Abstract:
:Low pH medium has been shown to activate the 'efferent' function of capsaicin-sensitive primary sensory neurons. Calcitonin gene-related peptide (CGRP) is released from capsaicin-sensitive afferents of guinea-pig superior sagittal and transverse sinuses (SSTS), by capsaicin or bradykinin. Here, we report that low pH medium produces a remarkable release of CGRP from SSTS, which was dependent on the concentration of hydrogen ions of the medium (pH 7-5). Moreover, the pH 5-evoked release of CGRP-LI was markedly reduced (by about 70%) in a calcium-free medium containing 1 mM EDTA or abolished in samples pre-exposed to 10 microM capsaicin. The present observation that lowering of the pH promotes release of a powerful vasoactive peptide from perivascular capsaicin-sensitive sensory nerves may have some relevance in the pathophysiology of brain injury and migraine headaches.
journal_name
Life Scijournal_title
Life sciencesauthors
Fanciullacci M,Tramontana M,Del Bianco E,Alessandri M,Geppetti Pdoi
10.1016/0024-3205(91)90263-bsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
PL27-30issue
8eissn
0024-3205issn
1879-0631pii
0024-3205(91)90263-Bjournal_volume
49pub_type
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