Abstract：
:The distribution of thiamine-immunoreactive structures was studied in the brain of the monkey using an indirect immunoperoxidase technique. Fibers containing thiamine, but no thiamine-immunoreactive cell bodies, were found. The highest density of fibers containing thiamine was observed in the pulvinar nucleus and in the region extending from the pulvinar nucleus to the caudate nucleus. In the mesencephalon, immunoreactive fibers containing thiamine were only found at rostral level close to the medial lemniscus (at the mesencephalic-diencephalic junction). In the thalamus, the distribution of thiamine-immunoreactive structures was more widespread. Thus, immunoreactive fibers were found in nuclei close to the midline (centrum medianum/parafascicular complex), in the ventrolateral thalamus (medial geniculate nucleus, inferior pulvinar nucleus), and in the dorsolateral thalamus (lateral posterior nucleus, pulvinar nucleus). Finally, in the anterior commissure and in the cerebral cortex a low density immunoreactive fibers was visualized. Thus, in the brainstem, no immunoreactive structures were visualized in the medulla oblongata, pons, or in the medial-caudal mesencephalon, and no immunoreactive fibers were observed in the cerebellum, hypothalamus and in the basal ganglia. The present report describes the first visualization and the morphological characteristics (thick, smooth and short, medium or long in length) of the thiamine-immunoreactive fibers in the primate central nervous system using an antiserum directed against this vitamin. The distribution of thiamine-immunoreactive structures in the monkey brain suggests that this vitamin could be involved in several physiological mechanisms.
journal_name
Life Scijournal_title
Life sciencesauthors
Mangas A,Coveñas R,Geffard K,Geffard M,Marcos P,Insausti R,Dabadie MPdoi
10.1016/j.lfs.2006.03.017subject
Has Abstractpub_date
2006-08-15 00:00:00pages
1121-8issue
12eissn
0024-3205issn
1879-0631pii
S0024-3205(06)00246-3journal_volume
79pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Since the late 1960's, radioenzymatic assays have gradually come to replace the less sensitive and less specific spectrofluorometric and bioassay procedures previously used to determine many of the neurotransmitters. These assays provide the means to measure picogram quantities of most of these substances, and have en...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90185-8
更新日期：1987-08-17 00:00:00
abstract：:Macrophages and osteoclasts derive from related cell lines. In osteopetrotic mutants the function of osteoclasts is greatly reduced compared to that in normal animals or children and macrophage function is variably affected depending upon the mutation. To further explore macrophage function in osteopetrosis we examine...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90575-4
更新日期：1989-01-01 00:00:00
abstract：AIMS:Multiple sclerosis (MS) is one of the commonest neurologic disorders globally. LncRNA OIP5-AS1 has been found to be implicated in the etiology of MS. This study was to explore the roles and molecular mechanisms of OIP5-AS1 in the development of MS. MATERIALS AND METHODS:RT-qPCR assay was used to measure expressio...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2021.119108
更新日期：2021-01-27 00:00:00
abstract：:Advanced chronic kidney disease is associated with high rates of cardiovascular disease. Considering the crucial role of capillaries in renal function, our study aimed to evaluate microparticles related to vascular physiology examining the link between stages of chronic kidney disease with circulating endothelial (EMP...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118295
更新日期：2020-11-01 00:00:00
abstract：:Quercetin, a plant flavonoid, blocks signal transduction pathways by inhibiting 1-phosphatidylinositol 4-kinase (EC 2.7.1.67, PI kinase) and 1-phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68, PIP kinase), resulting in a reduction of inositol 1,4,5-trisphosphate (IP3) concentration which decreases the release of...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02085-w
更新日期：1995-01-01 00:00:00
abstract：AIM:Physical exercise is important in the prevention and treatment of cardiovascular diseases. Nevertheless, controversy remains around type and intensity of effort required for significant biochemical protective changes. This study investigates two exercise protocols on ventricular oxidative parameters in rats post-in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.01.018
更新日期：2012-04-09 00:00:00
abstract：:Besides an isomer of the cardenolide ouabain, a material with a similar HPLC retention time as ouabain but cross-reactivating with antibodies against the bufadienolide proscillaridin A and inhibiting the sodium pump is known to circulate in human blood plasma (B. SICH et al., Hypertension 27, 1073-1078 (1996).). The c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00023-x
更新日期：1998-01-01 00:00:00
abstract：:In the present work we have investigated to what extent somatostatin (SRIF) release from median eminence (ME) is affected by stress immobilization (IMO) in unanesthetized rats stereotaxically implanted with a push-pull cannula (PPC). One week after implantation, the ME was perfused with artificial cerebrospinal fluid ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90149-w
更新日期：1993-01-01 00:00:00
abstract：:Short-chain fatty acids (SCFA) are produced by fermentation of water-soluble fiber by anaerobic bacteria in the large bowel. Fiber-rich diets decrease the risk of developing inflammatory bowel disease (IBD) and butyrate enemas are effective as a therapy in some patients. Crohn's disease, one form of IBD, appears to in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00490-9
更新日期：2003-08-15 00:00:00
abstract：:Effects of lithium (Li) deficiency and/or immobilization stress on the thymus weight and differential blood count of rats were studied. The thymus weight of the rats fed a low Li diet were lighter than those of rats fed a Li supplemented diet, whether the rats were exposed to stress or not. Of the rats not exposed to ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00740-6
更新日期：1997-01-01 00:00:00
abstract：:Hydrolysis of fragments of the C-terminal and mid-portions of parathyroid hormone (PTH) by a phosphoramidon-insensitive metallo-endopeptidase, previously purified by us from the microvillar membranes of rat kidney, and by the microvillar membranes of rat kidney themselves were investigated using a reverse-phase HPLC, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00795-0
更新日期：1994-01-01 00:00:00
abstract：:Two-dimensional and line-scan analyses of the early phase Ca2+ transients in rat cardiomyocytes were performed with a rapid-scanning laser confocal microscope and fluo-3 to elucidate the mechanism of activation of Ca2+ release from the sarcoplasmic reticulum in atrial myocytes which lack a well developed T-tubular net...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01436-9
更新日期：2001-12-28 00:00:00
abstract：OBJECTIVE:This study investigated the role of long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) in kidney injury induced by urine-derived sepsis (US). MATERIALS AND METHODS:An Escherichia coli suspension was injected into the distal ureter of adult male Sprague Dawley rats to establish a US model. Lipo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.08.041
更新日期：2018-10-01 00:00:00
abstract：:An increase in the weight of the thyroid gland, accompanied by reductions in uptake and release of 1311, serum T3 and reverse T3 concentrations and an increase in serum TSH concentration, occurs during the development of renal hypertension in rats. Renal function, as assessed by BUN, serum and urinary creatinine conce...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90274-0
更新日期：1982-02-15 00:00:00
abstract：:The mechanism of the generation and the quantitative analysis of singlet oxygen (1O2) formed by the exposure of a hematoporphyrin derivative (HpD) to light was re-evaluated by electron spin resonance (ESR) combined with 2,2,6,6,-tetramethyl-4-piperidine (TMPD). The change from TMPD to 2,2,6,6,-tetramethyl-4-piperidine...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00835-7
更新日期：1997-01-01 00:00:00
abstract：:Dopamine (DA), one of the major sources of reactive oxygen species (ROS), is implicated in neuronal death associated with Parkinson's disease (PD). Preconditioning with oxidative stress has been shown to provide cytoprotection similar to ischemic preconditioning (IPC), against cell apoptosis. In this study, using the ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.04.048
更新日期：2005-11-19 00:00:00
abstract：AIMS:This study aims to explore factors that influence glucocorticoid (GC)-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction (IUGR) filial rats. MAIN METHODS:An IUGR animal model was established by starvation, and brain tissue was removed after birth. Affymetrix Rat Gene 2.0 S...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.02.079
更新日期：2016-04-01 00:00:00
abstract：:This study is aimed to investigate the effect of the prolonged intake of conspicuous amounts of licorice (LE), or its natural constituent glycyrrhizin (G) on murine liver CYP-catalyzed drug metabolism. For this purpose the modulation of the regio- and stereo-selective hydroxylation of testosterone, together with the u...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01154-5
更新日期：1998-01-01 00:00:00
abstract：AIMS:Ischemia-reperfusion (I/R) event in vascular and nervous system has been documented to rising ischemic and vasculitic neuropathic pain, clinically resembles the complex regional pain syndrome (CRPS). The present study evaluated the effect of montelukast, a cysteinyl leukotriene receptor (Cys-LTC(4) and Cys-LTD(4))...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.03.010
更新日期：2012-05-22 00:00:00
abstract：AIMS:Dietary habits are crucial factors affecting metabolic homeostasis. However, few animal experiments have addressed the effects of long-term feeding with soft food on parameters reflecting systemic health. MAIN METHODS:Using mice, we compared the effects of short (3 days) and long (17 weeks from weaning) feeding p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.03.022
更新日期：2014-05-08 00:00:00
abstract：:Coffee is consumed worldwide with greater than a billion cups of coffee ingested every day. Epidemiological studies have revealed an association of coffee consumption with reduced incidence of a variety of chronic diseases as well as all-cause mortality. Current research has primarily focused on the effects of coffee ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2015.11.005
更新日期：2015-12-15 00:00:00
abstract：:Aberrant methylation of promoter CpG islands (CGIs) can inactivate the expression of many tumor suppressor genes and play an important role in the carcinogenesis of gastric cancer. The tumor suppressor gene RB1, which encodes a cell cycle regulator, is hypermethylated and downregulated in multiple kinds of cancer. Act...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118580
更新日期：2020-12-15 00:00:00
abstract：:Responses to [Mpr14]-ADM(14-50), a novel analog of adrenomedullin, were investigated in the hindlimb vascular bed of the cat under conditions of controlled blood flow. Intraarterial injections of [Mpr14]-rADM(14-50) in doses of 0.003-1 nmol caused dose-related decreases in hindlimb perfusion pressure. In terms of rela...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00258-5
更新日期：1996-01-01 00:00:00
abstract：:Protein binding determination in post heparin plasma samples is complicated by the continued post heparin lipase activity, in vitro, during the binding analysis. The decomposition of lipoproteins and accumulation of nonesterified fatty acids (NEFA) results in artifically elevated free fractions of many drugs. This art...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90847-0
更新日期：1983-10-10 00:00:00
abstract：:Continuous three day administration via implanted minipumps of cocaine hydrochloride (50-450 mg/kg/day, sc and 100-250 mg/kg/day, iv) did not produce axonal degeneration in frontal agranular cortex or neostriatum that was detectable by Fink-Heimer silver staining or tyrosine hydroxylase immunolabeling. This is in cont...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90307-4
更新日期：1988-01-01 00:00:00
abstract：:Many persistent pesticides have been implicated in reproductive and developmental adverse effects, in man and wildlife. It has been hypothesized that these so-called xeno-hormones could upset the endocrine system function by binding to human estrogen receptor alpha and beta (ERalpha, beta) and thus be responsible for ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.03.023
更新日期：2006-08-15 00:00:00
abstract：:We provide direct evidence that verapamil inhibits active digoxin secretion in renal tubular cells (LLC-PK1), and that verapamil increases cellular accumulation of digoxin. These findings suggest that verapamil inhibits the digoxin active secretory transport at the apical membranes, supporting the theory that P-glycop...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90667-r
更新日期：1993-01-01 00:00:00
abstract：:This review analyses the knowledge about the incidence of transient apnoeic spells, induced by substances which activate vagal chemically sensitive afferents. It considers the specificity and expression of appropriate receptors, and relevant research on pontomedullary circuits contributing to a cessation of respiratio...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2018.12.021
更新日期：2019-01-15 00:00:00
abstract：:Loperamide effects on hepatobiliary function, analgesia and gut transit were studied in mice. Varying doses of the antidiarrheal drug, loperamide, were administered to mice by intracerebroventricular, intravenous, subcutaneous and intragastric routes. Gut motility was determined by intestinal transit of India ink, ana...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00609-1
更新日期：1994-01-01 00:00:00
abstract：:Long non-coding RNA (LncRNA) involved in types of physiological insults and diseases via regulating the responses of complex molecular, including cerebral ischemia-reperfusion (I/R) injury. LncRNA SNHG16 played a potential role in ketamine-induced neurotoxicity. In this study, we utilized an in vitro cell model of I/R...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117778
更新日期：2020-08-01 00:00:00
