therapeutic effect of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) on neuronal ischemia-reperfusion injury, we evaluated the neurological score in gerbils subjected to unilateral common carotid occlusion. Using the neurological score method, we selected animals which showed stroke s...

journal_title：Life sciences

authors： Hata R,Matsumoto M,Kitagawa K,Tagaya M,Matsuyama T,Sugita M,Kamada T

更新日期：1995-01-01 00:00:00

abstract：AIM:This study investigated the effect of voluntary motor effort during a low-intensity (30% maximal voluntary contraction [MVC]) muscle exercise training program on increasing muscle strength. MATERIALS AND METHODS:Eighteen young and healthy individuals were randomly assigned to one of three groups: high mental effor...

journal_title：Life sciences

authors： Jiang CH,Ranganathan VK,Siemionow V,Yue GH

更新日期：2017-06-01 00:00:00

abstract：:We explored the mechanism whereby maltitol causes an increase of calcium absorption in the lower small intestine using everted ileal segments of rats. Under the calcium concentrations tested (1-20mM), which enabled us to assess the diffusional calcium transfer, maltitol in the mucosal-side medium (100mM) caused a 155%...

journal_title：Life sciences

authors： Kishi K,Goda T,Takase S

更新日期：1996-01-01 00:00:00

abstract：:Upregulation of vascular NAD(P)H oxidase has been considered an important source for elevated levels of reactive oxygen species that contribute to several cardiovascular disease states, including the vascular complications of diabetes mellitus. Previous studies have shown that treatment with antioxidants corrects impa...

journal_title：Life sciences

authors： Cotter MA,Cameron NE

更新日期：2003-08-22 00:00:00

abstract：:Unfertilized ova from Shad, a North Atlantic herring, contains a cytostatic inhibitor of T lymphocyte blastogenesis. The inhibitor has an estimated molecular weight of 10,000-30,000 Da, is heat stable, non dialyzable, and resistant to protease digestion and periodate oxidation. Although the inhibitor functions at an e...

journal_title：Life sciences

authors： Sheid B,Nobiletti JB,Prat JC

更新日期：1990-01-01 00:00:00

abstract：:Male, 5 months old, massively obese, spontaneously hypertensive rats (Obese/SHR) were given 10 mg alloxan/100 g b.w., s.c., to induce diabetes. Control Obese and non-obese/SHR were given saline. Insulin therapy was withheld. All of the animals were killed at 6 months of age. Alloxan caused a slight but statistically s...

journal_title：Life sciences

authors： Wexler BC,Mc Murtry JP

更新日期：1983-09-12 00:00:00

abstract：:The effect of Bacillus Calmette-Guérin (BCG) treatment in allergic pulmonary reaction was studied in mice genetically selected accordingly to a High (H-IVA) or Low (L-IVA) antibody responsiveness. Mice were immunized with ovalbumin (OVA) or OVA plus BCG. Two days after nasal antigenic challenge, seric IgE and IgG1 ant...

journal_title：Life sciences

authors： Barros MT,Acencio MM,Garcia ML,Macedo Soares MF,Ibañez OM,Martins MA,Ribeiro OG,Kalil J,Perini A

更新日期：2005-08-12 00:00:00

abstract：AIM:Cadmium is a persistent ubiquitous environmental toxicant that elicits several biological defects on delicate body organs. Growing evidence suggests that cadmium (Cd) may perturb signaling pathways to induce oxidative pancreatitis. Thus, we explored whether hesperidin, a flavonone, could mitigate Cd-induced oxidati...

journal_title：Life sciences

authors： Aja PM,Izekwe FI,Famurewa AC,Ekpono EU,Nwite FE,Igwenyi IO,Awoke JN,Ani OG,Aloke C,Obasi NA,Udeh KU,Ale BA

更新日期：2020-10-15 00:00:00

abstract：:It has been reported that naloxone, an opioid antagonist, has antiarrhythmic activity in vivo. In Langendorff perfused rat hearts, we found that ischemia-reperfusion-induced ventricular tachyarrhythmia reverted to normal sinus rhythm after the treatment with naloxone (3 approximately 10 microM). The method of voltage ...

journal_title：Life sciences

authors： Hung CF,Wu MH,Tsai CH,Chu SH,Chi JF,Su MJ

更新日期：1998-01-01 00:00:00

abstract：:Green tea polyphenols like epigallocatechin gallate (EGCG) have been proposed as a cancer chemopreventative. Several studies have shown that EGCG can act as an antioxidant by trapping proxyl radicals and inhibiting lipid peroxidation. The main propose of this study is to investigate the antioxidant capacity of EGCG us...

journal_title：Life sciences

authors： Saffari Y,Sadrzadeh SM

更新日期：2004-02-06 00:00:00

abstract：:We assessed the anxiolytic effect of Kami-Shoyo-San (Jia-wei-xiao-yao-san; TJ-24), one of a traditional Chinese herbal medicine used for the treatment of menopausal anxiety, by the social interaction (SI) test in male mice. Acute administration of TJ-24 (25-100 mg/kg, p.o.), as well as the gamma-amino-butyric acidA/be...

journal_title：Life sciences

authors： Mizowaki M,Toriizuka K,Hanawa T

更新日期：2001-09-21 00:00:00

abstract：:There is a great deal of evidence that the ventromedial hypothalamic area (VMH) plays a significant role in glucoregulation. The present review synthesizes new and existing data in a coherent model of a hypothalamic glucoregulatory control system whose function is to stabilize blood glucose levels in the face of disco...

journal_title：Life sciences

authors： Storlien LH

更新日期：1985-02-11 00:00:00