Abstract：
:Flavonoids are frequently found in fruits and vegetables, and are currently under investigation as potential chemopreventive agents. The present study reports the inhibitory effects of six flavonoids, quercetin, genistein, daidzein, equol, (+)-catechin and flavone, on sulphation of p-nitrophenol, a model substrate for the P-form of PST (thermostable, TS) and dopamine, a model substrate for the M-form of PST (thermolabile, TL). Kinetic studies of the PST activity and the inhibitory effects of flavonoids on the P-form of PST activity (using Hanes-Wolf and Dixon plots) show low Km and Ki values. Quercetin was found to be the most potent inhibitor and flavone was the least active inhibitor among the flavonoids. Kinetic analysis showed that the inhibition was non-competitive and Ki values were determined for each flavonoid. These observations suggest the potential for clinically important pharmacological and toxicological interactions by flavonoids.
journal_name
Life Scijournal_title
Life sciencesauthors
Ghazali RA,Waring RHdoi
10.1016/s0024-3205(99)00423-3subject
Has Abstractpub_date
1999-01-01 00:00:00pages
1625-32issue
16eissn
0024-3205issn
1879-0631pii
S0024320599004233journal_volume
65pub_type
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