Abstract：
:Four Rhesus monkeys were subjected to daily administration of 2.5 mg of tetrahydrocannabinol (THC)/kg body wt, after establishing the norms for complete blood count, T- and B-cell concentrations, and the dose response of thymidine incorporation after PHA stimulation. THC was administered daily for 3 weeks, the treatment was stopped, and then the animals were allowed to recover for 4 weeks. Cellular responses, incorporation studies and fibrinogen levels were determined during the treatment and recovery phases. Compared to 4 vehicle-treated animals, the THC-treated animals experienced significant augmentation of both their total white cell and their neutrophil counts during the recovery phase which returned to normal levels during the recovery phase. There was no alteration in total lymphocyte count or T- or B-cell concentrations. Fibrinogen levels of the THC-treated animals during the treatment phase were also elevated compared to controls, and the levels diminished to the same values as the vehicle-treated animals during recovery phase. Possible mechanisms for the response of Rhesus monkeys to short-term administration of THC are discussed.
journal_name
Life Scijournal_title
Life sciencesauthors
Silverman AY,Darnell BJ,Montiel MM,Smith CG,Asch RHdoi
10.1016/0024-3205(82)90642-7subject
Has Abstractpub_date
1982-01-04 00:00:00pages
107-15issue
1eissn
0024-3205issn
1879-0631pii
0024-3205(82)90642-7journal_volume
30pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:A synthetic peptide corresponding to a sequence of 26 amino acids contained in endogenous rat atrial natriuretic factor (ANF), was infused into one renal artery of anesthetized dogs for a comprehensive in vivo evaluation of the renal and systemic effects of pure ANF. The results proved conclusively that ANF acted dire...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90283-8
更新日期：1985-01-07 00:00:00
abstract：:The role of endothelium-derived nitric oxide (NO) to cause smooth muscle phospholamban (PLB) phosphorylation was studied in the isolated perfused rat aorta precontracted with norepinephrine using a back-phosphorylation technique. NO-induced relaxation was associated with increased PLB-phosphorylation while norepinephr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90357-u
更新日期：1992-01-01 00:00:00
abstract：:It was possible to assess that ACE inhibitors bound to two different sites on the enzymes which consist in two homologous domains. Accordingly, it was also shown that testis ACE which consists in a single domain exhibits only one site for inhibitors. The common binding site of both enzymes contains Zn2+, bears the enz...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90489-c
更新日期：1992-01-01 00:00:00
abstract：:Swim therapy in the form of moderate physical activity has general health benefits. Regular exercise prevents the progression of chronic diseases affecting the different bodily systems. The metabolic alterations associated with following such lifestyle remain not fully understood. The aim of the present study was to e...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118516
更新日期：2020-12-01 00:00:00
abstract：:The structure of a new crystal form of leucine-enkephalin has been determined by X-ray diffraction. There are two independent molecules in the asymmetric unit and both have extended peptide backbone conformations with side-chains arranged alternately above and below the backbone planes. The two pentapeptides are hydro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90289-x
更新日期：1987-05-18 00:00:00
abstract：AIMS:Several lines of evidence support the hypothesis that the oxidation of low density lipoprotein (LDL) may play a crucial role in the initiation and progression of atherosclerosis. Various studies have shown a positive effect of antioxidant compounds on oxidative modification of LDL and atherogenesis. In view of thi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.10.005
更新日期：2008-12-19 00:00:00
abstract：:Extracts of brain and heart from rats at birth and postnatal days 2 and 10 were evaluated for naltrexone following maternal injection of 50 mg/kg opioid antagonist throughout gestation. Samples were prepared by ultrafiltration, lyophilized, reconstituted in mobile phase, and separated by reversed-phase high performanc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01090-4
更新日期：1998-01-01 00:00:00
abstract：:Of primary interest for every enzyme is the identification of its physiological substrates. However, the vast structural diversity of endogenous metabolites, coupled with the overlapping activities of numerous enzymes, makes it difficult to deduce the identity of natural substrates for a given enzyme based on in vitro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.05.019
更新日期：2005-08-19 00:00:00
abstract：:Grape seed extract (GSE) is a commonly available dietary supplement taken for the anti-oxidant activity that's attributed to its proanthocyanidin (oligomers of monomeric polyphenols) content. Similar polyphenol-enriched preparations from blueberries and soy have shown protection against ovariectomy-induced or age-rela...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.12.008
更新日期：2006-03-27 00:00:00
abstract：:Incubation of racemic methylenedioxyamphetamine (MDA) or methylenedioxymethamphetamine (MDMA) with rat hepatic microsomes, in the presence of NADPH, generated a spectrally observed inhibitory complex with cytochrome P-450. The complex inhibited product formation from MDA and MDMA as well as other P-450 dependent react...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90551-5
更新日期：1986-10-20 00:00:00
abstract：:Stonustoxin (SNTX) is a 148 kDa, dimeric, hypotensive and lethal protein factor isolated from the venom of the stonefish Synanceja horrida. SNTX (10-320 ng/ml) progressively causes relaxation of endothelium-intact, phenylephrine (PE)-precontracted rat thoracic aortic rings. The SNTX-induced vasorelaxation was inhibite...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.01.058
更新日期：2007-04-10 00:00:00
abstract：:The effects of taurine on hepatic cholesterol metabolism were investigated in hamsters fed a high-fat diet or normal chow. Two weeks-treatment of taurine at 1% in drinking water prevented high-fat diet-induced increase in cholesterol levels of serum and liver. The decrease in serum cholesterol by taurine was due to de...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01507-2
更新日期：2002-04-05 00:00:00
abstract：AIMS:Stroke-prone spontaneously hypertensive rats (SHRSP) show significantly lower body weight than normotensive Wistar-Kyoto rats (WKY). Our hypotheses are as follows: weight loss of the skeletal muscle is related to hypertension-related diseases, and muscle hypotrophy is useful as a therapeutic target for hypertensio...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116919
更新日期：2019-11-15 00:00:00
abstract：:The present investigation examined the correlation between the regulation of mucosal prostaglandin (PG) biosynthesis and the release of the neuropeptide substance P (SP) in rat stomachs by indomethacin, a cyclooxygenase inhibitor. When given subcutaneously at the dose of 5 mg/kg, indomethacin reduced mucosal biosynthe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00117-3
更新日期：1997-01-01 00:00:00
abstract：AIMS:To better understand mechanisms whereby Ajulemic acid (AjA), a synthetic antiinflammatory cannabinoid, promotes resolution of acute and chronic inflammation in animal models, we investigated its influence on cyclooxygenase 2 (COX2) expression and eicosanoid production in human fibroblast-like synovial cells (FLS)....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.09.004
更新日期：2008-11-07 00:00:00
abstract：:Inhaled antimuscarinics, often called anticholinergics in clinical medicine, are established as first line bronchodilators in COPD. Tiotropium has been developed as a new generation antimuscarinic following ipratropium. Tiotropium is a specific, highly potent antimuscarinic, demonstrating very slow dissociation from m...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(98)00588-8
更新日期：1999-01-01 00:00:00
abstract：:Administration of ovine-prolactin (O-PRL) stimulated Ca2+ uptake in isolated duodenal cells prepared from vitamin D-deficient rats. The time course of this effect was biphasic: uptake activity reached a peak in 2.5 hrs followed by a decrease at 5 hrs to original levels. This stimulatory effect of O-PRL was observed in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90568-c
更新日期：1990-01-01 00:00:00
abstract：:To clarify the mechanism by which Delta9-tetrahydrocannabinol, a major psychoactive component of marijuana, impairs spatial memory in the 8-arm radial maze in rats via the cholinergic system, we used two acetylcholinesterase inhibitors, physostigmine and tetrahydroaminoacridine. Moreover, we examined the effect of Del...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02274-9
更新日期：2002-12-20 00:00:00
abstract：:To analyze the metabolisms of platelet-activating factor (PAF) and Thromboxane A2 (TxA2) when platelets and mesangial cells (MC) interact, immunoreactive thromboxane B2 (TxB2) and PAF were measured after incubation of cultured rat MC with platelets (P) and with platelet supernatants (PS). In both cases, TxB2 significa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02030-m
更新日期：1995-01-01 00:00:00
abstract：AIMS:In this study, we used a cross-junction microfluidic device for preparation of alendronate-loaded chitosan nanoparticles with desired characteristics to introduce a suitable element for bone tissue engineering scaffolds. MAIN METHODS:By controlling the reaction condition in microfluidic device, six types of alend...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117768
更新日期：2020-08-01 00:00:00
abstract：AIMS:This study sought to determine the impact of in vitro exposure to the herbicide atrazine (ATR) or its major mammalian metabolite diaminochlorotriazine (DACT) on dopaminergic cell differentiation. MAIN METHODS:N27 dopaminergic cells were exposed for 24 or 48 h to ATR or DACT (12-300 μM) and their effects on cell v...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.10.027
更新日期：2013-01-17 00:00:00
abstract：:The neuropeptide substance P (SP) is a mediator of neurogenic inflammation. Also, beta-amyloid protein (beta AP) can directly activate the cell types involved in inflammatory processes. The relationship between SP and beta AP on their biological actions has attracted much interest. SP is trophic in neuronal cells and ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00235-x
更新日期：1995-01-01 00:00:00
abstract：:TNF production has been studied in peritoneal macrophages and splenic T cells of Arctic Yakutian ground squirrel (Citellus Undulatus Pallas) in hibernating and awake animals in winter and in prehibernating autumn as well as in active euthermic spring-summer animals. A high level of TNF production in macrophages of gro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00698-6
更新日期：2000-01-01 00:00:00
abstract：:The effects of central administration of two serotonin receptor agonists, 8-OH-DPAT and mCPP, on tuberoinfundibular dopaminergic (TIDA) neuron activity and serum prolactin (PRL) levels in ovariectomized, estrogen-treated rats were determined. 8-OH-DPAT dose-dependently (0.1-10 microgram/rat, icv) stimulated serum PRL ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00077-x
更新日期：1996-01-01 00:00:00
abstract：:The colchicine-induced accumulation of vasopressin (AVP) and oxytocin (OXT) has recently been applied to estimate the synthesis and turnover rates for these neuropeptides in whole rat hypothalamus. In the present studies, this pharmacologic procedure has been examined as a potential method for estimating hypothalamic ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90441-d
更新日期：1991-01-01 00:00:00
abstract：:Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors, CysLT1 and CysLT2, have been cloned and functionally characterised using potent CysLT1 receptor antagonists and the dual CysLT1/CysLT2 receptor...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(02)01733-2
更新日期：2002-06-28 00:00:00
abstract：:Addition of a nitroxybutyl moiety to diclofenac greatly reduces its damaging effects on the gastric mucosa without altering its ability to suppress prostaglandin synthesis and exert anti-inflammatory actions. The present study was performed in order to determine if this derivative of diclofenac, called nitrofenac, wou...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90083-3
更新日期：1994-01-01 00:00:00
abstract：AIMS:Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, has been reported to be a novel marker for the progression of chronic kidney disease (CKD). We have recently found that accumulation of ADMA could trigger peritubular capillary loss, thus contributing to tubulointerstitial ischemia ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.03.018
更新日期：2009-06-05 00:00:00
abstract：:In order to further elucidate a possible role of neuropeptides and GABA in the pathogenesis of febrile convulsions, we studied changes of immunoreactive-arginine vasopressin (IR-AVP), IR-somatostatin (IR-SRIF) and gamma-aminobutyric acid (GABA) in the rat brain after febrile convulsions induced by ultra-red light (UR)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00218-4
更新日期：1996-01-01 00:00:00
abstract：:We contrast the effects of three intermediate electron acceptors (IEAs) on the highly quantitative ESTA bioassay for human growth hormone. This is a microculture tetrazolium assay based upon the in vitro reduction of the tetrazolium salt MTT, by Nb2 cells which have been activated with hGH. Each of the IEAs influenced...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00512-7
更新日期：1996-01-01 00:00:00
