The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys.

abstract：AIMS:Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. MAIN METHODS:Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assay...

journal_title：Life sciences

authors： Sogawa N,Hirai K,Sogawa C,Ohyama K,Miyazaki I,Tsukamoto G,Asanuma M,Sasaki A,Kitayama S

更新日期：2013-04-09 00:00:00

abstract：:We examined whether H(+)-ATPase is involved in the control of cellular action of arginine vasopressin (AVP) to produce adenosine 3', 5'-monophosphate (cAMP) and mobilize cellular free calcium ([Ca2+]i) in rat renal papillary collecting tubule cells in culture. N-Ethylmaleimide (NEM), an inhibitor of H(+)-ATPase, reduc...

journal_title：Life sciences

authors： Ishikawa S,Sakuma N,Okada K,Saito T

更新日期：1993-01-01 00:00:00

abstract：:Liquid chromatography of porcine duodenal extracts, in conjugation with bioassay on guinea-pig ileum myenteric plexus longitudinal muscle preparation, yielded substances which inhibited electrically-evoked twitches of the preparations, but whose actions could not be reversed by naloxone, an opioid antagonist. The subs...

journal_title：Life sciences

authors： Arakawa Y,Tachibana S

更新日期：1984-12-17 00:00:00

abstract：:Alpha adrenergic receptors are identified on basolateral plasma membranes derived from proximal tubular epithelial cells. The density of alpha 2 receptors was over two-fold greater than alpha 1 receptors. The basolateral membranes were devoid of beta receptors. These results support previous demonstrations of alpha ad...

journal_title：Life sciences

authors： Jensen RE,Berndt WO

更新日期：1988-01-01 00:00:00

abstract：:Aromatase transforms irreversibly androgens into estrogens and is present in the endoplasmic reticulum of various tissues including the mammalian testis. In rat all testicular cells except peritubular cells express aromatase. Indeed in adult rat germ cells (pachytene spermatocytes and round spermatids) we have demonst...

journal_title：Life sciences

authors： Carreau S,Bois C,Zanatta L,Silva FR,Bouraima-Lelong H,Delalande C

更新日期：2011-10-10 00:00:00

abstract：:The use of more than one drug to achieve a desired effect has been a common practice in pharmacologic testing and in clinical practice. For example, combinations of analgesics are frequently prescribed with a view to enhancing pain relief and reducing adverse effects. It is also well established that administration of...

journal_title：Life sciences

authors： Tallarida RJ,Porreca F,Cowan A

更新日期：1989-01-01 00:00:00

abstract：:The present paper describes the role of conjugating enzymes in the development of hepatotoxicity after administration of repeated doses of a novel monoamine oxidase type-A (MAO-A) inhibitor, (5R)-3-[2-(( 1S)-3-cyano-1-hydroxypropyl)benzothiazol-6-yl]-5-methoxymethyl-2-oxazolidinone (E2011). The effects of pretreatment...

journal_title：Life sciences

authors： Sato G,Aoki T,Hosokawa S,Sagami F,Tsukidate K

更新日期：2001-05-04 00:00:00

abstract：:Anandamide (arachidonylethanolamide), isolated from porcine brain, has been shown to bind to the cannabinoid receptor and also to produce cannabimimetic activity in pharmacological assays. This study examined structure-activity relationships in alkylated anandamide analogs. The analogs were evaluated for their ability...

journal_title：Life sciences

authors： Adams IB,Ryan W,Singer M,Razdan RK,Compton DR,Martin BR

更新日期：1995-01-01 00:00:00

abstract：:The O2 affinity of "stripped" (cofactor-free) hemoglobin (Hb) of the elasmobranch, Squalus acanthias is decreased by ATP, the main erythrocytic phosphate cofactor but increased by urea at physiological concentration. When both compounds are present, as in life, urea decreases the ATP sensitivity, indicating that previ...

journal_title：Life sciences

authors： Weber RE,Wells RM,Tougaard S

更新日期：1983-05-02 00:00:00

abstract：:Elevated levels of serum free fatty acids (FFA) may be the metabolic alteration in obesity that leads to insulin resistance (IR) and type 2 diabetes mellitus (DM). The obese Zucker rat (ZR) is a genetic model of juvenile-onset obesity and type 2 DM. Compared with its lean sibling, the obese ZR is hyperinsulinemic, hyp...

journal_title：Life sciences

authors： Abadie JM,Malcom GT,Porter JR,Svec F

更新日期：2001-10-19 00:00:00

abstract：AIMS:TsTX-I scorpion toxin, also known as γ-toxin, is a β-toxin which binds to site 4 of the sodium channel, shifting its activation potential. There are few studies about its pharmacological action in the central nervous system. The objective of this work was to determine the electroencephalographic, behavioral and hi...

journal_title：Life sciences

authors： Teixeira VF,Conceição IM,Lebrun I,Nencioni AL,Coronado Dorce VA

更新日期：2010-10-09 00:00:00

abstract：:Doxorubicin (DOX) induced cardiotoxicity is a life-threatening side effect of chemotherapy and decreased cardiac function can present years after treatment. Despite the investigation of a broad range of pharmacologic interventions, to date the only drug shown to reduce DOX-related cardiotoxicity in preclinical studies...

journal_title：Life sciences

authors： Zhen J,Yu H,Ji H,Cai L,Leng J,Keller BB

更新日期：2019-12-15 00:00:00

abstract：AIMS:The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats. MATERIALS AND METHODS:CFB (10, 20 and 40mg/kg), berbe...

journal_title：Life sciences

authors： Luo C,Chen H,Wang Y,Lin G,Li C,Tan L,Su Z,Lai X,Xie J,Zeng H

更新日期：2018-01-15 00:00:00

abstract：:The chloromethyl ketone derivative of D-Ala2-Leu5-enkephalin was synthesized in a radioactive form, and the resulting compound (3H-DALECK) was used to label opioid receptors. 3H-DALECK binds with high affinity, specificity and saturability to rat brain membranes. The number of sites labeled is 130 fmoles/mg protein. U...

journal_title：Life sciences

authors： Szücs M,Belcheva M,Simon J,Benyhe S,Tóth G,Hepp J,Wollemann M,Medzihradszky K

更新日期：1987-07-13 00:00:00

abstract：:The neuropeptide substance P (SP) is a mediator of neurogenic inflammation. Also, beta-amyloid protein (beta AP) can directly activate the cell types involved in inflammatory processes. The relationship between SP and beta AP on their biological actions has attracted much interest. SP is trophic in neuronal cells and ...

journal_title：Life sciences

authors： Takenouchi T,Munekata E

更新日期：1995-01-01 00:00:00

abstract：:11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors have been shown to treat type 2 diabetes (T2D). Since gossypol is an 11β-HSD1 inhibitor, the objective of the present study was to treat T2D and T2D-related liver fibrosis in rat model using low-dose gossypol. T2D was induced by feeding with high fat diet plus i...

journal_title：Life sciences

authors： Chen G,Wang R,Chen H,Wu L,Ge RS,Wang Y

更新日期：2016-03-15 00:00:00

abstract：:The effect on thermonociceptive threshold of intrathecally (i.t.) administered angiotensin II (Ang II) was assessed in the rat tail-flick test. Rats were pretreated, 15 min earlier, with i.t. naloxone (opiate antagonist), losartan (Ang II selective antagonist at AT1 receptor) or [Sar1, Leu8] Ang II (non selective Ang ...

journal_title：Life sciences

authors： Toma N,Sgambato V,Couture R

更新日期：1997-01-01 00:00:00

abstract：:Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that peripar...

journal_title：Life sciences

authors： Kristal MB,Thompson AC,Abbott P,Di Pirro JM,Ferguson EJ,Doerr JC

更新日期：1990-01-01 00:00:00

abstract：:Green tea and its major constituent epigallocatechin gallate (EGCG) have been extensively studied as a potential treatment for a variety of diseases, including cancer. Epidemiological data have suggested that EGCG may provide protective effects against hormone related cancers, namely breast or prostate cancer. Extensi...

journal_title：Life sciences

authors： Stuart EC,Scandlyn MJ,Rosengren RJ

更新日期：2006-11-17 00:00:00

abstract：:NF-kappaB that plays an important role in iNOS expression is one of the targets of various potential anti-inflammatory agents including resveratrol. Resveratrol contains a structural similarity with estrogen, and there has been speculation about resveratrol as estrogen agonist. In this study, the mechanism and structu...

journal_title：Life sciences

authors： Cho DI,Koo NY,Chung WJ,Kim TS,Ryu SY,Im SY,Kim KM

更新日期：2002-09-13 00:00:00

abstract：:The purpose of this investigation was to determine the effects of experimental dicrocoeliosis on bile formation in the hamster. Studies were carried out at 120 days after infection with an oral dose of 40 metacercariae of Dicrocoelium dendriticum. A significant elevation in bile flow (+20%) and in the biliary output o...

journal_title：Life sciences

authors： Sánchez-Campos S,Tuñón MJ,González P,Marín JJ,González-Gallego J

更新日期：1998-01-01 00:00:00

abstract：:The effects of unilateral intracarotid administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in sheep were studied with the goal of producing a non-primate, large animal model of Parkinson's Disease. Adult female sheep were given an acute (over 30 min) or chronic (over 1 week) injection of MPTP (0.4-5....

journal_title：Life sciences

authors： Baskin DS,Browning JL,Widmayer MA,Zhu ZQ,Grossman RG

更新日期：1994-01-01 00:00:00

abstract：:Exposure of rats to an acute, uncontrollable stressor can increase brain norepinephrine (NE) turnover and decrease locomotor and exploratory behavior. We examined the ability of exogenous tyrosine, NE's amino acid precursor, to protect rats from developing these neurochemical and behavioral changes when stressed. Anim...

journal_title：Life sciences

authors： Reinstein DK,Lehnert H,Scott NA,Wurtman RJ

更新日期：1984-06-04 00:00:00

abstract：:Lymphocyte apoptosis occurs in response to stressors such as thermal injury, trauma, sepsis, and surgery. This study evaluated the effect of a single bout of physical exercise stress on the induction of apoptosis in murine thymocytes and splenic lymphocytes. Female C57BL/6 mice, treadmill exercised at a submaximal int...

journal_title：Life sciences

authors： Hoffman-Goetz L,Zajchowski S,Aldred A

更新日期：1999-01-01 00:00:00

abstract：AIMS:To identify the target of an adipose specific aptamer adipo-8, predict the potential interaction between adipo-8 and its target, and investigate lipid-lowering effect of adipo-8 in vitro and in vivo. MAIN METHODS:Distinct membranous protein of 3T3-L1 adipocyte pulled-down by adipo-8 was mass-spectrometry analyzed...

journal_title：Life sciences

authors： Zhong W,Zhang Y,Tan W,Zhang J,Liu J,Wang G,Liao J,Liu B,Chen K,Yu B,Deng Y,Zou Y,Pu Y,Liu H

更新日期：2020-06-15 00:00:00

abstract：:1-Aminocyclopropane carboxylic acid (ACPC), a partial agonist of the glycine site on the NMDA receptor, prevents tolerance to the mu opioid morphine and the delta ligand [D-Pen2,D-Pen5]enkephalin (DPDPE) when co-administered with the opioid. In contrast, ACPC does not significantly influence tolerance to the kappa1 op...

journal_title：Life sciences

authors： Kolesnikov YA,Maccechini ML,Pasternak GW

更新日期：1994-01-01 00:00:00

abstract：:Effects of PK 11195 and flumazenil on cardiac responses to diazepam, clonazepam and zolpidem were compared. Coronary flow rate was increased at relatively low doses of diazepam and decreased at higher doses. Clonazepam induced a dose-dependent increase, and zolpidem a decrease of coronary flow rate. PK 11195 reduced t...

journal_title：Life sciences

authors： Zeegers A,van Wilgenburg H,Leeuwin RS

更新日期：1998-01-01 00:00:00

abstract：:The effect of diabetes mellitus on serum cholesterol and aortic microsomal prostanoid synthesis was studied in cholesterol fed male Lewis rats. Normal, diabetic and diabetic rats treated with pancreatic islets were divided into three diet subgroups, control diet, control +2% cholesterol for 8 weeks and control +2% cho...

journal_title：Life sciences

authors： Myers SI,Bartula L,Linzel M,Phan T,Jung PJ,Merrell RC

更新日期：1990-01-01 00:00:00

abstract：AIMS:Dysfunction of the Hippo-Yes-Associated Protein (YAP) signaling pathway is known to be associated with hepatocellular carcinoma (HCC). Evodiamine (Evo), a plant-derived bioactive alkaloid, exerts inhibitory effects on cancer. However, the precise influence of Evo on HCC and its potential effects on Hippo-YAP signa...

journal_title：Life sciences

authors： Zhao S,Xu K,Jiang R,Li DY,Guo XX,Zhou P,Tang JF,Li LS,Zeng D,Hu L,Ran JH,Li J,Chen DL

更新日期：2020-06-15 00:00:00

abstract：:In this study, we have identified the E-NTPDase family members and ecto-5'-nucleotidase/CD73 in rat heart left ventricle. Moreover, we characterize the biochemical properties and enzyme activities from synaptosomes of the nerve terminal endings of heart left ventricle. We observe divalent cation-dependent enzymes that...

journal_title：Life sciences

authors： Rücker B,Almeida ME,Libermann TA,Zerbini LF,Wink MR,Sarkis JJ

更新日期：2008-02-27 00:00:00