Abstract：
:Incubation of the nonsteroidal antiestrogen nitromiphene (CI628) with rat cecal content suspension under aerobic or anaerobic conditions resulted in extensive biotransformation, yielding three metabolites, as determined by thin-layer chromatography. These metabolites were not recovered from incubation mixtures containing previously frozen suspension, and recoveries were decreased (that of nitromiphene was increased) when incubations were carried out in the presence of 2mM EDTA. Spectral and chromatographic comparison of two of the purified metabolites resulted in their structural characterization, as p-[beta(N-pyrrolidinyl)ethoxy]p'-methoxybenzophenone, and a similarly substituted alpha, alpha-diphenyl-acetophenone. These metabolites are, in turn, due formally to ethylenic bond cleavage and nitro group reduction/hydrolysis of nitromiphene.
journal_name
Life Scijournal_title
Life sciencesauthors
Ruenitz PC,Bagley JRdoi
10.1016/0024-3205(83)90660-4subject
Has Abstractpub_date
1983-09-12 00:00:00pages
1051-6issue
11eissn
0024-3205issn
1879-0631pii
0024-3205(83)90660-4journal_volume
33pub_type
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