Abstract:
:The effect of endothelin (END) on the release of atrial natriuretic peptides (ANP) was studied in isolated rat atria and in conscious rats. END stimulates the ANP release in vitro in a dose-dependent manner. An increase in ANP plasma levels and cyclic GMP plasma levels was also observed in conscious rats after injection of END. When a monoclonal antibody directed against ANP was injected together with END the increase in cyclic GMP was completely blocked. From this study it is concluded that END is a potent secretagogue for ANP both in vitro and in vivo.
journal_name
Life Scijournal_title
Life sciencesauthors
Stasch JP,Hirth-Dietrich C,Kazda S,Neuser Ddoi
10.1016/0024-3205(89)90200-2subject
Has Abstractpub_date
1989-01-01 00:00:00pages
869-75issue
10eissn
0024-3205issn
1879-0631pii
0024-3205(89)90200-2journal_volume
45pub_type
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