The intrinsic activity of (-)-3-PPP (preclamol) on pituitary DA receptors in female rats is enhanced following chronic DA depletion.


:The present investigation was aimed at comparing the influence of the partial dopamine (DA) receptor agonist (-)-3-PPP (preclamol) on prolactin release in acutely hyperprolactinemic but otherwise intact female rats and female rats subjected to chronic DA depletion. One group of animals received daily vehicle injections (controls) and another group daily reserpine (1 mg/kg) injections for a period of seven days. On the eighth day all animals were administered 10 mg/kg of reserpine in order to eliminate endogenous DA and elevate serum prolactin levels. In the control group (-)-3-PPP lowered serum prolactin levels only moderately. In contrast, in the chronically reserpinized female rats, a pronounced reduction of prolactin secretion was observed. It is suggested that this increase in intrinsic activity of (-)-3-PPP following chronic DA depletion reflects an enhanced responsiveness of hypophyseal DA receptors, possibly due to conformational changes in the receptor molecules. Our observations lend further support to the hypothesis that an inverse relationship exists between the intrinsic activity of a mixed agonist/antagonist and the degree of previous receptor occupancy.


Life Sci


Life sciences


Carlsson M,Eriksson E




Has Abstract


1988-01-01 00:00:00














  • The protective effects of prolactin on brain injury.

    abstract:AIMS:Brain injuries based on their causes are divided into two categories, TBI and NTBI. TBI is caused by damages such as head injury, but non-physical injury causes NTBI. Prolactin is one of the blood factors that increase during brain injury. It has been assumed to play a regenerative role in post-injury recovery. M...

    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Yousefvand S,Hadjzadeh MA,Vafaee F,Dolatshad H

    更新日期:2020-12-15 00:00:00

  • Insulin receptor and IRS-1 co-immunoprecipitation with SOCS-3, and IKKα/β phosphorylation are increased in obese Zucker rat skeletal muscle.

    abstract:AIMS:We evaluated if selected pro-inflammatory cytokines and/or the protein suppressor of cytokine signaling 3 (SOCS-3) could account for decreased insulin-stimulated phosphatidylinositol 3-kinase (PI3-K) activity in the skeletal muscle of the obese Zucker rat. MAIN METHODS:Eight lean and eight obese Zucker rats ~4wee...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Zolotnik IA,Figueroa TY,Yaspelkis BB 3rd

    更新日期:2012-10-22 00:00:00

  • Antigenic role of the adaptive immune response to d-ribose glycated LDL in diabetes, atherosclerosis and diabetes atherosclerotic patients.

    abstract:AIMS:Glycation of proteins leads to the formation of advanced glycation end products (AGEs, which have significant role in the pathophysiology of diabetes complications. d-ribose appears to be the most reactive among the naturally occurring sugars and contribute significantly to the generation of AGEs. Glycation also r...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Akhter F,Khan MS,Alatar AA,Faisal M,Ahmad S

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  • The effect of ultrasound for increasing neural differentiation in hBM-MSCs and inducing neurogenesis in ischemic stroke model.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Cho SE,Kim YM,Jeong JS,Seo YK

    更新日期:2016-11-15 00:00:00

  • Pathways and roadblocks in muscarinic receptor-mediated growth regulation.

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    journal_title:Life sciences

    pub_type: 杂志文章,评审


    authors: Brown JH,Sah V,Moskowitz S,Ramirez T,Collins L,Post G,Goldstein D

    更新日期:1997-01-01 00:00:00

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Ali MA,Eid RMHM,Hanafi MY

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  • Enhanced lithogenicity of bile following chronic morphine administration to female guinea pigs.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Malave A,Kuta C,Yim GW

    更新日期:1993-01-01 00:00:00

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    journal_title:Life sciences

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    authors: Bustamante N,Cantarino MH,Arahuetes RM,Cubero FJ,Ortiz A

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Miyazaki Y,Imamura I,Shinomura Y,Wada H,Tarui S

    更新日期:1991-01-01 00:00:00

  • Enhanced vesiculation exacerbates complement-dependent hemolysis in glucose-6-phosphate dehydrogenase deficient red blood cells.

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    journal_title:Life sciences

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  • Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms.

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    journal_title:Life sciences

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    authors: Chabannes B,Sarda N,Cronenberger L,Pacheco H

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Zhou Q,You C,Ling Y,Wu H,Sun B

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    journal_title:Life sciences

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    journal_title:Life sciences

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    journal_title:Life sciences

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Lysle DT,Lyte M,Fowler H,Rabin BS

    更新日期:1987-10-12 00:00:00

  • Evaluation of interferon-gamma release assays in extrasanguinous body fluids for diagnosing tuberculosis: A systematic review and meta-analysis.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Murrin LC,Ferrer JR,Zeng WY,Haley NJ

    更新日期:1987-04-27 00:00:00

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Saldívar-González JA,Posadas-Andrews A,Rodríguez R,Gómez C,Hernández-Manjarrez ME,Ortiz-León S,Martínez-Pineda A,Gómez-Laguna D,Salgado V,Manjarrez J,Alvarado R

    更新日期:2003-01-03 00:00:00

  • Stress-dependent changes in fibrinolysis, serotonin and platelet aggregation in rats.

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Malyszko J,Urano T,Takada Y,Takada A

    更新日期:1994-01-01 00:00:00

  • Endothelin-1 and -2: two amino acids matter.

    abstract:AIMS:Endothelin-1 (ET-1) and endothelin-2 (ET-2; Trp(6)Leu(7)ET-1) are expressed by different cell types, but are considered to display identical pharmacological properties on endothelin receptors. We studied agonist-dependent aspects of endothelin(A) (ET(A))-receptor function and the importance of amino acids 6 and 7 ...

    journal_title:Life sciences

    pub_type: 杂志文章


    authors: Compeer MG,Suylen DP,Hackeng TM,De Mey JG

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    journal_title:Life sciences

    pub_type: 杂志文章


    authors: McPherson GA,Summers RJ

    更新日期:1983-07-04 00:00:00