Abstract：
:Changes in AMP-activated protein kinase (AMPK) activity contribute to the regulation of insulin secretion. Troglitazone has been shown to lower serum insulin levels and protect beta cell function. The aim of the present study was to examine the effects of troglitazone on AMPK activity and insulin secretion in beta cells. Isolated rat islets and MIN6 cells were treated for a short (1 h) or a long time (20 h) with troglitazone. One-hour troglitazone treatment activated AMPK and inhibited both glucose-stimulated insulin secretion (GSIS) and the response of insulin secretion to combined stimuli of glucose and palmitate. Long (20 h) treatment with troglitazone caused a sustained phosphorylation of AMPK and acetyl-CoA carboxylase, and increased GSIS after withdrawal of the drug. This study provided evidence that troglitazone activated AMPK in beta cells. In addition to the insulin-sensitizing effects in peripheral tissues, troglitazone also directly inhibits insulin hypersecretion by the elevated glucose and fatty acids, and thus protects beta cells from glucolipotoxicity.
journal_name
Life Scijournal_title
Life sciencesauthors
Wang X,Zhou L,Shao L,Qian L,Fu X,Li G,Luo T,Gu Y,Li F,Li J,Zheng S,Luo Mdoi
10.1016/j.lfs.2007.04.034subject
Has Abstractpub_date
2007-06-20 00:00:00pages
160-5issue
2eissn
0024-3205issn
1879-0631pii
S0024-3205(07)00351-7journal_volume
81pub_type
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