Abstract:
AIMS:Brain injuries based on their causes are divided into two categories, TBI and NTBI. TBI is caused by damages such as head injury, but non-physical injury causes NTBI. Prolactin is one of the blood factors that increase during brain injury. It has been assumed to play a regenerative role in post-injury recovery. MATERIALS AND METHODS:In this review, various valid papers from electronic sources (including Web of Science, Scopus, PubMed, SID, Google Scholar, and ISI databases) used, which in them the protective effect of prolactin on brain injury investigated. KEY FINDINGS:Inflammation following brain injury with the production of pro-inflammatory cytokines in the affected area can even lead to excitotoxicity and cell death in the damaged area. Medical brain damage treatments are long-term, and can have several side effects. Therefore, it is better to consider medication treatments that have fewer side effects and greater efficacy. Research suggests that prolactin has numerous regenerative effects on brain injury, and prevents cell death. Prolactin is one of the hormones produced in the body; therefore it has fewer side effects and may be more effective because it increases during brain injury. SIGNIFICANCE:Prolactin can be used peripherally and centrally, and exerts its neuro regenerative effects against further damage post-TBI and NTBI.
journal_name
Life Scijournal_title
Life sciencesauthors
Yousefvand S,Hadjzadeh MA,Vafaee F,Dolatshad Hdoi
10.1016/j.lfs.2020.118547subject
Has Abstractpub_date
2020-12-15 00:00:00pages
118547eissn
0024-3205issn
1879-0631pii
S0024-3205(20)31300-Xjournal_volume
263pub_type
杂志文章,评审相关文献
LIFE SCIENCES文献大全abstract::The anticonvulsant activity of U-54494A was studied in a 4-aminopyridine (4-AP) epilepsy model using extracellular recordings in in vitro hippocampal slices. Field potentials were evoked by stimulation of Schaffer collaterals, and recorded from the CA1 region of the hippocampus after infusion of 4-AP in the absence an...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90381-x
更新日期:1992-01-01 00:00:00
abstract::Methodological shortcomings present in elicitation of male sexual reflexes in anesthetized animals. The present study has demonstrated, however, that intraperitoneal (i.p.) injection of p-chloroamphetamine (PCA), an indirect serotonin (5-HT) agonist, elicited simultaneously both penile erection and ejaculation in anes...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00895-x
更新日期:2000-11-10 00:00:00
abstract:AIMS:We have shown that diabetes causes cerebrovascular remodeling in part by the activation of the endothelin (ET-1) system in a glucose-dependent manner. We also reported increased yet dysfunctional cerebral angiogenesis in diabetes. Here, we tested the hypothesis that dual ET-1 receptor antagonism or glycemic contro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.01.008
更新日期:2014-11-24 00:00:00
abstract::Specific 125I-CCK receptor binding was significantly increased in brain tissue taken from guinea pig or mouse following chronic (2-3 week) daily administration of haloperidol (2-3 mg/kg/day). Scatchard analysis indicated the increase in CCK binding was due to an increased receptor number (B max) with no change in affi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90224-2
更新日期:1983-02-21 00:00:00
abstract:AIMS:The mechanisms underlying the fetal origin of renal disease remains unknown. This study aimed to investigate the profiles of ion channel and transporter proteins in the fetal kidney in fetal growth restriction (FGR)rats, and to explore their association with the fetal origin of renal disease. MAIN METHODS:An FGR ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118276
更新日期:2020-10-15 00:00:00
abstract::Epidemiological studies have shown that cigarette smoke, an oxidant agent, is a risk factor for the development of diabetic nephropathy (DN), in which pathogenesis transforming growth factor beta(1) (TGFbeta(1)) plays a key role. In our experimental model we exposed mesangial cell cultures to cigarette smoke concentra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.12.026
更新日期:2004-06-18 00:00:00
abstract::Earlier studies from the authors' laboratory showed that malnourishment induces alterations in the cardiovascular homeostasis increasing the basal mean arterial pressure and heart rate. In this study, the authors evaluated whether the sympathetic and parasympathetic efferent activities contribute to changes in the car...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.08.005
更新日期:2007-08-23 00:00:00
abstract::Met-enkephalin, administered microiontophoretically, produced a greater increase in firing in cells in area CA 3-4 in the hippocampus of both young and aged Fisher 344 rats than it did in the CA 1 area. Furthermore, the effect of met-enkephalin on neuronal firing rates was not as great in old rats as it was in young r...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90360-2
更新日期:1987-01-12 00:00:00
abstract::Hyperlipidemia and the glomerular accumulation of atherogenic lipoproteins (low density lipoprotein, LDL; and its oxidatively-modified variants, ox-LDL) are commonly associated with the development of glomerular mesangial proliferative diseases. However, cellular signaling mechanisms by which atherogenic lipoproteins ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.08.010
更新日期:2008-10-24 00:00:00
abstract::Uncoupling proteins (UCPs) are supposed to be involved in diet-induced thermogenesis. Their activities are usually elevated by feeding and reduced by fasting in normal animals. To investigate whether fasting affects the expression of UCPs mRNA in brown adipose tissue (BAT) of bilateral ventromedial hypothalamus (VMH)-...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00225-x
更新日期:2003-05-16 00:00:00
abstract:AIMS:To investigate whether the expression of nerve growth factor precursor (proNGF) changes during cardiopulmonary bypass (CPB) and whether neutralizing interleukin-6 (IL-6) during CPB has cardiac benefits. MAIN METHODS:Thirty patients undergoing CPB were recruited and their serum proNGF and troponin-I (TNI) were det...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.04.007
更新日期:2017-06-01 00:00:00
abstract::We studied Na,K-ATPase mRNA expression in cardiomyopathic (Bio 14.6) and normal (F1b) Syrian hamster ventricles. In Northern blot analysis, Na,K-ATPase alpha 1, alpha 2, alpha 3 and beta 1 isoform mRNAs were detected in 3-week-old Bio 14.6 and F1b hamster ventricles. We then investigated the expression of alpha 1 subu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00776-4
更新日期:1994-01-01 00:00:00
abstract:AIMS:DNA methylation and hydroxymethylation are significantly related to the occurrence and development of coronary heart disease (CHD) and atherosclerosis (AS). 5-Methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) are used to assess DNA methylation and hydroxymethylation levels, respectively. However, 5-mC and ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.03.021
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To investigate the expression and time-dependent manner of bradykinin (BK) as well as its receptors (Bradykinin receptors 1 and 2, B1R and B2R) in spinal cord ischemia-reperfusion injury (SCII) in rat model. METHODS:Sprague-Dawley (SD) rats were subjected to 1 h of infra-renal abdominal aorta occlusion and r...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.12.034
更新日期:2019-02-01 00:00:00
abstract::Ancylostoma ceylanicum, the human hookworm parasite, exhibited significant secretion of cholinesterase when maintained in vitro in RPMI-1640 medium. Secretion of the enzyme was linear up-to 4 hours of incubation. About 40 percent of the total cholinesterase activity was localized in the soluble fraction, while remaini...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90478-8
更新日期:1992-01-01 00:00:00
abstract::The COVID-19 pandemic raised by SARS-CoV-2 is a public health emergency. However, lack of antiviral drugs and vaccine against human coronaviruses demands a concerted approach to challenge the SARS-CoV-2 infection. Under limited resource and urgency, combinatorial computational approaches to identify the potential inhi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118080
更新日期:2020-09-15 00:00:00
abstract::1-Aminocyclopropane carboxylic acid (ACPC), a partial agonist of the glycine site on the NMDA receptor, prevents tolerance to the mu opioid morphine and the delta ligand [D-Pen2,D-Pen5]enkephalin (DPDPE) when co-administered with the opioid. In contrast, ACPC does not significantly influence tolerance to the kappa1 op...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00753-5
更新日期:1994-01-01 00:00:00
abstract::Preconditioning (PC) is a potential approach to myocardial protection. We hypothesize that brief ischemia or adenosine given prior to an extended period of warm ischemia may prevent myocardial stunning by altering myocardial metabolism. Using a global ischemia model, 19 dogs were subjected to no PC(control), two episo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.08.037
更新日期:2007-10-13 00:00:00
abstract::The available preclinical literature on the antihyperlipidemic properties of beta-pyridylcarbinol is reviewed. Similarities between the pharmacological profiles for beta-pyridylcarbinol and nicotinic acid, and evidence for the metabolic conversion of beta-pyridylcarbinol to nicotinic acid are discussed. Several review...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(85)90026-8
更新日期:1985-11-25 00:00:00
abstract:AIMS:Diabetes increases oxidant stress and impairs endothelium-dependent relaxation. We investigated whether the antioxidant 3',4'-dihydroxyflavonol (DiOHF) reduces the release of superoxide (O(2)(-)) and preserves endothelial function in aortae from diabetic rats. MAIN METHODS:Type-1 diabetes was induced in Sprague-D...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2009.04.012
更新日期:2009-07-03 00:00:00
abstract:AIMS:Enhancing myogenesis has been identified as a possible target to improve insulin sensitivity and protect against metabolic diseases. Catalpol, an iridoid glycoside, has been shown to exert a hypoglycaemic effect by improvement of insulin sensitivity; however, the underlying mechanism remains unknown. In this study...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.08.028
更新日期:2018-09-15 00:00:00
abstract::Plants are potentially important for novel therapeutic drug leads, but the slowness of conventional methods for investigation of plants limits enthusiasm in the pharmaceutical industry. To overcome some of the drawbacks, we have applied high throughput pharmacological screening (HTPS) to crude plant extracts. Using a ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.09.013
更新日期:2005-12-22 00:00:00
abstract::The effect of maternal glucocorticoid depletion upon the fetal development of the organ of Zuckerkandl (OZ) in rats was determined. Maternal hypophysectomy at 13d8h gestation resulted in a fifty percent decrease in plasma corticosterone levels at 18d8h when compared to both sham operated and unoperated controls. No di...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90609-6
更新日期:1987-09-14 00:00:00
abstract:AIMS:To investigate the therapeutic effects of human amniotic mesenchymal stem cells (hAMSCs) on paraquat (PQ)-induced pulmonary fibrosis in rats and investigate the inflammatory mechanisms. MAIN METHODS:hAMSCs were identified by morphological, flow cytometry and immunocytochemistry. A pulmonary fibrosis model was ind...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117290
更新日期:2020-02-15 00:00:00
abstract:AIMS:Obesity represents a global health problem. Excessive caloric intake promotes the release of inflammatory mediators by hypertrophic adipocytes and obesity-induced inflammation is now recognized as a risk factor for the development of several diseases, such as cardiovascular diseases, insulin resistance, type-II di...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118618
更新日期:2021-01-01 00:00:00
abstract::In canine renal tubular cells, the effect of Y-24180, a presumed specific platelet activating factor (PAF) receptor antagonist, on intracellular Ca(2+) concentration ([Ca(2+)](i)) was measured by using fura-2 as a Ca(2+)-sensitive fluorescent probe. Y-24180 (0.1-10 microM) caused a rapid and sustained [Ca(2+)](i) rise...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.09.033
更新日期:2004-01-02 00:00:00
abstract::We produced thiamine-deficient (TD) mice by TD diet treatment. The growth curve of mice on TD feeding was sharply increased until on the 10th day and subsequently the body weight gradually decreased. The mortality rate in mice was about 67% on the 30th day after the start of TD feeding. We performed the forced swimmin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01206-1
更新日期:2001-07-27 00:00:00
abstract::Amyloid beta-protein (A beta), the major protein of cerebrovascular and plaque amyloid in Alzheimer disease, is considered a primary factor in the pathology of this disease. The effect of synthetic A beta (1-40) on the activity of protein kinase C (PKC) was studied with histones for a substrate in a mixed micellar ass...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90328-9
更新日期:1991-01-01 00:00:00
abstract:AIMS:Parathyroid hormone-related protein (PTHrP) is a peptide growth factor produced in a wide range of tissues from brain and parathyroid, to kidney and uterus. The purpose of this study was to determine whether the adrenal cortical hormones, hydrocortisone (cortisol), modulate PTHrP expression and glucocorticoid rece...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.08.001
更新日期:2011-10-24 00:00:00
abstract::Since many patients complain about halitosis without there being any clinical evidence of its cause, psychological symptoms have been pointed out as halitosis-inducing factors. The aim of this study was to evaluate the influence of anxiety on the production of volatile sulfur compounds (VSC). Seventeen undergraduate m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.02.010
更新日期:2006-07-10 00:00:00