High FOXK1 expression correlates with poor outcomes in hepatocellular carcinoma and regulates stemness of hepatocellular carcinoma cells.

abstract：:Effect of mitragynine, an indole alkaloid isolated from Thai medicinal plant kratom (Mitragyna speciosa), on electrically stimulated contraction was studied in the guinea-pig ileum. Mitragynine (1 nM-3 microM) inhibited the ileum contraction elicited by electrical stimulation, and its pD2 value was 6.91 +/- 0.04 (n = ...

journal_title：Life sciences

authors： Watanabe K,Yano S,Horie S,Yamamoto LT

更新日期：1997-01-01 00:00:00

abstract：AIMS:Serotonergic neurons and amino acid neurons are involved in the central nervous control of lower urinary tract function. We investigated the role of the serotonergic system in the central regulation of micturition, as well as the relationship between serotonergic neurons and amino acid neurons in the lumbosacral c...

journal_title：Life sciences

authors： Kadekawa K,Nishijima S,Sugaya K,Miyazato M,Saito S

更新日期：2009-10-07 00:00:00

abstract：:The in vitro oxidative hemolysis of human red blood cells (RBCs) was used as a model to study the free radical-induced damage of biological membranes and the protective effect of flavonols and their glycosides (FOHs), i.e., myricetin (MY), quercetin (Q), morin (MO), kaempferol (K), rutin (R), quercetin galactopyranosi...

journal_title：Life sciences

authors： Dai F,Miao Q,Zhou B,Yang L,Liu ZL

更新日期：2006-04-18 00:00:00

abstract：:Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1 receptors (a...

journal_title：Life sciences

authors： Filloux F,Richards TJ,Huff GF,Wamsley JK

更新日期：1991-01-01 00:00:00

abstract：AIMS:This study was performed to examine whether hypertension affects the sympathetic transmission to resistance vessels of pithed rats via inhibitory presynaptic cannabinoid CB1 receptors and whether endocannabinoids are involved in this response. MATERIALS AND METHODS:We compared uninephrectomised rats rendered hype...

journal_title：Life sciences

authors： Toczek M,Schlicker E,Grzęda E,Malinowska B

更新日期：2015-10-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is the most prevalent neuromuscular disease worldwide. It is a lethal and progressive neurodegenerative disease, principally affecting motor neurons; patient clinical characteristics are muscle weakness, dysphagia and respiratory failure. The mean age is related to family history (4...

journal_title：Life sciences

authors： Recabarren-Leiva D,Alarcón M

更新日期：2018-01-15 00:00:00

abstract：:We investigated whether nitric oxide (NO) exposure alters the balance between NO and endothelium-derived hyperpolarizing factor (EDHF) released from rat renal arteries. To produce states of acutely or chronically excessive NO, lipopolysaccharide (LPS) was administered intraperitoneally to rats in a single dose of 4 mg...

journal_title：Life sciences

authors： Kagota S,Yamaguchi Y,Nakamura K,Shinozuka K,Kunitomo M

更新日期：2004-04-16 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive impairments in AD, but the molecular signaling pathways underlying its neurotoxic consequences have not yet been completely explored. Additional...

journal_title：Life sciences

authors： Amidfar M,de Oliveira J,Kucharska E,Budni J,Kim YK

更新日期：2020-09-15 00:00:00

abstract：:We examined the effects of arginine-vasopressin (AVP) C-terminal fragment 4-9, which facilitates learning and memory, on the extracellular acetylcholine (ACh) release in hippocampus of freely-moving rats using the microdialysis technique. Following administration of AVP4-9, p-Glu-Asn-Cys[Cys]-Pro-Arg-Gly-NH2, through ...

journal_title：Life sciences

authors： Maegawa H,Katsube N,Okegawa T,Aishita H,Kawasaki A

更新日期：1992-01-01 00:00:00

abstract：:We examined the direct effect of magnesium ion on aldosterone production by adrenal cells using collagenase-dispersed zona-glomerulosa cells in rats. The effects of magnesium on aldosterone production stimulated by angiotensin II or ACTH were also investigated. Both magnesium sulphate (MgSO4) and magnesium chloride (M...

journal_title：Life sciences

authors： Atarashi K,Matsuoka H,Takagi M,Sugimoto T

更新日期：1989-01-01 00:00:00

abstract：:We investigated the effects of VA-045, an apovincaminic acid derivative, on isolated blood vessels. VA-045 (10(-7)-10(-5) M) and vinpocetine (10(-7)-10(-5) M) inhibited the 64 mM KCl-induced and 10(-6)M norepinephrine (NE)-induced contraction of rat aortic strips. VA-045 (10(-7)-10(-4) M) and vinpocetine (10(-7)-10(-4...

journal_title：Life sciences

authors： Miyata N,Yamaura H,Tanaka M,Muramatsu M,Tsuchida K,Okuyama S,Otomo S

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Quercetin is a major flavonoid in various plants. It possesses the multiple pharmacological actions like vascular integrity and regulatory action of the blood-brain barrier. AIMS:The present study is focused on evaluating the role of solid lipid nanoparticle of quercetin in pentylenetetrazole (PTZ) induced ...

journal_title：Life sciences

authors： Rishitha N,Muthuraman A

更新日期：2018-04-15 00:00:00

abstract：:Human, dog and rabbit corpus cavernosum type 5 phosphodiesterases (PDE5) were isolated and their characteristics were compared. The three enzymes showed Km values of 0.8, 2.1 and 2.3 uM, respectively. They exhibited similar pH-dependence with optimal pH being 7.5. They required Mg++ for activity and the activity was s...

journal_title：Life sciences

authors： Wang P,Wu P,Myers JG,Stamford A,Egan RW,Billah MM

更新日期：2001-03-16 00:00:00

abstract：:We studied the different effects of three kinds of somatostatin (somatostatin 1-14, somatostatin 15-28, somatostatin 1-28) on the aggregation of rabbit's platelets. It was clarified that somatostatin 15-28 had inhibitory effects on rabbit's platelet aggregation stronger than somatostatin 1-14 did, and that somatostati...

journal_title：Life sciences

authors： Fuse I,Ito S,Takagi A,Shibata A

更新日期：1985-05-27 00:00:00

abstract：:Hypoxia-induced neuronal damage and glutamate release were investigated in a N(2)- or in xenon-atmosphere for embryonic rat cortical neurons; cellular damage and glutamate over-release were observed in N(2)-treated cells whereas xenon protected the cells from the hypoxic insult. The protective effect of xenon was stro...

journal_title：Life sciences

authors： Petzelt C,Blom P,Schmehl W,Müller J,Kox WJ

更新日期：2003-03-14 00:00:00

abstract：:Bacterial endotoxin or lipopolysaccharide (LPS) can trigger inflammatory responses and cause damage in organs such as liver and lungs when it is introduced into mammals, but the exact molecular events that mediate these responses have remained obscure. In this study, by using 2D gel electrophoresis and cDNA microarray...

journal_title：Life sciences

authors： Xie W,Shao N,Ma X,Ling B,Wei Y,Ding Q,Yang G,Liu N,Wang H,Chen K

更新日期：2006-10-04 00:00:00

abstract：:The distribution pattern of ascorbic acid in the endocrine organs and/or tissues was investigated during various sexual states of female rats to demonstrate a correlation between ascorbic acid concentration and sex hormone activity. The concentration of ascorbic acid was estimated in the plasma, liver, pancreas, thyro...

journal_title：Life sciences

authors： Das PC,Das KP,Bagchi K,Dey CD

更新日期：1993-01-01 00:00:00

abstract：AIM:Although constitutive autophagy is linked to redox state and participates in cell homeostasis, it is scarcely known if redox state, autophagy, and lysosomal function depend on sex, a factor that largely influences health and diseases. Therefore, we evaluated the existence of sex differences in redox state and const...

journal_title：Life sciences

authors： Campesi I,Straface E,Occhioni S,Montella A,Franconi F

更新日期：2013-08-06 00:00:00

abstract：:In this paper, we describe the characterization of the expression of monoamine oxidase (MAO) in whole pancreas and in isolated islets of Langerhans from human. Classical monamine oxidase activity assays reveal that both isoforms A & B are present in human pancreas. Two complementary approaches indicated that both MAO ...

journal_title：Life sciences

authors： Pizzinat N,Chan SL,Remaury A,Morgan NG,Parini A

更新日期：1999-01-01 00:00:00

abstract：:Inert gas narcosis is a neurological syndrome appearing when humans or animals are exposed to hyperbaric inert gases (nitrogen, argon) composed by motor and cognitive impairments. Inert gas narcosis induces a decrease of the dopamine release at the striatum level, structure involved in the regulation of the extrapyram...

journal_title：Life sciences

authors： Balon N,Risso JJ,Blanc F,Rostain JC,Weiss M

更新日期：2003-05-02 00:00:00

abstract：:Coxsackievirus B3 (CVB3) is a major pathogen for acute and chronic viral myocarditis. The aim of this study was to investigate the antiviral effects of sophoridine, an alkaloid extracted from Chinese medicinal herb, Sophora flavescens, against CVB3, and the underlying pharmacokinetics. First, we determined the antivir...

journal_title：Life sciences

authors： Zhang Y,Zhu H,Ye G,Huang C,Yang Y,Chen R,Yu Y,Cui X

更新日期：2006-03-20 00:00:00

abstract：:The study was designed to investigate the role of molybdenum iron-sulfur flavin hydroxylases in the pathogenesis of liver injuries induced by structurally and mechanistically diverse hepatotoxicants. While carbon tetrachloride (CCl4), thioacetamide (TAA) and chloroform (CHCl3) inflict liver damage by producing free ra...

journal_title：Life sciences

authors： Ali S,Pawa S,Naime M,Prasad R,Ahmad T,Farooqui H,Zafar H

更新日期：2008-03-26 00:00:00

abstract：:Arginine vasotocin has been proposed as a hormone of the mammalian pineal gland. This claim is largely based on biological and immunological results, although some chemical evidence has also been provided. Yet, more and more researchers have recently disclaimed the presence of this nonapeptide in mammalian tissue. The...

journal_title：Life sciences

authors： Nieuwenhuis JJ

更新日期：1984-10-22 00:00:00

abstract：:Recent studies have shown that acyl-CoA:cholesterol acyltransferase (ACAT) plays an important role in the initiation of diabetes-associated hypercholesterolemia. To confirm this hypothesis, effects of a potent ACAT inhibitor, FR145237, on diet-induced hypercholesterolemia were examined in streptozotocin (STZ)-induced ...

journal_title：Life sciences

authors： Sakuma Y,Hagihara H,Nagayoshi A,Ohne K,Mutoh S,Ito Y,Nakahara K,Notsu Y,Okuhara M

更新日期：1997-01-01 00:00:00

abstract：:Previous studies with N-terminal fragments of substance P (SP) have suggested the existence of two separate SP receptor populations. SP1 receptors are found in guinea pig ilea and rat colons. SP2 receptors are found in mouse spinal cords and rat salivary glands. We have now found that substitution of Gly9 in substance...

journal_title：Life sciences

authors： Piercey MF,Dobry-Schreur PJ,Masiques N,Schroeder LA

更新日期：1985-02-25 00:00:00

abstract：:Superoxide dismutase (SOD), neuron specific enolase (NSE) and lactic dehydrogenase (LDH) were measured in the serum and cerebrospinal fluid (CSF) of ischemic cerebrovascular patients, other neurological patients and in age-matched healthy controls (serum only). The levels of SOD in the CSF or serum of the ischemic pat...

journal_title：Life sciences

authors： Gruener N,Gross B,Gozlan O,Barak M

更新日期：1994-01-01 00:00:00

abstract：AIMS:Keratinocytes are the predominant cells in the epidermis, exerting their primary role of physical barrier through sophisticated differentiation process. In addition, keratinocytes contribute to the activation of innate immunity, providing the surveillant role against external pathogens. It has been known that chro...

journal_title：Life sciences

authors： Zhou MW,Jiang RH,Kim KD,Lee JH,Kim CD,Yin WT,Lee JH

更新日期：2016-06-15 00:00:00

abstract：:Regulation of glucose-induced oscillations in intracellular Ca2+ concentration ([Ca2+]i) was investigated by using a novel technique, electroporation from an electrolyte-filled capillary, to deliver energy metabolites to the intracellular compartment of mouse islets. Intracellular application of ATP resulted in a nife...

journal_title：Life sciences

authors： Dahlgren GM,Nolkrantz K,Kennedy RT

更新日期：2005-10-21 00:00:00

abstract：AIMS:Cisplatin is an anticancer agent marred by nephrotoxicity. Limiting this adverse effect may allow the use of higher doses to improve its efficacy. The Wnt/β-catenin signaling pathway plays a critical role in nephrogenesis and repair of renal diseases. BIO, a small molecule agonist of this pathway, exerted a protec...

journal_title：Life sciences

authors： Sun Z,Xu S,Cai Q,Zhou W,Jiao X,Bao M,Yu X

更新日期：2020-12-15 00:00:00

abstract：:In fish liver catecholamines bind to beta-adrenoceptors (AR) and increase glucose release via cAMP augmentation. Alpha1-AR have recently been shown to mediate IP3 and Ca2+ elevation in catfish and eel hepatocytes, although their coupling to a physiological response has remained doubtful. We have perifused isolated cat...

journal_title：Life sciences

authors： Fabbri E,Buzzi M,Biondi C,Capuzzo A

更新日期：1999-01-01 00:00:00