Protective effects of flavonols and their glycosides against free radical-induced oxidative hemolysis of red blood cells.

Abstract:

:The in vitro oxidative hemolysis of human red blood cells (RBCs) was used as a model to study the free radical-induced damage of biological membranes and the protective effect of flavonols and their glycosides (FOHs), i.e., myricetin (MY), quercetin (Q), morin (MO), kaempferol (K), rutin (R), quercetin galactopyranoside (QG), quercetin rhamnopyranoside (QR), and kaempferol glucopyranoside (KG). The hemolysis of RBCs was induced by a water-soluble free radical initiator 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH). It was found that addition of AAPH at 37 degrees C to the suspension of RBCs caused fast hemolysis after a short period of inhibition period, and addition of FOHs significantly suppressed the hemolysis. The FOHs (MY, Q, R, QG and QR) which bears an ortho-dihydroxyl functionality showed much more effective anti-hemolysis activity than that of the other FOHs (MO, K and KG) bearing no such functionality.

journal_name

Life Sci

journal_title

Life sciences

authors

Dai F,Miao Q,Zhou B,Yang L,Liu ZL

doi

10.1016/j.lfs.2005.10.009

subject

Has Abstract

pub_date

2006-04-18 00:00:00

pages

2488-93

issue

21

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(05)01120-3

journal_volume

78

pub_type

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