Abstract:
:The effects of elevated glucose and aldose reductase inhibitor (ARI:ONO-2235) on nitric oxide (NO) production in cultured human umbilical endothelial cells (HUVEC) were evaluated. Aldose reductase and nitric oxide synthase(NOS) share NADPH as an obligate cofactor, therefore it is suggested that the enhanced of glucose flux (27.5 mM) by aldose reductase inhibited NO production by blunting NOS activity. However, the addition of ONO-2235 (100 microM) prevented the inhibition of [NO2-] production. Since ARI decreases glucose-mediated inhibition of NO production in HUVEC. this agent might ameliorate endothelial function associated with diabetes.
journal_name
Life Scijournal_title
Life sciencesauthors
Okuda Y,Kawashima K,Suzuki S,Asakura Y,Asano M,Tsurumaru K,Dai H,Tachi Y,Bannai C,Saitoh M,Yamashita Kdoi
10.1016/s0024-3205(96)00622-4subject
Has Abstractpub_date
1997-01-01 00:00:00pages
PL53-6issue
3eissn
0024-3205issn
1879-0631pii
S0024-3205(96)00622-4journal_volume
60pub_type
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