Abstract:
:The requirement for calcium in the serotonin-mediated aldosterone secretion was investigated using rat adrenal capsular cells. In the calcium-free medium both basal as well as serotonin-stimulated aldosterone secretion (at concentrations of 10(-7) M and 10(-8) M of serotonin) were significantly impaired. The effects of calcium-channel blockers were then examined. Verapamil (10(-5) M and 10(-6) M markedly inhibited basal and serotonin-evoked aldosterone secretion. In equimolar concentrations nifedipine had much less effect and diltiazem produced no apparent attenuation of either basal or serotonin-stimulated aldosterone secretion. These results indicate the calcium-dependence of serotonin-induced aldosterone secretion. The variable effects of the calcium-channel blockers suggest different or multiple mechanisms of action of these agents.
journal_name
Life Scijournal_title
Life sciencesauthors
Ganguly A,Hampton Tdoi
10.1016/0024-3205(85)90053-0subject
Has Abstractpub_date
1985-04-15 00:00:00pages
1459-64issue
15eissn
0024-3205issn
1879-0631pii
0024-3205(85)90053-0journal_volume
36pub_type
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