Effect of short-term constant light or constant darkness on the nyctohemeral rhythm of type-II iodothyronine 5'-deiodinase activity in rat anterior pituitary and pineal.

abstract：:In the present investigation, Fischer-344 rats were trained to discriminate 10.0 mg/kg of ibogaine from water using a pretreatment time of 60 minutes. Analysis of dose response data generated an ED50 of 4.6 mg/kg. The time course of the ibogaine (10.0 mg/kg) cue was also determined. The stimulus reached a maximum leve...

journal_title：Life sciences

authors： Helsley S,Rabin RA,Winter JC

更新日期：1997-01-01 00:00:00

abstract：:The prokaryotic CRISPR-Cas systems could be applied as revolutionized genome editing tool in live cells of various species to modify, visualize and identify definite sequences of DNA and RNA. CRISPR-Cas could edit the genome by homology-directed repair and non-homologous end joining mechanisms. Furthermore, DNA-target...

journal_title：Life sciences

authors： Ghaemi A,Bagheri E,Abnous K,Taghdisi SM,Ramezani M,Alibolandi M

更新日期：2021-02-15 00:00:00

abstract：:The effects of methadone and morphine on fetal behavior were studied following their administration to either the mother (5micrograms/kg/min) or fetus (0.5micrograms/kg maternal wt./min) using the chronically-instrumented pregnant ewe model. Fourteen unanesthetized, unrestrained pregnant ewes between 130-141 days gest...

journal_title：Life sciences

authors： Umans JG,Szeto HH

更新日期：1983-01-01 00:00:00

abstract：AIM:Although constitutive autophagy is linked to redox state and participates in cell homeostasis, it is scarcely known if redox state, autophagy, and lysosomal function depend on sex, a factor that largely influences health and diseases. Therefore, we evaluated the existence of sex differences in redox state and const...

journal_title：Life sciences

authors： Campesi I,Straface E,Occhioni S,Montella A,Franconi F

更新日期：2013-08-06 00:00:00

abstract：:Repeated intermittent administration of amphetamine in mice caused reverse tolerance to 5-hydroxy-L-tryptophan (5-HTP)-induced head twitch, as well as to amphetamine-induced stereotypy. The repeated administration of 5-HTP alone also resulted in reverse tolerance in the head-twitch test. Daily pretreatment with halope...

journal_title：Life sciences

authors： Karler R,Calder LD,Turkanis SA

更新日期：1990-01-01 00:00:00

abstract：:We have previously demonstrated that isatin (indole-2,3 dione), an endogenous compound widely distributed in mammalian tissues and body fluids, effectively inhibits atrial natriuretic peptide (ANP) receptor binding and ANP-stimulated guanylyl cyclase activity of rat membrane preparations. In the present study the effe...

journal_title：Life sciences

authors： Medvede AE,Abakumova OYu,Podobed OV,Tsvetkova TA,Sandler M,Glover V

更新日期：2001-08-31 00:00:00

abstract：:Gloriosaols A-C, isolated from Yucca gloriosa (Agavaceae), are novel phenolic compounds structurally related to resveratrol. In the present study, we show that gloriosaols possess antiproliferative and pro-apoptotic activity on tumor cells of different histogenetic origin and that their cell growth inhibition potentia...

journal_title：Life sciences

authors： Nigro P,Bloise E,Turco MC,Skhirtladze A,Montoro P,Pizza C,Piacente S,Belisario MA

更新日期：2007-08-23 00:00:00

abstract：AIMS:TsTX-I scorpion toxin, also known as γ-toxin, is a β-toxin which binds to site 4 of the sodium channel, shifting its activation potential. There are few studies about its pharmacological action in the central nervous system. The objective of this work was to determine the electroencephalographic, behavioral and hi...

journal_title：Life sciences

authors： Teixeira VF,Conceição IM,Lebrun I,Nencioni AL,Coronado Dorce VA

更新日期：2010-10-09 00:00:00

abstract：AIM:Irisin, the adipomyokine, released mainly by exercised muscles, participate in the browning of adipose tissue and contribute to the restriction of insulin resistance and diabetes mellitus 2 development. Because of the limited reports describing the effect of irisin on inflammation and immunocompetent cells activati...

journal_title：Life sciences

authors： Mazur-Bialy AI

更新日期：2017-05-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), a major steroid secreted by the adrenal gland, is known to have antiproliferative effects but the mechanism is unclear. We recently reported that DHEA induces growth inhibition and apoptosis in BV-2 cells and these effects are inversely associated with glucose concentrations in the mediu...

journal_title：Life sciences

authors： Yang NC,Jeng KC,Ho WM,Hu ML

更新日期：2002-03-15 00:00:00

abstract：:Nitric oxide (NO) surprisingly caused the opposite effect on histamine and serotonin edema. The local injection of acidified nitrite (0.3-30 micrograms/paw which correspond 10 micrograms-1 mg/kg) increased histamine edema of mice up to 45 +/- 4% and suppressed serotonin edema to 90 +/- 3%. Other NO-generators (nitropr...

journal_title：Life sciences

authors： Oyanagui Y,Sato S

更新日期：1993-01-01 00:00:00

abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells (RBCs) are known to be more susceptible to oxidant-induced hemolysis. Erythrocytes from G6PD-deficient individuals are significantly more susceptible to Ca(2+)-induced vesiculation than normal control cells. The enhanced susceptibility of G6PD-deficien...

journal_title：Life sciences

authors： Tsai KJ,Shih LY,Hung IJ,Huang SW,Wei JS,Liu TZ,Chiu DT

更新日期：1996-01-01 00:00:00

abstract：:We examined the effects of cyrneine A, a novel diterpene isolated from the mushroom Sarcodon cyrneus, on morphology of rat pheochromocytoma cells (PC12). In response to cyrneine A, PC12 cells extended their neurites, an effect partially blocked by the extracellular signal-regulated kinase (ERK) kinase inhibitor PD9805...

journal_title：Life sciences

authors： Obara Y,Hoshino T,Marcotullio MC,Pagiotti R,Nakahata N

更新日期：2007-04-10 00:00:00

abstract：:Overexpression of vascular endothelial growth factor (VEGF) and the extent of neoangiogenesis are closely correlated with tumor development and cancer metastases. To assess whether VEGF mediated angiogenesis is regulated by HDM2, we treated the GI-101A and HL-60 cells with HDM2 gene specific antisense phosphorothioate...

journal_title：Life sciences

authors： Narasimhan M,Rose R,Ramakrishnan R,Zell JA,Rathinavelu A

更新日期：2008-06-20 00:00:00

abstract：:The mechanism of the generation and the quantitative analysis of singlet oxygen (1O2) formed by the exposure of a hematoporphyrin derivative (HpD) to light was re-evaluated by electron spin resonance (ESR) combined with 2,2,6,6,-tetramethyl-4-piperidine (TMPD). The change from TMPD to 2,2,6,6,-tetramethyl-4-piperidine...

journal_title：Life sciences

authors： Ando T,Yoshikawa T,Tanigawa T,Kohno M,Yoshida N,Kondo M

更新日期：1997-01-01 00:00:00

abstract：:In vitro competition binding experiments with the selective muscarinic antagonists AF-DX 116 and pirenzepine (PZ) vs 3H-N-methylscopolamine as radioligand revealed a characteristic distribution of muscarinic receptor subtypes in different regions of rat brain. Based on non linear least squares analysis, the binding da...

journal_title：Life sciences

authors： Giraldo E,Hammer R,Ladinsky H

更新日期：1987-03-02 00:00:00

abstract：:Chronic administration of narcotic mu opioid agonists results in tolerance and dependence. We propose that agonist stimulation causes a gradual conversion of mu receptors to a constitutively active state (mu*) as a key step in tolerance and physical dependence. We provide evidence in support of the existence of mu* in...

journal_title：Life sciences

authors： Wang Z,Bilsky EJ,Porreca F,Sadée W

更新日期：1994-01-01 00:00:00

abstract：:The metabolism of benzene and toluene was investigated in preparations of human bone marrow incubated with S-adenosyl-L-methionine. Benzene undergoes a methyl-substitution reaction to yield toluene as a metabolite. Furthermore, toluene undergoes methyl-substitution in preparations of human bone marrow incubated with S...

journal_title：Life sciences

authors： Flesher JW,Myers SR

更新日期：1991-01-01 00:00:00

abstract：:The effects of taurine on hepatic cholesterol metabolism were investigated in hamsters fed a high-fat diet or normal chow. Two weeks-treatment of taurine at 1% in drinking water prevented high-fat diet-induced increase in cholesterol levels of serum and liver. The decrease in serum cholesterol by taurine was due to de...

journal_title：Life sciences

authors： Murakami S,Kondo Y,Toda Y,Kitajima H,Kameo K,Sakono M,Fukuda N

更新日期：2002-04-05 00:00:00

abstract：:Multiple classes of cell surface receptors and ion channels participate in the detection of changes in environmental stimuli, and thereby influence animal behavior. Among the many classes of ion channels, Transient Receptor Potential (TRP) cation channels are notable in contributing to virtually every sensory modality...

journal_title：Life sciences

authors： Fowler MA,Montell C

更新日期：2013-03-19 00:00:00

abstract：:It is currently believed that oxidative stress and inflammation play a significant role in atherogenesis. Artichoke extract exhibits hypolipemic properties and contains numerous active substances with antioxidant properties in vitro. We have studied the influence of aqueous and ethanolic extracts from artichoke on int...

journal_title：Life sciences

authors： Zapolska-Downar D,Zapolski-Downar A,Naruszewicz M,Siennicka A,Krasnodebska B,Kołdziej B

更新日期：2002-11-01 00:00:00

abstract：:Studies were performed in conscious, chronically catheterized male Sprague-Dawley rats to investigate the effect of administered atrial natriuretic peptide (ANP) on blood pressure, renal hemodynamics and urinary electrolyte excretion. Studies were performed on young adult (3-4 month old) rats and on aging rats (18-24 ...

journal_title：Life sciences

authors： DePriest D,Zimmermann C,Baylis C

更新日期：1990-01-01 00:00:00

abstract：:Nitric oxide (NO) is the mediator of ischemic preconditioning against myocardial infarction. Desflurane produces anesthetic preconditioning to protect the myocardium against infarction. In the model of myocardial ischemia-reperfusion injury in rabbits, we evaluated desflurane-induced ischemic preconditioning and studi...

journal_title：Life sciences

authors： Tsai SK,Lin SM,Huang CH,Hung WC,Chih CL,Huang SS

更新日期：2004-12-24 00:00:00

abstract：:Acetyltransferase was isolated by histone-Sepharose affinity chromatography from human cord blood red cells. The enzyme was detected only in very young red cells. The semipurified enzyme and [14C]acetyl-CoA were used to acetylate isolated Hb F tetramer and alpha and gamma subunits. The in vitro acetylated products wer...

journal_title：Life sciences

authors： Qiu CC,Kasten-Jolly J,Abraham EC

更新日期：1988-01-01 00:00:00

abstract：:The recently discovered highly specific delta opioid antagonist H-Tyr-Tic-Phe-Phe-OH (TIPP) was radiolabelled by catalytic tritiation of its precursor [Tyr (3', 5'-I2)1]TIPP. The tritiated ligand labelled rat brain membrane binding sites with a Kd value of 0.64 nM and a Bmax of 82 fmol/mg protein. Binding competition ...

journal_title：Life sciences

authors： Nevin ST,Toth G,Nguyen TM,Schiller PW,Borsodi A

更新日期：1993-01-01 00:00:00

abstract：:Female mice of the inbred strains C57BL/6J, BALB/cJ and DBA/2J were used to determine the possible existence of a genetically-based differential susceptibility to the effects of treatment with an extract of Ginkgo biloba (EGb 761). Timm's silver-sulphide staining method was used to visualize and determine changes in t...

journal_title：Life sciences

authors： Barkats M,Venault P,Christen Y,Cohen-Salmon C

更新日期：1995-01-01 00:00:00

abstract：:This paper describes the use of complex liposomes as real membrane models to evaluate the potential benefits of several antioxidants in relation to lipid peroxidation. The xanthine oxidase/Fe(3+)-ADP-EDTA and the Fe(2+)/H2O2 systems have been used to generate hydroxyl radicals and the water soluble azo-compound 2,2'-a...

journal_title：Life sciences

authors： Gutiérrez ME,García AF,Africa de Madariaga M,Sagrista ML,Casadó FJ,Mora M

更新日期：2003-04-11 00:00:00

abstract：:The biosynthesis of digitalis-like compounds (DLC) was determined in bovine and rat adrenal homogenates, as well as in primary rat adrenal cells, by following changes in the concentration of DLC using three independent sensitive bioassays: inhibition of [3H]-ouabain binding to red blood cells and competitive ouabain a...

journal_title：Life sciences

authors： Lichtstein D,Steinitz M,Gati I,Samuelov S,Deutsch J,Orly J

更新日期：1998-01-01 00:00:00

abstract：AIMS:Cisplatin is an anticancer agent marred by nephrotoxicity. Limiting this adverse effect may allow the use of higher doses to improve its efficacy. The Wnt/β-catenin signaling pathway plays a critical role in nephrogenesis and repair of renal diseases. BIO, a small molecule agonist of this pathway, exerted a protec...

journal_title：Life sciences

authors： Sun Z,Xu S,Cai Q,Zhou W,Jiao X,Bao M,Yu X

更新日期：2020-12-15 00:00:00

abstract：:The present study examines the signal transduction mechanism that is involved in the growth of vascular smooth muscle cells exposed to 4-hydroxynonenal (HNE) in vitro. This aldehyde component of oxidized low-density lipoprotein has been identified in atherosclerotic lesion. Exposure to HNE caused ERK, JNK, and p38 MAP...

journal_title：Life sciences

authors： Kakishita H,Hattori Y

更新日期：2001-06-29 00:00:00