Thromboxane A2 and platelet-activating factor decrease in the platelet-mesangial cell interactions.

Abstract:

:To analyze the metabolisms of platelet-activating factor (PAF) and Thromboxane A2 (TxA2) when platelets and mesangial cells (MC) interact, immunoreactive thromboxane B2 (TxB2) and PAF were measured after incubation of cultured rat MC with platelets (P) and with platelet supernatants (PS). In both cases, TxB2 significantly decreased with respect to the P synthesis and to the PS content, suggesting an increased degradation of this metabolite or even the existence of a specific effect of MC upon platelet TxB2. When immunoreactive PAF was measured, results were comparable to those observed for TxB2. Moreover, when intrinsic mesangial cell synthesis of PAF was assessed by analyzing the [3H]-acetate incorporation by prelabeled MC in the HPLC fraction coeluting with cold PAF standards, it was possible to demonstrate that P or PS did not modify PAF synthesis in these cells. In summary, present results support the existence of a specific effect of mesangial cells upon platelet TxA2 and PAF.

journal_name

Life Sci

journal_title

Life sciences

authors

Arribas I,Rodríguez-Puyol D,García-Escribano MC,Díez-Marques ML,Pérez de Lema G,Rodríguez-Puyol M

doi

10.1016/0024-3205(95)02030-m

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

957-65

issue

10

eissn

0024-3205

issn

1879-0631

pii

002432059502030M

journal_volume

57

pub_type

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