Abstract:
:Earlier studies from the authors' laboratory showed that malnourishment induces alterations in the cardiovascular homeostasis increasing the basal mean arterial pressure and heart rate. In this study, the authors evaluated whether the sympathetic and parasympathetic efferent activities contribute to changes in the cardiovascular homeostasis through altered modulation of the arterial baroreflex of malnourished rats. After weaning, male Fischer rats were given 15% (Normal Protein--NP) or 6% (Low Protein--LP) protein diet for 35 d. The baroreflex gain and latency were evaluated before and after selective autonomic blockades in control and malnourished rats. It was observed that malnourishment affected the baroreflex gain in response to activation and deactivation of the arterial baroreflex. Moreover, malnourished rats showed increased baroreflex latency as compared to that of control rats. Regarding the autonomic efferent activity directed to the heart, the data showed increased sympathetic and decreased parasympathetic efferent activities in malnourished rats, and such alterations could be related to the observed changes in the arterial baroreflex gain as well as in the basal mean arterial pressure and heart rate.
journal_name
Life Scijournal_title
Life sciencesauthors
Loss Ide O,Fernandes LG,Martins CD,Cardoso LM,Silva ME,Dias-da-Silva VJ,Moraes MF,Chianca DA Jrdoi
10.1016/j.lfs.2007.08.005subject
Has Abstractpub_date
2007-08-23 00:00:00pages
944-50issue
11eissn
0024-3205issn
1879-0631pii
S0024-3205(07)00584-Xjournal_volume
81pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Recent studies have shown that acyl-CoA:cholesterol acyltransferase (ACAT) plays an important role in the initiation of diabetes-associated hypercholesterolemia. To confirm this hypothesis, effects of a potent ACAT inhibitor, FR145237, on diet-induced hypercholesterolemia were examined in streptozotocin (STZ)-induced ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(96)00658-3
更新日期:1997-01-01 00:00:00
abstract::The molecular dynamics (MD) simulations study in the formation of the complex between compound SWR-0342SA and beta-ARs suggested that upon binding SWR-0342SA stimulates receptor activation through residues network (Asp104, Leu335 in beta(1)-AR; Asp117, Ser209, Leu303, Ser191 in beta(3)-AR) in an active conformation st...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.09.023
更新日期:2006-03-20 00:00:00
abstract::Male and female rats with two permanently indwelling intravenous catheters were infused for 2 hours with ovine prolactin. During equilibrium conditions the effects of intravenously injected L-DOPA and benzerazide (a blocker of dopa-decarboxylase) on steady state levels of ovine prolactin were measured. A dose of 4.5 m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90549-5
更新日期:1982-08-30 00:00:00
abstract::Active uptake of serotonin (5-hydroxytryptamine, 5-HT) into blood platelets from healthy donors exhibited a lower Vmax value in buffer media than in plasma. Also in plasma ultrafiltrate Vmax was reduced, but it returned to the level measured in plasma upon addition of human serum albumin (40 milligrams) containing fat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90361-5
更新日期:1989-01-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is the most prevalent neuromuscular disease worldwide. It is a lethal and progressive neurodegenerative disease, principally affecting motor neurons; patient clinical characteristics are muscle weakness, dysphagia and respiratory failure. The mean age is related to family history (4...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2017.12.016
更新日期:2018-01-15 00:00:00
abstract::As the relationship between emotional behavior and electrocardiographic (ECG) change induced by hypothalamic stimulation is poorly understood, eighty-four points in various areas within the hypothalamus in conscious cats were stimulated electrically through chronically implanted electrodes, the objective being to clar...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90494-1
更新日期:1985-03-18 00:00:00
abstract::It has been shown that the main psychoactive component of marihuana, delta9-tetrahydrocannabinol (THC) has mainly inhibitory effects on the regulation of reproduction. Recently, the purification and availability of the endogenous ligand of the cannabinoid receptor, arachidonyl ethanolamide, anandamide, (ANA) and its s...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/s0024-3205(99)00292-1
更新日期:1999-01-01 00:00:00
abstract::NMDA receptors are glutamate-regulated ion channels of critical importance for many neurophysiological and neuropathological processes. Mg2+ blocks the NMDA receptor by binding to the channel pore with an apparent affinity that depends on the membrane potential. We have investigated the effect of NMDA and the required...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)00975-4
更新日期:2001-03-09 00:00:00
abstract::We previously demonstrated that tissue-type plasminogen activator (t-PA) specifically bound to its receptor (t-PAR) on human umbilical vein endothelial cells (HUVEC). In addition to analyses of t-PA binding to plasminogen activator inhibitor-1 (PAI-1) in the extracellular matrix (ECM) and to the t-PAR, we further eval...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)80007-7
更新日期:2000-01-01 00:00:00
abstract::The present study was carried out in order to identify the changes in expression of multidrug resistance-associated protein (Mrp) 2 and P-glycoprotein (P-gp) in the intestine and remote organs after intestinal ischemia-reperfusion (I/R). Mrp2 expression in the jejunum and liver was decreased at 6 h after I/R. This dec...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.04.019
更新日期:2008-06-20 00:00:00
abstract::Hyaluronan (HA) is a multifunctional high molecular weight polysaccharide found throughout the animal kingdom, especially in the extracellular matrix (ECM) of soft connective tissues. HA is thought to participate in many biological processes, and its level is markedly elevated during embryogenesis, cell migration, wou...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2007.02.037
更新日期:2007-05-01 00:00:00
abstract::Chlorin e(6) and its derivatives are promising sensitizers for photodynamic therapy (PDT). In order to compare the photodynamic effects of 8 novel derivatives of chlorin e(6) and to explore some mechanisms of their effects at the cellular level, we studied PDT-induced changes in bioelectric activity of crayfish mechan...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.09.053
更新日期:2004-03-12 00:00:00
abstract:AIM:The aim of this study was to investigate the effect of protolichesterinic acid, a lichen secondary metabolite, on anti-proliferative activity of doxorubicin in three human cancer cell lines, HeLa, SH-SY5Y and K562 cells. MAIN METHODS:The data obtained from MTT assays, performed on cells treated with protolichester...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.06.023
更新日期:2016-08-01 00:00:00
abstract::Male Sprague-Dawley rats were castrated and given daily sc. injections of estradiol (E2, 10 micrograms/day), testosterone propionate (TP, 1.0 mg/day), dihydrotestosterone (DHT, 1.0 mg/day) or sesame oil (SO, 0.2 ml/day). A group of sham castrate males received daily sc. injections of SO (0.2 ml/day). On day 8 of stero...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90327-8
更新日期:1984-01-02 00:00:00
abstract:AIMS:Carbon nanotube (CNT) membranes offer an exciting opportunity to mimic natural protein channels due to 1) a mechanism of dramatically enhanced fluid flow 2) ability to place 'gatekeeper' chemistry at the entrance to pores 3) the ability for biochemical reactions to occur on gatekeeper molecules and 4) an ability t...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2009.04.006
更新日期:2010-04-10 00:00:00
abstract:AIMS:Thiamine is an important cofactor present in many biochemical reactions, and its deprivation can lead to heart dysfunction. Little is known about the influence of thiamine deprivation on the electrophysiological behavior of the isolated heart cells and information about thiamine deficiency in heart morphology is c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2009.03.011
更新日期:2009-06-05 00:00:00
abstract::The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is rapidly metabolized to a 1-methyl-4-phenylpyridinium species (MPP+) in the squirrel monkey. After administration of toxic doses of MPTP, the concentration of MPP+ in the substantia nigra appears to increase during the first 72 hours, reaching the hi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90060-8
更新日期:1985-01-21 00:00:00
abstract::The effect of various fractions of black tea [(Camellia Sinensis) (L) O. Kuntze (Theaceae)] on the function of mammalian skeletomotor apparatus was studied. The theaflavin fraction (Tfs) produced a concentration- dependent facilitation of indirect twitch responses of the rat phrenic nerve diaphragm preparation and the...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.12.018
更新日期:2005-05-13 00:00:00
abstract::The effect of the diterpene forskolin on vascular permeability alone and in combination with bradykinin, prostaglandin E1, adenosine or histamine has been investigated in rats. Vascular permeability in rat skin was measured using [125I]-labelled bovine serum albumin ([125I]BSA) as a tracer. In addition, the effect of ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90712-9
更新日期:1983-07-04 00:00:00
abstract::Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the mesenteric hyperemia after intraduodenal acidification. The hyperemia plays a role in protecting the duodenal mucosa against acid damage. We tested the hypothesis that bradykinin contributes to this protective hyperemia. A specific antagonist...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01455-2
更新日期:2002-01-04 00:00:00
abstract::The endogenous cannabinoid anandamide (AEA) exerts the majority of its effects at CB1 and CB2 receptors and is degraded by fatty acid amide hydrolase (FAAH). FAAH KO mice and animals treated with FAAH inhibitors are impaired in their ability to hydrolyze AEA and other non-cannabinoid lipid signaling molecules, such as...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2012.05.015
更新日期:2013-03-19 00:00:00
abstract::A series of studies were conducted to determine the effects of leucine-(leu-) enkephalin and methionine-(met-) enkephalin on perfusion pressure. These experiments utilized isolated perfused femoral arterial preparations in pentobarbital-anesthetized cats. The enkephalins were administered intraarterially into the femo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90047-9
更新日期:1982-10-11 00:00:00
abstract::Hydroxyethyl starch (HES) found in rat serum and spleen after single and daily administrations of 0.9 g/kg for 1 week was characterized by gas-liquid chromatography. There was very little difference in the degree of substitution (D.S.) and molar substitution (M.S.) of HES in serum samples obtained at 1 hour and 57 day...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90737-3
更新日期:1983-11-14 00:00:00
abstract::Certain things have not changed since my colleague and I last reviewed the role of dietary salt in hypertension [Haddy, F.J., Pamnani, M.B., 1995. Role of dietary salt in hypertension. Journal of the American College of Nutrition 14, 428-438]. Over half of hypertensives are still salt sensitive, i.e., they respond to ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2006.05.017
更新日期:2006-09-20 00:00:00
abstract::Using a specific radioimmunoassay, we measured concentrations of plasma 7B2 (a novel pituitary polypeptide) immunoreactivity (7B2-IR) in normal human subjects, patients with chronic renal failure and those with liver cirrhosis. Mean (+/- SEM) values of plasma 7B2-IR in normal healthy men and women were 55.8 +/- 1.2 pg...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90685-0
更新日期:1987-08-24 00:00:00
abstract:AIMS:Two natural alkaloids, methyl (M) and isopropyl (I) N-methylanthranilates, with recently demonstrated significant pharmacological activities, were assayed for their possible overall effect on intact gastric mucosa and their protective properties towards the onset of gastric lesions induced by diclofenac (a non-ste...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.10.002
更新日期:2013-11-19 00:00:00
abstract::The purpose of this research is to elucidate the pharmacological mechanism mediating vesicating effects of sulfur mustard (HD) and identify an antidote to its action. HD causes blisters because epithelial cells lose their attachments. Epithelial cell adhesion is under control of the local cytotransmitter acetylcholine...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00074-2
更新日期:2003-03-28 00:00:00
abstract::Human histiocytic lymphoma cells (U-937) undergo similar differentiation when incubated with the phorbol ester 12-0-tetradecanoyl phorbol-13-acetate (TPA) and 1,25-dihydroxycholecalciferol. In this action, TPA somehow implicates calcium-sensitive and phospholipid-dependent protein kinase (protein kinase C), which is r...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90105-6
更新日期:1987-05-25 00:00:00
abstract::The epicardial release of immunoreactive atrial natriuretic peptides (ir-ANPs) in inside-out perfused rabbit atria has been reported. In order to determine the presence of ir-ANPs in pericardial fluid and to evaluate their biochemical characteristics, we measured the concentration of ir-ANPs in pericardial fluid obtai...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90514-r
更新日期:1990-01-01 00:00:00
abstract::The effects of environmental cues explicitly paired or unpaired with pentobarbital on the thermic effects of pentobarbital and amphetamine were investigated. Rats received 19 injections of pentobarbital in a distinctive environment and were subsequently tested for the thermic effects of pentobarbital and amphetamine i...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90051-1
更新日期:1984-06-25 00:00:00