Abstract:
:The effect of Bacillus Calmette-Guérin (BCG) treatment in allergic pulmonary reaction was studied in mice genetically selected accordingly to a High (H-IVA) or Low (L-IVA) antibody responsiveness. Mice were immunized with ovalbumin (OVA) or OVA plus BCG. Two days after nasal antigenic challenge, seric IgE and IgG1 anti-OVA, eosinophils in pulmonary tissue, inflammatory cells in bronchoalveolar lavage and the compliance and conductance of respiratory system were evaluated. H-IVA mice were found more susceptible than L-IVA, and BCG was able to inhibit simultaneously the production of IgE, the bronchopulmonary inflammation and bronchial hyperresponsiveness in these genetically selected mice.
journal_name
Life Scijournal_title
Life sciencesauthors
Barros MT,Acencio MM,Garcia ML,Macedo Soares MF,Ibañez OM,Martins MA,Ribeiro OG,Kalil J,Perini Adoi
10.1016/j.lfs.2005.04.003subject
Has Abstractpub_date
2005-08-12 00:00:00pages
1480-92issue
13eissn
0024-3205issn
1879-0631pii
S0024-3205(05)00399-1journal_volume
77pub_type
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