Calcium-dependence of serotonin-mediated aldosterone secretion and differential effects of calcium antagonists.

Abstract:

:The requirement for calcium in the serotonin-mediated aldosterone secretion was investigated using rat adrenal capsular cells. In the calcium-free medium both basal as well as serotonin-stimulated aldosterone secretion (at concentrations of 10(-7) M and 10(-8) M of serotonin) were significantly impaired. The effects of calcium-channel blockers were then examined. Verapamil (10(-5) M and 10(-6) M markedly inhibited basal and serotonin-evoked aldosterone secretion. In equimolar concentrations nifedipine had much less effect and diltiazem produced no apparent attenuation of either basal or serotonin-stimulated aldosterone secretion. These results indicate the calcium-dependence of serotonin-induced aldosterone secretion. The variable effects of the calcium-channel blockers suggest different or multiple mechanisms of action of these agents.

journal_name

Life Sci

journal_title

Life sciences

authors

Ganguly A,Hampton T

doi

10.1016/0024-3205(85)90053-0

subject

Has Abstract

pub_date

1985-04-15 00:00:00

pages

1459-64

issue

15

eissn

0024-3205

issn

1879-0631

pii

0024-3205(85)90053-0

journal_volume

36

pub_type

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