Cocaine, in contrast to D-amphetamine, does not cause axonal terminal degeneration in neostriatum and agranular frontal cortex of Long-Evans rats.

abstract：:CCK-octapeptide (CCK-8) (EC50 = 0.5 nM), in the presence of Li+, increased 3H-inositol phosphate (IP) accumulation in guinea pig gastric glands prelabeled with 3H-inositol. CCK-8 desulfate, human gastrin I and pentagastrin were much less potent than CCK-8. Antagonists of CCK receptors such as proglumide, dibutyryl-c-G...

journal_title：Life sciences

authors： Chang RS,Lotti VJ,Chen TB

更新日期：1985-03-11 00:00:00

abstract：:The progeny of rats born and breastfed by mothers receiving dexamethasone (DEX) during pregnancy exhibits permanent reduction in body weight and adiposity but the precise mechanisms related to this programming are not fully understood. In order to clarify this issue, the present study investigated key aspects of lipop...

journal_title：Life sciences

authors： de Souza DN,Teixeira CJ,Veronesi VB,Murata GM,Santos-Silva JC,Hecht FB,Vicente JM,Bordin S,Anhê GF

更新日期：2021-01-15 00:00:00

abstract：:2',6'-Dimethyl substitution of the Tyr(1) residue of opioid agonist peptides and deletion of the positively charged N-terminal amino group or its replacement with a methyl group has recently been shown to represent a general structural modification to convert opioid peptide agonists into antagonists. This conversion r...

journal_title：Life sciences

authors： Schiller PW,Weltrowska G,Nguyen TM,Lemieux C,Chung NN,Lu Y

更新日期：2003-06-27 00:00:00

abstract：:Cardiovascular effects of the essential oil of Croton zehntneri (EOCZ) were investigated in conscious rats. In these preparations, intravenous (i.v.) injections of EOCZ (1-20 mg kg(-1)) and its main constituents anethole and estragole (both at 1-10 mg kg(-1)) elicited brief and dose-dependent hypotension and bradycard...

journal_title：Life sciences

authors： de Siqueira RJ,Magalhães PJ,Leal-Cardoso JH,Duarte GP,Lahlou S

更新日期：2006-04-11 00:00:00

abstract：:Unfertilized ova from Shad, a North Atlantic herring, contains a cytostatic inhibitor of T lymphocyte blastogenesis. The inhibitor has an estimated molecular weight of 10,000-30,000 Da, is heat stable, non dialyzable, and resistant to protease digestion and periodate oxidation. Although the inhibitor functions at an e...

journal_title：Life sciences

authors： Sheid B,Nobiletti JB,Prat JC

更新日期：1990-01-01 00:00:00

abstract：:A modification of beta-adrenoceptor binding has been observed in different human and animal tissues after glucocorticoid administration. In this study we observed that hydrocortisone increased human intact lymphocyte beta-adrenoceptors labelled with 3H-dyhydroalprenolol in vitro, in physiological and pharmacological c...

journal_title：Life sciences

authors： Cotecchia S,De Blasi A

更新日期：1984-12-03 00:00:00

abstract：AIM:This study was undertaken to examine the effect of cyclooxygenase (COX) 2 inhibition on the development of muscular insulin resistance in high-fat-induced obese rats. MAIN METHODS:The rats were on a regular chow diet (C) or high-fat enriched diet (HFD) energy-restrictedly (HFr), or ad libitum (HFa) for 12weeks. Th...

journal_title：Life sciences

authors： Tian YF,Hsia TL,Hsieh CH,Huang DW,Chen CH,Hsieh PS

更新日期：2011-07-18 00:00:00

abstract：AIMS:Coronavirus disease 2019 (COVID-19) has appeared in Wuhan, China but the fast transmission has led to its widespread prevalence in various countries, which has made it a global concern. Another concern is the lack of definitive treatment for this disease. The researchers tried different treatment options which are...

journal_title：Life sciences

authors： Hosseini FS,Amanlou M

更新日期：2020-10-01 00:00:00

abstract：:We investigated whether calcium channel antagonists would alter the induction of nitric oxide (NO) synthesis by bacterial lipopolysaccharide (LPS) alone or in combination with interferon-gamma (IFN gamma) in cultured J774 macrophages, rat vascular smooth muscle cells, rat renal mesangial cells, and rat cardiac myocyte...

journal_title：Life sciences

authors： Hattori Y,Kasai K,So S,Hattori S,Banba N,Shimoda S

更新日期：1995-01-01 00:00:00

abstract：:The effects of pretreatment with selective mu-, delta- and kappa-opioid receptor antagonists on the enhancement of the pentobarbital-induced loss of the righting reflex by morphine were examined in mice. Mice injected with pentobarbital (50 mg/kg, i.p.) showed an increased duration for the loss of the righting reflex ...

journal_title：Life sciences

authors： Kamei J,Ohsawa M,Nagase H

更新日期：1996-01-01 00:00:00

abstract：:Amino acid and reduced glutathione (GSH) levels in substantia nigra (SN) as well as striatal monoamine levels were measured in acetyl-L-carnitine (ALCar) treated and control Swiss-Webster mice. ALCar, L carnitine, or saline were administered i.p. to mice for 5 days and mice were decapitated 24 hours following the last...

journal_title：Life sciences

authors： Fariello RG,Ferraro TN,Golden GT,DeMattei M

更新日期：1988-01-01 00:00:00

abstract：:The present report investigated whether percentages of circulating natural killer (NK) cells and NK cell activity (NKCA) are associated with psychological variables. Subjects (n = 95) were selected, based on a combination of low or high scores on questionnaires on daily hassles and self-reported symptoms, to create fo...

journal_title：Life sciences

authors： Benschop RJ,Jabaaij L,Oostveen FG,Vingerhoets AJ,Kirschbaum C,Duivenvoorden HJ,Ballieux RE

更新日期：1993-01-01 00:00:00

abstract：AIM:The study is aimed at evaluating the chemosensitization and apoptotic effect of aglycone rich extracts of dietary phytoestrogens (derived from soybean and flaxseed) on estrogen receptor positive, MCF-7 and estrogen receptor negative, MDA-MB-231 cells. The extracts show potent activity on both the cell lines, hence,...

journal_title：Life sciences

authors： Dutta S,Kharkar PS,Sahu NU,Khanna A

更新日期：2017-09-15 00:00:00

abstract：:Histamine is a biogenic amine that plays an essential role in controlling many physiological functions, both in the central nervous system (CNS) and the peripheral nervous system (PNS). Most of these physiological effects are mediated through interactions with four histamine receptor subtypes, all of which are members...

journal_title：Life sciences

authors： Micallef S,Stark H,Sasse A

更新日期：2013-10-10 00:00:00

abstract：:Intravenous (640 micrograms/kg) or intracerebroventricular (0.5 and 1 microgram) injection of Escherichia coli endotoxin (LPS) causes inhibition of water intake induced by 24 hour period of water deprivation in the rat. Tumor necrosis factor alpha (TNF-alpha; 20 and 40 ng/rat) given into the lateral cerebral ventricle...

journal_title：Life sciences

authors： Calapai G,Mazzaglia G,Marciano MC,Squadrito F,Altavilla D,Zingarelli B,Prosdocimi M,Caputi AP

更新日期：1992-01-01 00:00:00

abstract：:We examined the direct effect of magnesium ion on aldosterone production by adrenal cells using collagenase-dispersed zona-glomerulosa cells in rats. The effects of magnesium on aldosterone production stimulated by angiotensin II or ACTH were also investigated. Both magnesium sulphate (MgSO4) and magnesium chloride (M...

journal_title：Life sciences

authors： Atarashi K,Matsuoka H,Takagi M,Sugimoto T

更新日期：1989-01-01 00:00:00

abstract：:Incubation of the nonsteroidal antiestrogen nitromiphene (CI628) with rat cecal content suspension under aerobic or anaerobic conditions resulted in extensive biotransformation, yielding three metabolites, as determined by thin-layer chromatography. These metabolites were not recovered from incubation mixtures contain...

journal_title：Life sciences

authors： Ruenitz PC,Bagley JR

更新日期：1983-09-12 00:00:00

abstract：:Osteoarthritis (OA) is a complex joint disorder with a number of underlying physical, biochemical, biomechanical and genetic causes. Obesity is considered to be one of the major risk factors for the development and progression of OA. It actively contributes to the inflammatory status and to cartilage degradation in th...

journal_title：Life sciences

authors： Scotece M,Mobasheri A

更新日期：2015-11-01 00:00:00

abstract：:Increased ventricular ANF-mRNA is observed as a compensating mechanism in response to many forms of overload including chronic exercise. It is unknown if exercise-induced increases in ANF expression are mediated at the transcriptional level and whether specific cis-element(s) may be involved. To study this, rats were ...

journal_title：Life sciences

authors： Edwards JG

更新日期：2002-04-26 00:00:00

abstract：:[3H]-Spiroperidol specifically binds at sites in human prefrontal cortex. The binding of this ligand is apparently anomalous at 37 degrees C, with a substantial loss of specific binding occurring between 5 and 40 min incubation. However, at 21 degrees C, this loss of binding is not observed even at 60 min. At 21 degre...

journal_title：Life sciences

authors： Andorn AC,Huang EH,Warren AE

更新日期：1984-06-18 00:00:00

abstract：:Environmental estrogens (endocrine disruptive chemicals) have been shown to affect reproduction in wild life and it has been reported that maternal exposure with those chemicals have adverse effects on the male reproductive tract. However, little is known about the potential effects of prepubertal or pubertal exposure...

journal_title：Life sciences

authors： Takao T,Nanamiya W,Nagano I,Asaba K,Kawabata K,Hashimoto K

更新日期：1999-01-01 00:00:00

abstract：:In this study we compared the antioxidant properties of five different extracts of different composition obtained from Achyrocline satureioides' inflorescences (Compositae), a widely used Brazilian folk medicinal herb. All of the extracts presented significant antioxidant potential identified by TRAP assay, which incr...

journal_title：Life sciences

authors： Polydoro M,de Souza KC,Andrades ME,Da Silva EG,Bonatto F,Heydrich J,Dal-Pizzol F,Schapoval EE,Bassani VL,Moreira JC

更新日期：2004-04-23 00:00:00

abstract：:The objective of this study was to investigate whether age induces changes on vasodilator response induced by cromakalim, an ATP-sensitive K+ (K(ATP)) channel opener, as well as the underlying mechanism involved in this possible alteration. For this purpose, aortic segments from young (3-5 months) and old (3 years) ra...

journal_title：Life sciences

authors： Ferrer M,Tejera N,Marín J,Balfagón G

更新日期：1998-01-01 00:00:00

abstract：:The present study was conducted to characterize the binding of neurotransmitter receptors (dopamine D(2), serotonin 5-HT(2), histamine H(1), adrenaline alpha(1) and muscarine M(l) receptors) in the rat's brain after the oral administration of haloperidol, risperidone, and olanzapine. Haloperidol at 1 and 3 mg/kg displ...

journal_title：Life sciences

authors： Uchida S,Kato Y,Hirano K,Kagawa Y,Yamada S

更新日期：2007-04-03 00:00:00

abstract：:We have investigated the effect of calcitonin (CT) on adenylate cyclase in membranes from different rat brain areas. Salmon calcitonin (sCT) dose-dependently inhibited the enzyme activity in midbrain, hypothalamus, medulla, pons and caudate nucleus, but was ineffective in adenohypophysis. The inhibitory effect was enh...

journal_title：Life sciences

authors： Nicosia S,Guidobono F,Musanti M,Pecile A

更新日期：1986-12-08 00:00:00

abstract：:Intracellular calcium plays an important role on the pathogenesis of hypoxia-induced cellular injury. Calbindin-D(28k), a cytosolic vitamin D-dependent calcium binding protein, can serve as a buffer to limit a surge in intracellular Ca2+ concentration ([Ca2+]i) induced by various stimulations. To evaluate the possible...

journal_title：Life sciences

authors： Wu MJ,Lai LW,Lien YH

更新日期：2002-06-21 00:00:00

abstract：AIM:Membranous nephropathy remains the most common form of the nephrotic syndrome in adults. The combination therapy of steroid and cyclophosphamide has routinely been used. Although satisfactory therapeutic efficacy can be achieved, its side effect on reproductive system has been a concern. Mizoribine is an imidazole ...

journal_title：Life sciences

authors： Wang X,Song X,Liu Y,Zhang W,An W,Tu Y

更新日期：2016-06-01 00:00:00

abstract：:Previous studies from this laboratory have shown that rats with experimental cirrhosis of the liver induced by the combined administration of oral phenobarbital and inhaled carbon tetrachloride show an hyperdynamic status with enhanced cardiac output (CO), and decreased mean arterial pressure (MAP) and peripheral vasc...

journal_title：Life sciences

authors： Villamediana LM,Sanz E,Fernandez-Gallardo S,Caramelo C,Sanchez Crespo M,Braquet P,Lopez-Novoa JM

更新日期：1986-07-21 00:00:00

abstract：:Ocimum sanctum, the Indian holy basil, has significant ability to scavenge highly reactive free radicals. Shade dried leaf powder of the plant was extracted with water and alcohol, and then fractionated with different solvents. Both extracts and their fractions have in vitro anti-lipidperoxidative activity at very low...

journal_title：Life sciences

authors： Geetha RK,Vasudevan DM

更新日期：2004-11-19 00:00:00

abstract：:The ATP-binding cassette (ABC) and solute carrier (SLC) transporter families consist of common drug transporters that mediate the efflux and uptake of drugs, respectively, and play an important role in the absorption, distribution, metabolism and excretion of drugs in vivo. Rheumatoid arthritis (RA) is an autoimmune d...

journal_title：Life sciences

authors： Gao J,Wang C,Wei W

更新日期：2021-01-08 00:00:00