Abstract：
:Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is vital to the regulation of inflammatory responses, as it has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pro-inflammatory functions of PECAM-1 include the facilitation of leukocyte transendothelial migration and the transduction of mechanical signals in endothelial cells emanating from fluid shear stress. Anti-inflammatory functions include the dampening of leukocyte activation, suppression of pro-inflammatory cytokine production, and the maintenance of vascular barrier integrity. Although PECAM-1 has been well-characterized and studied, the mechanisms through which PECAM-1 regulates these seemingly opposing functions, and how they influence each other, are still not completely understood. The purpose of this review, therefore, is to provide an overview of the pro- and anti-inflammatory functions of PECAM-1 with special attention paid to mechanistic insights that have thus far been revealed in the literature in hopes of gaining a clearer picture of how these opposing functions might be integrated in a temporal and spatial manner on the whole organism level. A better understanding of how inflammatory responses are regulated should enable the development of new therapeutics that can be used in the treatment of acute and chronic inflammatory disorders.
journal_name
Life Scijournal_title
Life sciencesauthors
Privratsky JR,Newman DK,Newman PJdoi
10.1016/j.lfs.2010.06.001subject
Has Abstractpub_date
2010-07-17 00:00:00pages
69-82issue
3-4eissn
0024-3205issn
1879-0631pii
S0024-3205(10)00242-0journal_volume
87pub_type
杂志文章,评审相关文献
LIFE SCIENCES文献大全abstract：:Microvascular changes in the brain are significant causes of cerebral edema and ischemia injury. A number of studies suggest that angiotensin (Ang) II may be involved in the initiation and regulation of processes occurring in brain ischemia. We recently reported that Ang II injures brain microvascular endothelial cell...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.06.049
更新日期：2006-02-16 00:00:00
abstract：:Since reduced levels of brain serotonin are known to cause behavioural abnormalities, to which diabetics are also prone, we investigated the effect, in rats, of chronic diabetes on brain serotonin concentration and on the numbers of 5-HT(1A) and 5-HT2 receptors in cerebral cortex and brainstem. Our data show that stre...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00084-2
更新日期：1997-01-01 00:00:00
abstract：:Lipocalin2 (Lcn2) has been shown to be a vital regulator of tumorigenesis in a variety of different cancers. However, its expression patterns and possible roles in ovarian cancer remain obscure. The aim of this study was to investigate the expression of Lcn2 in ovarian cancer cells and to determine any potential assoc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118492
更新日期：2020-12-01 00:00:00
abstract：AIMS:The aim of this study was to evaluate the antinociceptive (acute assays) and anti-inflammatory (chronic assays) effects of kramecyne (KACY), a peroxide isolated from Krameria cytisoides. MAIN METHODS:The antinociceptive activity of KACY was evaluated using the hot plate, acetic acid and formalin tests. The effect...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.11.015
更新日期：2015-01-15 00:00:00
abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are widely applied in various clinical disorders, including acute lung injury (ALI). We aimed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs)-derived exosomal microRNA-22-3p (miR-22-3p) on lipopolysaccharid (LPS)-induced ALI via...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.119004
更新日期：2021-01-06 00:00:00
abstract：:The aim of the present study was to assess the effects of peanut (Arachis hypogaea L.) shell extracts (PSE) on lipases and to evaluate its potential development for the treatment of obesity. The peanut shells were extracted in 95% ethanol, and the extracts were screened for inhibitory effects on pancreatic lipase (PL)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.11.012
更新日期：2006-05-08 00:00:00
abstract：:Chemokines constitute a large family of structurally-related small cytokines originally identified as factors regulating the migration of leukocytes in inflammatory and immune responses. Production of chemokines and their receptors in the brain has been reported under various pathological conditions. We revealed that ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2003.09.019
更新日期：2003-12-05 00:00:00
abstract：OBJECTIVE:Stem cell transplantation is a promising tool to treat burn injuries. However, the inflammatory microenvironment in damaged skin limits the efficiency of stem cell-based therapy via poorly understood mechanisms. The aim of our study is to explore the contribution and mechanism of Sirtuin-1 (Sirt1) in TNFα-med...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.10.003
更新日期：2018-11-01 00:00:00
abstract：:We have examined the role of membrane hyperpolarization in mediating vascular hyporeactivity induced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat thoracic aorta ex vivo. The injection of rats with LPS caused a significant fall of blood pressure and a severe vascular hyporeactivity to nore...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00978-4
更新日期：2000-12-29 00:00:00
abstract：:The role of Na+ and Ca2+ channels in glutamate-mediated hypoxic injury was investigated in slices of the rat cerebral cortex. Hypoxic injury was determined by mitochondrial reduction of 3-(4,5-dimethyl-2-thiazol)-2,5-diphenyltetrazolium bromide after exposure of brain slices to 30-min of hypoxia/glucose deprivation fo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00814-6
更新日期：2000-09-29 00:00:00
abstract：:Diltiazem, diazepam, and clonazepam effectively inhibit Na+-induced Ca2+ release from mitochondria isolated from rabbit heart and rat brain. At 10 mM NaCl, the 50% inhibition of the rate of Ca2+ release occurred at 5, 7, 40 and 350 microM of clonazepam d-cis-diltiazem, diazepam and 1-cis-diltiazem, respectively. Ro 15...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90319-3
更新日期：1983-06-20 00:00:00
abstract：:Clinical data indicate that hydroalcoholic extracts of Hypericum perforatum might be as valuable as conventional antidepressants in mild-to-moderate depression, with fewer side effects. One clinical trial using two extracts with different hyperforin contents indicated it as the main active principle responsible for th...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2004.04.005
更新日期：2004-07-16 00:00:00
abstract：:We evaluated the effects of FR901533, endothelin converting enzyme inhibitor, on development of right ventricular overload and medial thickening of pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension. Pulmonary hypertension was induced by a single injection of monocrotaline (80 mg/kg). Twenty-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00347-6
更新日期：1998-01-01 00:00:00
abstract：:This study examines the role of dopaminergic mechanisms in the regulation of human pancreatic polypeptide (hPP) secretion in 11 normal male volunteers. Administration of domperidone (20 mg iv), an extracerebral inhibitor of dopamine receptors, resulted in a hPP rise (p less than 0.05) within 10 min and a peak response...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90063-7
更新日期：1982-12-27 00:00:00
abstract：:This investigation was designed to determine whether St. John's wort (SJW)(435 mg/kg/d), a readily available antidepressant, or its purported active constituents hypericin (1 mg/kg/d) and hyperforin (10 mg/kg/d) were able to induce various hepatic cytochrome P450 (CYP450) isoforms. SJW, hypericin and hyperforin were a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01499-0
更新日期：2002-02-01 00:00:00
abstract：:Although lipid peroxidation of biological samples may be assessed by different chemical and physical methods, those based on the measurement of malondialdehyde formed from the breakdown of endoperoxides during the last stages of the oxidation of a polyunsaturated fatty acid, appear as the most widely used. Among the v...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(91)90550-u
更新日期：1991-01-01 00:00:00
abstract：:Chronic administration of narcotic mu opioid agonists results in tolerance and dependence. We propose that agonist stimulation causes a gradual conversion of mu receptors to a constitutively active state (mu*) as a key step in tolerance and physical dependence. We provide evidence in support of the existence of mu* in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90022-1
更新日期：1994-01-01 00:00:00
abstract：:Recent reports indicate that some imidazole-5-acetic acid derivatives are competitive antagonists of angiotensin II receptors. However, to our knowledge, there is no published information regarding: 1) what constant infusion rate of these non-peptide angiotensin receptor blockers is necessary to effectively antagonize...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90096-a
更新日期：1990-01-01 00:00:00
abstract：:Gastric mucosal lipid peroxide levels, based on the amounts of thiobarbituric acid reacting substances, increased soon after oral application of absolute ethanol. On the other hand, gastric mucosal nonprotein sulfhydryl levels slightly but significantly decreased. Administration of 20% ethanol, a mild irritant which c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90216-x
更新日期：1986-06-09 00:00:00
abstract：:The influence of stressful experiences on the development of vacuous chewing movements (VCM) was investigated in non-medicated rats. After an initial baseline period one group of rats was housed in a noisy environment while another group was housed in quiet surroundings. The development of VCM was recorded during a 16...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90146-3
更新日期：1991-01-01 00:00:00
abstract：:In order to estimate the intestinal stability of ebiratide [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8-NH2], a novel adrenocorticotropic hormone (ACTH) analogue, after oral administration, the hydrolytic properties of ebiratide were determined in the rat small intestinal fluid and mucosal homogenates. Ebiratide was extr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00674-1
更新日期：1994-01-01 00:00:00
abstract：:Proteinaceous inhibitors with high inhibitory activities against human neutrophil elastase (HNE) were found in seeds of the Tamarind tree (Tamarindus indica). A serine proteinase inhibitor denoted PG50 was purified using ammonium sulphate and acetone precipitation followed by Sephacryl S-300 and Sephadex G-50 gel filt...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.053
更新日期：2005-05-06 00:00:00
abstract：:TNF production has been studied in peritoneal macrophages and splenic T cells of Arctic Yakutian ground squirrel (Citellus Undulatus Pallas) in hibernating and awake animals in winter and in prehibernating autumn as well as in active euthermic spring-summer animals. A high level of TNF production in macrophages of gro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00698-6
更新日期：2000-01-01 00:00:00
abstract：AIMS:The type 2 muscarinic receptor (M2R) differs from the other G-protein-coupled muscarinic receptor (type 4, or M4R) in tissue distribution and physiologic effects. We studied the impact of these receptors on sleep and arousal by using M2R and M4R knock-out (KO) mice. MAIN METHODS:M2R and M4R KO and genetically int...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.11.019
更新日期：2010-01-30 00:00:00
abstract：:The pressor effect of hemoglobin-based blood substitutes is due partly to their capacity to scavenge nitric oxide (NO), a potent vasodilator. NO also appears to modulate the release of norepinephrine (NE) from sympathetic nerve endings in some blood vessels. Thus studies were designed to determine if contraction occur...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00269-x
更新日期：1996-01-01 00:00:00
abstract：AIMS:This study was performed to assess isolated and combined effects of nandrolone and resistance training on the blood pressure, cardiac electrophysiology, and expression of the β1- and β2-adrenergic receptors in the heart of rats. MAIN METHODS:Wistar rats were randomly divided into four groups and submitted to a 6-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.04.002
更新日期：2013-05-30 00:00:00
abstract：:Leukemias are a heterogenous group of diseases characterized by uncontrolled proliferation of abnormal blood cells of hematopoietic system. Evodiamine, a characteristic alkaloid extracted from Evodia fruits, has been reported to exhibit inhibitory effect on cell proliferation and migration in several types of cancer c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.11.025
更新日期：2004-05-21 00:00:00
abstract：:Peroxisome-proliferator activated receptor-gamma (PPARgamma) has been demonstrated to exert an inhibitory effect on cell growth in most cell types studied, but its role in colon cancer is still uncertain. The molecular mechanism between the activation of PPARgamma and its consequence is unknown. In the present report,...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01510-2
更新日期：2002-04-19 00:00:00
abstract：:Nuclear factor erythroid 2-related factor 2 (Nrf-2) binds to a specific polyamine responsive element (PRE) in the promoter region of the spermidine-spermine acetyltransferase (SSAT) gene, a key component of the polyamine catabolic pathway. Regulation of SSAT gene transcription requires the additional interaction of Nr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.03.042
更新日期：2006-08-22 00:00:00
abstract：AIMS:The clinical utilization of the combinations of all-trans-retinoic acid (RA) with antiestrogens, which present synergism of action in breast cancer, has been limited by RA adverse effects, including hepatotoxicity, which may be related with mitochondrial damage. This work evaluated the effects of RA alone and in c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.05.027
更新日期：2013-07-30 00:00:00
