Abstract:
:Thyrotropin-releasing hormone (TRH) produces a marked pressor effect, which may be mediated by central cholinergic neurons, which in turn enhance sympathetic nervous system activity. In this study, 22 subjects (10 patients with Alzheimer's disease and 12 elderly controls) were administered IV scopolamine or placebo prior to administration of IV high-dose TRH (0.5 mg/kg). Systolic blood pressure was less on the day scopolamine was administered prior to TRH administration, as compared with placebo (F[1,20] = 6.12, p < 0.02). Results indicate that the pressor effect of TRH is attenuated by scopolamine, indicating a role of the cholinergic system in this response in humans.
journal_name
Life Scijournal_title
Life sciencesauthors
Molchan SE,Hill JL,Minichiello M,Vitiello B,Sunderland Tdoi
10.1016/0024-3205(94)00629-6subject
Has Abstractpub_date
1994-01-01 00:00:00pages
933-8issue
13eissn
0024-3205issn
1879-0631pii
0024-3205(94)00629-6journal_volume
54pub_type
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