Abstract:
:The effects of the benzodiazepines diazepam and midazolam on the rigidity produced by systemic administration of morphine (15 mg/kg i.p.) were studied in rats. The rigidity was recorded as a tonic activity from the gastrocnemius-soleus muscle of non-anesthetized rats in the electromyogram. Both diazepam (1-5 mg/kg i.p.) and midazolam (2.5 and 5 mg/kg i.p.), when administered 45 min after morphine, temporarily antagonized the muscular rigidity. When the competitive antagonist Ro 15-1788 (ethyl-8-fluoro-5, 6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5a]-[1,4]benzodiazepine-3 -carboxylate) (5 mg/kg i.p.) was administered together with diazepam (5 mg/kg i.p.), it prevented the effect of diazepam, although by itself it did not affect the morphine-induced muscular rigidity. Our results suggest that diazepam, by acting on benzodiazepine receptors, can antagonize the morphine-induced muscular rigidity. The latter phenomenon might serve as a model for some types of muscular rigidity observed in humans.
journal_name
Life Scijournal_title
Life sciencesauthors
Turski L,Havemann U,Kuschinsky Kdoi
10.1016/0024-3205(83)90612-4subject
Has Abstractpub_date
1983-01-01 00:00:00pages
755-8eissn
0024-3205issn
1879-0631journal_volume
33 Suppl 1pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::The available preclinical literature on the antihyperlipidemic properties of beta-pyridylcarbinol is reviewed. Similarities between the pharmacological profiles for beta-pyridylcarbinol and nicotinic acid, and evidence for the metabolic conversion of beta-pyridylcarbinol to nicotinic acid are discussed. Several review...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(85)90026-8
更新日期:1985-11-25 00:00:00
abstract:AIMS:Mancozeb is a dithiocarbamate fungicide known to be genotoxic and induces tumors in rodents at various sites. There is no report in the literature about its genotoxicity in humans. Here, we investigated the association between mancozeb exposure and induction of genotoxic and proapoptotic changes in cultured human ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.12.013
更新日期:2012-06-06 00:00:00
abstract::DHEA improves insulin sensitivity and has anti-obesity effect in animal models and men. However, the molecular mechanisms by which DHEA improves insulin action have not been clearly understood. In the present study, we examined the protein levels and phosphorylation state of insulin receptor (IR), IRS-1 and IRS-2, the...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.06.017
更新日期:2004-11-19 00:00:00
abstract::Using a laterality questionnaire, 138 normal healthy individuals were classified as right-sided and 25 as non-right sided. Interleukin-2 (IL-2) was generated from whole blood obtained from these subjects using mitogen (PHA) stimulation. IL-2 was quantitated in picograms/ml using an enzyme immunoassay (ELISA). Addition...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90035-n
更新日期:1992-01-01 00:00:00
abstract::Pitavastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor that is used for suppressing cholesterol biosynthesis. Previously, we have reported that pitavastatin induces the activation of endothelial nitric oxide synthase (eNOS) and increases nitric oxide (NO) production in vascular endothelial cells (...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.12.003
更新日期:2005-03-25 00:00:00
abstract::The heterogeneity of muscarine receptors was examined in two brain regions (cerebral cortex and cerebellum) and in some parasympathetically innervated peripheral tissues (heart, salivary gland and intraorbital lacrimal gland), by in vitro binding techniques. As a tool, we used a new antimuscarinic compound, AF-DX 116 ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90409-1
更新日期:1986-05-05 00:00:00
abstract::When s-triazolo[3,4-a]phthalazine (Tri-P) was orally administered in rats, a more lipophilic metabolite M-1 than the parent compound was isolated from the urine. The metabolite M-1 was identified as 7-methylthio Tri-P by means of high resolution MS and two-dimensional NMR spectrometry. Furthermore, the 7-methylthio co...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.06.032
更新日期:2003-11-21 00:00:00
abstract::Green tea and its major constituent epigallocatechin gallate (EGCG) have been extensively studied as a potential treatment for a variety of diseases, including cancer. Epidemiological data have suggested that EGCG may provide protective effects against hormone related cancers, namely breast or prostate cancer. Extensi...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2006.07.036
更新日期:2006-11-17 00:00:00
abstract:AIMS:To better understand mechanisms whereby Ajulemic acid (AjA), a synthetic antiinflammatory cannabinoid, promotes resolution of acute and chronic inflammation in animal models, we investigated its influence on cyclooxygenase 2 (COX2) expression and eicosanoid production in human fibroblast-like synovial cells (FLS)....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.09.004
更新日期:2008-11-07 00:00:00
abstract:AIMS:Previous study demonstrated that Ginsenoside Rd. (GS-Rd) could improve cognitive and memory function in animal model of Alzheimer's disease. This study was aimed to investigate whether GS-Rd could improve non-amyloidogenic pathway by activating estrogen receptor (ER). MAIN METHODS:10mg/kg GS-Rd in ovariectomy (OV...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.11.002
更新日期:2017-01-01 00:00:00
abstract::The release of endogenous dopamine (DA) has been measured in the rat striatum following the intracardial administration of various doses of beta-phenylethylamine (PEA) or alpha,alpha-dideutero-beta-phenylethylamine (deuterated PEA). The release was significantly increased for a period of approximately 15 minutes by a ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90480-7
更新日期:1986-12-22 00:00:00
abstract:OBJECTIVE:The present study aimed to investigate the ability of hesperidin to suppress the migration and invasion of A549 cells, and to investigate the role of the SDF-1/CXCR-4 cascade in this suppression. METHODS:We performed a Transwell migration assay to measure the migratory capability of A549 cells treated with 0...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.03.046
更新日期:2018-05-15 00:00:00
abstract::Overexpression of vascular endothelial growth factor (VEGF) and the extent of neoangiogenesis are closely correlated with tumor development and cancer metastases. To assess whether VEGF mediated angiogenesis is regulated by HDM2, we treated the GI-101A and HL-60 cells with HDM2 gene specific antisense phosphorothioate...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.04.004
更新日期:2008-06-20 00:00:00
abstract::The behavioral response induced by the intravesical instillation of capsaicin has been investigated in catheter-implanted, freely moving, conscious male and female rats. Intravesical instillation of capsaicin (25 nmol/rat in 0.5 ml) evoked an intense licking directed toward the lower abdominal and perineal skin which ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90054-x
更新日期:1994-01-01 00:00:00
abstract::Neuropeptide Y (NPY) is a major hypothalamic peptide which is implicated in the regulation of energy balance and in the activation of the hypothalamo-pituitary adrenal axis. This study aimed primarily to determine the effects on regional hypothalamic NPY levels, of catabolism and weight loss induced in rats by the syn...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90020-p
更新日期:1992-01-01 00:00:00
abstract::Adult rat offspring earlier exposed to maternally ingested caffeine during both gestation and lactation were observed in an open field following acute administration of diazepam or cyclohexyladenosine. While both drugs reduced measures of locomotion and emotional reactivity, caffeine-exposed rats showed evidence of gr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(96)80009-9
更新日期:1996-01-01 00:00:00
abstract::LncRNA small nucleolar RNA host gene 3 (Snhg3) has been involved in cell proliferation and migration in malignant cells. However, its role in regulating functions of non-malignant cells has been hardly reported. Here, we found Snhg3 expression was sharply induced in primary brain microvascular endothelial cells (BMVEC...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116929
更新日期:2019-11-15 00:00:00
abstract::The effects of cloricromene, a coumarine derivative, were studied in an anaesthetized rat model of coronary artery ligation (60 min) followed by reperfusion (60 min; MI/R). Sham operated rats were used as controls (Sham MI/R). Myocardial ischaemia-reperfusion injury produced a marked myocardial injury (necrotic area/a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90753-p
更新日期:1993-01-01 00:00:00
abstract:AIMS:Peptides and a dysregulated immune system play a role in the pathophysiology of autism. Dysfunctions in prolyl endopeptidase (PEP) and dipeptidyl peptidase IV (DPP-IV) may underpin both the peptidergic and immune alterations in autism. The aims of this study are to: (i) delineate serum PEP and DPP-IV enzyme activi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.07.003
更新日期:2015-09-01 00:00:00
abstract::In experienced marijuana smokers, marijuana smoking was accompanied by a significant bilateral increase in cerebral blood flow (CBF) especially in the frontal regions and cerebral blood velocity. The post-marijuana CBF increase could not be explained on the basis on changes in general circulation or respiration. Simil...
journal_title:Life sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0024-3205(93)90239-y
更新日期:1993-01-01 00:00:00
abstract:AIMS:Cancer Stem Cells (CSCs) refers to heterogeneous tumor cells retaining the abilities of self-renewal and differentiation. This study used mRNAsi, which is an index to describe the similarity between tumor cells and CSCs, to define genes involved in endometrial carcinoma. MATERIALS AND METHODS:The mRNA expression ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118231
更新日期:2020-10-01 00:00:00
abstract::We administered a series of alpha-blocking drugs to the nucleus reticularis lateralis (NRL) of the medulla oblongata, the main site for the hypotensive action of clonidine. These experiments were performed on pentobarbital anaesthetized cats. Drugs were injected through a needle which was stereotaxically inserted. Pra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90566-2
更新日期:1987-03-16 00:00:00
abstract:AIMS:Constant development of chemotherapeutic strategies has considerably improved the efficiency of tumor treatment. However, adverse effects of chemotherapeutics enforce premature treatment cessation, which leads to the tumor recurrence and accelerated death of oncologic patients. Recently, sodium ascorbate (ASC) has...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116657
更新日期:2019-09-01 00:00:00
abstract::Although exposure to broad band (0.2-20 MHz) electromagnetic fields (EMF) is part of the treatment of several diseases, little is known as to their effects on myocardial protein expression and resistance to ischemia-reperfusion (I/R). We exposed Sprague-Dawley rats to either high (H, 10 min/day at 200 V/m, 36.1 microT...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.12.033
更新日期:2004-09-03 00:00:00
abstract::The effect of endothelin (END) on the release of atrial natriuretic peptides (ANP) was studied in isolated rat atria and in conscious rats. END stimulates the ANP release in vitro in a dose-dependent manner. An increase in ANP plasma levels and cyclic GMP plasma levels was also observed in conscious rats after injecti...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90200-2
更新日期:1989-01-01 00:00:00
abstract::Hypotensive responses to tryptophan and 5-hydroxytryptophan infusions were studied in normotensive male Sprague-Dawley rats. Results showed that 5-hydroxytryptophan but not tryptophan lowered pressure in a dose dependent way in direct relation to the production of brain serotonin and 5-HIAA. Intrinsic release of serot...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90220-6
更新日期:1985-11-11 00:00:00
abstract:AIM:Despite recent advances in therapeutic strategies, cancer is still a leading cause of mortality worldwide. Mitochondrial dysfunction is implicated in cancer initiation and metastasis, and even in chemo- and radio-resistance. However, the precise role of mitochondria in cancer is crosstalk and controversial. This st...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117339
更新日期:2020-03-01 00:00:00
abstract::Intracerebroventricularly (i.c.v.)-administered [D-Ala2]deltorphin II (20 micrograms) produced a marked locomotor hyperactivity in male ICR mice. The locomotor hyperactivity induced in response to i.c.v. [D-Ala2]deltorphin II (20 micrograms) was suppressed by pretreatment with naltriben (NTB, 10 micrograms) but not 7-...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00307-4
更新日期:1996-01-01 00:00:00
abstract::Following a report that nortriptyline was found useful in the control of enuresis in adults, presumably as an anticholinergic, its likely mechanism of action and apparent bladder specificity have now been investigated in vitro. The ratios of anticholinergic potencies (reciprocal of dissociation contents, Ki) for four ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90093-2
更新日期:1987-05-04 00:00:00
abstract:AIMS:This study aims to investigate the value of the expression of miR-208, miR-494, miR-499 and miR-1303 in the early diagnosis of acute myocardial infarction (AMI). MAIN METHODS:Patients were divided into two groups: AMI group (n = 41), and Stable angina pectoris (SAP) group (n = 32). Peripheral venous blood was sam...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116547
更新日期:2019-09-01 00:00:00