Abstract：
:Activation of the sympathetic system by phencyclidine (PCP) should result in catecholamine release from the adrenals. However, adrenalectomy does not reduce PCP-induced hypertension. In an attempt to rectify this inconsistency, the direct effects of PCP on the bovine adrenal medulla were examined. At (3 X 10(-6) M), PCP reduced the acetylcholine-(ACh)-induced catecholamine release by 50%. Surprisingly, barium-induced secretion of catecholamines was also reduced by PCP. ACh-induced catecholamine release was not altered by 10(-3)M 4-aminopyridine (4 AP), the potassium channel blocker. Thus, calcium antagonist actions of PCP and consequent block of catecholamine secretion from adrenal medulla may explain the lack of effect of adrenalectomy on PCP-induced hypertension. Possible contributions of calcium and/or potassium channel blockade to other manifestations of PCP overdosage are discussed.
journal_name
Life Scijournal_title
Life sciencesauthors
Malavé A,Borowitz JL,Yim GKdoi
10.1016/0024-3205(83)90124-8subject
Has Abstractpub_date
1983-08-08 00:00:00pages
511-6issue
6eissn
0024-3205issn
1879-0631pii
0024-3205(83)90124-8journal_volume
33pub_type
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