Possible involvement of mu 2-opioid receptor-mediated mechanisms in morphine-induced enhancement of the pentobarbital-induced loss of the righting reflex in the mouse.

abstract：AIMS:Oxidative stress has been largely implicated in the pathogenesis of anoxia/reoxygenation injury. Ganoderma atrum polysaccharide (PSG-1), the most abundant component extracted from the fruiting bodies of G. atrum, has been shown to possess potent antioxidant activity. In this study, we investigated whether PSG-1 at...

journal_title：Life sciences

authors： Li WJ,Nie SP,Yan Y,Zhu SB,Xie MY

更新日期：2009-10-21 00:00:00

abstract：:The gastric mucosa is frequently exposed to different exogenous and endogenous ulcerative agents. Alcoholism is one of the risk factors for the development of mucosal damage in the stomach. This study aimed to assess if a probiotic strain Lactobacillus rhamnosus GG (LGG) is capable of protecting the gastric mucosa fro...

journal_title：Life sciences

authors： Lam EKY,Tai EKK,Koo MWL,Wong HPS,Wu WKK,Yu L,So WHL,Woo PCY,Cho CH

更新日期：2007-05-16 00:00:00

abstract：:The effects of sucrose feeding on parameters associated with (Na+,K+)-ATPase in brown adipose tissue were compared in rats treated with parenteral 6-hydroxydopamine and vehicle. Sucrose feeding significantly increased K+-p-nitrophenylphosphatase and ouabain binding in brown adipose tissue from rats treated with vehicl...

journal_title：Life sciences

authors： Swann AC

更新日期：1984-01-23 00:00:00

abstract：:The purpose of this study was to determine the effects of the 7288ctc Morris hepatoma on heart size and performance. Hearts from tumor bearing and control animals were perfused in the working configuration one to three weeks post implantation. As tumor growth progressed there was an inverse linear relationship between...

journal_title：Life sciences

authors： Broussard HJ,Lang C,Burns AH

更新日期：1994-01-01 00:00:00

abstract：:Chlordimeform (CDM) and demethylchloridimeform (DCDM) mimic the action of octopamine in elevating adenylate cyclase activity in intact nerve cords of the American cockroach, Periplaneta americana. At a concentration of 1 x 10(-5)M, DCDM (13.5x increase within 20 minutes) is a more potent effector of the response than ...

journal_title：Life sciences

authors： Gole JW,Orr GL,Downer RG

更新日期：1983-06-27 00:00:00

abstract：:Opiate binding sites have been characterized on membranes from bovine adrenal medullas and six human pheochromocytomas. In human tumors, large variations in site distribution were observed. Kappa and benzomorphan sites represented the majority of the sites detected. The heterogeneity of the opiate sites on these tissu...

journal_title：Life sciences

authors： Castanas E,Giraud P,Audigier Y,Drissi R,Boudouresque F,Conte-Devolx B,Oliver C

更新日期：1983-01-01 00:00:00

abstract：:In recent years, serum S100B has been used as a secondary endpoint in some clinical trials, in which serum S100B has successfully indicated the benefits or harm done by the tested agents. Compared to clinical stroke studies, few experimental stroke studies report using serum S100B as a surrogate marker for estimating ...

journal_title：Life sciences

authors： Tanaka Y,Koizumi C,Marumo T,Omura T,Yoshida S

更新日期：2007-08-02 00:00:00

abstract：:It has been reported that naloxone, an opioid antagonist, has antiarrhythmic activity in vivo. In Langendorff perfused rat hearts, we found that ischemia-reperfusion-induced ventricular tachyarrhythmia reverted to normal sinus rhythm after the treatment with naloxone (3 approximately 10 microM). The method of voltage ...

journal_title：Life sciences

authors： Hung CF,Wu MH,Tsai CH,Chu SH,Chi JF,Su MJ

更新日期：1998-01-01 00:00:00

abstract：AIM:Despite recent advances in therapeutic strategies, cancer is still a leading cause of mortality worldwide. Mitochondrial dysfunction is implicated in cancer initiation and metastasis, and even in chemo- and radio-resistance. However, the precise role of mitochondria in cancer is crosstalk and controversial. This st...

journal_title：Life sciences

authors： Kheirandish-Rostami M,Roudkenar MH,Jahanian-Najafabadi A,Tomita K,Kuwahara Y,Sato T,Roushandeh AM

更新日期：2020-03-01 00:00:00

abstract：:C57BL6/J (B6) mice lacking Se-dependent GSH peroxidase 1 and 2 (GPx1/2-DKO) develop mild to moderate ileocolitis around weaning. These DKO mice have a disease resembling human very-early-onset inflammatory bowel disease (VEOIBD), which is associated with mutations in NADPH oxidase genes. Drugs including dexamethasone ...

journal_title：Life sciences

authors： Chu FF,Esworthy RS,Shen B,Gao Q,Doroshow JH

更新日期：2019-12-15 00:00:00

abstract：:Within 4 minutes a single, intravenous injection of nicotine (0.3 mg/Kg) induced increases in somatostatin-like immunoreactivity concentrations in the rat hypothalamus but not in the striatum. These changes were associated with a significant increase in the specific binding of somatostatin to putative receptor sites i...

journal_title：Life sciences

authors： Barrios V,González-Parra S,Arilla E

更新日期：1992-01-01 00:00:00

abstract：:We previously showed that N1-phenyl-3,5-dinitro-N4,N4-di-n-butylsulfanilamide (denoted GB-II-150) possesses selective antimicrotubule activity against Leishmania donovani and Trypanosoma brucei in vitro [Bhattacharya, G., Herman, J., Delfin, D., Salem, M.M., Barszcz, T., Mollet, M., Riccio, G., Brun, R., Werbovetz, K....

journal_title：Life sciences

authors： Wu D,George TG,Hurh E,Werbovetz KA,Dalton JT

更新日期：2006-08-08 00:00:00

abstract：:The release of endogenous dopamine (DA) has been measured in the rat striatum following the intracardial administration of various doses of beta-phenylethylamine (PEA) or alpha,alpha-dideutero-beta-phenylethylamine (deuterated PEA). The release was significantly increased for a period of approximately 15 minutes by a ...

journal_title：Life sciences

authors： Philips SR

更新日期：1986-12-22 00:00:00

abstract：:In this study we examined if sleep time, caloric intake and energy expenditure are important contributors to development of ovariectomy-induced obesity in mice fed control or high fat diet (HFD). Twelve female mice at 6 weeks of age were divided into 2 groups: Sham (n = 5) and ovariectomized (OVX, n = 7). Mice were fe...

journal_title：Life sciences

authors： do Carmo JM,da Silva AA,Moak SP,Browning JR,Dai X,Hall JE

更新日期：2018-11-01 00:00:00

abstract：:To determine whether rat retinal photoreceptor cells produce inhibin, a molecule closely related to activin, a multifunctional growth factor in the transforming growth factor beta superfamily (TGF beta), we have conducted immunohistochemistry using specific antibodies for inhibin which were raised against a synthetic ...

journal_title：Life sciences

authors： Ying SY,Li SQ,Zhang Z

更新日期：1995-01-01 00:00:00

abstract：AIMS:The present work evaluated the anti-inflammatory/antioxidant activity of a well characterized extract from Citrus bergamia Risso and Poiteau (CBE), containing neoeriocitrin, naringin, neohesperidin and other flavonoids, on human NCTC 2544 keratinocytes treated with interferon-gamma (IFN-γ) and histamine (H). MAIN...

journal_title：Life sciences

authors： Graziano AC,Cardile V,Crascì L,Caggia S,Dugo P,Bonina F,Panico A

更新日期：2012-06-27 00:00:00

abstract：:Kinetics of activation of the NADPH oxidase in a fully soluble cell-free system from phorbol myristate acetate (PMA)-stimulated human neutrophils were investigated. In a cell-free system in which Mg2+ and sodium dodecyl sulfate, an anionic detergent required for the activation of NADPH oxidase are contained, cytosol p...

journal_title：Life sciences

authors： Umeki S

更新日期：1990-01-01 00:00:00

abstract：:We studied the effect of interleukin-1 alpha (IL-1) on corticotropin-releasing hormone (CRH) secretion by explanted rat hypothalami in vitro. We also assessed possible mediation of arachidonic acid metabolites on IL-1-stimulated CRH secretion, by preincubating hypothalami with the cyclooxygenase inhibitor indomethacin...

journal_title：Life sciences

authors： Bernardini R,Calogero AE,Mauceri G,Chrousos GP

更新日期：1990-01-01 00:00:00

abstract：:The immunosuppressive effects of microcolin A, a lipopeptide extracted from the marine blue green alga Lyngbya majuscula were investigated. Microcolin A suppressed concanavalin A (IC50 = 5.8 nM), phytohemagglutinin (IC50 = 12.5 nM) and lipopolysaccharide (IC50 = 8.0 nM) induced proliferation of murine splenocytes. Mix...

journal_title：Life sciences

authors： Zhang LH,Longley RE,Koehn FE

更新日期：1997-01-01 00:00:00

abstract：AIMS:Liver fibrosis is a difficult problem in the medical field. We previously reported that curcumol, a bioactive substance, may inhibit the pathological angiogenesis of liver sinusoidal endothelial cells (LSECs) and play a good anti-hepatic fibrosis effect. However, the mechanism of curcumol inhibiting angiogenesis i...

journal_title：Life sciences

authors： Gao L,Yang X,Li Y,Wang Z,Wang S,Tan S,Chen A,Cao P,Shao J,Zhang Z,Zhang F,Zheng S

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Sepsis is a life-threatening organ dysfunction syndrome arising from uncontrolled inflammatory responses. Liver injury is a crucial factor for the prognosis of sepsis. Camptothecins (CPTs) have been reported to suppress the inflammatory response induced by sepsis. G2, a CPT-bile acid conjugate...

journal_title：Life sciences

authors： Xiao LX,Qi L,Zhang XL,Zhou YQ,Yue HL,Yu ED,Li QY

更新日期：2020-09-15 00:00:00

abstract：AIMS:The dysregulation of circular RNAs (circRNAs) has been implicated in the progression of diabetic retinopathy (DR). This study aims to explore the role and underlying mechanism of hsa_circ_0081108 (circCOL1A2) in DR. MATERIALS AND METHODS:circCOL1A2, vascular endothelial growth factor (VEGF) and miR-29b expression...

journal_title：Life sciences

authors： Zou J,Liu KC,Wang WP,Xu Y

更新日期：2020-09-01 00:00:00

abstract：:The aim of this study was to investigate whether the A1/A2 receptor agonist, 5'-N-ethylcarboxamidoadenosine (NECA), and the selective A1 agonist, N6-cyclopentyladenosine (CPA), induced physical dependence by quantifying specific antagonist-precipitated withdrawal syndromes in conscious rats. In addition, the presence ...

journal_title：Life sciences

authors： Coupar IM,Tran BL

更新日期：2001-07-06 00:00:00

abstract：:Morphine and oxycodone are potent opioid analgesics most commonly used for the management of moderate to severe acute and chronic pain. Their clinical utility is limited by undesired side effects like analgesic tolerance, dependence, and withdrawal. We have previously demonstrated that endothelin-A (ETA) receptor anta...

journal_title：Life sciences

authors： Bhalla S,Andurkar SV,Gulati A

更新日期：2016-08-15 00:00:00

abstract：:The effects of GABA antagonists, picrotoxin and bicuculline were studied on hyperphagia caused by insulin in free feeding rats. It was found that peripheral administration of GABA antagonists inhibited this hyperphagia. These agents were administered in the VMH and LH through stereotaxically implanted cannulae. It was...

journal_title：Life sciences

authors： Kamatchi GL,Bhakthavatsalam P,Chandra D,Bapna JS

更新日期：1984-06-04 00:00:00

abstract：:The purpose of this present study was to develop a method for stimulation of acid secretion by the isolated perfused rat stomach. Rat stomachs were perfused in situ via the abdominal aorta and celiac axis with Krebs-Ringer bicarbonate buffer in the presence or absence of 10% ovine erythrocytes. The gastric lumen was p...

journal_title：Life sciences

authors： Short GM,Wolfe MM,McGuigan JE

更新日期：1984-06-18 00:00:00

abstract：:The effects of morphine-3-glucuronide (M3G) and morphine on the K+-evoked release of [14C]-gamma-aminobutyric acid (GABA) and [3 H]-glutamic acid were investigated in rat brain synaptosomes using superfusion techniques. K+-evoked release of both [14C]-GABA and [3H]-glutamic acid from rat brain synaptosomes was elimina...

journal_title：Life sciences

authors： Bartlett SE,Smith MT

更新日期：1996-01-01 00:00:00

abstract：:Inflammation, inflammatory mediators, cyclooxygenase (COX)-2, and inducible nitric oxide (iNOS) are all influenced by age-related oxidative status. To investigate the effect of dietary fish oil (FO) and calorie restriction (CR) on oxidative stress-related inflammatory status with age, (NZB/NZW) F1 (B/W) mice were fed ...

journal_title：Life sciences

authors： Kim YJ,Kim HJ,No JK,Chung HY,Fernandes G

更新日期：2006-04-18 00:00:00

abstract：:2',6'-Dimethyl substitution of the Tyr(1) residue of opioid agonist peptides and deletion of the positively charged N-terminal amino group or its replacement with a methyl group has recently been shown to represent a general structural modification to convert opioid peptide agonists into antagonists. This conversion r...

journal_title：Life sciences

authors： Schiller PW,Weltrowska G,Nguyen TM,Lemieux C,Chung NN,Lu Y

更新日期：2003-06-27 00:00:00

abstract：AIMS:Nitric oxide (NO) is synthesized from L-arginine (L-Arg) by three different isoforms of NO synthase (NOS), i.e. the constitutive neuronal and endothelial NOS (nNOS and eNOS) and the inducible NOS (iNOS). NO has been involved in the pathophysiology of epilepsy, but available data are conflicting and the actual role...

journal_title：Life sciences

authors： Prieto-Martín AI,Llorens S,Pardal-Fernández JM,Muñoz LJ,López DE,Escribano J,Nava E,de Cabo C

更新日期：2012-04-09 00:00:00