The intrinsic activity of (-)-3-PPP (preclamol) on pituitary DA receptors in female rats is enhanced following chronic DA depletion.

abstract：AIMS:Ventilatory disturbance is a fatal side-effect of opioid analgesics. Separation of analgesia from ventilatory depression is important for therapeutic use of opioids. It has been suggested that opioid-induced ventilatory depression results from a decrease in adenosine 3',5'-cyclic monophosphate content in the respi...

journal_title：Life sciences

authors： Kimura S,Ohi Y,Haji A

更新日期：2015-04-15 00:00:00

abstract：:We investigated the effect of social isolation stress on the formation of experimental liver metastasis resulted from intraportal vein (i.p.v.) injection of colon 26-L5 carcinoma cells in male Balb/c mice, and elucidated some of the underlying mechanism involving the effects of this stress on cellular immunity. Increa...

journal_title：Life sciences

authors： Wu W,Yamaura T,Murakami K,Murata J,Matsumoto K,Watanabe H,Saiki I

更新日期：2000-03-31 00:00:00

abstract：:Differences in prevalence and mortality from coronary artery disease (CAD) were observed among the different Israeli ethnic groups. The incidence of CAD in Israel is highest among Ashkenazi Jews and is much lower among Yemenite Jews. In this present study, we selected 15 single nucleotide polymorphisms (SNPs) from 14 ...

journal_title：Life sciences

authors： Nakai K,Habano W,Nakai K,Fukushima N,Fujita T,Gurwitz D

更新日期：2004-07-09 00:00:00

abstract：BACKGROUND/AIMS:Previous studies have demonstrated that Galactooligosaccharides (GOS), known as "bifidus factor", has anti-inflammatory effects. Colitis, a kind of colonic inflammatory damage could be induced by different chemicals. The pathogenesis and mechanism of colitis remains unclear, and may be related to intest...

journal_title：Life sciences

authors： Chu H,Tao X,Sun Z,Hao W,Wei X

更新日期：2020-02-01 00:00:00

abstract：:In this study we compared the antioxidant properties of five different extracts of different composition obtained from Achyrocline satureioides' inflorescences (Compositae), a widely used Brazilian folk medicinal herb. All of the extracts presented significant antioxidant potential identified by TRAP assay, which incr...

journal_title：Life sciences

authors： Polydoro M,de Souza KC,Andrades ME,Da Silva EG,Bonatto F,Heydrich J,Dal-Pizzol F,Schapoval EE,Bassani VL,Moreira JC

更新日期：2004-04-23 00:00:00

abstract：:Increased oxidative stress and antioxidant deficit have been suggested to play a major role in adriamycin induced cardiomyopathy and congestive heart failure due to multiple treatments with adriamycin. In this study the cardio protective effect of Centella asiatica on myocardial marker enzymes and antioxidant enzymes ...

journal_title：Life sciences

authors： Gnanapragasam A,Ebenezar KK,Sathish V,Govindaraju P,Devaki T

更新日期：2004-12-17 00:00:00

abstract：AIMS:Azelnidipine, a third-generation dihydropyridine calcium channel blocker (DHP CCB), has a characteristic hypotensive effect that persists even after it has disappeared from the plasma, which is thought to be due to its high hydrophobicity. However, because azelnidipine is unique, it might have other unknown effect...

journal_title：Life sciences

authors： Nasu F,Obara Y,Okamoto Y,Yamaguchi H,Kurakami K,Norota I,Ishii K

更新日期：2021-01-13 00:00:00

abstract：:Glucocorticoids (GCs) are hormones with anti-inflammatory and immuno-suppressive effects. The use of hormonal medicine like GCs may cause systemic adverse effects. In the present study, the cellular response of murine pre-osteoclast cell line RAW264.7 to dexamethasone (DEX) was investigated and the result demonstrated...

journal_title：Life sciences

authors： Zhang Q,Fong CC,Zhang Y,Tzang CH,Fong WF,Yang M

更新日期：2008-01-16 00:00:00

abstract：AIMS:Lung cancer represents as the most prevalent tumor globally, among which non-small cell lung cancer (NSCLC) takes up for more than 80%. Lysine demethylase 4A (KDM4A) was dysregulated in NSCLC, but its role on the tumorigenesis in NSCLC cells and the mechanisms of actions are unclear. In this work, we evaluated its...

journal_title：Life sciences

authors： Sun S,Yang F,Zhu Y,Zhang S

更新日期：2020-12-01 00:00:00

abstract：:Since the discovery of leptin in 1994 by Zhang et al., there have been a number of reports showing its implication in the development of a wide range of cardiovascular diseases. However, there exists some controversy about how leptin can induce or preserve cardiovascular function, as different authors have found contr...

journal_title：Life sciences

authors： Feijóo-Bandín S,Portolés M,Roselló-Lletí E,Rivera M,González-Juanatey JR,Lago F

更新日期：2015-11-01 00:00:00

abstract：:Exposure to Cd(2+) via inhalation or intratracheal instillation results in pulmonary edema, which is followed by the influx of leukocytes, the proliferation of type II pneumocytes and eventual scarring and fibrotic changes. While the general toxic effects of Cd(2+) in the lung have been well characterized, the specifi...

journal_title：Life sciences

authors： Pearson CA,Lamar PC,Prozialeck WC

更新日期：2003-01-31 00:00:00

abstract：AIMS:This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain extract (GCMHB) on formalin-induced damage to cartilage tissue in the rat knee joint and evaluates t...

journal_title：Life sciences

authors： Ucuncu Y,Celik N,Ozturk C,Turkoglu M,Cetin N,Kockara N,Sener E,Dundar C,Arslan A,Dogan H,Kurt N,Suleyman H

更新日期：2015-06-01 00:00:00

abstract：:An experimental model which resembles human drug addiction was developed to study the effect of chronic drug (cocaine or morphine) administration on the immune system. As malnutrition has been associated with drug use, a low protein diet has been evaluated for its contribution to the impairment of the immune system du...

journal_title：Life sciences

authors： Lopez MC,Huang DS,Watzl B,Chen GJ,Watson RR

更新日期：1991-01-01 00:00:00

abstract：AIMS:Fcγ receptor I (FcγRI/CD64) that is restrictedly expressed on monocytes and macrophages, acts as the single high-affinity receptor of immunoglobulin G (IgG) in human. The expression of FcγRI is positively correlated with immune inflammation. The primary aim of this study was to explore the effects of FcγRI express...

journal_title：Life sciences

authors： Zhang H,Li L,Liu L

更新日期：2018-08-15 00:00:00

abstract：:An increase in natural killer (NK) cell activity can be conditioned with a one trial learning paradigm to demonstrate the interaction between the central nervous system (CNS) and the immune system. In order to demonstrate learning possibilities during 'non-conscious' state, mice were anesthetized with a ketamin/rompun...

journal_title：Life sciences

authors： Hsueh CM,Lorden JF,Hiramoto RN,Ghanta VK

更新日期：1992-01-01 00:00:00

abstract：:In an in vitro bioassay system for adrenocorticotropic hormone using isolated rat adrenal cells, kaurenol, a diterpene alcohol, stimulated corticosterone production and augmented the steroidogenic effect of adrenocorticotropin or forskolin, dose-dependently. Kaurenol had no effect on cyclic AMP production by the cells...

journal_title：Life sciences

authors： Moriwaki K,Gomi M,Itoh Y,Iida S,Tsugawa M,Tarui S,Fuji K,Node M,Kajimoto T

更新日期：1986-02-03 00:00:00

abstract：:The density of bovine peripheral-type benzodiazepine receptors (PBR) in four tissues was highest in adrenal cortex. The adrenal cortex PBR cofractionated with a mitochondrial membrane marker enzyme and could be solubilized with intact ligand binding properties using digitonin. The membrane bound and soluble mitochondr...

journal_title：Life sciences

authors： Parola AL,Laird HE 2nd

更新日期：1991-01-01 00:00:00

abstract：:To characterize the pharmacokinetics of protein-free granisetron in blood and brain we implanted microdialysis probes into the jugular vein and cerebral frontal cortex of the rat. Granisetron (3 or 6 mg/kg, i.v., n=6) was then administered, and microdialysates from blood and brain were collected from both sites and as...

journal_title：Life sciences

authors： Huang CT,Chen CF,Tsai TH

更新日期：1999-01-01 00:00:00

abstract：AIMS:Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthase, an enzyme responsible for the generation of NO. Plasma concentrations of ADMA increase in the elderly and in postmenopausal women. In fact, an elevated ADMA level is a risk factor of cardiovascular disease. Aer...

journal_title：Life sciences

authors： Tanahashi K,Akazawa N,Miyaki A,Choi Y,Ra SG,Matsubara T,Kumagai H,Oikawa S,Miyauchi T,Maeda S

更新日期：2014-07-11 00:00:00

abstract：:The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response ...

journal_title：Life sciences

authors： Schedel JM,Tanaka H,Kiyonaga A,Shindo M,Schutz Y

更新日期：1999-10-29 00:00:00

abstract：:Endothelins (ET) are 21-amino acid peptides that bind to membrane receptors to initiate a wide range of pathophysiological effects. PD-156707, L-749329, Ro-470203, and A-127722 are potent non-peptide ET receptor antagonists developed recently. When tested in human and rat plasma, both ET-1 and -3 and the four aforemen...

journal_title：Life sciences

authors： Wu-Wong JR,Chiou WJ,Hoffman DJ,Winn M,von Geldern TW,Opgenorth TJ

更新日期：1996-01-01 00:00:00

abstract：AIMS:Various investigations have demonstrated the protective capacity of general anesthetics as neuroprotective agents. The effects of propofol against ischemia are known to reside in its antioxidant properties and its GABAergic activity. Other aromatic alcohols have also been reported as able to protect neurons agains...

journal_title：Life sciences

authors： Delgado-Marín L,Sánchez-Borzone M,García DA

更新日期：2017-04-15 00:00:00

abstract：AIMS:Acetylcholine is synthesized in more or less all mammalian cells. However, little is known about the subcellular location of acetylcholine synthesis. Therefore, in the present experiments the subcellular location of the synthesizing enzyme choline acetyltransferase (ChAT) was investigated by anti-ChAT immunogold e...

journal_title：Life sciences

authors： Wessler I,Michel-Schmidt R,Brochhausen C,Kirkpatrick CJ

更新日期：2012-11-27 00:00:00

abstract：:Protein binding determination in post heparin plasma samples is complicated by the continued post heparin lipase activity, in vitro, during the binding analysis. The decomposition of lipoproteins and accumulation of nonesterified fatty acids (NEFA) results in artifically elevated free fractions of many drugs. This art...

journal_title：Life sciences

authors： Pearce GA,Brown KF

更新日期：1983-10-10 00:00:00

abstract：AIMS:Paraquat (PQ) is known to induce pulmonary injury via a redox cyclic reaction. The present study was aimed to determine the protective effects of quercetin against PQ-induced pulmonary injury in association with its antioxidant activity. MAIN METHODS:Male rats were challenged acutely by PQ (50 mg/kg, i.p.) with o...

journal_title：Life sciences

authors： Park HK,Kim SJ,Kwon DY,Park JH,Kim YC

更新日期：2010-07-31 00:00:00

abstract：:Antroduodenal myoelectric activity was recorded in conscious sheep by electrodes chronically implanted in the muscular wall. Furthermore, plasma immunoreactive (i.r.) motilin, somatostatin and bombesin concentrations were determined by RIA. The intravenous infusion of somatostatin (20 ng/kg/min), bombesin (10 ng/kg/mi...

journal_title：Life sciences

authors： Plaza MA,Arruebo MP,Murillo MD

更新日期：1996-01-01 00:00:00

abstract：AIMS:Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are...

journal_title：Life sciences

authors： Cui YL,Xue RQ,Xi He,Ming Zhao,Yu XJ,Liu LZ,Wu Q,Si Yang,Li DL,Zang WJ

更新日期：2019-04-01 00:00:00

abstract：:Nitric oxide (NO) is present in the exhaled breath of humans and experimental animals, but its physiologic role and cellular source(s) remain to be determined. Possible sites of origin are pulmonary endothelial cells and/or resident macrophages. Here we have tested the hypothesis that changes in cardiovascular status ...

journal_title：Life sciences

authors： Bauer JA,Wald JA,Doran S,Soda D

更新日期：1994-01-01 00:00:00

abstract：:A simple procedure has been developed for the large scale purification of fetal bovine serum acetylcholinesterase (AChE) (EC 3.1.1.7). The procedure involves two steps: batch adsorption of the AChE from 250 L of serum onto a procainamide affinity Sepharose 4B gel; and analytical procainamide affinity chromatography of...

journal_title：Life sciences

authors： De la Hoz D,Doctor BP,Ralston JS,Rush RS,Wolfe AD

更新日期：1986-07-21 00:00:00

abstract：:Dopaminergic agents ameliorate experimentally induced gastroduodenal mucosal injury, but there is no information about their effect on small intestinal mucosa. We studied the effect of L-dopa and related substances on indomethacin-induced intestinal ulceration in the rat. Ulceration was produced by s.c. injection of 3...

journal_title：Life sciences

authors： Kiro A,Zahavi I,Marcus H,Dinari G

更新日期：1992-01-01 00:00:00