Scopolamine effects on the pressor response to thyrotropin-releasing hormone in humans.

Abstract:

:Thyrotropin-releasing hormone (TRH) produces a marked pressor effect, which may be mediated by central cholinergic neurons, which in turn enhance sympathetic nervous system activity. In this study, 22 subjects (10 patients with Alzheimer's disease and 12 elderly controls) were administered IV scopolamine or placebo prior to administration of IV high-dose TRH (0.5 mg/kg). Systolic blood pressure was less on the day scopolamine was administered prior to TRH administration, as compared with placebo (F[1,20] = 6.12, p < 0.02). Results indicate that the pressor effect of TRH is attenuated by scopolamine, indicating a role of the cholinergic system in this response in humans.

journal_name

Life Sci

journal_title

Life sciences

authors

Molchan SE,Hill JL,Minichiello M,Vitiello B,Sunderland T

doi

10.1016/0024-3205(94)00629-6

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

933-8

issue

13

eissn

0024-3205

issn

1879-0631

pii

0024-3205(94)00629-6

journal_volume

54

pub_type

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