Abstract：
:TNF production has been studied in peritoneal macrophages and splenic T cells of Arctic Yakutian ground squirrel (Citellus Undulatus Pallas) in hibernating and awake animals in winter and in prehibernating autumn as well as in active euthermic spring-summer animals. A high level of TNF production in macrophages of ground squirrel is observed over the active period and during arousals in winter. There are no significant season variations in TNF production in splenic T lymphocytes of ground squirrels. This suggests the major role of activated macrophages in the arousals of hibernating animals. T lymphocyte proliferation in ground squirrels in the active period is higher than in winter, and the most significant seasonal variations are found in T cell mitogenic response, which increases in spring-summer period. Evidence is presented that functional activity of macrophages of squirrel in autumn has much in common with that in winter rather than in spring-summer period.
journal_name
Life Scijournal_title
Life sciencesauthors
Novoselova EG,Kolaeva SG,Makar VR,Agaphonova TAdoi
10.1016/s0024-3205(00)00698-6subject
Has Abstractpub_date
2000-01-01 00:00:00pages
1073-80issue
9eissn
0024-3205issn
1879-0631pii
S0024320500006986journal_volume
67pub_type
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