Abstract：
:Nitric oxide (NO) may play an important regulatory role in airway function. We have, thus, investigated in vitro whether epithelium derived NO may modulate cholinergic neurotransmission, via release of NO in guinea pig trachea, by using L-arginine (L-ARG), a precursor of NO synthesis, and L-N(G)-nitro-arginine-methyl-ester (L-NAME), an inhibitor of NO synthase. Results show that L-ARG and L-NAME modify acetylcholine sensitivity in epithelium-intact smooth muscle preparations, suggesting a probable NO synthesis by tracheal guinea pig epithelium.
journal_name
Life Scijournal_title
Life sciencesauthors
Matera MG,D'agostino B,Cardone M,Calderaro V,Rossi Fdoi
10.1016/0024-3205(95)00053-9subject
Has Abstractpub_date
1995-02-17 00:00:00pages
PL231-5issue
13eissn
0024-3205issn
1879-0631pii
0024320595000539journal_volume
56pub_type
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