Distribution of muscarinic receptor subtypes in rat brain as determined in binding studies with AF-DX 116 and pirenzepine.

abstract：:The association of [3H] [D-Ala2, D-Leu5] enkephalin ([3H]DADLE]) with mouse neuroblastoma cells (N4TG1) was investigated. Under identical conditions the time course, dose response curve and temperature dependence for ligand uptake were similar to those for ligand-induced receptor loss (down regulation). Uptake of [3H]...

journal_title：Life sciences

authors： Blanchard SG,Chang KJ,Cuatrecasas P

更新日期：1982-09-20 00:00:00

abstract：:Since somatostatin inhibits basal and stimulated gastric acid secretion and gastrin release, it is conceivable that decreased gastric somatostatin concentration may be one of the factors responsible for gastric hypersecretion found in patients who have undergone long-term pylorotomy for hypertrophic pyloric stenosis. ...

journal_title：Life sciences

authors： Barrios V,Urrutia MJ,Hernández M,Lama R,García-Novo MD,Hernanz A,Arilla E

更新日期：1994-01-01 00:00:00

abstract：:The effects of the cannabinoid receptor agonist Win 55,212-2 and of the competitive cannabinoid receptor antagonist SR 141716A on the electrically-evoked peristalsis of isolated distal colon of mouse were studied. Intraluminal pressure, longitudinal displacement, ejected fluid volume and changes in morphology of exter...

journal_title：Life sciences

authors： Mancinelli R,Fabrizi A,Del Monaco S,Azzena GB,Vargiu R,Colombo GC,Gessa GL

更新日期：2001-05-25 00:00:00

abstract：:The aims of this study were to determine whether endothelin-1 (ET-1), a positive inotropic agent, altered the production of cyclic AMP (cAMP) in adult feline cardiac myocytes and to characterize the effect with respect to G-protein-coupling and calcium regulation of adenylyl cyclase. ET-1 inhibited basal and/or stimul...

journal_title：Life sciences

authors： Jones LG

更新日期：1996-01-01 00:00:00

abstract：:Interleukin (IL)-1 beta is a pro-inflammatory cytokine that has been shown to play a pivotal role in the onset of inflammatory bowel disease (IBD), however, the molecular mechanisms underlying the production of IL-1 beta in IBD are not fully understood. We investigated dextran sulfate sodium (DSS)-induced IL-1 beta pr...

journal_title：Life sciences

authors： Kwon KH,Ohigashi H,Murakami A

更新日期：2007-07-12 00:00:00

abstract：:Effects of baicalein and wogonin, the major flavonoids of Scutellariae radix, on cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and glutathione S-transferase (GST) were studied in C57BL/6J mice. One-week treatment of mice with a liquid diet containing 5 mM baicalein resulted in 29%, 14%, 36%, 28%, and 46% ...

journal_title：Life sciences

authors： Ueng YF,Shyu CC,Lin YL,Park SS,Liao JF,Chen CF

更新日期：2000-09-22 00:00:00

abstract：AIMS:Smooth muscle cells (SMCs) play a role in medial vascular calcification, which can be stimulated by high levels of serum phosphate and inflammatory mediators. The aim of this study was to investigate whether mitogen-activated protein kinases (MAPKs) (p38 MAPK, ERK1/2, and JNK) and protein kinase A (PKA) can partic...

journal_title：Life sciences

authors： Toita R,Otani K,Kawano T,Fujita S,Murata M,Kang JH

更新日期：2018-09-15 00:00:00

abstract：:We examined the effects of various oleanolic acid oligoglycosides obtained from traditional herbs on ethanol- or indomethacin-induced gastric mucosal lesions in rats and on gastric secretion in pylorus-ligated rats. Test samples were given orally to fasted rats 1 h before absolute ethanol (1.5 ml/rat, p.o.) or indomet...

journal_title：Life sciences

authors： Matsuda H,Li Y,Murakami T,Yamahara J,Yoshikawa M

更新日期：1998-01-01 00:00:00

abstract：:Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task, were challenged with various doses of the 4-methoxy, 4-methylthio and 5-methylthio derivatives of DMT. The 5-OMe DMT cue was found to generalize to all t...

journal_title：Life sciences

authors： Glennon RA,Young R,Benington F,Morin RD

更新日期：1982-02-01 00:00:00

abstract：:Castanospermine is a potent inhibitor of rat intestinal glycohydrolases in vitro and prevents the hyperglycemic response to an oral sucrose challenge in vivo. Among the glycohydrolases tested, castanospermine was most effective against sucrase with an IC50 of 1.1 x 10(-7) M. In vivo, a significant effect was seen at d...

journal_title：Life sciences

authors： Rhinehart BL,Robinson KM,Payne AJ,Wheatley ME,Fisher JL,Liu PS,Cheng W

更新日期：1987-11-16 00:00:00

abstract：AIMS:Ideally, mesenchymal stem cells (MSC) home to and/or remain at the site of damaged myocardium when administered after myocardial infarction. However, MSC may not remain in the heart, but instead relocate to other areas. We investigated quantitatively the distribution of labeled rat MSC, given by two routes after c...

journal_title：Life sciences

authors： Hale SL,Dai W,Dow JS,Kloner RA

更新日期：2008-09-26 00:00:00

abstract：:Net water, Na+, Cl- and HCO3- fluxes were measured in in vivo rabbit ileal loops, while mucus secretion was assessed by measuring the glycoprotein or total sialic acid secreted into the lumen, or by measuring the luminal fluid viscosity. Inoculating loops with cholera enterotoxin (CT) produced a sustained secretion of...

journal_title：Life sciences

authors： George MH,Leitch GJ

更新日期：1983-02-21 00:00:00

abstract：:Depression is a leading cause of disability worldwide. However, the biological and molecular mechanisms underlying this disease remain unclear. Stress, a disposing factor in the development of depression, leads to hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoids release. Glucocorticoids at phys...

journal_title：Life sciences

authors： Chen J,Wang ZZ,Zhang S,Zuo W,Chen NH

更新日期：2016-05-01 00:00:00

abstract：:Angiogenesis-targeted therapy of cancer is considered a promising strategy for therapeutic management of cancer progression. Over the last two decades, a few anti-angiogenesis monoclonal antibodies (mAbs) blocking VEGF signaling have been developed and approved by the FDA. The most widely used anti-angiogenesis drug i...

journal_title：Life sciences

authors： Fallah A,Heidari HR,Bradaran B,Sisakht MM,Zeinali S,Molavi O

更新日期：2019-12-15 00:00:00

abstract：AIM:Up-regulation of inflammasome proteins was reported in dystrophin-deficient muscles. However, it remains to be determined whether inflammasome activation plays a role in the pathogenesis of Duchenne muscular dystrophy. This study was therefore set out to investigate whether genetic disruption of the inflammasome pa...

journal_title：Life sciences

authors： Lau YS,Zhao L,Zhang C,Li H,Han R

更新日期：2020-09-15 00:00:00

abstract：:This study examined the role of marijuana smoking in the pathogenesis of human lung cancer by measuring DNA damage in alveolar macrophages (AM). The alkaline unwinding method was used to determine DNA single-strand breaks in AM lavaged from non-smokers [NS] and smokers of marijuana [MS], tobacco [TS] or cocaine [CS], ...

journal_title：Life sciences

authors： Sherman MP,Aeberhard EE,Wong VZ,Simmons MS,Roth MD,Tashkin DP

更新日期：1995-01-01 00:00:00

abstract：:The central interference induced by dexamethasone and RU-38486, (a glucocorticoid receptor antagonist) on morphine antinociception were studied by using the tail flick test in mice. Dexamethasone, injected intracerebrally (i.c.v.) 10 minutes before morphine, dose-dependently reduced morphine antinociception, whereas R...

journal_title：Life sciences

authors： Capasso A,Di Giannuario A,Loizzo A,Pieretti S,Sorrentino L

更新日期：1992-01-01 00:00:00

abstract：:For the first time the involvement of C-Reactive protein (CRP) in early (acute) and delayed ischemic (IPC) and pharmacological (chemical) preconditioning (CPC) in an in vivo model of rat myocardial infarction was presented. Acute IPC was produced by three 5 minute occlusion (ischemia) periods interspersed with 5 minut...

journal_title：Life sciences

authors： Valtchanova-Matchouganska A,Gondwe M,Nadar A

更新日期：2004-07-09 00:00:00

abstract：:When injected into the substantia nigra reticulata of naive rats, dynorphin-(1-17) caused a dose dependent contralateral rotation which was inhibited by naloxone in a dose dependent manner. Met-enkephalin injected in the same coordinates as the ones used with dynorphin also induced rotation but of lower intensity, whi...

journal_title：Life sciences

authors： Herrera-Marschitz M,Hökfelt T,Ungerstedt U,Terenius L

更新日期：1983-01-01 00:00:00

abstract：:The substituted glucopyranose ring structure 2-hydroxypropyl-beta-cyclodextrin (CDEX) increases the solubility of molecules by inclusion of the agent in the lipophilic interior of the ring. This property is of particular use for the administration of molecules by the intracerebral (ICV) or intrathecal (IT) routes. In ...

journal_title：Life sciences

authors： Yaksh TL,Jang JD,Nishiuchi Y,Braun KP,Ro SG,Goodman M

更新日期：1991-01-01 00:00:00

abstract：:Incubation of the nonsteroidal antiestrogen nitromiphene (CI628) with rat cecal content suspension under aerobic or anaerobic conditions resulted in extensive biotransformation, yielding three metabolites, as determined by thin-layer chromatography. These metabolites were not recovered from incubation mixtures contain...

journal_title：Life sciences

authors： Ruenitz PC,Bagley JR

更新日期：1983-09-12 00:00:00

abstract：:Sleep is crucial to improve athlete performance and their circadian rhythm, but sleep patterns may be disturbed because athletes participate in several competitions. In addition, intensive training programs can cause muscle pain and psychological stress in athletes, resulting in a lack of sleep. Sleep also plays a cri...

journal_title：Life sciences

authors： Yang DF,Shen YL,Wu C,Huang YS,Lee PY,Er NX,Huang WC,Tung YT

更新日期：2019-10-15 00:00:00

abstract：:A simple and sensitive method for the determination of isoprenaline (ISO) in plasma by high performance liquid chromatography (HPLC) with electrochemical detection is presented. Blood pressure and heart rate responses to i.v. infusion of ISO (15, 38 and 76 ng/kg/min) were studied in 15 subjects. Blood samples for ISO ...

journal_title：Life sciences

authors： Hjemdahl P,Martinsson A,Larsson K

更新日期：1986-08-18 00:00:00

abstract：:Changes in AMP-activated protein kinase (AMPK) activity contribute to the regulation of insulin secretion. Troglitazone has been shown to lower serum insulin levels and protect beta cell function. The aim of the present study was to examine the effects of troglitazone on AMPK activity and insulin secretion in beta cel...

journal_title：Life sciences

authors： Wang X,Zhou L,Shao L,Qian L,Fu X,Li G,Luo T,Gu Y,Li F,Li J,Zheng S,Luo M

更新日期：2007-06-20 00:00:00

abstract：:We investigated whether nitric oxide (NO) exposure alters the balance between NO and endothelium-derived hyperpolarizing factor (EDHF) released from rat renal arteries. To produce states of acutely or chronically excessive NO, lipopolysaccharide (LPS) was administered intraperitoneally to rats in a single dose of 4 mg...

journal_title：Life sciences

authors： Kagota S,Yamaguchi Y,Nakamura K,Shinozuka K,Kunitomo M

更新日期：2004-04-16 00:00:00

abstract：:Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten. We have recently shown that GE-B5 stimulates prolactin (PRL) secretion in rats; this effect is abolished by preadministration of the opioid receptor antagonist naloxone. However, since the structure of naloxone allows it...

journal_title：Life sciences

authors： Fanciulli G,Dettori A,Demontis MP,Tomasi PA,Anania V,Delitala G

更新日期：2005-02-25 00:00:00

abstract：:Differences in prevalence and mortality from coronary artery disease (CAD) were observed among the different Israeli ethnic groups. The incidence of CAD in Israel is highest among Ashkenazi Jews and is much lower among Yemenite Jews. In this present study, we selected 15 single nucleotide polymorphisms (SNPs) from 14 ...

journal_title：Life sciences

authors： Nakai K,Habano W,Nakai K,Fukushima N,Fujita T,Gurwitz D

更新日期：2004-07-09 00:00:00

abstract：:The effects of 100 microM norepinephrine (NE), GABA, aspartate, glutamate, and carbachol on the release of endogenous NE, GABA, aspartate, and glutamate from slices of rat cerebellum were examined. The 35 mM K+-stimulated release of NE was potentiated by GABA (136% of control), glutamate (123%), and carbachol (123%); ...

journal_title：Life sciences

authors： Flint RS,McBride WJ

更新日期：1986-01-20 00:00:00

abstract：:Activation of GABA(B) receptors produces analgesia in acute and chronic pain models. Data indicate that a possible mechanism for this effect is a GABA(B) receptor-induced blockade of neurokinin-1 (NK-1) receptor gene expression in the spinal cord. While much more potent GABA(B) receptor agonists (CGP 44532) have been ...

journal_title：Life sciences

authors： Enna SJ,Harstad EB,McCarson KE

更新日期：1998-01-01 00:00:00

abstract：AIMS:To investigate the effects of high doses of pentazocine on antinociception induced by a high dose of morphine and the role of the kappa-opioid receptors (KORs) in these effects in mice. MAIN METHODS:Sixty-six C57BL/6J mice were pretreated with a KOR antagonist, nor-binaltorphimine (nor-BNI) (10mg·kg(-1)), or a no...

journal_title：Life sciences

authors： Shu H,Wang Z,Ye F,Li Q,Dou Y,Lin Y,Huang W,Xiao X

更新日期：2015-06-01 00:00:00