Abstract：
:The structure of a new crystal form of leucine-enkephalin has been determined by X-ray diffraction. There are two independent molecules in the asymmetric unit and both have extended peptide backbone conformations with side-chains arranged alternately above and below the backbone planes. The two pentapeptides are hydrogen-bonded to each other and to other molecules forming an extended antiparallel beta-pleated sheet. The structure differs from that in similar crystals of methionine enkephalin primarily in side-chain orientations and inter-sheet interactions.
journal_name
Life Scijournal_title
Life sciencesauthors
Mastropaolo D,Camerman A,Ma LY,Camerman Ndoi
10.1016/0024-3205(87)90289-xsubject
Has Abstractpub_date
1987-05-18 00:00:00pages
1995-9issue
20eissn
0024-3205issn
1879-0631pii
0024-3205(87)90289-Xjournal_volume
40pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The microscopic localization of angiotensin II receptors in the rat brainstem has been accomplished utilizing in vitro receptor autoradiographic techniques. These receptors are highly localized to discrete nuclear regions of the brainstem. Significant densities of autoradiographic grains, indicating the presence of sp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90611-8
更新日期：1984-04-16 00:00:00
abstract：:The release of liver enzymes is typically used to assess tissue damage following ischemia-reperfusion. The present study was designed to determine the impact of ischemia-reperfusion on liver function and compare these findings with enzyme release. Isolated, perfused rat livers were subjected to low flow ischemia follo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00668-2
更新日期：2000-01-01 00:00:00
abstract：:The effect of brief inhalation of carbon dioxide (CO2) was studied in a conflict situation (Vogel test) in the rat. This treatment, which inhibits gamma-aminobutyric acid (GABA)-mediated transmission in rat brain and induces anxiety and panic attacks in humans, elicited a proconflict effect. Exposure of rats for 1 min...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00093-3
更新日期：1995-03-10 00:00:00
abstract：:Different receptors mediating the release of endothelium-derived nitric oxide (EDNO) have been identified at endothelial level. In the present study we aimed to characterise, on rabbit aorta by means of pharmacological tools, the generation of EDNO by receptors located on endothelial cell membrane (M3, P2u, P2y) and b...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01144-2
更新日期：1998-01-01 00:00:00
abstract：:We administered intravenous adenosine to 11 neonatal rabbits. Adenosine depressed respiration in 10 of 11 rabbits. For the group as a whole the adenosine-induced respiratory depression was highly significant (p less than 0.001). After aminophylline administration to the same animals the respiratory effect of intraveno...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90248-7
更新日期：1987-01-05 00:00:00
abstract：:Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the protective mesenteric hyperemia after intraduodenal acidification. Mechanisms associated the sensory neuropeptides, e.g. calcitonin gene-related peptide (CGRP), substance P, and ruthenium red-sensitive cation channels contribute to acid-induc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02106-9
更新日期：2002-10-18 00:00:00
abstract：:In view of the toxicity of cocaine and recent reports on the antimuscarinic properties of cocaine, the present study evaluated the effects of manipulations in cholinergic neurotransmission on the lethal effects of cocaine. Physostigmine pretreatment significantly altered the lethality of cocaine, increasing the LD 50 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90111-2
更新日期：1989-01-01 00:00:00
abstract：:The presence of met5-enkephalin-arg6-phe7 (YGGFMRF) and opiate receptors in rat, guinea pig and human lung was investigated with specific and sensitive radio immuno- and radio-receptor assays. 1) High and low molecular weight YGGFMRF-like immunoreactivity were detected in lung extracts using Bio-Gel P-2 column chromat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90768-3
更新日期：1983-05-16 00:00:00
abstract：AIMS:Benidipine is a dihydropyridine (DHP) derived Ca2+ antagonist, can block triple Ca2+ channels (L, N, and T). It has been used as a safety anti-hypertensive drug because of its long-acting relaxant effect on vascular smooth muscle (VSM). However, whether benidipine has similar pharmacological actions in airway smoo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.04.036
更新日期：2019-06-15 00:00:00
abstract：:Flavonoids are frequently found in fruits and vegetables, and are currently under investigation as potential chemopreventive agents. The present study reports the inhibitory effects of six flavonoids, quercetin, genistein, daidzein, equol, (+)-catechin and flavone, on sulphation of p-nitrophenol, a model substrate for...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00423-3
更新日期：1999-01-01 00:00:00
abstract：:The effects of the benzodiazepines diazepam and midazolam on the rigidity produced by systemic administration of morphine (15 mg/kg i.p.) were studied in rats. The rigidity was recorded as a tonic activity from the gastrocnemius-soleus muscle of non-anesthetized rats in the electromyogram. Both diazepam (1-5 mg/kg i.p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90612-4
更新日期：1983-01-01 00:00:00
abstract：:Comparison of neuronal and non-neuronal membrane transport of, and neuroexcitation by, the dicarboxylic amino acids bring out provocative similarities in structural selectivity, and hence in the strategies for studying them. Parallel anomalies in stereoselectivity show for both phenomena that the recognition sites are...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(83)90258-8
更新日期：1983-12-05 00:00:00
abstract：:In saturation binding experiments, (+)pentazocine, (+)3-(3-hydroxyphenyl)-N-propylpiperidine (3-PPP), haloperidol and rimcazole did not inhibit the binding of [3H]DTG in a purely competitive fashion. Although Scatchard analysis indicated that [3H]DTG bound to a single site, the inhibition curves of some, but not all, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90255-n
更新日期：1992-01-01 00:00:00
abstract：:Bupleuri radix, a traditional Chinese herb, has been widely used to treat liver diseases such as hepatitis and cirrhosis. The acetone extract of Bupleurum scorzonerifolium (AE-BS) showed a dose-dependently antiproliferative effect on the proliferation of A549 human lung cancer cells. The IC(50) of AE-BS, i.e., the con...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00648-9
更新日期：2003-09-19 00:00:00
abstract：AIMS:Alterations in the expression of antioxidant enzymes are associated with changes in cancer cell sensitivity to chemotherapeutic drugs (menadione and β-lapachone). Mechanisms of acquisition of resistance to pro-oxidant drugs were investigated using a model of oxidative stress-resistant MCF-7 breast cancer cells (Re...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.12.017
更新日期：2016-01-15 00:00:00
abstract：:Cannabinoid agonists such as Delta9-tetrahydrocannabinol (THC) produce a wide range of pharmacological effects both in the central nervous system and in the periphery. One of the most striking features of cannabinoids such as THC is the magnitude to tolerance that can be produced upon repetitive administration of this...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2005.05.005
更新日期：2005-08-19 00:00:00
abstract：AIMS:Nicotine is known to promote body weight loss and to disturb glucose homeostasis and lipoprotein metabolism. Electronic cigarettes, as a substitute to nicotine, are becoming increasingly popular, although there is no evidence regarding their safety. Considering the dearth of information about e-cigarette toxicity,...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.12.049
更新日期：2016-02-01 00:00:00
abstract：AIMS:The aim of study is to investigate the effect of nifedipine on viral myocarditis in an animal model. MAIN METHODS:Four-week-old male DBA/2 mice were inoculated with 2 pfu of encephalomyocarditis virus (EMCV) and randomized to nifedipine (n=10) or control (n=10) group. The control group was fed by regular chow and...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.05.018
更新日期：2009-07-31 00:00:00
abstract：:The present study investigates the effect of a pituitary hormone (LH) and a thymic factor (Thymosin Fraction 5 = TF5) on in vitro and in vivo spleen cell proliferative response of 2, 6 and 8-month-old Balb/c mice. In vitro experiments showed that the addition of LH at various concentrations (0.5, 5, 50 or 500 ng/ml) t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90031-l
更新日期：1990-01-01 00:00:00
abstract：:Incubation of unfixed, frozen sections of rat pancreas with tritiated guanidinoethylmercaptosuccinic acid (GEMSA) resulted in a localization of [3H]-GEMSA autoradiographic grains over the islets of Langerhans, suggesting that a carboxypeptidase H-like enzyme occurs in the islet. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90072-5
更新日期：1987-06-29 00:00:00
abstract：:The interactions of aminoglycoside, 3',4'-dideoxykanamycin B(DKB) with ATP and its related compounds were investigated. ATP, ADP, cyclic AMP and FAD bound to the DKB-conjugated Sepharose 4B column. The binding of DKB to ATP was also confirmed by equilibrium gel filtration. In the acidic pH region, the fluorescence of ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90332-2
更新日期：1986-10-13 00:00:00
abstract：:The centrally mediated pharmacological effects of thyrotropin releasing hormone (TRH), their mechanistic basis and therapeutic implications, along with the possible physiological significance of extrahypothalamic TRH, have been the subject of numerous investigations for over a decade. Despite this effort a holistic pe...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(83)90403-4
更新日期：1983-07-11 00:00:00
abstract：:The role of alpha 1-adrenoceptors in the mediation of autonomic functions, particularly in the control of the cardiovascular system, is widely known. It has been shown that alpha 1-adrenoceptors localized in human prostate mediate the contraction of prostatic smooth muscles which produces an increase in the intraureth...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(94)90141-4
更新日期：1994-01-01 00:00:00
abstract：:Ocimum sanctum, the Indian holy basil, has significant ability to scavenge highly reactive free radicals. Shade dried leaf powder of the plant was extracted with water and alcohol, and then fractionated with different solvents. Both extracts and their fractions have in vitro anti-lipidperoxidative activity at very low...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.05.036
更新日期：2004-11-19 00:00:00
abstract：:Hepatic tryptophan 2,3-dioxygenase (TDO) is one of the rate-limiting enzymes in tryptophan catabolism and plays an important role in regulating the physiological flux of tryptophan into relevant metabolic pathways. In this study, we determined the effect of the non-steroidal anti-inflammatory agents, tolmetin and suli...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.07.028
更新日期：2006-11-10 00:00:00
abstract：:High performance liquid chromatography combined with either single quad or triple quad mass spectral detectors (LC/MS) was used to measure the brain distribution of receptor occupancy tracers targeting dopamine D2, serotonin 5-HT2A and neurokinin NK-1 receptors using the ligands raclopride, MDL-100907 and GR205171, re...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.04.075
更新日期：2005-12-12 00:00:00
abstract：AIMS:Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthase, an enzyme responsible for the generation of NO. Plasma concentrations of ADMA increase in the elderly and in postmenopausal women. In fact, an elevated ADMA level is a risk factor of cardiovascular disease. Aer...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.05.003
更新日期：2014-07-11 00:00:00
abstract：:The present investigation was aimed at comparing the influence of the partial dopamine (DA) receptor agonist (-)-3-PPP (preclamol) on prolactin release in acutely hyperprolactinemic but otherwise intact female rats and female rats subjected to chronic DA depletion. One group of animals received daily vehicle injection...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90100-2
更新日期：1988-01-01 00:00:00
abstract：AIMS:In the oviduct, muscarinic acetylcholine receptors (MR) are linked with motility regulation and nicotinic receptors (nAChR) with ectopic pregnancy. We here aimed to determine the repertoire of cholinergic receptor expression in the murine oviduct and their functional coupling to regulation of intracellular calcium...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.03.016
更新日期：2012-11-27 00:00:00
abstract：:We examined the effect of beta-alanyl-L-histidinato zinc (AHZ) on the differentiation of human periodontal ligament (HPDL) cells. HPDL cells were cultured with alpha-minimum essential medium containing 10% fetal bovine serum with or without 10(-4) or 10(-5) M AHZ for up to 10 days. The expression of runt-related trans...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.09.069
更新日期：2004-04-02 00:00:00
