Inhibition of insulin hyperphagia by gamma aminobutyric acid antagonists in rats.

Abstract:

:The effects of GABA antagonists, picrotoxin and bicuculline were studied on hyperphagia caused by insulin in free feeding rats. It was found that peripheral administration of GABA antagonists inhibited this hyperphagia. These agents were administered in the VMH and LH through stereotaxically implanted cannulae. It was found that the food intake was inhibited when injected into the VMH, but not in the LH. These findings suggest that LH plays a relatively passive role as compared to VMH, where GABA appears to be an important neurotransmitter.

journal_name

Life Sci

journal_title

Life sciences

authors

Kamatchi GL,Bhakthavatsalam P,Chandra D,Bapna JS

doi

10.1016/0024-3205(84)90220-0

subject

Has Abstract

pub_date

1984-06-04 00:00:00

pages

2297-301

issue

23

eissn

0024-3205

issn

1879-0631

pii

0024-3205(84)90220-0

journal_volume

34

pub_type

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