Abstract：
:The release of endogenous dopamine (DA) has been measured in the rat striatum following the intracardial administration of various doses of beta-phenylethylamine (PEA) or alpha,alpha-dideutero-beta-phenylethylamine (deuterated PEA). The release was significantly increased for a period of approximately 15 minutes by a dose of 25 mg/kg PEA. Both the dose required to stimulate DA release and the duration of the effect were in good agreement with previously reported behavioral and locomotor effects of administered PEA. When the animals were given 25 mg/kg of deuterated PEA, the increase in DA release was both longer lasting and significantly greater in magnitude than that observed in response to the non-deuterated amine. The results of these experiments provide direct evidence that DA release is stimulated by amounts of PEA known to cause behavioral effects and locomotor activity in rats, and suggest that these effects are likely to be mediated, at least in part, by DA.
journal_name
Life Scijournal_title
Life sciencesauthors
Philips SRdoi
10.1016/0024-3205(86)90480-7subject
Has Abstractpub_date
1986-12-22 00:00:00pages
2395-400issue
25eissn
0024-3205issn
1879-0631pii
0024-3205(86)90480-7journal_volume
39pub_type
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