Abstract：
:Alzheimer's disease (AD) as a dementia and neurodegenerative disease, is mostly prevalent among people more than 65 years. AD is mostly manifested in the form of degraded mental function, such as losing memory and impaired cognitive function. Due to inefficiency of traditional pharmacological therapeutic approaches with no long-term cure, cell therapy can be considered as a capable approach in AD management. Therapies based on mesenchymal stem cells (MSCs) have provided hopeful results in experimental models regarding several disorders. MSCs enhance the levels of functional recoveries in pathologic experimental models of central nervous system (CNS) and are being investigated in clinical trials in neurological disorders. However, there is limited knowledge on the protective capabilities of MSCs in AD management. Almost, several experiments have suggested positive effects of MSCs and helped to better understand of AD-related dementia mechanism. MSCs have the potential to be used in AD treatment through amyloid-β peptide (AB), Tau protein and cholinergic system. This review aimed to clarify the promising perspective of MSCs in the context of AD.
journal_name
Life Scijournal_title
Life sciencesauthors
Chakari-Khiavi F,Dolati S,Chakari-Khiavi A,Abbaszadeh H,Aghebati-Maleki L,Pourlak T,Mehdizadeh A,Yousefi Mdoi
10.1016/j.lfs.2019.116564subject
Has Abstractpub_date
2019-08-15 00:00:00pages
116564eissn
0024-3205issn
1879-0631pii
S0024-3205(19)30490-4journal_volume
231pub_type
杂志文章,评审相关文献
LIFE SCIENCES文献大全abstract：:Heterotrimeric G-protein signalling systems are primarily activated via cell surface receptors possessing the seven membrane span motif. Several observations suggest the existence of other modes of input to such signalling systems either downstream of effectors or at the level of G-proteins themselves. Using a functio...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(01)01019-0
更新日期：2001-04-06 00:00:00
abstract：:Adult rat offspring earlier exposed to maternally ingested caffeine during both gestation and lactation were observed in an open field following acute administration of diazepam or cyclohexyladenosine. While both drugs reduced measures of locomotion and emotional reactivity, caffeine-exposed rats showed evidence of gr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)80009-9
更新日期：1996-01-01 00:00:00
abstract：:Even though conventional systemic doses of cimetidine and other histamine H(2) antagonists display minimal brain penetration, central nervous system (CNS) effects (including seizures and analgesia) have been reported after administration of these drugs in animals and man. To test the hypothesis that cimetidine-like dr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.05.020
更新日期：2004-10-08 00:00:00
abstract：:The pressor effect of hemoglobin-based blood substitutes is due partly to their capacity to scavenge nitric oxide (NO), a potent vasodilator. NO also appears to modulate the release of norepinephrine (NE) from sympathetic nerve endings in some blood vessels. Thus studies were designed to determine if contraction occur...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00269-x
更新日期：1996-01-01 00:00:00
abstract：:In the course of investigating the binding of imipramine to soluble cellular fractions from brain and leukocytes using equilibrium dialysis, an artifactual binding component was produced. On Scatchard and double-reciprocal plots of the data, the component appeared as a homogenous population of sites displaying a bindi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90405-8
更新日期：1983-07-11 00:00:00
abstract：:Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118847
更新日期：2021-02-01 00:00:00
abstract：:The effect of the diterpene forskolin on vascular permeability alone and in combination with bradykinin, prostaglandin E1, adenosine or histamine has been investigated in rats. Vascular permeability in rat skin was measured using [125I]-labelled bovine serum albumin ([125I]BSA) as a tracer. In addition, the effect of ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90712-9
更新日期：1983-07-04 00:00:00
abstract：:The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.05.043
更新日期：2016-07-15 00:00:00
abstract：:Linoleic acid (LA) (n-6) and α-linolenic acid (ALA) (n-3) are essential fatty acids (EFAs) as they cannot be synthesized by humans or other higher animals. In the human body, these fatty acids (FAs) give rise to arachidonic acid (ARA, n-6), eicosapentaenoic acid (EPA, n-3), and docosahexaenoic acid (DHA, n-3) that pla...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2018.04.049
更新日期：2018-06-15 00:00:00
abstract：:The ileal Na+/bile acid cotransporter (IBAT) maintains the reabsorption of bile acids from the intestine in the enterohepatic circulation of bile acids. In the present study, we showed that S-8921 could dose-dependently inhibit the uptake of [3H] taurocholate in the COS7 cell line which constitutively expresses hamste...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00242-7
更新日期：1997-01-01 00:00:00
abstract：:The bradykinin-induced sensitization of cutaneous nociceptors to heat was previously shown to be abolished by cyclooxygenase blockade suggesting that endogenous prostaglandins exerted a heat-sensitizing action. The present study aimed at investigating the effects of exogenous prostaglandin E(2) (PGE(2)) and I(2) (PGI(...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.10.001
更新日期：2007-12-14 00:00:00
abstract：:Examination was made of the effects of 17 synthetic and naturally occurring flavonoids on human lymphocyte proliferation in the presence of concanavalin A as a mitogen. Twelve of the flavonoids examined were mono-hydroxy or methoxy derivatives. The mitogen-induced response of lymphocytes was evaluated from the extent ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90028-3
更新日期：1989-01-01 00:00:00
abstract：:Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous potential as well as cardioprotective effects may hold a great potent...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.05.021
更新日期：2018-07-15 00:00:00
abstract：:The structure of a new crystal form of leucine-enkephalin has been determined by X-ray diffraction. There are two independent molecules in the asymmetric unit and both have extended peptide backbone conformations with side-chains arranged alternately above and below the backbone planes. The two pentapeptides are hydro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90289-x
更新日期：1987-05-18 00:00:00
abstract：:The systemic administration of neurotensin (NT) dose-dependently increased plasma adrenocorticotropin (ACTH) concentration in rats, and this effect was annulled by (alpha-helical)-CRH9-41, an antagonist of corticotropin-releasing hormone (CRH). The systemic administration of [D-Trp11]-neurotensin (NT-A), a specific NT...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90250-s
更新日期：1992-01-01 00:00:00
abstract：AIMS:The aim of study is to investigate the effect of nifedipine on viral myocarditis in an animal model. MAIN METHODS:Four-week-old male DBA/2 mice were inoculated with 2 pfu of encephalomyocarditis virus (EMCV) and randomized to nifedipine (n=10) or control (n=10) group. The control group was fed by regular chow and...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.05.018
更新日期：2009-07-31 00:00:00
abstract：:The effect of thapsigargin, a specific inhibitor of intracellular Ca(2+)-ATPases, on endothelium-dependent relaxation was studied in the guinea pig thoracic aorta. Thapsigargin (1 nM-1 microM) produced a concentration-dependent relaxation of aortic strips precontracted by phenylephrine (0.1 microM) in the presence and...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90244-w
更新日期：1993-01-01 00:00:00
abstract：:Low pH medium has been shown to activate the 'efferent' function of capsaicin-sensitive primary sensory neurons. Calcitonin gene-related peptide (CGRP) is released from capsaicin-sensitive afferents of guinea-pig superior sagittal and transverse sinuses (SSTS), by capsaicin or bradykinin. Here, we report that low pH m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90263-b
更新日期：1991-01-01 00:00:00
abstract：:Amino acid and reduced glutathione (GSH) levels in substantia nigra (SN) as well as striatal monoamine levels were measured in acetyl-L-carnitine (ALCar) treated and control Swiss-Webster mice. ALCar, L carnitine, or saline were administered i.p. to mice for 5 days and mice were decapitated 24 hours following the last...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90319-0
更新日期：1988-01-01 00:00:00
abstract：:Evidence for a drug-induced activation of central sigma systems is presented. The model is the locomotor activation initiated by a subcutaneous (SC) challenge of 1.6 mg/kg of (+)-butaclamol, (+)-BUT, given 30 min before 10 mg/kg SC of (-)-N-allylnormetazocine, (-)-NAN, in Sprague-Dawley male rats which have been pretr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90448-7
更新日期：1989-01-01 00:00:00
abstract：:The effects of 100 microM norepinephrine (NE), GABA, aspartate, glutamate, and carbachol on the release of endogenous NE, GABA, aspartate, and glutamate from slices of rat cerebellum were examined. The 35 mM K+-stimulated release of NE was potentiated by GABA (136% of control), glutamate (123%), and carbachol (123%); ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90308-5
更新日期：1986-01-20 00:00:00
abstract：:In December 2019, a novel virus, namely COVID-19 caused by SARS-CoV-2, developed from Wuhan, (Hubei territory of China) used its viral spike glycoprotein receptor-binding domain (RBD) for the entrance into a host cell by binding with ACE-2 receptor and cause acute respiratory distress syndrome (ARDS). Data revealed th...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118421
更新日期：2020-11-01 00:00:00
abstract：:We observed a significant increase in plasma atrial natriuretic factor (ANF) in antiorthostatic hypokinetic suspension (AOH) rats after 2 h of suspension when the experiment was made during day. Plasma ANF was investigated in relation to renal glomerular ANF receptors during AOH at night. The aim of this study was 1) ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(88)80008-0
更新日期：1988-01-01 00:00:00
abstract：AIMS:Hepatocyte growth factor (HGF) modulates intestinal epithelial cell proliferation and migration. We previously reported that systemic administration of recombinant human HGF (rh-HGF) ameliorated experimental colitis. However, an increase in serum HGF concentrations may induce undesired systemic effects, limiting t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.06.019
更新日期：2011-08-15 00:00:00
abstract：:Atherosclerosis (AS) is a chronic inflammatory disease that results from Oxidized low-density lipoprotein (Ox-LDL) induced endothelial dysfunction. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is closely related to the development of epithelial cells, but the role of CPEB1 in AS remains unknown. The R...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116874
更新日期：2019-12-15 00:00:00
abstract：:We have examined the role of membrane hyperpolarization in mediating vascular hyporeactivity induced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat thoracic aorta ex vivo. The injection of rats with LPS caused a significant fall of blood pressure and a severe vascular hyporeactivity to nore...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00978-4
更新日期：2000-12-29 00:00:00
abstract：:In order to capture hepatocellular carcinoma (HCC) cells in circulating peripheral blood, we made analysis to see if alpha-fetoprotein (AFP) mRNA exists in the peripheral blood obtained from patients with HCC and also, as a control, from hepatitis-viral-marker-positive patients without HCC and a healthy volunteer. As ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02138-9
更新日期：1995-01-01 00:00:00
abstract：AIMS:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel member of the betacoronaviruses family affecting the lower respiratory tract mainly through binding to angiotensin converting enzyme 2 (ACE2) via its S-protein. Genetic analysis of (ACE2) gene revealed several variants that have been suggested t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118219
更新日期：2020-10-15 00:00:00
abstract：:Muscarinic receptors on epithelial cells mediate intestinal secretion, while those in intestinal smooth muscle mediate motility. Experiments were carried out to determine whether the muscarinic receptors mediating each of these two functions in intestinal tissue might be associated with differences in the way agonist ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90444-8
更新日期：1985-05-20 00:00:00
abstract：:Previous research in this laboratory has shown that chronic treatment of adult male rats with an anabolic-androgenic steroid (AAS) produced anxiolytic behavior and increased the functional response of cortical gamma-aminobutyric acid(A) (GABA(A)) receptors. The experiments reported here were aimed at further character...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02326-7
更新日期：1996-01-01 00:00:00
