Abstract:
:The in vitro oxidative hemolysis of human red blood cells (RBCs) was used as a model to study the free radical-induced damage of biological membranes and the protective effect of flavonols and their glycosides (FOHs), i.e., myricetin (MY), quercetin (Q), morin (MO), kaempferol (K), rutin (R), quercetin galactopyranoside (QG), quercetin rhamnopyranoside (QR), and kaempferol glucopyranoside (KG). The hemolysis of RBCs was induced by a water-soluble free radical initiator 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH). It was found that addition of AAPH at 37 degrees C to the suspension of RBCs caused fast hemolysis after a short period of inhibition period, and addition of FOHs significantly suppressed the hemolysis. The FOHs (MY, Q, R, QG and QR) which bears an ortho-dihydroxyl functionality showed much more effective anti-hemolysis activity than that of the other FOHs (MO, K and KG) bearing no such functionality.
journal_name
Life Scijournal_title
Life sciencesauthors
Dai F,Miao Q,Zhou B,Yang L,Liu ZLdoi
10.1016/j.lfs.2005.10.009subject
Has Abstractpub_date
2006-04-18 00:00:00pages
2488-93issue
21eissn
0024-3205issn
1879-0631pii
S0024-3205(05)01120-3journal_volume
78pub_type
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