Selective accumulation of MPP+ in the substantia nigra: a key to neurotoxicity?

abstract：AIMS:Anaphylactic shock sometimes accompanies pulmonary vaso- and broncho-constriction. We previously reported the hemodynamic features of mouse anaphylaxis (Life Sci. 2014; 116: 98-105). However, the effects of anaphylactic chemical mediators on the hemodynamics of in vivo mice are not well known. Furthermore, it is u...

journal_title：Life sciences

authors： Wang M,Shibamoto T,Kuda Y,Tanida M,Zhang T,Song J,Kurata Y

更新日期：2016-02-15 00:00:00

abstract：AIMS:We investigated the effects of chemical stimulation of cerebellum fastigial nucleus (FN) on the chronic visceral hypersensitivity (CVH) and its possible mechanism in rats. MAIN METHODS:We stimulated the FN by microinjecting glutamate into the FN, in order to explore whether the cerebellum fastigial nucleus played...

journal_title：Life sciences

authors： Zhen LL,Miao B,Chen YY,Su Z,Xu MQ,Fei S,Zhang J

更新日期：2018-06-15 00:00:00

abstract：:Rabbits were made reticulocytotic by repeated bleeding or by injection of phenylhydrazine. Up to reticulocyte levels of 70%, the baseline activity of magnesium-dependent calcium-stimulated adenosine triphosphatase ( ( Ca + Mg)-ATPase, EC 3.6.1.3.) of the red cell plasma membrane was not significantly changed. Maximal ...

journal_title：Life sciences

authors： Cameron BF,Green L

更新日期：1983-08-29 00:00:00

abstract：AIMS:Active immunization with human vascular endothelial growth factor (hVEGF) vaccines provides a therapeutic option instead of bevacizumab therapy. However, the immunity to self-molecule is difficult to elicit due to immune tolerance. A bioactive peptide of two tandem repeats of mHSP70407-426 (M2) has exhibited poten...

journal_title：Life sciences

authors： Xu M,Zhang Y,Dong W,Jiang L,Zhang J,Yu P,Xie S,Zhou L

更新日期：2018-05-15 00:00:00

abstract：:Rats were submitted to 110 dB white noise exposure for 1, and 6 hours and brain alpha 1, beta 1 and benzodiazepine receptor binding was evaluated with selective ligands. An increase in cerebral benzodiazepine receptor (CBR) concentration, without any significant change in affinity constant, occurred after the 6 h trea...

journal_title：Life sciences

authors： Breschi MC,Martini C,Scatizzi R,Cristofani R,Giannaccini G,Martinotti E,Lucacchini A

更新日期：1995-01-01 00:00:00

abstract：:Ovine fetal renal responses to ANF decrease during the last third of gestation, although circulating fetal plasma atrial natriuretic factor (ANF) levels are higher than in the maternal circulation, and do not change with gestation. This study examined whether previously reported maturational changes in fetal renal res...

journal_title：Life sciences

authors： Dodd A,Kullama LK,Ervin MG,Leake RD,Ross MG

更新日期：1994-01-01 00:00:00

abstract：:A new simplified procedure for determination of nitric oxide (NO) in biological solutions is described utilizing a new reducing system of nitric oxide prior to chemiluminescence. Advantages of the new method makes heating of the reducing solution unnecessary and avoids cooling and condensation of generated vapors. Onl...

journal_title：Life sciences

authors： Termin A,Hoffmann M,Bing RJ

更新日期：1992-01-01 00:00:00

abstract：:Responses to [Mpr14]-ADM(14-50), a novel analog of adrenomedullin, were investigated in the hindlimb vascular bed of the cat under conditions of controlled blood flow. Intraarterial injections of [Mpr14]-rADM(14-50) in doses of 0.003-1 nmol caused dose-related decreases in hindlimb perfusion pressure. In terms of rela...

journal_title：Life sciences

authors： Champion HC,Duperier CD,Fitzgerald WE,Lambert DG,Murphy WA,Coy DH,Kadowitz PJ

更新日期：1996-01-01 00:00:00

abstract：AIMS:The study investigated the antidepressant-like effect and acute toxicity of 4-phenyl-1-(phenylselanylmethyl)-1,2,3-triazole (Se-TZ), an organoselenium-containing heterocycle compound in mice. MAIN METHODS:The antidepressant-like effect of Se-TZ (1-50mg/kg) and its mechanism of action, was analyzed in the tail sus...

journal_title：Life sciences

authors： Donato F,de Gomes MG,Goes AT,Seus N,Alves D,Jesse CR,Savegnago L

更新日期：2013-09-17 00:00:00

abstract：:The changes in the energy charge (ATP + 0.5 ADP)/(ATP + ADP + AMP) levels of the remnant liver were studied in relation to changes in the incorporation rate of methyl-3H-thymidine into DNA, the blood ratio of acetoacetate/beta-hydroxybutyrate and indocyanine green (ICG) clearance in 70% hepatectomized rabbits. The ene...

journal_title：Life sciences

authors： Ozawa K,Fujimoto T,Nakatani T,Asano M,Aoyama H,Tobe T

更新日期：1982-08-16 00:00:00

abstract：:Since the discovery of leptin in 1994 by Zhang et al., there have been a number of reports showing its implication in the development of a wide range of cardiovascular diseases. However, there exists some controversy about how leptin can induce or preserve cardiovascular function, as different authors have found contr...

journal_title：Life sciences

authors： Feijóo-Bandín S,Portolés M,Roselló-Lletí E,Rivera M,González-Juanatey JR,Lago F

更新日期：2015-11-01 00:00:00

abstract：:The extract of Crataegus, a mixture of flavonoids and procyanidins extracted from hawthorn, Crataegus oxyacantha, L. and C. monogyna Jacq., relaxed vascular tone or increased production of cyclic GMP in the rat aorta, but flavonoid components of Crataegus extract, hyperoside, rutin and vitexin, did not affect the vasc...

journal_title：Life sciences

authors： Kim SH,Kang KW,Kim KW,Kim ND

更新日期：2000-01-01 00:00:00

abstract：:Glycation-modified hemoglobin in diabetes mellitus has been suggested to be a source of enhanced catalytic iron and free radicals causing pathological complications. The present study aims to verify this idea in experimental diabetes. Pelargonidin, an anthocyanidin, has been tested for its antidiabetic potential with ...

journal_title：Life sciences

authors： Roy M,Sen S,Chakraborti AS

更新日期：2008-05-23 00:00:00

abstract：:In 6-[18F]fluoro-L-dopa (Fdopa)/positron emission tomography (PET) studies, carbidopa pretreatment increases the Fdopa bioavailability to the brain and enhances the intensity of striatal PET images. Different PET research teams have used various carbidopa doses and routes of administration in non-human primate studies...

journal_title：Life sciences

authors： Chan GL,Doudet DJ,Dobko T,Hewitt KA,Schofield P,Pate BD,Ruth TJ

更新日期：1995-01-01 00:00:00

abstract：:Castration increases the central nervous system (CNS) sensitivity to hexobarbital as measured by an EEG-threshold method. Testosterone treatment in doses from 1 to 5 mg/kg/day decreases CNS-sensitivity and restores threshold values in castrated rats to a level found in normal young adult male rats. ...

journal_title：Life sciences

authors： Bolander HG,Kourtopoulos H

更新日期：1985-03-11 00:00:00

abstract：:Studies have adequately demonstrated the importance of maternal nutrition, particularly, micronutrients (folic acid, vitamin B12) and long chain polyunsaturated fatty acids (LCPUFAs) in determining pregnancy outcome. Reports indicate that children born preterm or to mothers with preeclampsia are at increased risk of d...

journal_title：Life sciences

authors： Khot V,Chavan-Gautam P,Joshi S

更新日期：2015-05-15 00:00:00

abstract：:We have examined the role of membrane hyperpolarization in mediating vascular hyporeactivity induced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat thoracic aorta ex vivo. The injection of rats with LPS caused a significant fall of blood pressure and a severe vascular hyporeactivity to nore...

journal_title：Life sciences

authors： Chen SJ,Wu CC,Yang SN,Lin CI,Yen MH

更新日期：2000-12-29 00:00:00

abstract：:Methodological shortcomings present in elicitation of male sexual reflexes in anesthetized animals. The present study has demonstrated, however, that intraperitoneal (i.p.) injection of p-chloroamphetamine (PCA), an indirect serotonin (5-HT) agonist, elicited simultaneously both penile erection and ejaculation in anes...

journal_title：Life sciences

authors： Yonezawa A,Watanabe C,Ando R,Furuta S,Sakurada S,Yoshimura H,Iwanaga T,Kimura Y

更新日期：2000-11-10 00:00:00

abstract：:Incubation of unfixed, frozen sections of rat pancreas with tritiated guanidinoethylmercaptosuccinic acid (GEMSA) resulted in a localization of [3H]-GEMSA autoradiographic grains over the islets of Langerhans, suggesting that a carboxypeptidase H-like enzyme occurs in the islet. ...

journal_title：Life sciences

authors： Powell AM,Wells MR,Timmers KI,Recant L

更新日期：1987-06-29 00:00:00

abstract：:Nitric oxide (NO) may play an important regulatory role in airway function. We have, thus, investigated in vitro whether epithelium derived NO may modulate cholinergic neurotransmission, via release of NO in guinea pig trachea, by using L-arginine (L-ARG), a precursor of NO synthesis, and L-N(G)-nitro-arginine-methyl-...

journal_title：Life sciences

authors： Matera MG,D'agostino B,Cardone M,Calderaro V,Rossi F

更新日期：1995-02-17 00:00:00

abstract：:Increased oxidative stress plays a role in the pathogenesis of beta-cell dysfunction and death. We studied isoforms of NADPH oxidase components in islets of Langerhans isolated from rat pancreas and tumoral rat beta-cell line RINm5F cells by RT-PCR and sequencing of its products. RT-PCR revealed that isolated islets c...

journal_title：Life sciences

authors： Uchizono Y,Takeya R,Iwase M,Sasaki N,Oku M,Imoto H,Iida M,Sumimoto H

更新日期：2006-12-14 00:00:00

abstract：:In the biosynthesis of adrenomedullin (AM), glycine-extended AM, an intermediate form (iAM) processed from proAM is converted to AM[1-52]-NH2, the bioactive mature form of AM (mAM), by enzymatic amidation. We earlier showed that both molecular forms of AM circulate in human plasma. In the present study, to investigate...

journal_title：Life sciences

authors： Hirayama N,Kitamura K,Imamura T,Kato J,Koiwaya Y,Eto T

更新日期：1999-01-01 00:00:00

abstract：:Semi-purified dog kidney Na+,K+-ATPase cross-linked with ovalbumin was used in batch-wise affinity chromatography for the detection of endogenous Na+,K+-ATPase inhibitor in human plasma and urine. Ammonium acetate 1 M washed off the endogenous inhibitor from the immobilized enzyme. The inhibitory activity of the eluat...

journal_title：Life sciences

authors： Henning G,Cloix JF,Wainer IW,Pernollet MG,Devynck MA,Meyer P

更新日期：1985-05-06 00:00:00

abstract：:Recently, single-dose drug packaging systems, allowing the administration of multiple drugs in a single pill, have become popular for the convenience of the patient. The quality of drugs and an accurate measurement of their photostabilities within this system, however, have not been carefully addressed. Drugs that are...

journal_title：Life sciences

authors： Uwai K,Tani M,Ohtake Y,Abe S,Maruko A,Chiba T,Hamaya Y,Ohkubo Y,Takeshita M

更新日期：2005-12-12 00:00:00

abstract：AIMS:We have developed biochemical and cell based assays to characterize small therapeutic molecules that inhibit the DNA damage checkpoint enzyme, Chk1 (Checkpoint kinase 1). MAIN METHODS:To prepare a screen of large chemical libraries, we purified the full-length and the catalytic domain versions of human Chk1. We c...

journal_title：Life sciences

authors： Ferry G,Studeny A,Bossard C,Kubara PM,Zeyer D,Renaud JP,Casara P,de Nanteuil G,Wierzbicki M,Pfeiffer B,Prudhomme M,Leonce S,Pierré A,Boutin JA,Golsteyn RM

更新日期：2011-08-15 00:00:00

abstract：AIMS:Transforming growth factor-β1 (TGF-β1) plays a significant role in epithelial-mesenchymal transition (EMT). Furthermore, endoplasmic reticulum (ER) stress also can induce EMT. However, the relationship among TGF-β1, ER stress and EMT in podocytes is still unclear. Consequently, this study examines the crosstalk ef...

journal_title：Life sciences

authors： Chen CA,Chang JM,Chang EE,Chen HC,Yang YL

更新日期：2018-09-15 00:00:00

abstract：:We have examined factors that alter the effect of diazepam (DZ) on plasma corticosterone (CS) in rats. DZ had a biphasic effect on plasma CS levels: CS decreased with doses below 5 mg/kg and increased with higher doses. Peak response occurred 90 minutes post injection in both sexes. Plasma DZ levels were significantly...

journal_title：Life sciences

authors： Pohorecky LA,Cotler S,Carbone JJ,Roberts P

更新日期：1988-01-01 00:00:00

abstract：AIMS:Hypercholesterolemia is a hazard for increasing susceptibility of the heart to myocardial infarction (MI) by inducing platelet hyperaggregability. Clopidogrel and prasugrel have documented cardioprotective effects in clinical studies. Herein, we investigated whether clopidogrel and prasugrel could protect against ...

journal_title：Life sciences

authors： Mohammad HMF,Makary S,Atef H,El-Sherbiny M,Atteia HH,Ibrahim GA,Mohamed AS,Zaitone SA

更新日期：2020-04-15 00:00:00

abstract：:Extracellular phospholipase A2 (PLA2) with proinflammatory activity has recently been discovered in synovial fluids in inflammatory arthritides. In the search for the sources of synovial fluid PLA2, human synovium and articular cartilage were found to contain large quantities of the enzyme. In rheumatoid arthritis (RA...

journal_title：Life sciences

authors： Pruzanski W,Bogoch E,Stefanski E,Wloch M,Vadas P

更新日期：1991-01-01 00:00:00

abstract：:The role of serotonin (5-HT) in the regulation of steroidogenesis in the ovary via 5-HT2 receptor was studied in normal cycling rats and their preovulatory follicles. Oral administration of ketanserin (KET), a selective 5-HT2 antagonist, at 10 mg/kg BW at 1100h on the day of proestrus resulted in a marked decrease in ...

journal_title：Life sciences

authors： Tanaka E,Baba N,Toshida K,Suzuki K

更新日期：1993-01-01 00:00:00