Abstract：
:Recent studies in animals have demonstrated that the steroid, 3 alpha-hydroxy-5 alpha-pregnan-20-one (3A5P), is a potent analgesic when given intracerebroventricularly. Several studies in humans report that spinal steroids are effective in the treatment of chronic low-back pain when given in combination with morphine. The spinal antinociceptive effect of steroids, in particular a progesterone metabolite has not been studied in a visceral pain model. The experiments in the following study were designed to test, first, if the intrathecally-administered (i.t.) steroid, 3A5P, has analgesic properties in a mechanical visceral nociceptive assay, and second, if the intrathecal coadministration of this steroid and morphine is more effective than either therapy alone. Our mechanical visceral pain model (VPM) consists of a chronic indwelling duodenal balloon catheter implanted in the rat. The balloon is inflated to elicit a writhing response. Protection values are defined as the percentage of rats in each group which did not writhe. In this model, 3A5P was found to provide a dose-independent, though significant (p less than 0.01), antinociception when administered alone (33-67% protection vs. 0-25% for controls). Yet, protection offered by the coadministration of 3A5P and morphine (79%) was not significantly greater than that offered by morphine alone (85%). Unlike a dose and time-dependent response observed in a thermal cutaneous nociceptive assay, the antinociception of 3A5P was not dose-dependent when challenged with a mechanical visceral noxious stimulus.
journal_name
Life Scijournal_title
Life sciencesauthors
Winfree CJ,Coombs DW,DeLeo JA,Colburn RWdoi
10.1016/0024-3205(92)90095-7subject
Has Abstractpub_date
1992-01-01 00:00:00pages
1007-12issue
14eissn
0024-3205issn
1879-0631pii
0024-3205(92)90095-7journal_volume
50pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Experiments were done to examine the analgesic effect of thiorphan alone or in combination with stress in mice. Analgesia was assessed by measuring jump latencies from a 55 degrees C hot plate. Thiorphan exhibited weak analgesic properties evidenced by significant increases in jump latencies only after 300 mg/kg i.p. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90338-1
更新日期：1982-09-20 00:00:00
abstract：AIMS:The effects of chronic administration of Ferutinin (phytoestrogen found in the plants of genus Ferula), compared with those elicited by estradiol benzoate, were evaluated, following ovariectomy, on the uterus of ovariectomized rats as regard weight, size, structure and histomorphometry. MAIN METHODS:The experimen...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.11.001
更新日期：2012-01-16 00:00:00
abstract：:Iron imbalance has been implicated in oxidative injury associated with many brain diseases. The present study investigated the importance of iron location in hydroxyl radical (.OH) generation and the link between .OH production evaluated by the salicylate method and lipid peroxidation monitored by thiobarbituric acid-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00638-x
更新日期：2000-06-16 00:00:00
abstract：:Neuropeptide Y (NPY) is a 36 amino acid peptide released in central and peripheral mammalian neurons, which appears to contribute to adiposity regulation by increasing food intake, thus promoting weight gain on animals. Nevertheless, little is known about NPY direct actions on white adipocytes. This trial, which was d...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00916-4
更新日期：2000-11-24 00:00:00
abstract：:There is a great deal of evidence that the ventromedial hypothalamic area (VMH) plays a significant role in glucoregulation. The present review synthesizes new and existing data in a coherent model of a hypothalamic glucoregulatory control system whose function is to stabilize blood glucose levels in the face of disco...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(85)90631-9
更新日期：1985-02-11 00:00:00
abstract：AIM:We previously reported the possible involvement of mucosal nitric oxide (NO)-triggered 5-HT release in luminal glutamate sensing by the gastric vagus nerve, and we proposed that the stomach, like the duodenum, could "taste" luminal nutrients. Nitric oxide synthase (NOS) is widely distributed in the gastric mucosa, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.10.009
更新日期：2009-12-16 00:00:00
abstract：:In an in vitro bioassay system for adrenocorticotropic hormone using isolated rat adrenal cells, kaurenol, a diterpene alcohol, stimulated corticosterone production and augmented the steroidogenic effect of adrenocorticotropin or forskolin, dose-dependently. Kaurenol had no effect on cyclic AMP production by the cells...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90070-6
更新日期：1986-02-03 00:00:00
abstract：:A single intravenous injection of alloxan in mice induced hyperglycemia in a dose dependent fashion. This diabetogenic action of alloxan was prevented by a single intraperitoneal injection of the alpha 2-adrenergic agonists, i.e. oxymetazoline, clonidine or epinephrine 40 min prior to the injection of alloxan. The alp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90301-6
更新日期：1983-02-14 00:00:00
abstract：:We recently labeled with carbon-11, a high affinity, selective, 5-HT3 receptor (5-HT3R) ligand, S21007, for potential positron emission tomography (PET) applications. To evaluate the in vivo binding properties of [11C]S21007, its brain regional distribution, tissue and plasma pharmacokinetics and plasma metabolisation...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01058-8
更新日期：1998-01-01 00:00:00
abstract：:Kinin release and its involvement in inflammatory exudation were assessed by immuno-blot analysis of the kinin-precursor protein, high molecular weight kininogen (HK). HK consists of heavy (H) chain, bradykinin and light (L) chain. After bradykinin was released by plasma kallikrein, HK remains two-chain-kinin-free for...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90206-i
更新日期：1993-01-01 00:00:00
abstract：:The effect of 32 mM ascorbate on the time courses of phosphocreatine (PCr), inorganic phosphate (Pi), adenosine triphosphate (ATP) and intracellular pH in rat skeletal muscle during ischemia and reperfusion was investigated in vivo using 31P nuclear magnetic resonance (NMR) spectroscopy. Ascorbate was administered int...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00904-x
更新日期：1995-01-01 00:00:00
abstract：AIMS:Ginsenoside-Rg1 (G-Rg1), a saponin that is a primary component of ginseng, is very useful and important in traditional Chinese medicine for stroke. The objective of this study was to explore the mechanisms underlying the neuroprotective effect of G-Rg1 on focal cerebral ischemia/reperfusion. MAIN METHODS:Focal ce...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.12.002
更新日期：2015-01-15 00:00:00
abstract：:The cardiovascular and respiratory effects of alfentanil in conscious freely moving rats, were evaluated after initial and subsequent injections. Doses of alfentanil (50, 130, 260, and 500 ug/kg) were given to naive rats (n = 4-5) and 1 hour later this dose was repeated. The resultant cardiovascular and respiratory ef...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90114-2
更新日期：1988-01-01 00:00:00
abstract：:Cancer is a disease of high complexity. Resistance to therapy is a major challenge in cancer targeted therapies. Overcoming this resistance requires a deep knowledge of the cellular interactions within tumor. Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) are the main anti-cancer immune cells, while T re...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2019.116960
更新日期：2019-12-01 00:00:00
abstract：:Kappa (kappa) opioid agonists induce a water diuresis and inhibit vasopressin (AVP) secretion. Hypothalamic and neurohypophysial sites have both been implicated in the response. The present study was designed to ascertain if kappa-agonist inhibition of osmotically-stimulated AVP secretion is associated with parallel c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00931-4
更新日期：1997-01-01 00:00:00
abstract：:Recent immunohistochemical and radioimmunochemical observations have demonstrated a differential distribution of immunoreactive dynorphin (DYN) in rat brain. The presence of DYN immunoreactivity in a major intrinsic fiber pathway within the rat hippocampus (the mossy fiber system) has led us to evaluate the possible r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90210-7
更新日期：1982-10-18 00:00:00
abstract：:Decreased sweat secretion is a primary side effect of topiramate in pediatric patients, but the mechanism underlying this effect remains unclear. This study aimed to better understand how topiramate decreases sweat secretion by examining its effect on the expression of carbonic anhydrase (CA) II and aquaporin-5 (AQP5)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.04.018
更新日期：2007-06-06 00:00:00
abstract：:Significant elevation in plasma corticosterone of rats achieved by intraperitoneal (i.p.) administration of corticosterone (2.4 mg/kg) was associated with a rapid (2.5 min) and significant increase in hypothalamic histamine (HA) levels which persisted for 60 min. Midbrain and cortical HA concentrations were not affect...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90115-7
更新日期：1983-03-07 00:00:00
abstract：OBJECTIVE:To explore the correlation of the viscus fat area (VFA) with the Framingham 10-year general cardiovascular disease risk in patients with type 2 diabetes mellitus (T2DM). METHODS:A total of 202 patients with T2DM were divided into two groups based on VFA (a VFA ≥ 100 cm2 group and a VFA < 100 cm2 group), or f...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.01.036
更新日期：2019-03-01 00:00:00
abstract：AIMS:slc26a proteins are responsible for a large number of functions either in normal physiology or in human disease. We have previously reported that proximal tubular epithelial (PTE) cells immortalized from spontaneously hypertensive rats (SHRs) were endowed with increased Cl(-)/HCO3(-) exchanger activity and slc26a6...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.07.026
更新日期：2013-10-06 00:00:00
abstract：:Our recent report demonstrated that apoptosis-specific autoantibodies against granzyme B-induced cleavage fragments of SS-B (La) were found in the sera from patients with primary Sjögren's syndrome. The objective of this study was identified by the intracellular redistribution of La autoantigen during granzyme B-induc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.09.017
更新日期：2007-10-27 00:00:00
abstract：:Thymol induced superoxide production (O2-) by blood leukocytes was examined in various primates including man. Leukocytes of chimpanzee and hamadryas baboon cells showed only 35% of the maximal O2- production rate obtained in human cells, and those of the Japanese monkey and orang-utan failed to respond. In contrast, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90735-1
更新日期：1987-09-28 00:00:00
abstract：:The in vivo effect of trazodone on the density of [(3)H]5-HT binding sites and 5-HT(1A) receptors and adenylyl cyclase (AC) response was studied in regions of rat brain. The chronic administration of trazodone (10 mg/Kg body wt, 40 days) resulted in a significant downregulation of [(3)H]5-HT binding sites and 5-HT(1A)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01926-4
更新日期：2002-08-16 00:00:00
abstract：:Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin. Residues in TM3 and TM6 where amino acid sub...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(01)01046-3
更新日期：2001-04-27 00:00:00
abstract：AIMS:The antihypertensive mechanism (s) of the epigallocatechin-3-gallate (EGCG), a major effective component in green tea, might associate with microRNAs (miRNAs). Here, we aimed to investigate which microRNA in aorta of spontaneously hypertensive rats (SHRs) were modulated by administration of EGCG and its mechanism....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.04.041
更新日期：2018-06-15 00:00:00
abstract：:Human histiocytic lymphoma cells (U-937) undergo similar differentiation when incubated with the phorbol ester 12-0-tetradecanoyl phorbol-13-acetate (TPA) and 1,25-dihydroxycholecalciferol. In this action, TPA somehow implicates calcium-sensitive and phospholipid-dependent protein kinase (protein kinase C), which is r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90105-6
更新日期：1987-05-25 00:00:00
abstract：OBJECTIVE:Metformin, introduced in 1957, is widely used as an anti-diabetic drug and has considerable benefits in cardiovascular disease reportedly, dependent or independent on its glucose-lowering effects. Aim of this study was to investigate the effect of metformin on gap junction and the inducibility of AF. METHODS...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117759
更新日期：2020-08-01 00:00:00
abstract：:Type-II iodothyronine 5'-deiodinase activity (5'-D) in both anterior pituitary and pineal was significantly elevated at 2400 h, approximately 0.5- and 20-fold higher than the noon value, respectively. The nocturnal rise in both organs was abolished by 6 h additional light. Short-term constant darkness did not alter 5'...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90027-6
更新日期：1988-01-01 00:00:00
abstract：:A microiontophoretic study using rats anesthetized with chloral hydrate and immobilized with gallamine triethiodide was carried out to compare the effect of talipexole (B-HT 920 CL2:2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo [4,5-d]-azepine-dihydrochloride), a dopamine autoreceptor agonist, on dopaminergic neurons...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90071-i
更新日期：1991-01-01 00:00:00
abstract：:Classical studies have demonstrated that the visual centers in primates consist of cortical areas V1, V2 and V4 and their branches. However, nothing is known about how these visual areas change in postnatal development. In the present studies, therefore, pigs aged 2, 4, and 6 months old, were stimulated visually with ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.06.030
更新日期：2006-02-09 00:00:00
