Streptozotocin-induced diabetes provokes changes in serotonin concentration and on 5-HT1A and 5-HT2 receptors in the rat brain.

abstract：:We have developed and utilized a photoaffinity probe to identify the adenosine transporter in cardiac sarcolemmal (SL) vesicles. The probe is an azidosalicylate derivative of adenosine made by reacting adenosine with N-hydroxysuccinimidyl-4-azidosalicylic acid (NHS-ASA). Following synthesis and radiolabeling of the pr...

journal_title：Life sciences

authors： Hale CC,Rovetto MJ

更新日期：1995-01-01 00:00:00

abstract：:Although nitrosation plays an important role in initiation of carcinogenesis, the reactive nitrogen oxygen species (RNOS) mediating this reaction by multiple pathways have not been determined. The heterocyclic amine carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was used as a target to investigate RNOS and pa...

journal_title：Life sciences

authors： Lakshmi VM,Zenser TV

更新日期：2007-01-23 00:00:00

abstract：:Thermodynamic analysis of pharmacologic data potentially offers an insight into the molecular events underlying drug-receptor interactions not obtainable by other techniques. Embodied in thermodynamics are the laws governing the interconvertibility of heat and work and, hence, it is a particularly apt framework for th...

journal_title：Life sciences

authors： Raffa RB,Porreca F

更新日期：1989-01-01 00:00:00

abstract：:In the present study the possibility of provoking an irreversible blockade of P2-receptors in vivo by photolyzing ANAPP3 was investigated. ANAPP3 administered as an intraarterial infusion produced a short-lived blockade of P2-receptor mediated contractions of cat urinary bladders in situ. However, irradiation of the b...

journal_title：Life sciences

authors： Theobald RJ Jr,Hoffman V

更新日期：1986-04-28 00:00:00

abstract：AIMS:Several experimental studies have demonstrated that removal of the spleen accelerates liver regeneration after partial hepatectomy. While the mechanism of splenectomy promotes liver regeneration by the improvement of the formation of tight junction and the establishment of hepatocyte polarity is still unknown. MA...

journal_title：Life sciences

authors： Liu G,Xie C,Fang Y,Qian K,Liu Q,Liu G,Cao Z,Du H,Fu J,Xu X

更新日期：2018-01-01 00:00:00

abstract：:Our previous indirect evidences suggested that the adrenergic nervous system is involved in the mechanisms responsible for the time-dependent changes in the effects of furosemide in Wistar rats. In the present study, the role of this system was examined more directly by means of 6-hydroxydopamine-induced sympathectomy...

journal_title：Life sciences

authors： Fujimura A,Ebihara A

更新日期：1990-01-01 00:00:00

abstract：AIMS:Tianeptine is an atypical antidepressant drug that has a different mechanism of action than other antidepressants. Olanzapine is an atypical antipsychotic drug used for the treatment of schizophrenia. The present study was undertaken to investigate effects of chronic administration of tianeptine or olanzapine on u...

journal_title：Life sciences

authors： Mutlu O,Gumuslu E,Ulak G,Celikyurt IK,Kokturk S,Kır HM,Akar F,Erden F

更新日期：2012-12-17 00:00:00

abstract：AIMS:Ginsenoside-Rg1 (G-Rg1), a saponin that is a primary component of ginseng, is very useful and important in traditional Chinese medicine for stroke. The objective of this study was to explore the mechanisms underlying the neuroprotective effect of G-Rg1 on focal cerebral ischemia/reperfusion. MAIN METHODS:Focal ce...

journal_title：Life sciences

authors： Xie CL,Li JH,Wang WW,Zheng GQ,Wang LX

更新日期：2015-01-15 00:00:00

abstract：:Species-related specific differences in the pharmacological profile of vasopressin V1a receptors have been reported. Thus, the aim of the present study was to identify a vascular preparation of human origin expressing V1a receptors. Vasopressin was found to contract human gastric artery strips without endothelium with...

journal_title：Life sciences

authors： Calò G,Rizzi A,Traina L,Regoli D

更新日期：1997-01-01 00:00:00

abstract：:Opiate antagonists have been shown to reliably attenuate drinking behavior. Recent research points to a central site of action for this antidipsogenic effect. To pursue this issue of site specificity, naloxone, a specific opiate antagonist, was delivered into a number of discrete subcortical areas in 23 hour water-dep...

journal_title：Life sciences

authors： Czech DA,Stein EA,Blake MJ

更新日期：1983-08-22 00:00:00

abstract：AIMS:A growing body of evidence shows the cardiovascular benefits of fish oil ingredients, including eicosapentaenoic acid (EPA), in humans and experimental animals. However, the effects of EPA on endothelin (ET)-1-induced cardiomyocyte hypertrophy and the involved signaling cascade are largely unknown. A previous stud...

journal_title：Life sciences

authors： Shimojo N,Jesmin S,Sakai S,Maeda S,Miyauchi T,Mizutani T,Aonuma K,Kawano S

更新日期：2014-11-24 00:00:00

abstract：:In critically ill patients various conditions may lead to the activation of poly(ADP-ribose) polymerase (PARP). By promoting cellular energetic dysfunction, and by enhancing pro-inflammatory gene expression, PARP activation significantly contributes to the pathogenesis of shock. PARP activation is usually triggered by...

journal_title：Life sciences

authors： Horváth EM,Benko R,Gero D,Kiss L,Szabó C

更新日期：2008-01-16 00:00:00

abstract：:Among hepatic diseases, cholestatic ductopenic cholangiopathies are poorly studied, and they are rarely given the importance they deserve, especially considering their high incidence in clinical practice. Although cholestatic ductopenic cholangiopathies have different etiologies and pathogenesis, all have the same tar...

journal_title：Life sciences

authors： Salas-Silva S,Simoni-Nieves A,Lopez-Ramirez J,Bucio L,Gómez-Quiroz LE,Gutiérrez-Ruiz MC,Roma MG

更新日期：2019-02-01 00:00:00

abstract：:Nuclear factor erythroid 2-related factor 2 (Nrf-2) binds to a specific polyamine responsive element (PRE) in the promoter region of the spermidine-spermine acetyltransferase (SSAT) gene, a key component of the polyamine catabolic pathway. Regulation of SSAT gene transcription requires the additional interaction of Nr...

journal_title：Life sciences

authors： Stephenson AH,Seidel ER

更新日期：2006-08-22 00:00:00

abstract：:Oxymorphazone (at doses of 50-200 mg/kg) was found to be a relatively weak antinociceptive drug in intact frog (Rana esculenta) when acetic acid was used as pain stimulus. Frogs remained analgesic for at least 48 hrs following oxymorphazone (200 mg/kg) administration. The ligand increased the latency of wiping reflex ...

journal_title：Life sciences

authors： Benyhe S,Hoffmann G,Varga E,Hosztafi S,Toth G,Borsodi A,Wollemann M

更新日期：1989-01-01 00:00:00

abstract：AIMS:Endothelin A receptor (ET(A)R) and epidermal growth factor receptor (EGFR) cross-talk enhances the metastatic potential of epithelial ovarian cancer (EOC) cells activating different pathways, including β-catenin signalling. Here, we evaluated β-catenin as one of ET(A)R/EGFR downstream pathway in the invasive behav...

journal_title：Life sciences

authors： Cianfrocca R,Tocci P,Spinella F,Di Castro V,Bagnato A,Rosanò L

更新日期：2012-10-15 00:00:00

abstract：:Neuropeptide Y (NPY) is a major hypothalamic peptide which is implicated in the regulation of energy balance and in the activation of the hypothalamo-pituitary adrenal axis. This study aimed primarily to determine the effects on regional hypothalamic NPY levels, of catabolism and weight loss induced in rats by the syn...

journal_title：Life sciences

authors： McKibbin PE,Cotton SJ,McCarthy HD,Williams G

更新日期：1992-01-01 00:00:00

abstract：:Visual evoked responses (VER) to counterphased gratings were recorded from area 17 of cat visual cortex prior to and following administration of diisopropylfluorophosphate (DFP). The VER and acetylcholinesterase (AChE) activity of blood, retina, and visual cortex were reduced significantly following DFP administration...

journal_title：Life sciences

authors： Kirby AW,Harding TH,Wiley RW

更新日期：1987-12-14 00:00:00

abstract：:This study was designed to evaluate the synergistic cytotoxicity of herb prescription, Palgin, in adriamycin-treated cancer cells. The combination of Palgin and adriamycin synergistically augmented the cytotoxicity of Chang and HL-60 cells, but not in Hep3B and Alexander cells. The cytotoxicity of two drugs was reveal...

journal_title：Life sciences

authors： Lim YS,So HS,Kim MS,Moon G,Won JH,Baek SW,Moon SR,Yang SH,Kim BJ,Ko CB,Park R

更新日期：2002-10-04 00:00:00

abstract：:Intravenous injection of prostacyclin (100 micrograms/kg) in rats resulted in a decrease of systolic blood pressure within 2 minutes. Concentrations of cAMP in 15 brain regions and nuclei were determined by radioimmunoassay. In lower brain stem nuclei, such as the nucleus of the solitary tract and the lateral reticula...

journal_title：Life sciences

authors： Schmid G,Bahner U,Palkovits M,Geiger H,Heidland A

更新日期：1987-12-07 00:00:00

abstract：:When HeLa cells were incubated with tritiated dexamethasone mesylate at 2 degrees C, sodium dodecyl sulfate-polyacrylamide gel electrophoresis of cytosolic and nuclear extracts revealed the presence of two monomeric receptor complex forms with estimated molecular masses of about 98 and 87 kDa. If cells were subjected ...

journal_title：Life sciences

authors： Rossini GP,Malaguti C

更新日期：1992-01-01 00:00:00

abstract：AIMS:Circular RNAs (circRNAs) are relevant to atherosclerosis progression. However, the role and mechanism of circRNA hsa_circ_0029589 (circ_0029589) in atherosclerosis are not fully understood. This research aims to explore the function and mechanism of circ_0029589 in oxidized low-density lipoprotein (ox-LDL)-caused ...

journal_title：Life sciences

authors： Huang Z,Li P,Wu L,Zhang D,Du B,Liang C,Gao L,Zhang Y,Yao R

更新日期：2020-10-15 00:00:00

abstract：:Recent studies suggest that protein kinase C and, thus, possibly the rate of inositol phospholipid hydrolysis may regulate the function and distribution of the asialoglycoprotein (or galactosyl) receptor on isolated rat hepatocytes (Takahashi et al., Biochem. Biophys. Res. Commun., 1985, 126, 1054; Fallon and Schwartz...

journal_title：Life sciences

authors： Medh JD,Haynes PA,Weigel PH,LaBelle EF

更新日期：1989-01-01 00:00:00

abstract：AIMS:Neurocardiac dysfunction is a life-threatening systemic consequence of subarachnoid hemorrhage (SAH) that contributes to triggering delayed cerebral ischemia (DCI). This study aimed to determine the impact of dobutamine cardiac support during isoflurane postconditioning on post-SAH DCI. MAIN METHODS:Male C57BL/6 ...

journal_title：Life sciences

authors： Mutoh T,Mutoh T,Sasaki K,Yamamoto Y,Tsuru Y,Tsubone H,Ishikawa T,Taki Y

更新日期：2016-05-15 00:00:00

abstract：AIMS:Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its...

journal_title：Life sciences

authors： Wang X,Pan J,Liu H,Zhang M,Liu D,Lu L,Tian J,Liu M,Jin T,An F

更新日期：2019-03-15 00:00:00

abstract：OBJECTIVE:This study aims to evaluate the effective of azoles and MTX for patients with invasive candidiasis. METHODS:We used the disk diffusion assay and the checkerboard assay to evaluate the in vitro interactions between MTX and antifungals. In addition, we used the transmission electron microscopy to observe the u...

journal_title：Life sciences

authors： Yang J,Gao L,Yu P,Kosgey JC,Jia L,Fang Y,Xiong J,Zhang F

更新日期：2019-10-15 00:00:00

abstract：:Almost all diabetic complications are known to be associated with vascular dysfunctions of different tissues. Oxidative stress, on the other hand, has been implicated in the pathogenesis of diabetes mellitus. Therefore in the present study we have investigated the correlation between redox status and oxidative stress ...

journal_title：Life sciences

authors： Yue KK,Chung WS,Leung AW,Cheng CH

更新日期：2003-10-03 00:00:00

abstract：:The objective of this study was to determine the primary event that occurs in Ca2+-regulatory sarcoplasmic-reticular (SR) proteins during subacute transition from concentric/mechanically-compensated left ventricular (LV) hypertrophy to eccentric/decompensated hypertrophy. Using Dahl salt-sensitive rats with hypertensi...

journal_title：Life sciences

authors： Yoneda T,Kihara Y,Ohkusa T,Iwanaga Y,Inagaki K,Takeuchi Y,Hayashida W,Ueyama T,Hisamatsu Y,Fujita M,Hatac S,Matsuzaki M,Sasayama S

更新日期：2001-11-30 00:00:00

abstract：:There is a growing literature indicating that opioid abuse by human addicts and opioid administration to animals have profound effects on the immune system. In the present study, implantation of morphine pellets in mice was associated with reduced phenotypic expression of the cell surface antigens specific to T-lympho...

journal_title：Life sciences

authors： Kimes AS,Smith WJ,Winchell CJ,London ED

更新日期：1992-01-01 00:00:00

abstract：:Salicylate displaces phenytoin from protein binding leading to an increase in free phenytoin concentration. We observed unexpected decreases in free phenytoin concentration in the presence of salicylate. Serum pools containing no phenytoin or salicylate were supplemented with the same concentrations of phenytoin. Then...

journal_title：Life sciences

authors： Biddle DA,Wells A,Dasgupta A

更新日期：2000-01-01 00:00:00