Abstract:
:We investigated the effects of VA-045, an apovincaminic acid derivative, on isolated blood vessels. VA-045 (10(-7)-10(-5) M) and vinpocetine (10(-7)-10(-5) M) inhibited the 64 mM KCl-induced and 10(-6)M norepinephrine (NE)-induced contraction of rat aortic strips. VA-045 (10(-7)-10(-4) M) and vinpocetine (10(-7)-10(-4) M) inhibited the activity of cyclic AMP and cyclic GMP phosphodiesterase in porcine coronary artery. VA-045 (3 x 10(-9-3 x 10(-6) M) relaxed the 64 mM KCl-induced contraction of the canine basilar artery without affecting the peripheral arteries. These results indicate that VA-045 selectively dilates canine cerebral artery, and that it may be a useful agent for the treatment of cerebrovascular diseases such as stroke.
journal_name
Life Scijournal_title
Life sciencesauthors
Miyata N,Yamaura H,Tanaka M,Muramatsu M,Tsuchida K,Okuyama S,Otomo Sdoi
10.1016/0024-3205(93)90115-jsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
PL181-6issue
18eissn
0024-3205issn
1879-0631pii
0024-3205(93)90115-Jjournal_volume
52pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Immunization with plasmid DNA encoding antigenic proteins elicits both antibody and cell-mediated immune responses. This method of producing the protein antigens of interest directly in host cells can provide appropriate tertiary structure for the induction of conformationally specific antibodies, and also facilitates...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/s0024-3205(96)00502-4
更新日期:1997-01-01 00:00:00
abstract::The study of opioid distribution in blood and cerebrospinal fluid (CSF) is required to understand pharmacokinetic-pharmacodynamic relationships following lumbar intrathecal (it) and intracerebroventicular (i.c.v.) administration, and to investigate the contributions of spinal or supraspinal sites of action. The sheep ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00456-0
更新日期:1996-01-01 00:00:00
abstract::Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2018.10.044
更新日期:2018-12-01 00:00:00
abstract:AIMS:Hypoxia makes cells death but it is not always true. Short term anoxia can boost remaining cells activities and promote tissue repair. This study is to explore the effects of hypoxic preconditioning (HP) on osteoblasts and analyze the involved lncRNA and mRNA. MAIN METHODS:Human osteoblast was used. Normoxic cont...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.07.014
更新日期:2018-09-01 00:00:00
abstract::miRNAs are a group of non-coding RNAs that have regulatory functions in post-transcriptional gene expression. These molecules play a fundamental role in cellular processes, for instance cell proliferation, apoptosis, migration, and invasion. Scientific investigations have previously established that miRNAs can either ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.117865
更新日期:2020-09-01 00:00:00
abstract::This study examines the role of dopaminergic mechanisms in the regulation of human pancreatic polypeptide (hPP) secretion in 11 normal male volunteers. Administration of domperidone (20 mg iv), an extracerebral inhibitor of dopamine receptors, resulted in a hPP rise (p less than 0.05) within 10 min and a peak response...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90063-7
更新日期:1982-12-27 00:00:00
abstract::In vivo microdialysis was used to investigate the effects of acute injections of norharman on extraneuronal concentrations of dopamine (DA) in the nucleus accumbens of rats. Administration of norharman (2.44 and 43.97 mumol/kg, i.p.) elicited an increase of the DA efflux by 70% and 160% respectively which returned to ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)98578-4
更新日期:1995-01-01 00:00:00
abstract::Incubation of the nonsteroidal antiestrogen nitromiphene (CI628) with rat cecal content suspension under aerobic or anaerobic conditions resulted in extensive biotransformation, yielding three metabolites, as determined by thin-layer chromatography. These metabolites were not recovered from incubation mixtures contain...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90660-4
更新日期:1983-09-12 00:00:00
abstract:AIMS:7-Ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxidized low-density lipoprotein (oxLDL), has been reported to be a crucial ligand of beta2-glycoprotein I (β(2)-GPI), and plays a potential role in the development of atherosclerosis (AS), however, the role of the sole oxLig-1 in the development of...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.09.028
更新日期:2010-11-20 00:00:00
abstract::Central dopaminergic (DA) function in children was assessed by monitoring plasma-free homovanillic acid (pHVA) levels after brief (18 hour) administration with debrisoquin sulfate, a peripherally active antihypertensive agent that blocks peripheral, but not central, HVA production. Brief debrisoquin administration res...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90239-0
更新日期:1986-03-17 00:00:00
abstract:AIMS:Amiodarone (AMIO) is currently used in medical practice to reverse ventricular tachycardia. Here we determine the effects of AMIO in the electromechanical properties of isolated left ventricle myocyte (LVM) from mice and guinea pig and in a cellular model of Long QT Syndrome Type 3 (LQTS-3) using anemone neurotoxi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117814
更新日期:2020-08-15 00:00:00
abstract:AIMS:The mechanisms underlying the changes in blood-brain barrier (BBB) integrity and the generation of seizures in childhood associated with preexisting brain lesions like cortical dysplasia (CD) are poorly understood. We investigated the effects of levetiracetam (LEV) on BBB integrity and the survival during hyperthe...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.09.014
更新日期:2010-11-20 00:00:00
abstract::Fenfluramine, a drug that induces increased synaptic serotonin, was used to train Fawn-Hooded rats in a drug discrimination paradigm. This strain of rats is thought to possess a genetic serotonin storage abnormality. The intent of the study was to see if the Fawn-Hooded rat was similar or dissimilar to the more freque...
journal_title:Life sciences
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::It has been shown that the main psychoactive component of marihuana, delta9-tetrahydrocannabinol (THC) has mainly inhibitory effects on the regulation of reproduction. Recently, the purification and availability of the endogenous ligand of the cannabinoid receptor, arachidonyl ethanolamide, anandamide, (ANA) and its s...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/s0024-3205(99)00292-1
更新日期:1999-01-01 00:00:00
abstract::Oxytocin (OT) and arginine-8-vasopressin (AVP) were measured by radioimmunoassay in micropunched hypothalamic neurosecretory nuclei of estrous cycling female Sprague-Dawley rats. In the paraventricular nucleus (PVN): the concentration (pg/microgram protein) of OT was significantly higher in rats in diestrus than durin...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90638-7
更新日期:1986-06-23 00:00:00
abstract::This study aimed to evaluate the role for adenosine A2A receptors in the autoregulatory vasodilation to hypotension in relation with cerebral blood flow (CBF) autoregulation in rat pial arteries. Changes in pial artery diameters were observed directly through a closed cranial window. Vasodilation induced by adenosine ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00737-2
更新日期:2000-08-11 00:00:00
abstract::Two types of plasma membranes isolated from rat brain cortex were used to study the membrane-perturbing properties of ethanol. Rats administered ethanol in the form of a liquid diet showed an increase in levels of phosphatidylserines, phosphatidylinositols and phosphatidic acids as compared to controls. The results pr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90512-5
更新日期:1984-11-19 00:00:00
abstract::Dialyzed aqueous extracts of plant pollen are widely used in the clinical practice of allergy for diagnostic and therapeutic purposes. The present investigation shows that such allergenic extracts are capable of consuming complement in every human serum, independent of the clinical condition. Complement is engaged by ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00101-x
更新日期:1997-01-01 00:00:00
abstract::Phosphoesterase complex (Pho), a major active component of barley malt, has been demonstrated to be clinically effective in relieving alcoholic fatty liver disease (AFLD), and several lines of evidence have suggested that microbial dysbiosis, caused by chronic alcohol overconsumption, plays a key role in the progressi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118509
更新日期:2020-12-01 00:00:00
abstract:AIMS:Skeletal muscle diseases have become to be the most common complication in patients with type 2 diabetic mellitus (T2DM). However, the effective therapies against skeletal muscle diseases are not yet available. Sulforaphane (SFN) is an organic isothiocyanate found in cruciferous plants. Our aim was to explore whet...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117823
更新日期:2020-08-15 00:00:00
abstract::Experiments were undertaken to examine the characteristics of the adrenergic receptor-coupled cAMP system in rat brain slices. It was found that the potentiation of isoproterenol-stimulated cAMP accumulation by 6-fluoronorepinephrine, an alpha-adrenergic agonist, is largely dependent upon the degree of beta-receptor o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90129-8
更新日期:1985-09-30 00:00:00
abstract::Estrogen has diverse effects on the vasculature, such as vasodilation, endothelial growth and inhibition of vascular smooth muscle cell (VSMC) proliferation and migration. However, little is known about the genes that are regulated by estrogen in the vascular wall. Wistar rats were ovariectomized or sham-operated (Sha...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.03.004
更新日期:2004-07-23 00:00:00
abstract::Recent studies suggest that the time of day at which food is consumed dramatically influences clinically-relevant cardiometabolic parameters (e.g., adiposity, insulin sensitivity, and cardiac function). Meal feeding benefits may be the result of daily periods of feeding and/or fasting, highlighting the need for improv...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.01.031
更新日期:2018-03-15 00:00:00
abstract::N-acyl dehydroalanines have been shown to react with and scavenge oxygen derived free radicals. One of those compounds, the AD-5 (N-(paramethoxyphenylacetyl) dehydroalanine) has been examined for its ability to decrease the amount of reactive oxygen species which appeared when liver microsomes (isolated from rats pret...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90106-2
更新日期:1990-01-01 00:00:00
abstract::The activation of cholinergic pathways by nicotine elicits various physiological and pharmacological effects in mammals. For example, the stimulation of nicotinic acetylcholine receptors (nAChRs) leads to an antinociceptive effect. However, it remains to be elucidated which subtypes of nAChR are involved in the antino...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.08.011
更新日期:2006-12-03 00:00:00
abstract::The thyrotropin receptor is proposed to contain both a glycoprotein and a ganglioside component. Monoclonal antibodies have been developed against soluble thyroid TSH receptor preparations and using Graves' lymphocytes. These show that initial recognition of thyrotropin requires the glycoprotein component, but that mo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90170-4
更新日期:1983-01-03 00:00:00
abstract::This study, conducted on isolated guinea pig ileum, was designed to establish the mechanism of presynaptic alpha 2-adrenoreceptor blockade by the tetramine disulfides, benextramine and pyrextramine. At 1 microM these drugs irreversibly blocked norepinephrine (NE)-induced inhibition of the twitch response to electrical...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90407-8
更新日期:1986-05-05 00:00:00
abstract::Premazepam (PRZ) in vitro competitively displaced 3H-diazepam (DIA), 3H-flunitrazepam (FLU) and 3H-RO 15-1788 from their binding sites on rat brain synaptosomes, with a potency intermediate to other benzodiazepines (BDZs), and Hill coefficients near 1 in different brain regions. Incubation at 37 degrees C reduced prem...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90646-5
更新日期:1984-07-23 00:00:00
abstract:AIM:A variety of evidence suggests that vitamin D can prevent the development of multiple sclerosis (MS). TGF-β pathway genes also play important roles in MS. Here, we aim to study whether vitamin D affects TGF-β pathway gene expression and Expanded Disability Status Scale (EDSS) scores in MS patients. MAIN METHODS:A ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.05.017
更新日期:2015-08-01 00:00:00
abstract::Bovine brain phospholipid liposomes (BC-PL) reduce plasma prolactin (PRL) levels in humans after acute administration and counteract the metoclopramide- and sulpiride-induced hyperprolactinaemia. However, BC-PL, like nomifensine, a dopamine (DA) reuptake inhibitor and therefore an indirect dopaminergic compound, does ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90395-2
更新日期:1982-07-05 00:00:00