Abstract：
:The reproductive system effects of cocaine were studied in male rats. The analysis included measurements of circulating levels of luteinizing hormone (LH) and testosterone (T) by radioimmunoassay (RIA). The weights of the testes and sex accessory organs were also assessed and compared with control animals. Dosage level, duration of treatment, and interval between injection and sacrifice were the parameters examined. Following a single intraperitoneal (IP) injection, LH levels decreased over a 3-hour period. At a high dosage (40 mg/kg), cocaine caused a significant elevation in serum T followed by a significant depression of T for at least 2 hours. When administered chronically for 15 days, the low dose group (10 mg/kg) did not vary significantly from the vehicle controls. However, the high dose group had lower LH and T levels, as well as correspondingly lighter weight seminal vesicles and epididymis. No changes were noted in the weights of the ventral prostate or testes. This research suggests that cocaine acts primarily at the hypothalamic-hypophyseal axis with a possible secondary action at the gonadal level.
journal_name
Life Scijournal_title
Life sciencesauthors
Berul CI,Harclerode JEdoi
10.1016/0024-3205(89)90440-2subject
Has Abstractpub_date
1989-01-01 00:00:00pages
91-5issue
1eissn
0024-3205issn
1879-0631pii
0024-3205(89)90440-2journal_volume
45pub_type
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