Somatostatin-20: a novel NH2-terminally extended form of somatostatin isolated from porcine duodenum together with somatostatin-28 and somatostatin-25.

Abstract:

:Liquid chromatography of porcine duodenal extracts, in conjugation with bioassay on guinea-pig ileum myenteric plexus longitudinal muscle preparation, yielded substances which inhibited electrically-evoked twitches of the preparations, but whose actions could not be reversed by naloxone, an opioid antagonist. The substances were determined to be NH2-terminally extended forms of somatostatin, i.e. somatostatin-28, somatostatin-25 and somatostatin-20. This is the first time that somatostatin-20 has been isolated from animal tissues.

journal_name

Life Sci

journal_title

Life sciences

authors

Arakawa Y,Tachibana S

doi

10.1016/0024-3205(84)90439-9

subject

Has Abstract

pub_date

1984-12-17 00:00:00

pages

2529-36

issue

25

eissn

0024-3205

issn

1879-0631

pii

0024-3205(84)90439-9

journal_volume

35

pub_type

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